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Aliases for KRTAP19-7 Gene

Aliases for KRTAP19-7 Gene

  • Keratin Associated Protein 19-7 2 3
  • KAP19.7 3 4
  • Keratin-Associated Protein 19-7 3

External Ids for KRTAP19-7 Gene

Previous GeneCards Identifiers for KRTAP19-7 Gene

  • GC21U900024
  • GC21M030853
  • GC21M030855
  • GC21M031933
  • GC21M017342

Summaries for KRTAP19-7 Gene

GeneCards Summary for KRTAP19-7 Gene

KRTAP19-7 (Keratin Associated Protein 19-7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP19-7 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP19-7 Gene

Genomics for KRTAP19-7 Gene

Regulatory Elements for KRTAP19-7 Gene

Genomic Location for KRTAP19-7 Gene

Start:
30,541,660 bp from pter
End:
30,561,314 bp from pter
Size:
19,655 bases
Orientation:
Minus strand

Genomic View for KRTAP19-7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP19-7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP19-7 Gene

Proteins for KRTAP19-7 Gene

  • Protein details for KRTAP19-7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SYF9-KR197_HUMAN
    Recommended name:
    Keratin-associated protein 19-7
    Protein Accession:
    Q3SYF9
    Secondary Accessions:
    • Q08EP7

    Protein attributes for KRTAP19-7 Gene

    Size:
    63 amino acids
    Molecular mass:
    6644 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP19-7 Gene

Proteomics data for KRTAP19-7 Gene at MOPED

Post-translational modifications for KRTAP19-7 Gene

No Post-translational modifications

Other Protein References for KRTAP19-7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP19-7 Gene

Domains for KRTAP19-7 Gene

Gene Families for KRTAP19-7 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP19-7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP19-7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SYF9

UniProtKB/Swiss-Prot:

KR197_HUMAN :
  • Q3SYF9
Family:
  • Belongs to the KRTAP type 19 family.
genes like me logo Genes that share domains with KRTAP19-7: view

Function for KRTAP19-7 Gene

Molecular function for KRTAP19-7 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP19-7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP19-7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP19-7 Gene

Localization for KRTAP19-7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP19-7 Gene COMPARTMENTS Subcellular localization image for KRTAP19-7 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP19-7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP19-7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP19-7 Gene

Pathways for KRTAP19-7 Gene

SuperPathways for KRTAP19-7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP19-7 Gene

None

No data available for Pathways by source for KRTAP19-7 Gene

Transcripts for KRTAP19-7 Gene

mRNA/cDNA for KRTAP19-7 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP19-7 Gene

No ASD Table

Relevant External Links for KRTAP19-7 Gene

GeneLoc Exon Structure for
KRTAP19-7
ECgene alternative splicing isoforms for
KRTAP19-7

Expression for KRTAP19-7 Gene

mRNA expression in normal human tissues for KRTAP19-7 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP19-7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.6) and Skin - Sun Exposed (Lower leg) (4.3).

SOURCE GeneReport for Unigene cluster for KRTAP19-7 Gene Hs.553696

genes like me logo Genes that share expressions with KRTAP19-7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP19-7 Gene

Orthologs for KRTAP19-7 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP19-7 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia 16 16
Species with no ortholog for KRTAP19-7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP19-7 Gene

ENSEMBL:
Gene Tree for KRTAP19-7 (if available)
TreeFam:
Gene Tree for KRTAP19-7 (if available)

Paralogs for KRTAP19-7 Gene

No data available for Paralogs for KRTAP19-7 Gene

Variants for KRTAP19-7 Gene

Sequence variations from dbSNP and Humsavar for KRTAP19-7 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs768554 -- 30,560,713(+) ATAAC(A/G)TATTG downstream-variant-500B
rs1395776 -- 30,561,733(-) AACAT(C/T)CTTGG upstream-variant-2KB
rs1395777 -- 30,561,687(-) GAAAG(A/G)GTGCA upstream-variant-2KB
rs1702401 -- 30,561,407(-) TAACA(C/T)GTTCT upstream-variant-2KB
rs2032173 -- 30,562,391(+) TATAT(A/G)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP19-7 Gene

Variant ID Type Subtype PubMed ID
nsv913677 CNV Loss 21882294

Relevant External Links for KRTAP19-7 Gene

HapMap Linkage Disequilibrium report
KRTAP19-7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP19-7 Gene

Disorders for KRTAP19-7 Gene

No disorders were found for KRTAP19-7 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP19-7 Gene

Publications for KRTAP19-7 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP19-7 Gene

Sources for KRTAP19-7 Gene

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