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Aliases for KRTAP15-1 Gene

Aliases for KRTAP15-1 Gene

  • Keratin Associated Protein 15-1 2 3 5
  • KAP15.1 3 4

External Ids for KRTAP15-1 Gene

Previous GeneCards Identifiers for KRTAP15-1 Gene

  • GC21P028473
  • GC21U900075
  • GC21P030733
  • GC21P030734
  • GC21P031812
  • GC21P017221

Summaries for KRTAP15-1 Gene

GeneCards Summary for KRTAP15-1 Gene

KRTAP15-1 (Keratin Associated Protein 15-1) is a Protein Coding gene. An important paralog of this gene is KRTAP13-2.

UniProtKB/Swiss-Prot for KRTAP15-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP15-1 Gene

Genomics for KRTAP15-1 Gene

Regulatory Elements for KRTAP15-1 Gene

Enhancers for KRTAP15-1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRTAP15-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP15-1 Gene

Chromosome:
21
Start:
30,440,275 bp from pter
End:
30,440,945 bp from pter
Size:
671 bases
Orientation:
Plus strand

Genomic View for KRTAP15-1 Gene

Genes around KRTAP15-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP15-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP15-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP15-1 Gene

Proteins for KRTAP15-1 Gene

  • Protein details for KRTAP15-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI76-KR151_HUMAN
    Recommended name:
    Keratin-associated protein 15-1
    Protein Accession:
    Q3LI76
    Secondary Accessions:
    • Q2M3F4

    Protein attributes for KRTAP15-1 Gene

    Size:
    137 amino acids
    Molecular mass:
    14979 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP15-1 Gene

Proteomics data for KRTAP15-1 Gene at MOPED

Post-translational modifications for KRTAP15-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP15-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP15-1 Gene

Domains & Families for KRTAP15-1 Gene

Gene Families for KRTAP15-1 Gene

Protein Domains for KRTAP15-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP15-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI76

UniProtKB/Swiss-Prot:

KR151_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP15-1: view

Function for KRTAP15-1 Gene

Molecular function for KRTAP15-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP15-1 Gene

GenomeRNAi human phenotypes for KRTAP15-1:
genes like me logo Genes that share phenotypes with KRTAP15-1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP15-1 Gene

Localization for KRTAP15-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP15-1 Gene COMPARTMENTS Subcellular localization image for KRTAP15-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP15-1 Gene

Pathways & Interactions for KRTAP15-1 Gene

SuperPathways for KRTAP15-1 Gene

No Data Available

Interacting Proteins for KRTAP15-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP15-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP15-1 Gene

Drugs & Compounds for KRTAP15-1 Gene

No Compound Related Data Available

Transcripts for KRTAP15-1 Gene

mRNA/cDNA for KRTAP15-1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP15-1 Gene

No ASD Table

Relevant External Links for KRTAP15-1 Gene

GeneLoc Exon Structure for
KRTAP15-1
ECgene alternative splicing isoforms for
KRTAP15-1

Expression for KRTAP15-1 Gene

mRNA expression in normal human tissues for KRTAP15-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP15-1 Gene Hs.553654

genes like me logo Genes that share expression patterns with KRTAP15-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRTAP15-1 Gene

Orthologs for KRTAP15-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP15-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRTAP15-1 35
  • 77.15 (n)
  • 62.9 (a)
KRTAP13-1 36
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap15 35
  • 71.08 (n)
  • 54.41 (a)
Krtap15 16
2310057N15Rik 36
  • 31 (a)
ManyToMany
Gm5965 36
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Krtap15-1 35
  • 67.4 (n)
  • 51.47 (a)
dog
(Canis familiaris)
Mammalia KRTAP15-1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for KRTAP15-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP15-1 Gene

ENSEMBL:
Gene Tree for KRTAP15-1 (if available)
TreeFam:
Gene Tree for KRTAP15-1 (if available)

Paralogs for KRTAP15-1 Gene

Paralogs for KRTAP15-1 Gene

(3) SIMAP similar genes for KRTAP15-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP15-1: view

Variants for KRTAP15-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP15-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_047019 -

Structural Variations from Database of Genomic Variants (DGV) for KRTAP15-1 Gene

Variant ID Type Subtype PubMed ID
esv2657178 CNV Deletion 23128226

Variation tolerance for KRTAP15-1 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRTAP15-1 Gene

Disorders for KRTAP15-1 Gene

Relevant External Links for KRTAP15-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP15-1

No disorders were found for KRTAP15-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP15-1 Gene

Publications for KRTAP15-1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP15-1 Gene

Sources for KRTAP15-1 Gene

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