Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRTAP21-2 Gene

Aliases for KRTAP21-2 Gene

  • Keratin Associated Protein 21-2 2 3 5
  • KAP21.2 3 4

External Ids for KRTAP21-2 Gene

Previous GeneCards Identifiers for KRTAP21-2 Gene

  • GC00U906265
  • GC21U900113
  • GC21M031039
  • GC21M031041
  • GC21M032119
  • GC21M017528

Summaries for KRTAP21-2 Gene

GeneCards Summary for KRTAP21-2 Gene

KRTAP21-2 (Keratin Associated Protein 21-2) is a Protein Coding gene. GO annotations related to this gene include structural constituent of cutaneous appendage.

UniProtKB/Swiss-Prot for KRTAP21-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP21-2 Gene

Genomics for KRTAP21-2 Gene

Regulatory Elements for KRTAP21-2 Gene


Genomic Location for KRTAP21-2 Gene

Chromosome:
21
Start:
30,746,794 bp from pter
End:
30,747,233 bp from pter
Size:
440 bases
Orientation:
Minus strand

Genomic View for KRTAP21-2 Gene

Genes around KRTAP21-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP21-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP21-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP21-2 Gene

Proteins for KRTAP21-2 Gene

  • Protein details for KRTAP21-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI59-KR212_HUMAN
    Recommended name:
    Keratin-associated protein 21-2
    Protein Accession:
    Q3LI59

    Protein attributes for KRTAP21-2 Gene

    Size:
    83 amino acids
    Molecular mass:
    8564 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP21-2 Gene

Proteomics data for KRTAP21-2 Gene at MOPED

Post-translational modifications for KRTAP21-2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP21-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP21-2 Gene

Domains & Families for KRTAP21-2 Gene

Gene Families for KRTAP21-2 Gene

Protein Domains for KRTAP21-2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP21-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTAP21-2: view

No data available for UniProtKB/Swiss-Prot for KRTAP21-2 Gene

Function for KRTAP21-2 Gene

Molecular function for KRTAP21-2 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP21-2 Gene

genes like me logo Genes that share phenotypes with KRTAP21-2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRTAP21-2 Gene

Localization for KRTAP21-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP21-2 Gene COMPARTMENTS Subcellular localization image for KRTAP21-2 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP21-2 Gene

Pathways & Interactions for KRTAP21-2 Gene

SuperPathways for KRTAP21-2 Gene

No Data Available

Interacting Proteins for KRTAP21-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP21-2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP21-2 Gene

Drugs & Compounds for KRTAP21-2 Gene

No Compound Related Data Available

Transcripts for KRTAP21-2 Gene

mRNA/cDNA for KRTAP21-2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP21-2 Gene

No ASD Table

Relevant External Links for KRTAP21-2 Gene

GeneLoc Exon Structure for
KRTAP21-2
ECgene alternative splicing isoforms for
KRTAP21-2

Expression for KRTAP21-2 Gene

mRNA expression in normal human tissues for KRTAP21-2 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP21-2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.4), Testis (x18.2), and Skin - Sun Exposed (Lower leg) (x7.8).

SOURCE GeneReport for Unigene cluster for KRTAP21-2 Gene Hs.553699

genes like me logo Genes that share expression patterns with KRTAP21-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRTAP21-2 Gene

Orthologs for KRTAP21-2 Gene

Evolution for KRTAP21-2 Gene

ENSEMBL:
Gene Tree for KRTAP21-2 (if available)
TreeFam:
Gene Tree for KRTAP21-2 (if available)

No data available for Orthologs for KRTAP21-2 Gene

Paralogs for KRTAP21-2 Gene

(3) SIMAP similar genes for KRTAP21-2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP21-2: view

No data available for Paralogs for KRTAP21-2 Gene

Variants for KRTAP21-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP21-2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2833074 -- 30,747,258(+) TGTGA(C/G)TGTCC upstream-variant-2KB
rs2833075 -- 30,747,839(+) TCTTG(A/C)TTGAA upstream-variant-2KB
rs2833076 -- 30,748,150(+) TCATT(A/G)GATAT upstream-variant-2KB
rs5843466 -- 30,747,614(+) GAGTT(-/CTA)CTCAC upstream-variant-2KB
rs768515 -- 30,747,440(+) GAAAA(A/G)AAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP21-2 Gene

Variant ID Type Subtype PubMed ID
nsv459237 CNV Gain 19166990

Variation tolerance for KRTAP21-2 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRTAP21-2 Gene

Disorders for KRTAP21-2 Gene

Relevant External Links for KRTAP21-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP21-2

No disorders were found for KRTAP21-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP21-2 Gene

Publications for KRTAP21-2 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 67

Products for KRTAP21-2 Gene

Sources for KRTAP21-2 Gene

Content