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Aliases for KRTAP2-3 Gene

Aliases for KRTAP2-3 Gene

  • Keratin Associated Protein 2-3 2 3
  • High Sulfur Keratin-Associated Protein 2.4 3 4
  • Keratin-Associated Protein 2.3 3 4
  • KRTAP2.3 3 4
  • KAP2.3 3 4
  • Keratin-Associated Protein 2-3 3

External Ids for KRTAP2-3 Gene

Summaries for KRTAP2-3 Gene

GeneCards Summary for KRTAP2-3 Gene

KRTAP2-3 (Keratin Associated Protein 2-3) is a Protein Coding gene. An important paralog of this gene is KRTAP2-2.

UniProtKB/Swiss-Prot for KRTAP2-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP2-3 Gene

Genomics for KRTAP2-3 Gene

Genomic Location for KRTAP2-3 Gene

Start:
41,059,240 bp from pter
End:
41,060,114 bp from pter
Size:
875 bases
Orientation:
Minus strand

Genomic View for KRTAP2-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP2-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP2-3 Gene

No data available for Regulatory Elements for KRTAP2-3 Gene

Proteins for KRTAP2-3 Gene

  • Protein details for KRTAP2-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7H8-KRA23_HUMAN
    Recommended name:
    Keratin-associated protein 2-3
    Protein Accession:
    P0C7H8
    Secondary Accessions:

    Protein attributes for KRTAP2-3 Gene

    Size:
    128 amino acids
    Molecular mass:
    13480 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP2-3 Gene

Proteomics data for KRTAP2-3 Gene at MOPED

Post-translational modifications for KRTAP2-3 Gene

No Post-translational modifications

Other Protein References for KRTAP2-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP2-3 Gene

Domains for KRTAP2-3 Gene

Gene Families for KRTAP2-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP2-3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP2-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7H8

UniProtKB/Swiss-Prot:

KRA23_HUMAN
Family:
  • Belongs to the KRTAP type 2 family.:
    • P0C7H8
genes like me logo Genes that share domains with KRTAP2-3: view

Function for KRTAP2-3 Gene

Molecular function for KRTAP2-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Gene Ontology (GO) - Molecular Function for KRTAP2-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP2-3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP2-3 Gene

Localization for KRTAP2-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP2-3 Gene COMPARTMENTS Subcellular localization image for KRTAP2-3 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP2-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP2-3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP2-3 Gene

Pathways for KRTAP2-3 Gene

SuperPathways for KRTAP2-3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP2-3 Gene

None

No data available for Pathways by source for KRTAP2-3 Gene

Transcripts for KRTAP2-3 Gene

mRNA/cDNA for KRTAP2-3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP2-3 Gene

Keratin associated protein 2-3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP2-3 Gene

No ASD Table

Relevant External Links for KRTAP2-3 Gene

GeneLoc Exon Structure for
KRTAP2-3
ECgene alternative splicing isoforms for
KRTAP2-3

Expression for KRTAP2-3 Gene

mRNA expression in normal human tissues for KRTAP2-3 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP2-3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (46.7).

SOURCE GeneReport for Unigene cluster for KRTAP2-3 Gene Hs.406714

genes like me logo Genes that share expressions with KRTAP2-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP2-3 Gene

Orthologs for KRTAP2-3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP2-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToMany
LOC468246 35
  • 98.96 (n)
  • 98.44 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
LOC777598 35
  • 88.53 (n)
  • 86.4 (a)
dog
(Canis familiaris)
Mammalia LOC102157302 35
  • 87.24 (n)
  • 83.59 (a)
mouse
(Mus musculus)
Mammalia Gm11562 36
  • 82 (a)
ManyToMany
Gm11937 36
  • 85 (a)
ManyToMany
Gm11938 16
Gm11938 36
  • 85 (a)
ManyToMany
Krtap2-4 35
  • 85.83 (n)
  • 88.19 (a)
Krtap2-4 36
  • 85 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia RGD1561684 35
  • 85.71 (n)
  • 88.1 (a)
Species with no ortholog for KRTAP2-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP2-3 Gene

ENSEMBL:
Gene Tree for KRTAP2-3 (if available)
TreeFam:
Gene Tree for KRTAP2-3 (if available)

Paralogs for KRTAP2-3 Gene

Paralogs for KRTAP2-3 Gene

Selected SIMAP similar genes for KRTAP2-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP2-3: view

Variants for KRTAP2-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP2-3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs349774 -- 41,060,286(+) TGTCT(A/G)CTTTT upstream-variant-2KB
rs349775 -- 41,060,344(+) CATCT(A/C/T)TCAGC upstream-variant-2KB
rs349776 -- 41,060,769(+) AGTTT(C/T)CTATC upstream-variant-2KB
rs349777 -- 41,061,127(+) TAGTT(G/T)AGCTG upstream-variant-2KB
rs382513 -- 41,058,921(+) ACTTA(A/G)CTTAG downstream-variant-500B

Relevant External Links for KRTAP2-3 Gene

HapMap Linkage Disequilibrium report
KRTAP2-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRTAP2-3 Gene

Disorders for KRTAP2-3 Gene

No disorders were found for KRTAP2-3 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP2-3 Gene

Publications for KRTAP2-3 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for KRTAP2-3 Gene

Sources for KRTAP2-3 Gene

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