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Aliases for KRTAP19-3 Gene

Aliases for KRTAP19-3 Gene

  • Keratin Associated Protein 19-3 2 3
  • Glycine/Tyrosine-Rich Protein 3 4
  • KAP19.3 3 4
  • GTHRP 3 4
  • Keratin-Associated Protein 19-3 3
  • GTRHP 3

External Ids for KRTAP19-3 Gene

Summaries for KRTAP19-3 Gene

GeneCards Summary for KRTAP19-3 Gene

KRTAP19-3 (Keratin Associated Protein 19-3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP19-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP19-3 Gene

Genomics for KRTAP19-3 Gene

Genomic Location for KRTAP19-3 Gene

Start:
30,480,048 bp from pter
End:
30,491,985 bp from pter
Size:
11,938 bases
Orientation:
Minus strand

Genomic View for KRTAP19-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP19-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP19-3 Gene

Regulatory Elements for KRTAP19-3 Gene

Proteins for KRTAP19-3 Gene

  • Protein details for KRTAP19-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4W3-KR193_HUMAN
    Recommended name:
    Keratin-associated protein 19-3
    Protein Accession:
    Q7Z4W3
    Secondary Accessions:

    Protein attributes for KRTAP19-3 Gene

    Size:
    81 amino acids
    Molecular mass:
    8247 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP19-3 Gene

Proteomics data for KRTAP19-3 Gene at MOPED

Post-translational modifications for KRTAP19-3 Gene

No Post-translational modifications

Other Protein References for KRTAP19-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP19-3 Gene

Domains for KRTAP19-3 Gene

Gene Families for KRTAP19-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP19-3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KR193_HUMAN
Family:
  • Belongs to the KRTAP type 19 family.:
    • Q7Z4W3
genes like me logo Genes that share domains with KRTAP19-3: view

Function for KRTAP19-3 Gene

Molecular function for KRTAP19-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP19-3 Gene

Localization for KRTAP19-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP19-3 Gene COMPARTMENTS Subcellular localization image for KRTAP19-3 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP19-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP19-3: view

Pathways for KRTAP19-3 Gene

SuperPathways for KRTAP19-3 Gene

No Data Available

Interacting Proteins for KRTAP19-3 Gene

Gene Ontology (GO) - Biological Process for KRTAP19-3 Gene

None

No data available for Pathways by source for KRTAP19-3 Gene

Transcripts for KRTAP19-3 Gene

mRNA/cDNA for KRTAP19-3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP19-3 Gene

Keratin associated protein 19-3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP19-3 Gene

No ASD Table

Relevant External Links for KRTAP19-3 Gene

GeneLoc Exon Structure for
KRTAP19-3
ECgene alternative splicing isoforms for
KRTAP19-3

Expression for KRTAP19-3 Gene

mRNA expression in normal human tissues for KRTAP19-3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTAP19-3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (43.1) and Muscle - Skeletal (6.0).

SOURCE GeneReport for Unigene cluster for KRTAP19-3 Gene Hs.60480

genes like me logo Genes that share expressions with KRTAP19-3: view

Orthologs for KRTAP19-3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP19-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP19-3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap19-4 16
Species with no ortholog for KRTAP19-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP19-3 Gene

ENSEMBL:
Gene Tree for KRTAP19-3 (if available)
TreeFam:
Gene Tree for KRTAP19-3 (if available)

Paralogs for KRTAP19-3 Gene

No data available for Paralogs for KRTAP19-3 Gene

Variants for KRTAP19-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP19-3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1048494 -- 30,491,760(-) GGCTG(A/C)TACCG stop-gained, reference
rs2251071 -- 30,491,529(+) CAAAA(C/G)TAGAG utr-variant-3-prime
rs2251276 -- 30,493,472(+) TTCAG(C/T)AAGAG upstream-variant-2KB
rs2298436 -- 30,491,989(+) GCTGC(G/T)CAAGG upstream-variant-2KB
rs2832915 -- 30,493,862(+) CTCAT(A/G)GAAAT upstream-variant-2KB

Relevant External Links for KRTAP19-3 Gene

HapMap Linkage Disequilibrium report
KRTAP19-3

No data available for Structural Variations from Database of Genomic Variants (DGV) for KRTAP19-3 Gene

Disorders for KRTAP19-3 Gene

No disorders were found for KRTAP19-3 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP19-3 Gene

Publications for KRTAP19-3 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Structure and biochemistry of mammalian hard keratin. (PMID: 1714783) Marshall R.C. … Gillespie J.M. (Electron Microsc. Rev. 1991) 23
  4. Isolation of a mRNA encoding a glycine-proline-rich beta-keratin expressed in the regenerating epidermis of lizard. (PMID: 16217734) Dalla Valle L. … Alibardi L. (Dev. Dyn. 2005) 23
  5. Scale keratin in lizard epidermis reveals amino acid regions homologous with avian and mammalian epidermal proteins. (PMID: 16761287) Alibardi L. … Toni M. (Anat Rec A Discov Mol Cell Evol Biol 2006) 23

Products for KRTAP19-3 Gene

Sources for KRTAP19-3 Gene

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