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Aliases for KRTAP13-4 Gene

Aliases for KRTAP13-4 Gene

  • Keratin Associated Protein 13-4 2 3
  • KAP13.4 3 4
  • Keratin-Associated Protein 13-4 3

External Ids for KRTAP13-4 Gene

Previous GeneCards Identifiers for KRTAP13-4 Gene

  • GC21P028458
  • GC21U900072
  • GC21P030723
  • GC21P030724
  • GC21P031802
  • GC21P017211

Summaries for KRTAP13-4 Gene

GeneCards Summary for KRTAP13-4 Gene

KRTAP13-4 (Keratin Associated Protein 13-4) is a Protein Coding gene. An important paralog of this gene is KRTAP13-2.

UniProtKB/Swiss-Prot for KRTAP13-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP13-4 Gene

Genomics for KRTAP13-4 Gene

Regulatory Elements for KRTAP13-4 Gene

Genomic Location for KRTAP13-4 Gene

Start:
30,430,230 bp from pter
End:
30,431,026 bp from pter
Size:
797 bases
Orientation:
Plus strand

Genomic View for KRTAP13-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP13-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP13-4 Gene

Proteins for KRTAP13-4 Gene

  • Protein details for KRTAP13-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI77-KR134_HUMAN
    Recommended name:
    Keratin-associated protein 13-4
    Protein Accession:
    Q3LI77
    Secondary Accessions:
    • A2RRL3

    Protein attributes for KRTAP13-4 Gene

    Size:
    160 amino acids
    Molecular mass:
    17755 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP13-4 Gene

Proteomics data for KRTAP13-4 Gene at MOPED

Post-translational modifications for KRTAP13-4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP13-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP13-4 Gene

Domains for KRTAP13-4 Gene

Gene Families for KRTAP13-4 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP13-4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP13-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI77

UniProtKB/Swiss-Prot:

KR134_HUMAN :
  • Q3LI77
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP13-4: view

Function for KRTAP13-4 Gene

Molecular function for KRTAP13-4 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP13-4 Gene

Localization for KRTAP13-4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP13-4 Gene COMPARTMENTS Subcellular localization image for KRTAP13-4 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP13-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP13-4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP13-4 Gene

Pathways for KRTAP13-4 Gene

SuperPathways for KRTAP13-4 Gene

No Data Available

Interacting Proteins for KRTAP13-4 Gene

Gene Ontology (GO) - Biological Process for KRTAP13-4 Gene

None

No data available for Pathways by source for KRTAP13-4 Gene

Transcripts for KRTAP13-4 Gene

mRNA/cDNA for KRTAP13-4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP13-4 Gene

No ASD Table

Relevant External Links for KRTAP13-4 Gene

GeneLoc Exon Structure for
KRTAP13-4
ECgene alternative splicing isoforms for
KRTAP13-4

Expression for KRTAP13-4 Gene

mRNA expression in normal human tissues for KRTAP13-4 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP13-4 Gene

This gene is overexpressed in Adipose - Subcutaneous (23.3), Adipose - Visceral (Omentum) (11.8), and Skin - Sun Exposed (Lower leg) (4.1).

SOURCE GeneReport for Unigene cluster for KRTAP13-4 Gene Hs.553677

genes like me logo Genes that share expressions with KRTAP13-4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP13-4 Gene

Orthologs for KRTAP13-4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP13-4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 4930553J12Rik 36
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for KRTAP13-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP13-4 Gene

ENSEMBL:
Gene Tree for KRTAP13-4 (if available)
TreeFam:
Gene Tree for KRTAP13-4 (if available)

Paralogs for KRTAP13-4 Gene

Paralogs for KRTAP13-4 Gene

Selected SIMAP similar genes for KRTAP13-4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP13-4: view

Variants for KRTAP13-4 Gene

Sequence variations from dbSNP and Humsavar for KRTAP13-4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs999597 - 30,430,736(-) AGAAG(C/T)GAGAT missense, reference
rs1539783 -- 30,430,841(+) ATATC(C/T)TTTTA downstream-variant-500B
rs1539784 -- 30,430,892(+) GACTG(C/T)GAAAT downstream-variant-500B
rs2226548 - 30,430,450(+) AGCCC(A/G)CCAGC missense, reference
rs2832862 -- 30,428,545(+) ACTCA(C/T)AAGTT upstream-variant-2KB

Relevant External Links for KRTAP13-4 Gene

HapMap Linkage Disequilibrium report
KRTAP13-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRTAP13-4 Gene

Disorders for KRTAP13-4 Gene

No disorders were found for KRTAP13-4 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP13-4 Gene

Publications for KRTAP13-4 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PMID: 20494980) Warnatz H.J. … Yaspo M.L. (Nucleic Acids Res. 2010) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for KRTAP13-4 Gene

Sources for KRTAP13-4 Gene

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