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Aliases for KRTAP15-1 Gene

Aliases for KRTAP15-1 Gene

  • Keratin Associated Protein 15-1 2 3 5
  • KAP15.1 3 4
  • Keratin-Associated Protein 15-1 3

External Ids for KRTAP15-1 Gene

Previous GeneCards Identifiers for KRTAP15-1 Gene

  • GC21P028473
  • GC21U900075
  • GC21P030733
  • GC21P030734
  • GC21P031812
  • GC21P017221

Summaries for KRTAP15-1 Gene

GeneCards Summary for KRTAP15-1 Gene

KRTAP15-1 (Keratin Associated Protein 15-1) is a Protein Coding gene. An important paralog of this gene is KRTAP13-2.

UniProtKB/Swiss-Prot for KRTAP15-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP15-1 Gene

Genomics for KRTAP15-1 Gene

Regulatory Elements for KRTAP15-1 Gene

Enhancers for KRTAP15-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KRTAP15-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP15-1 Gene

Chromosome:
21
Start:
30,440,275 bp from pter
End:
30,440,945 bp from pter
Size:
671 bases
Orientation:
Plus strand

Genomic View for KRTAP15-1 Gene

Genes around KRTAP15-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP15-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP15-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP15-1 Gene

Proteins for KRTAP15-1 Gene

  • Protein details for KRTAP15-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI76-KR151_HUMAN
    Recommended name:
    Keratin-associated protein 15-1
    Protein Accession:
    Q3LI76
    Secondary Accessions:
    • Q2M3F4

    Protein attributes for KRTAP15-1 Gene

    Size:
    137 amino acids
    Molecular mass:
    14979 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP15-1 Gene

Post-translational modifications for KRTAP15-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP15-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP15-1 Gene

Domains & Families for KRTAP15-1 Gene

Gene Families for KRTAP15-1 Gene

Protein Domains for KRTAP15-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP15-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI76

UniProtKB/Swiss-Prot:

KR151_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP15-1: view

Function for KRTAP15-1 Gene

Molecular function for KRTAP15-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP15-1 Gene

GenomeRNAi human phenotypes for KRTAP15-1:
genes like me logo Genes that share phenotypes with KRTAP15-1: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP15-1 Gene

Localization for KRTAP15-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP15-1 Gene COMPARTMENTS Subcellular localization image for KRTAP15-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP15-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP15-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP15-1 Gene

Pathways & Interactions for KRTAP15-1 Gene

SuperPathways for KRTAP15-1 Gene

No Data Available

Interacting Proteins for KRTAP15-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP15-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP15-1 Gene

Drugs & Compounds for KRTAP15-1 Gene

No Compound Related Data Available

Transcripts for KRTAP15-1 Gene

mRNA/cDNA for KRTAP15-1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP15-1 Gene

No ASD Table

Relevant External Links for KRTAP15-1 Gene

GeneLoc Exon Structure for
KRTAP15-1
ECgene alternative splicing isoforms for
KRTAP15-1

Expression for KRTAP15-1 Gene

mRNA expression in normal human tissues for KRTAP15-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP15-1 Gene:

Hs.553654
genes like me logo Genes that share expression patterns with KRTAP15-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KRTAP15-1 Gene

Orthologs for KRTAP15-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP15-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRTAP15-1 34
  • 77.15 (n)
  • 62.9 (a)
KRTAP13-1 35
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap15 34
  • 71.08 (n)
  • 54.41 (a)
Krtap15 16
2310057N15Rik 35
  • 31 (a)
ManyToMany
Gm5965 35
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Krtap15-1 34
  • 67.4 (n)
  • 51.47 (a)
dog
(Canis familiaris)
Mammalia KRTAP15-1 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
Species where no ortholog for KRTAP15-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP15-1 Gene

ENSEMBL:
Gene Tree for KRTAP15-1 (if available)
TreeFam:
Gene Tree for KRTAP15-1 (if available)

Paralogs for KRTAP15-1 Gene

Paralogs for KRTAP15-1 Gene

(3) SIMAP similar genes for KRTAP15-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP15-1: view

Variants for KRTAP15-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP15-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_047019 -

Structural Variations from Database of Genomic Variants (DGV) for KRTAP15-1 Gene

Variant ID Type Subtype PubMed ID
dgv810e214 CNV loss 21293372
esv2657178 CNV deletion 23128226
nsv1057467 CNV gain 25217958
nsv1060328 CNV loss 25217958
nsv587354 CNV gain 21841781
nsv587357 CNV loss 21841781

Variation tolerance for KRTAP15-1 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP15-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP15-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP15-1 Gene

Disorders for KRTAP15-1 Gene

Relevant External Links for KRTAP15-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP15-1

No disorders were found for KRTAP15-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP15-1 Gene

Publications for KRTAP15-1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for KRTAP15-1 Gene

Sources for KRTAP15-1 Gene

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