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Aliases for KRTAP2-4 Gene

Aliases for KRTAP2-4 Gene

  • Keratin Associated Protein 2-4 2 3
  • High Sulfur Keratin-Associated Protein 2.4 3 4
  • Keratin-Associated Protein 2.4 3 4
  • KRTAP2.4 3 4
  • KAP2.4 3 4
  • Keratin Associated Protein 2.1B 3
  • Keratin-Associated Protein 2-4 3
  • KAP2.1B 3

External Ids for KRTAP2-4 Gene

Previous GeneCards Identifiers for KRTAP2-4 Gene

  • GC17M038721
  • GC00P9J0132
  • GC17M039130
  • GC17M039594
  • GC17P9W0062
  • GC17M036474
  • GC17M039221

Summaries for KRTAP2-4 Gene

Entrez Gene Summary for KRTAP2-4 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRTAP2-4 Gene

KRTAP2-4 (Keratin Associated Protein 2-4) is a Protein Coding gene. An important paralog of this gene is KRTAP2-2.

UniProtKB/Swiss-Prot for KRTAP2-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP2-4 Gene

Genomics for KRTAP2-4 Gene

Regulatory Elements for KRTAP2-4 Gene

Genomic Location for KRTAP2-4 Gene

Start:
41,065,116 bp from pter
End:
41,065,879 bp from pter
Size:
764 bases
Orientation:
Minus strand

Genomic View for KRTAP2-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP2-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP2-4 Gene

Proteins for KRTAP2-4 Gene

  • Protein details for KRTAP2-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYR9-KRA24_HUMAN
    Recommended name:
    Keratin-associated protein 2-4
    Protein Accession:
    Q9BYR9
    Secondary Accessions:
    • Q495J2

    Protein attributes for KRTAP2-4 Gene

    Size:
    128 amino acids
    Molecular mass:
    13480 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP2-4 Gene

Proteomics data for KRTAP2-4 Gene at MOPED

Post-translational modifications for KRTAP2-4 Gene

No Post-translational modifications

Other Protein References for KRTAP2-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP2-4 Gene

Domains for KRTAP2-4 Gene

Gene Families for KRTAP2-4 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP2-4 Gene

Suggested Antigen Peptide Sequences for KRTAP2-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYR9

UniProtKB/Swiss-Prot:

KRA24_HUMAN :
  • Q9BYR9
Family:
  • Belongs to the KRTAP type 2 family.
genes like me logo Genes that share domains with KRTAP2-4: view

Function for KRTAP2-4 Gene

Molecular function for KRTAP2-4 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP2-4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP2-4 Gene

Localization for KRTAP2-4 Gene

Gene Ontology (GO) - Cellular Components for KRTAP2-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP2-4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KRTAP2-4 Gene

Pathways for KRTAP2-4 Gene

SuperPathways for KRTAP2-4 Gene

No Data Available

Interacting Proteins for KRTAP2-4 Gene

Gene Ontology (GO) - Biological Process for KRTAP2-4 Gene

None

No data available for Pathways by source for KRTAP2-4 Gene

Transcripts for KRTAP2-4 Gene

mRNA/cDNA for KRTAP2-4 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP2-4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP2-4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP2-4 Gene

No ASD Table

Relevant External Links for KRTAP2-4 Gene

GeneLoc Exon Structure for
KRTAP2-4
ECgene alternative splicing isoforms for
KRTAP2-4

Expression for KRTAP2-4 Gene

mRNA expression in normal human tissues for KRTAP2-4 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP2-4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (49.1).

SOURCE GeneReport for Unigene cluster for KRTAP2-4 Gene Hs.560502

mRNA Expression by UniProt/SwissProt for KRTAP2-4 Gene

Q9BYR9-KRA24_HUMAN
Tissue specificity: Expressed specifically in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
genes like me logo Genes that share expressions with KRTAP2-4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP2-4 Gene

Orthologs for KRTAP2-4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP2-4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToMany
LOC468246 35
  • 99.22 (n)
  • 98.44 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
LOC777598 35
  • 88.8 (n)
  • 86.4 (a)
dog
(Canis familiaris)
Mammalia LOC102157302 35
  • 87.5 (n)
  • 83.59 (a)
mouse
(Mus musculus)
Mammalia Gm11562 36
  • 82 (a)
ManyToMany
Gm11937 36
  • 85 (a)
ManyToMany
Gm11938 36
  • 85 (a)
ManyToMany
Krtap2-4 35
  • 86.09 (n)
  • 88.19 (a)
Krtap2-4 36
  • 85 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia RGD1561684 35
  • 85.98 (n)
  • 88.1 (a)
Species with no ortholog for KRTAP2-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP2-4 Gene

ENSEMBL:
Gene Tree for KRTAP2-4 (if available)
TreeFam:
Gene Tree for KRTAP2-4 (if available)

Paralogs for KRTAP2-4 Gene

Paralogs for KRTAP2-4 Gene

Selected SIMAP similar genes for KRTAP2-4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP2-4: view

Variants for KRTAP2-4 Gene

Sequence variations from dbSNP and Humsavar for KRTAP2-4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs193244 -- 41,066,364(+) GTCAT(C/T)TGCTT upstream-variant-2KB
rs349782 -- 41,065,513(+) CAGGG(A/G)GGCCG reference, synonymous-codon
rs508285 -- 41,065,816(+) GAGGA(C/G)AAGGT missense, reference
rs509086 -- 41,065,877(+) GGGCT(A/G)TTGAG utr-variant-5-prime
rs509089 -- 41,065,879(+) GCTAT(G/T)GAGAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTAP2-4 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
dgv3167n71 CNV Loss 21882294
nsv908232 CNV Loss 21882294
esv2751681 CNV Loss 17911159
nsv833446 CNV Gain 17160897

Relevant External Links for KRTAP2-4 Gene

HapMap Linkage Disequilibrium report
KRTAP2-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP2-4 Gene

Disorders for KRTAP2-4 Gene

No disorders were found for KRTAP2-4 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP2-4 Gene

Publications for KRTAP2-4 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for KRTAP2-4 Gene

Sources for KRTAP2-4 Gene

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