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Aliases for KRTAP19-1 Gene

Aliases for KRTAP19-1 Gene

  • Keratin Associated Protein 19-1 2 3
  • High Tyrosine-Glycine Keratin-Associated Protein 19.1 3 4
  • KAP19.1 3 4
  • Keratin-Associated Protein 19-1 3
  • KRTAP19.1 4

External Ids for KRTAP19-1 Gene

Previous GeneCards Identifiers for KRTAP19-1 Gene

  • GC21U900013
  • GC21M030772
  • GC21M030774
  • GC21M031852
  • GC21M017261

Summaries for KRTAP19-1 Gene

GeneCards Summary for KRTAP19-1 Gene

KRTAP19-1 (Keratin Associated Protein 19-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP19-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP19-1 Gene

Genomics for KRTAP19-1 Gene

Regulatory Elements for KRTAP19-1 Gene

Genomic Location for KRTAP19-1 Gene

Start:
30,479,699 bp from pter
End:
30,480,344 bp from pter
Size:
646 bases
Orientation:
Minus strand

Genomic View for KRTAP19-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP19-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP19-1 Gene

Proteins for KRTAP19-1 Gene

  • Protein details for KRTAP19-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUB9-KR191_HUMAN
    Recommended name:
    Keratin-associated protein 19-1
    Protein Accession:
    Q8IUB9
    Secondary Accessions:
    • A4QN27
    • Q3LI75

    Protein attributes for KRTAP19-1 Gene

    Size:
    90 amino acids
    Molecular mass:
    9008 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP19-1 Gene

Proteomics data for KRTAP19-1 Gene at MOPED

Post-translational modifications for KRTAP19-1 Gene

No Post-translational modifications

Other Protein References for KRTAP19-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP19-1 Gene

Domains for KRTAP19-1 Gene

Gene Families for KRTAP19-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP19-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP19-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUB9

UniProtKB/Swiss-Prot:

KR191_HUMAN :
  • Q8IUB9
Family:
  • Belongs to the KRTAP type 19 family.
genes like me logo Genes that share domains with KRTAP19-1: view

Function for KRTAP19-1 Gene

Molecular function for KRTAP19-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Animal Model Products

CRISPR Products

miRNA for KRTAP19-1 Gene

miRTarBase miRNAs that target KRTAP19-1

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP19-1
    • Block miRNA regulation of KRTAP19-1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP19-1

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRTAP19-1 Gene

    Localization for KRTAP19-1 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP19-1 Gene COMPARTMENTS Subcellular localization image for KRTAP19-1 gene
    Compartment Confidence
    cytoskeleton 3
    extracellular 3
    cytosol 1
    nucleus 1

    Gene Ontology (GO) - Cellular Components for KRTAP19-1 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005882 intermediate filament IEA --
    genes like me logo Genes that share ontologies with KRTAP19-1: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP19-1 Gene

    Pathways for KRTAP19-1 Gene

    SuperPathways for KRTAP19-1 Gene

    No Data Available

    Interacting Proteins for KRTAP19-1 Gene

    Gene Ontology (GO) - Biological Process for KRTAP19-1 Gene

    None

    No data available for Pathways by source for KRTAP19-1 Gene

    Transcripts for KRTAP19-1 Gene

    mRNA/cDNA for KRTAP19-1 Gene

    (8) Selected AceView cDNA sequences:
    (4) Additional mRNA sequences :
    (1) REFSEQ mRNAs :
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for KRTAP19-1 Gene

    Keratin associated protein 19-1:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP19-1
      • Block miRNA regulation of KRTAP19-1 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP19-1

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP19-1

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP19-1 Gene

      No ASD Table

      Relevant External Links for KRTAP19-1 Gene

      GeneLoc Exon Structure for
      KRTAP19-1
      ECgene alternative splicing isoforms for
      KRTAP19-1

      Expression for KRTAP19-1 Gene

      mRNA expression in normal human tissues for KRTAP19-1 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP19-1 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (48.5) and Skin - Sun Exposed (Lower leg) (4.0).

      Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP19-1 Gene

      SOURCE GeneReport for Unigene cluster for KRTAP19-1 Gene Hs.61552

      mRNA Expression by UniProt/SwissProt for KRTAP19-1 Gene

      Q8IUB9-KR191_HUMAN
      Tissue specificity: Detected in the upper portion of the hair cortex
      genes like me logo Genes that share expressions with KRTAP19-1: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTAP19-1 Gene

      Orthologs for KRTAP19-1 Gene

      This gene was present in the common ancestor of human and mouse.

      Orthologs for KRTAP19-1 Gene

      Organism Taxonomy Gene Similarity Type Details
      mouse
      (Mus musculus)
      Mammalia Krtap16-3 16
      Species with no ortholog for KRTAP19-1:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • chimpanzee (Pan troglodytes)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP19-1 Gene

      ENSEMBL:
      Gene Tree for KRTAP19-1 (if available)
      TreeFam:
      Gene Tree for KRTAP19-1 (if available)

      Paralogs for KRTAP19-1 Gene

      No data available for Paralogs for KRTAP19-1 Gene

      Variants for KRTAP19-1 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP19-1 Gene

      SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
      rs2832908 -- 30,479,861(+) ACGGA(C/T)TCCGA downstream-variant-500B
      rs2898170 -- 30,482,160(+) GATAC(A/C)TCTCT upstream-variant-2KB
      rs4817335 -- 30,481,406(+) AGTTA(G/T)CTTTT upstream-variant-2KB
      rs5843447 -- 30,482,218(+) TTTTT(-/T)ACAAT upstream-variant-2KB
      rs8128202 -- 30,479,764(+) ATCTT(G/T)ATAGA downstream-variant-500B

      Relevant External Links for KRTAP19-1 Gene

      HapMap Linkage Disequilibrium report
      KRTAP19-1

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRTAP19-1 Gene

      Disorders for KRTAP19-1 Gene

      No disorders were found for KRTAP19-1 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP19-1 Gene

      Publications for KRTAP19-1 Gene

      1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 4
      2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
      3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
      4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

      Products for KRTAP19-1 Gene

      Sources for KRTAP19-1 Gene

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