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Aliases for KRTAP20-4 Gene

Aliases for KRTAP20-4 Gene

  • Keratin Associated Protein 20-4 2 3 5
  • KAP20.4 3 4
  • Keratin Associated Protein 20-1 Pseudogene 3
  • Putative Keratin-Associated Protein 20-4 3

External Ids for KRTAP20-4 Gene

Previous GeneCards Identifiers for KRTAP20-4 Gene

  • GC21P030915
  • GC21U900303
  • GC21P031992
  • GC21P017401

Summaries for KRTAP20-4 Gene

GeneCards Summary for KRTAP20-4 Gene

KRTAP20-4 (Keratin Associated Protein 20-4) is a Pseudogene.

UniProtKB/Swiss-Prot for KRTAP20-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP20-4 Gene

Genomics for KRTAP20-4 Gene

Regulatory Elements for KRTAP20-4 Gene


Genomic Location for KRTAP20-4 Gene

Chromosome:
21
Start:
30,620,627 bp from pter
End:
30,620,850 bp from pter
Size:
224 bases
Orientation:
Plus strand

Genomic View for KRTAP20-4 Gene

Genes around KRTAP20-4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP20-4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP20-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP20-4 Gene

Proteins for KRTAP20-4 Gene

  • Protein details for KRTAP20-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI62-KR204_HUMAN
    Recommended name:
    Putative keratin-associated protein 20-4
    Protein Accession:
    Q3LI62

    Protein attributes for KRTAP20-4 Gene

    Size:
    44 amino acids
    Molecular mass:
    4623 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP20-4 Gene

Proteomics data for KRTAP20-4 Gene at MOPED

Post-translational modifications for KRTAP20-4 Gene

No Post-translational modifications

Other Protein References for KRTAP20-4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for KRTAP20-4 Gene

Domains & Families for KRTAP20-4 Gene

Gene Families for KRTAP20-4 Gene

Protein Domains for KRTAP20-4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP20-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI62

UniProtKB/Swiss-Prot:

KR204_HUMAN :
  • Belongs to the KRTAP type 20 family.
Family:
  • Belongs to the KRTAP type 20 family.
genes like me logo Genes that share domains with KRTAP20-4: view

Function for KRTAP20-4 Gene

Molecular function for KRTAP20-4 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP20-4 Gene

Localization for KRTAP20-4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP20-4 Gene COMPARTMENTS Subcellular localization image for KRTAP20-4 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP20-4 Gene

Pathways & Interactions for KRTAP20-4 Gene

SuperPathways for KRTAP20-4 Gene

No Data Available

Interacting Proteins for KRTAP20-4 Gene

Gene Ontology (GO) - Biological Process for KRTAP20-4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP20-4 Gene

Drugs & Compounds for KRTAP20-4 Gene

No Compound Related Data Available

Transcripts for KRTAP20-4 Gene

mRNA/cDNA for KRTAP20-4 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP20-4 Gene

No ASD Table

Relevant External Links for KRTAP20-4 Gene

GeneLoc Exon Structure for
KRTAP20-4
ECgene alternative splicing isoforms for
KRTAP20-4

Expression for KRTAP20-4 Gene

mRNA expression in normal human tissues for KRTAP20-4 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP20-4 Gene

This gene is overexpressed in Testis (x53.0).

SOURCE GeneReport for Unigene cluster for KRTAP20-4 Gene Hs.580879

genes like me logo Genes that share expression patterns with KRTAP20-4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRTAP20-4 Gene

Orthologs for KRTAP20-4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for KRTAP20-4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP20-4 36
  • 100 (a)
OneToOne
Species with no ortholog for KRTAP20-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP20-4 Gene

ENSEMBL:
Gene Tree for KRTAP20-4 (if available)
TreeFam:
Gene Tree for KRTAP20-4 (if available)

Paralogs for KRTAP20-4 Gene

No data available for Paralogs for KRTAP20-4 Gene

Variants for KRTAP20-4 Gene

Sequence variations from dbSNP and Humsavar for KRTAP20-4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2253516 -- 30,620,998(+) AAATT(C/T)GTCAA downstream-variant-500B
rs1507393 -- 30,620,460(-) GTAAC(C/T)ATTTT upstream-variant-2KB
rs1702405 -- 30,620,545(-) CCGTT(C/T)GGTTT upstream-variant-2KB
rs1785486 -- 30,619,688(+) TTAAG(C/T)TAAAA upstream-variant-2KB
rs76646043 -- 30,620,852(+) CTCCA(A/G)CTTGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRTAP20-4 Gene

Variant ID Type Subtype PubMed ID
nsv913677 CNV Loss 21882294

Variation tolerance for KRTAP20-4 Gene

Gene Damage Index Score: 0.00; 0.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRTAP20-4 Gene

Disorders for KRTAP20-4 Gene

Relevant External Links for KRTAP20-4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP20-4

No disorders were found for KRTAP20-4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP20-4 Gene

Publications for KRTAP20-4 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 67

Products for KRTAP20-4 Gene

Sources for KRTAP20-4 Gene

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