Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRTAP20-1 Gene

Aliases for KRTAP20-1 Gene

  • Keratin Associated Protein 20-1 2 3
  • KAP20.1 3 4
  • Keratin-Associated Protein 20-1 3

External Ids for KRTAP20-1 Gene

Summaries for KRTAP20-1 Gene

GeneCards Summary for KRTAP20-1 Gene

KRTAP20-1 (Keratin Associated Protein 20-1) is a Protein Coding gene. Diseases associated with KRTAP20-1 include colorectal cancer.

UniProtKB/Swiss-Prot for KRTAP20-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP20-1 Gene

Genomics for KRTAP20-1 Gene

Genomic Location for KRTAP20-1 Gene

Start:
30,616,425 bp from pter
End:
30,616,699 bp from pter
Size:
275 bases
Orientation:
Plus strand

Genomic View for KRTAP20-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP20-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP20-1 Gene

Regulatory Elements for KRTAP20-1 Gene

Proteins for KRTAP20-1 Gene

  • Protein details for KRTAP20-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI63-KR201_HUMAN
    Recommended name:
    Keratin-associated protein 20-1
    Protein Accession:
    Q3LI63
    Secondary Accessions:

    Protein attributes for KRTAP20-1 Gene

    Size:
    56 amino acids
    Molecular mass:
    6202 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP20-1 Gene

Proteomics data for KRTAP20-1 Gene at MOPED

Post-translational modifications for KRTAP20-1 Gene

No Post-translational modifications

Other Protein References for KRTAP20-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP20-1 Gene

Domains for KRTAP20-1 Gene

Gene Families for KRTAP20-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP20-1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KR201_HUMAN
Family:
  • Belongs to the KRTAP type 20 family.:
    • Q3LI63
genes like me logo Genes that share domains with KRTAP20-1: view

Function for KRTAP20-1 Gene

Molecular function for KRTAP20-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP20-1 Gene

Localization for KRTAP20-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP20-1 Gene COMPARTMENTS Subcellular localization image for KRTAP20-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 3

Gene Ontology (GO) - Cellular Components for KRTAP20-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP20-1: view

Pathways for KRTAP20-1 Gene

SuperPathways for KRTAP20-1 Gene

No Data Available

Interacting Proteins for KRTAP20-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP20-1 Gene

None

No data available for Pathways by source for KRTAP20-1 Gene

Transcripts for KRTAP20-1 Gene

mRNA/cDNA for KRTAP20-1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP20-1 Gene

No ASD Table

Relevant External Links for KRTAP20-1 Gene

GeneLoc Exon Structure for
KRTAP20-1
ECgene alternative splicing isoforms for
KRTAP20-1

Expression for KRTAP20-1 Gene

mRNA expression in normal human tissues for KRTAP20-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP20-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (39.5) and Skin - Sun Exposed (Lower leg) (13.6).

SOURCE GeneReport for Unigene cluster for KRTAP20-1 Gene Hs.553697

genes like me logo Genes that share expressions with KRTAP20-1: view

Orthologs for KRTAP20-1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for KRTAP20-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP20-1 37
  • 98 (a)
OneToOne
Species with no ortholog for KRTAP20-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP20-1 Gene

ENSEMBL:
Gene Tree for KRTAP20-1 (if available)
TreeFam:
Gene Tree for KRTAP20-1 (if available)

Paralogs for KRTAP20-1 Gene

No data available for Paralogs for KRTAP20-1 Gene

Variants for KRTAP20-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP20-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1507392 -- 30,615,979(+) CCTTA(A/G)GCACA upstream-variant-2KB
rs1702403 -- 30,616,796(+) GAATA(G/T)GTTTT downstream-variant-500B
rs1785485 -- 30,616,801(+) GGTTT(C/T)AAAAT downstream-variant-500B
rs34500571 -- 30,617,072(+) ACTTG(-/T)AGCTT downstream-variant-500B
rs34890804 -- 30,617,073(+) CTTGA(-/T)GCTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRTAP20-1 Gene

Variant ID Type Subtype PubMed ID
nsv913677 CNV Loss 21882294

Relevant External Links for KRTAP20-1 Gene

HapMap Linkage Disequilibrium report
KRTAP20-1

Disorders for KRTAP20-1 Gene

(1) MalaCards Diseases for KRTAP20-1 Gene

Search for KRTAP20-1 Gene in MalaCards »
genes like me logo Genes that share disorders with KRTAP20-1: view

No data available for UniProtKB/Swiss-Prot for KRTAP20-1 Gene

Publications for KRTAP20-1 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP20-1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP20-1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP20-1
    • Block miRNA regulation of KRTAP20-1 using miScript Target Protectors

    Sources for KRTAP20-1 Gene

    Back to Top

    Content