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Aliases for KRTAP2-2 Gene

Aliases for KRTAP2-2 Gene

  • Keratin Associated Protein 2-2 2 3
  • KAP2.2 3 4
  • Putative Keratin-Associated Protein ENSP00000381495 3
  • High Sulfur Keratin-Associated Protein 2.2 4
  • Keratin-Associated Protein 2.2 4
  • KRTAP2.2 4

External Ids for KRTAP2-2 Gene

Summaries for KRTAP2-2 Gene

GeneCards Summary for KRTAP2-2 Gene

KRTAP2-2 (Keratin Associated Protein 2-2) is a Protein Coding gene. An important paralog of this gene is KRTAP2-3.

UniProtKB/Swiss-Prot for KRTAP2-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP2-2 Gene

Genomics for KRTAP2-2 Gene

Genomic Location for KRTAP2-2 Gene

Start:
41,054,498 bp from pter
End:
41,055,230 bp from pter
Size:
733 bases
Orientation:
Minus strand

Genomic View for KRTAP2-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP2-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP2-2 Gene

Regulatory Elements for KRTAP2-2 Gene

Proteins for KRTAP2-2 Gene

  • Protein details for KRTAP2-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYT5-KRA22_HUMAN
    Recommended name:
    Keratin-associated protein 2-2
    Protein Accession:
    Q9BYT5
    Secondary Accessions:
    • A8MTN3
    • A8MXM4

    Protein attributes for KRTAP2-2 Gene

    Size:
    123 amino acids
    Molecular mass:
    12957 Da
    Quaternary structure:
    • Interacts with hair keratins.
    SequenceCaution:
    • Sequence=CAC27564.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The N-terminal part is identical to the product of the KRTAP2-3 gene.; Evidence={ECO:0000305};

neXtProt entry for KRTAP2-2 Gene

Proteomics data for KRTAP2-2 Gene at MOPED

Post-translational modifications for KRTAP2-2 Gene

No Post-translational modifications

Other Protein References for KRTAP2-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP2-2 Gene

Domains for KRTAP2-2 Gene

Gene Families for KRTAP2-2 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP2-2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA22_HUMAN
Family:
  • Belongs to the KRTAP type 2 family.:
    • Q9BYT5
genes like me logo Genes that share domains with KRTAP2-2: view

Function for KRTAP2-2 Gene

Molecular function for KRTAP2-2 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP2-2 Gene

Localization for KRTAP2-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP2-2 Gene COMPARTMENTS Subcellular localization image for KRTAP2-2 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP2-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament --
genes like me logo Genes that share ontologies with KRTAP2-2: view

Pathways for KRTAP2-2 Gene

SuperPathways for KRTAP2-2 Gene

No Data Available

Interacting Proteins for KRTAP2-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP2-2 Gene

None

No data available for Pathways by source for KRTAP2-2 Gene

Transcripts for KRTAP2-2 Gene

mRNA/cDNA for KRTAP2-2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP2-2 Gene

Keratin associated protein 2-2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP2-2 Gene

No ASD Table

Relevant External Links for KRTAP2-2 Gene

GeneLoc Exon Structure for
KRTAP2-2
ECgene alternative splicing isoforms for
KRTAP2-2

Expression for KRTAP2-2 Gene

mRNA expression in normal human tissues for KRTAP2-2 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP2-2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.9) and Skin - Sun Exposed (Lower leg) (5.0).

SOURCE GeneReport for Unigene cluster for KRTAP2-2 Gene Hs.650131

genes like me logo Genes that share expressions with KRTAP2-2: view

Orthologs for KRTAP2-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP2-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 88 (a)
OneToMany
KRTAP2-4 36
  • 98.1 (n)
  • 97.56 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 83 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
-- 37
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm11562 37
  • 79 (a)
ManyToMany
Gm11937 37
  • 82 (a)
ManyToMany
Gm11938 37
  • 82 (a)
ManyToMany
Krtap2-4 37
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 46 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
Species with no ortholog for KRTAP2-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP2-2 Gene

ENSEMBL:
Gene Tree for KRTAP2-2 (if available)
TreeFam:
Gene Tree for KRTAP2-2 (if available)

Paralogs for KRTAP2-2 Gene

Paralogs for KRTAP2-2 Gene

Selected SIMAP similar genes for KRTAP2-2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRTAP2-2: view

Variants for KRTAP2-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP2-2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs365424 -- 41,055,656(+) GTTAG(C/T)ATTCT upstream-variant-2KB
rs366640 -- 41,056,891(+) CAGCC(A/T)CTTCA upstream-variant-2KB
rs384845 -- 41,054,520(+) TTGAG(C/T)TTATT utr-variant-3-prime
rs385843 -- 41,056,830(+) TAAGC(A/C)TTCTT upstream-variant-2KB
rs386298 -- 41,056,252(+) CTAAT(G/T)TTTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP2-2 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
dgv3167n71 CNV Loss 21882294
nsv908232 CNV Loss 21882294
esv24780 CNV Loss 19812545
esv2751681 CNV Loss 17911159

Relevant External Links for KRTAP2-2 Gene

HapMap Linkage Disequilibrium report
KRTAP2-2

Disorders for KRTAP2-2 Gene

No disorders were found for KRTAP2-2 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP2-2 Gene

Publications for KRTAP2-2 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for KRTAP2-2 Gene

Sources for KRTAP2-2 Gene

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