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Aliases for KRTAP21-1 Gene

Aliases for KRTAP21-1 Gene

  • Keratin Associated Protein 21-1 2 3 5
  • KAP21.1 3 4

External Ids for KRTAP21-1 Gene

Previous GeneCards Identifiers for KRTAP21-1 Gene

  • GC00U906264
  • GC21U900112
  • GC21M031047
  • GC21M031049
  • GC21M032127
  • GC21M017536

Summaries for KRTAP21-1 Gene

GeneCards Summary for KRTAP21-1 Gene

KRTAP21-1 (Keratin Associated Protein 21-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP21-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP21-1 Gene

Genomics for KRTAP21-1 Gene

Regulatory Elements for KRTAP21-1 Gene


Genomic Location for KRTAP21-1 Gene

Chromosome:
21
Start:
30,754,830 bp from pter
End:
30,755,428 bp from pter
Size:
599 bases
Orientation:
Minus strand

Genomic View for KRTAP21-1 Gene

Genes around KRTAP21-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP21-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP21-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP21-1 Gene

Proteins for KRTAP21-1 Gene

  • Protein details for KRTAP21-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI58-KR211_HUMAN
    Recommended name:
    Keratin-associated protein 21-1
    Protein Accession:
    Q3LI58

    Protein attributes for KRTAP21-1 Gene

    Size:
    79 amino acids
    Molecular mass:
    7937 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP21-1 Gene

Proteomics data for KRTAP21-1 Gene at MOPED

Post-translational modifications for KRTAP21-1 Gene

No Post-translational modifications

Other Protein References for KRTAP21-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP21-1 Gene

Domains & Families for KRTAP21-1 Gene

Gene Families for KRTAP21-1 Gene

Protein Domains for KRTAP21-1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP21-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTAP21-1: view

No data available for UniProtKB/Swiss-Prot for KRTAP21-1 Gene

Function for KRTAP21-1 Gene

Molecular function for KRTAP21-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP21-1 Gene

Localization for KRTAP21-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP21-1 Gene COMPARTMENTS Subcellular localization image for KRTAP21-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP21-1 Gene

Pathways & Interactions for KRTAP21-1 Gene

SuperPathways for KRTAP21-1 Gene

No Data Available

Interacting Proteins for KRTAP21-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP21-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP21-1 Gene

Drugs & Compounds for KRTAP21-1 Gene

No Compound Related Data Available

Transcripts for KRTAP21-1 Gene

mRNA/cDNA for KRTAP21-1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP21-1 Gene

No ASD Table

Relevant External Links for KRTAP21-1 Gene

GeneLoc Exon Structure for
KRTAP21-1
ECgene alternative splicing isoforms for
KRTAP21-1

Expression for KRTAP21-1 Gene

mRNA expression in normal human tissues for KRTAP21-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP21-1 Gene Hs.539723

genes like me logo Genes that share expression patterns with KRTAP21-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRTAP21-1 Gene

Orthologs for KRTAP21-1 Gene

Evolution for KRTAP21-1 Gene

ENSEMBL:
Gene Tree for KRTAP21-1 (if available)
TreeFam:
Gene Tree for KRTAP21-1 (if available)

No data available for Orthologs for KRTAP21-1 Gene

Paralogs for KRTAP21-1 Gene

(3) SIMAP similar genes for KRTAP21-1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRTAP21-1: view

No data available for Paralogs for KRTAP21-1 Gene

Variants for KRTAP21-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP21-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_036563 A breast cancer sample
rs998415 -- 30,756,770(-) GGGAC(G/T)AAACA upstream-variant-2KB
rs55641360 -- 30,755,323(+) CATAG(C/T)CACAG reference, missense
rs56073333 -- 30,754,880(+) GCAAC(C/T)GTAGA downstream-variant-500B
rs76860141 -- 30,754,784(+) AGATT(C/G)CAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRTAP21-1 Gene

Variant ID Type Subtype PubMed ID
nsv459237 CNV Gain 19166990

Variation tolerance for KRTAP21-1 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRTAP21-1 Gene

Disorders for KRTAP21-1 Gene

Relevant External Links for KRTAP21-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP21-1

No disorders were found for KRTAP21-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP21-1 Gene

Publications for KRTAP21-1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP21-1 Gene

Sources for KRTAP21-1 Gene

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