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Aliases for KRTAP21-2 Gene

Aliases for KRTAP21-2 Gene

  • Keratin Associated Protein 21-2 2 3
  • KAP21.2 3 4
  • Keratin-Associated Protein 21-2 3

External Ids for KRTAP21-2 Gene

Summaries for KRTAP21-2 Gene

GeneCards Summary for KRTAP21-2 Gene

KRTAP21-2 (Keratin Associated Protein 21-2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP21-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP21-2 Gene

Genomics for KRTAP21-2 Gene

Genomic Location for KRTAP21-2 Gene

Start:
30,746,794 bp from pter
End:
30,747,233 bp from pter
Size:
440 bases
Orientation:
Minus strand

Genomic View for KRTAP21-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP21-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP21-2 Gene

Regulatory Elements for KRTAP21-2 Gene

Proteins for KRTAP21-2 Gene

  • Protein details for KRTAP21-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI59-KR212_HUMAN
    Recommended name:
    Keratin-associated protein 21-2
    Protein Accession:
    Q3LI59
    Secondary Accessions:

    Protein attributes for KRTAP21-2 Gene

    Size:
    83 amino acids
    Molecular mass:
    8564 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP21-2 Gene

Proteomics data for KRTAP21-2 Gene at MOPED

Post-translational modifications for KRTAP21-2 Gene

No Post-translational modifications

Other Protein References for KRTAP21-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP21-2 Gene

Domains for KRTAP21-2 Gene

Gene Families for KRTAP21-2 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP21-2 Gene

Suggested Antigen Peptide Sequences for KRTAP21-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTAP21-2: view

No data available for UniProtKB/Swiss-Prot for KRTAP21-2 Gene

Function for KRTAP21-2 Gene

Molecular function for KRTAP21-2 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP21-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030281 structural constituent of cutaneous appendage IEA --
genes like me logo Genes that share ontologies with KRTAP21-2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP21-2 Gene

Localization for KRTAP21-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP21-2 Gene COMPARTMENTS Subcellular localization image for KRTAP21-2 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP21-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP21-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP21-2 Gene

Pathways for KRTAP21-2 Gene

SuperPathways for KRTAP21-2 Gene

No Data Available

Interacting Proteins for KRTAP21-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP21-2 Gene

None

No data available for Pathways by source for KRTAP21-2 Gene

Transcripts for KRTAP21-2 Gene

mRNA/cDNA for KRTAP21-2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP21-2 Gene

No ASD Table

Relevant External Links for KRTAP21-2 Gene

GeneLoc Exon Structure for
KRTAP21-2
ECgene alternative splicing isoforms for
KRTAP21-2

Expression for KRTAP21-2 Gene

mRNA expression in normal human tissues for KRTAP21-2 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP21-2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (25.4), Testis (18.2), and Skin - Sun Exposed (Lower leg) (7.8).

SOURCE GeneReport for Unigene cluster for KRTAP21-2 Gene Hs.553699

genes like me logo Genes that share expressions with KRTAP21-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP21-2 Gene

Orthologs for KRTAP21-2 Gene

Evolution for KRTAP21-2 Gene

ENSEMBL:
Gene Tree for KRTAP21-2 (if available)
TreeFam:
Gene Tree for KRTAP21-2 (if available)

No data available for Orthologs for KRTAP21-2 Gene

Paralogs for KRTAP21-2 Gene

Selected SIMAP similar genes for KRTAP21-2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP21-2: view

No data available for Paralogs for KRTAP21-2 Gene

Variants for KRTAP21-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP21-2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs768515 -- 30,747,440(+) GAAAA(A/G)AAAAC upstream-variant-2KB
rs2833074 -- 30,747,258(+) TGTGA(C/G)TGTCC upstream-variant-2KB
rs2833075 -- 30,747,839(+) TCTTG(A/C)TTGAA upstream-variant-2KB
rs2833076 -- 30,748,150(+) TCATT(A/G)GATAT upstream-variant-2KB
rs3055206 -- 30,747,616(+) GTTCT(-/A/ACT)CACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP21-2 Gene

Variant ID Type Subtype PubMed ID
nsv459237 CNV Gain 19166990

Relevant External Links for KRTAP21-2 Gene

HapMap Linkage Disequilibrium report
KRTAP21-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP21-2 Gene

Disorders for KRTAP21-2 Gene

No disorders were found for KRTAP21-2 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP21-2 Gene

Publications for KRTAP21-2 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 4

Products for KRTAP21-2 Gene

Sources for KRTAP21-2 Gene

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