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Aliases for KRTAP20-4 Gene

Aliases for KRTAP20-4 Gene

  • Keratin Associated Protein 20-4 2 3
  • KAP20.4 3 4
  • Keratin Associated Protein 20-1 Pseudogene 3
  • Putative Keratin-Associated Protein 20-4 3

External Ids for KRTAP20-4 Gene

Previous GeneCards Identifiers for KRTAP20-4 Gene

  • GC21P030915
  • GC21U900303
  • GC21P031992
  • GC21P017401

Summaries for KRTAP20-4 Gene

GeneCards Summary for KRTAP20-4 Gene

KRTAP20-4 (Keratin Associated Protein 20-4) is a Pseudogene.

UniProtKB/Swiss-Prot for KRTAP20-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP20-4 Gene

Genomics for KRTAP20-4 Gene

Regulatory Elements for KRTAP20-4 Gene

Genomic Location for KRTAP20-4 Gene

Start:
30,620,627 bp from pter
End:
30,620,850 bp from pter
Size:
224 bases
Orientation:
Plus strand

Genomic View for KRTAP20-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP20-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP20-4 Gene

Proteins for KRTAP20-4 Gene

  • Protein details for KRTAP20-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI62-KR204_HUMAN
    Recommended name:
    Putative keratin-associated protein 20-4
    Protein Accession:
    Q3LI62
    Secondary Accessions:

    Protein attributes for KRTAP20-4 Gene

    Size:
    44 amino acids
    Molecular mass:
    4623 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP20-4 Gene

Proteomics data for KRTAP20-4 Gene at MOPED

Post-translational modifications for KRTAP20-4 Gene

No Post-translational modifications

Other Protein References for KRTAP20-4 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for KRTAP20-4 Gene

Domains for KRTAP20-4 Gene

Gene Families for KRTAP20-4 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP20-4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP20-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI62

UniProtKB/Swiss-Prot:

KR204_HUMAN :
  • Q3LI62
Family:
  • Belongs to the KRTAP type 20 family.
genes like me logo Genes that share domains with KRTAP20-4: view

Function for KRTAP20-4 Gene

Molecular function for KRTAP20-4 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP20-4 Gene

Localization for KRTAP20-4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP20-4 Gene COMPARTMENTS Subcellular localization image for KRTAP20-4 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRTAP20-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP20-4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP20-4 Gene

Pathways for KRTAP20-4 Gene

SuperPathways for KRTAP20-4 Gene

No Data Available

Interacting Proteins for KRTAP20-4 Gene

Gene Ontology (GO) - Biological Process for KRTAP20-4 Gene

None

No data available for Pathways by source for KRTAP20-4 Gene

Transcripts for KRTAP20-4 Gene

mRNA/cDNA for KRTAP20-4 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP20-4
    • Block miRNA regulation of KRTAP20-4 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP20-4

    Primer Products

    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP20-4 Gene

    No ASD Table

    Relevant External Links for KRTAP20-4 Gene

    GeneLoc Exon Structure for
    KRTAP20-4
    ECgene alternative splicing isoforms for
    KRTAP20-4

    Expression for KRTAP20-4 Gene

    mRNA expression in normal human tissues for KRTAP20-4 Gene

    mRNA differential expression in normal tissues according to GTEx for KRTAP20-4 Gene

    This gene is overexpressed in Testis (53.0).

    SOURCE GeneReport for Unigene cluster for KRTAP20-4 Gene Hs.580879

    genes like me logo Genes that share expressions with KRTAP20-4: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP20-4 Gene

    Orthologs for KRTAP20-4 Gene

    This gene was present in the common ancestor of human and chimp.

    Orthologs for KRTAP20-4 Gene

    Organism Taxonomy Gene Similarity Type Details
    chimpanzee
    (Pan troglodytes)
    Mammalia KRTAP20-4 36
    • 100 (a)
    OneToOne
    Species with no ortholog for KRTAP20-4:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • chicken (Gallus gallus)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • cow (Bos Taurus)
    • dog (Canis familiaris)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • lizard (Anolis carolinensis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • mouse (Mus musculus)
    • oppossum (Monodelphis domestica)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • platypus (Ornithorhynchus anatinus)
    • rainbow trout (Oncorhynchus mykiss)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)
    • zebrafish (Danio rerio)

    Evolution for KRTAP20-4 Gene

    ENSEMBL:
    Gene Tree for KRTAP20-4 (if available)
    TreeFam:
    Gene Tree for KRTAP20-4 (if available)

    Paralogs for KRTAP20-4 Gene

    No data available for Paralogs for KRTAP20-4 Gene

    Variants for KRTAP20-4 Gene

    Sequence variations from dbSNP and Humsavar for KRTAP20-4 Gene

    SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
    rs1507393 -- 30,620,460(-) GTAAC(C/T)ATTTT upstream-variant-2KB
    rs1702405 -- 30,620,545(-) CCGTT(C/T)GGTTT upstream-variant-2KB
    rs1785486 -- 30,619,688(+) TTAAG(C/T)TAAAA upstream-variant-2KB
    rs2253516 -- 30,620,998(+) AAATT(C/T)GTCAA downstream-variant-500B
    rs76646043 -- 30,620,852(+) CTCCA(A/G)CTTGA downstream-variant-500B

    Structural Variations from Database of Genomic Variants (DGV) for KRTAP20-4 Gene

    Variant ID Type Subtype PubMed ID
    nsv913677 CNV Loss 21882294

    Relevant External Links for KRTAP20-4 Gene

    HapMap Linkage Disequilibrium report
    KRTAP20-4

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP20-4 Gene

    Disorders for KRTAP20-4 Gene

    No disorders were found for KRTAP20-4 Gene.

    No data available for UniProtKB/Swiss-Prot for KRTAP20-4 Gene

    Publications for KRTAP20-4 Gene

    1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3

    Products for KRTAP20-4 Gene

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP20-4
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat
      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP20-4
      • Block miRNA regulation of KRTAP20-4 using miScript Target Protectors

      Sources for KRTAP20-4 Gene

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