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Aliases for KRTAP20-2 Gene

Aliases for KRTAP20-2 Gene

  • Keratin Associated Protein 20-2 2 3
  • KAP20.2 3 4
  • Keratin-Associated Protein 20-2 3

External Ids for KRTAP20-2 Gene

Previous GeneCards Identifiers for KRTAP20-2 Gene

  • GC00U906263
  • GC21U900111
  • GC21P030929
  • GC21P030930
  • GC21P032007
  • GC21P017416

Summaries for KRTAP20-2 Gene

GeneCards Summary for KRTAP20-2 Gene

KRTAP20-2 (Keratin Associated Protein 20-2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP20-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP20-2 Gene

Genomics for KRTAP20-2 Gene

Regulatory Elements for KRTAP20-2 Gene

Genomic Location for KRTAP20-2 Gene

Start:
30,635,236 bp from pter
End:
30,635,619 bp from pter
Size:
384 bases
Orientation:
Plus strand

Genomic View for KRTAP20-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP20-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP20-2 Gene

Proteins for KRTAP20-2 Gene

  • Protein details for KRTAP20-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI61-KR202_HUMAN
    Recommended name:
    Keratin-associated protein 20-2
    Protein Accession:
    Q3LI61
    Secondary Accessions:

    Protein attributes for KRTAP20-2 Gene

    Size:
    65 amino acids
    Molecular mass:
    6961 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP20-2 Gene

Proteomics data for KRTAP20-2 Gene at MOPED

Post-translational modifications for KRTAP20-2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP20-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP20-2 Gene

Domains for KRTAP20-2 Gene

Gene Families for KRTAP20-2 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP20-2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP20-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI61

UniProtKB/Swiss-Prot:

KR202_HUMAN :
  • Q3LI61
Family:
  • Belongs to the KRTAP type 20 family.
genes like me logo Genes that share domains with KRTAP20-2: view

Function for KRTAP20-2 Gene

Molecular function for KRTAP20-2 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Phenotypes for KRTAP20-2 Gene

GenomeRNAi human phenotypes for KRTAP20-2:
genes like me logo Genes that share phenotypes with KRTAP20-2: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP20-2
    • Block miRNA regulation of KRTAP20-2 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP20-2

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP20-2 Gene

    Localization for KRTAP20-2 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP20-2 Gene COMPARTMENTS Subcellular localization image for KRTAP20-2 gene
    Compartment Confidence
    cytoskeleton 3
    extracellular 3

    Gene Ontology (GO) - Cellular Components for KRTAP20-2 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005882 intermediate filament IEA --
    genes like me logo Genes that share ontologies with KRTAP20-2: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP20-2 Gene

    Pathways for KRTAP20-2 Gene

    SuperPathways for KRTAP20-2 Gene

    No Data Available

    Interacting Proteins for KRTAP20-2 Gene

    Gene Ontology (GO) - Biological Process for KRTAP20-2 Gene

    None

    No data available for Pathways by source for KRTAP20-2 Gene

    Transcripts for KRTAP20-2 Gene

    mRNA/cDNA for KRTAP20-2 Gene

    (1) REFSEQ mRNAs :
    (1) Selected AceView cDNA sequences:
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP20-2
      • Block miRNA regulation of KRTAP20-2 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP20-2

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP20-2 Gene

      No ASD Table

      Relevant External Links for KRTAP20-2 Gene

      GeneLoc Exon Structure for
      KRTAP20-2
      ECgene alternative splicing isoforms for
      KRTAP20-2

      Expression for KRTAP20-2 Gene

      mRNA expression in normal human tissues for KRTAP20-2 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP20-2 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (42.0) and Skin - Sun Exposed (Lower leg) (8.5).

      Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP20-2 Gene

      SOURCE GeneReport for Unigene cluster for KRTAP20-2 Gene Hs.553698

      genes like me logo Genes that share expressions with KRTAP20-2: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRTAP20-2 Gene

      Orthologs for KRTAP20-2 Gene

      This gene was present in the common ancestor of human and mouse.

      Orthologs for KRTAP20-2 Gene

      Organism Taxonomy Gene Similarity Type Details
      mouse
      (Mus musculus)
      Mammalia Krtap20-2 16
      Species with no ortholog for KRTAP20-2:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • chimpanzee (Pan troglodytes)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP20-2 Gene

      ENSEMBL:
      Gene Tree for KRTAP20-2 (if available)
      TreeFam:
      Gene Tree for KRTAP20-2 (if available)

      Paralogs for KRTAP20-2 Gene

      No data available for Paralogs for KRTAP20-2 Gene

      Variants for KRTAP20-2 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP20-2 Gene

      SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
      rs198867 -- 30,635,956(+) ATTAT(A/C)TTTTG downstream-variant-500B
      rs8131539 - 30,635,301(+) GCGTT(A/G)TGGCT reference, missense
      rs8131999 -- 30,635,628(+) AGAGT(A/C)ACTGA downstream-variant-500B
      rs8132507 -- 30,635,688(+) GTACT(A/G)TCATT downstream-variant-500B
      rs8132553 -- 30,635,881(+) TTCTT(C/T)GGAGC downstream-variant-500B

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP20-2 Gene

      Variant ID Type Subtype PubMed ID
      nsv913677 CNV Loss 21882294

      Relevant External Links for KRTAP20-2 Gene

      HapMap Linkage Disequilibrium report
      KRTAP20-2

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP20-2 Gene

      Disorders for KRTAP20-2 Gene

      No disorders were found for KRTAP20-2 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP20-2 Gene

      Publications for KRTAP20-2 Gene

      1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
      2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
      3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

      Products for KRTAP20-2 Gene

      Sources for KRTAP20-2 Gene

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