KRTAP19-3 Gene
protein-coding GIFtS : 37 GCID: GC21 M031863
keratin associated protein 19-3
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Aliasesfor KRTAP19-3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Keratin Associated Protein 19-3 1 2 KAP19.31 2 3 Glycine/Tyrosine-Rich Protein2 3 GTHRP2 3 GTRHP2 Keratin-Associated Protein 19-32
External Ids: HGNC: 18938 1 Entrez Gene: 337970 2 Ensembl: ENSG00000244025 7 UniProtKB: Q7Z4W3 3 ORGUL members: NONCODE:n342527
Export aliases for KRTAP19-3 gene to outside databases Previous GC identifers: GC21U900020 GC21M030784 GC21M030785 GC21M017272
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Summariesfor KRTAP19-3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: KR193_HUMAN, Q7Z4W3 Function : In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins
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Genomic Viewsfor KRTAP19-3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000021.8 NC_018932.1 NT_011512.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KRTAP19-3 gene promoter:TBP Max1 USF1 ATF-2 E47 POU2F1 POU2F1a USF-1 Hand1 Hlf Other transcription factors Search SABiosciences Chromatin IP Primers for KRTAP19-3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP19-3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q22.1 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1 KRTAP19-3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 21 GeneLoc Exon Structure
GeneLoc location for GC21M031863: view genomic region
(about GC identifiers )
Start: 31,863,782 bp from pter End:
31,864,275 bp from pter
Size: 494 bases Orientation:
minus strand
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Proteinsfor KRTAP19-3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KR193_HUMAN, Q7Z4W3 See
protein sequence )Recommended Name: Size : 81 amino acids; 8247 DaSubunit : Interacts with hair keratins (By similarity)Explore the universe of human proteins at neXtProt for KRTAP19-3: NX_Q7Z4W3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7Z4W3 KRTAP19-3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_853640.1 ENSEMBL proteins: ENSP00000386376 Human Recombinant Protein Products for KRTAP19-3: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005882 intermediate filament
IEA --
About GeneDecksing KRTAP19-3 Antibody Products: Assay Products for KRTAP19-3:
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Protein
Domains /for KRTAP19-3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7Z4W3 ProtoNet protein and cluster: Q7Z4W3
UniProtKB/Swiss-Prot: KR193_HUMAN, Q7Z4W3 Similarity : Belongs to the KRTAP type 19 family
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Functionfor KRTAP19-3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: KR193_HUMAN, Q7Z4W3 Function : In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins Animal Models:
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KRTAP19-3 (NM_181609 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRTAP19-3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KRTAP19-3
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Pathways & Interactionsfor KRTAP19-3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP19-3
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Drugs & Compoundsfor KRTAP19-3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KRTAP19-3 KRTAP19-3 / KR193
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Transcriptsfor KRTAP19-3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for KRTAP19-3 gene: NM_181609.3 Unigene Cluster for KRTAP19-3:
Keratin associated protein 19-3 Hs.60480 [show with all ESTs ] Unigene Representative Sequence: AI288919 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000334063 (uc002yog.1 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KRTAP19-3 (NM_181609 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRTAP19-3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KRTAP19-3
Additional cDNA sequence: AB096944.1 AF139541.1 BC126280.1 BC126282.1
1 DOTS entry : DT.207678
6 AceView cDNA sequences :
NM_181609 AA011080 AA228095 AI288919 AF139541 AA011081 GeneLoc Exon Structure
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Expression for KRTAP19-3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KRTAP19-3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGCTACTACGAbout this image KRTAP19-3 expression in embryonic tissues and stem cells About this table
1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Kidney Afferent Arteriole Juxtaglomerular Cells Kidney, Smooth Muscle Expression: Experimental details:
In-situ hybridization
See KRTAP19-3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KRTAP19-3 SOURCE GeneReport for Unigene cluster: Hs.60480 SABiosciences Custom PCR Arrays for KRTAP19-3 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor KRTAP19-3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
ENSEMBL Gene Tree for KRTAP19-3 (if available)TreeFam Gene Tree for KRTAP19-3 (if available)
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Paralogsfor KRTAP19-3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KRTAP19-3 gene KRTAP19-6 2 KRTAP6-1 2 KRTAP21-2 2 KRTAP6-2 2 KRTAP19-7 2 KRTAP19-5 2 KRTAP21-1 2 KRTAP19-8 2 KRTAP6-3 2 KRTAP19-4 2 KRTAP20-2 2 LOC647264 2 KRTAP19-1 2 KRTAP20-1 2 About GeneDecksing
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Genomic Variantsfor KRTAP19-3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 21 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KRTAP19-3 (31863782 - 31864275 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KRTAP19-3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor KRTAP19-3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
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Publicationsfor KRTAP19-3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KRTAP19-3 gene integrated from 9 sources :(articles sorted by number of sources associating them with KRTAP19-3) Utopia : connect your pdf to the dynamic
Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PubMed id 12359730) 1 , 3(2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 (2002) Structural and immunocytochemical characterization of keratinization in vertebrate epidermis and epidermal derivatives. (PubMed id 17098057) 9 Alibardi L. (2006) Scale keratin in lizard epidermis reveals amino acid regions homologous with avian and mammalian epidermal proteins. (PubMed id 16761287) 9 Alibardi L....Toni M. (2006) Isolation of a mRNA encoding a glycine-proline-rich beta-keratin expressed in the regenerating epidermis of lizard. (PubMed id 16217734) 9 Dalla Valle L....Alibardi L. (2005) Structure and biochemistry of mammalian hard keratin. (PubMed id 1714783) 9 Marshall R.C....Gillespie J.M. (1991)
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External Searches for KRTAP19-3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KRTAP19-3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KRTAP19-3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KRTAP19-3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for KRTAP19-3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KRTAP19-3 gene: KRTAP19-3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KRTAP19-3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KRTAP19-3 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for KRTAP19-3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KRTAP19-3 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KRTAP19-3 OriGene Custom Protein Services for KRTAP19-3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRTAP19-3 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP19-3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
KRTAP19-3 Proteins, Antibodies, CLIAs, and ELISAs
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KRTAP19-3
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Selective marker
Curated
In-situ hybridization
