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Aliases for KRTAP13-3 Gene

Aliases for KRTAP13-3 Gene

  • Keratin Associated Protein 13-3 2 3 5
  • KAP13.3 3 4
  • Keratin-Associated Protein 13-3 3

External Ids for KRTAP13-3 Gene

Previous GeneCards Identifiers for KRTAP13-3 Gene

  • GC00U906260
  • GC21U900097
  • GC21M030718
  • GC21M030719
  • GC21M031797
  • GC21M017206

Summaries for KRTAP13-3 Gene

GeneCards Summary for KRTAP13-3 Gene

KRTAP13-3 (Keratin Associated Protein 13-3) is a Protein Coding gene. Among its related pathways are Developmental Biology. An important paralog of this gene is KRTAP13-1.

UniProtKB/Swiss-Prot for KRTAP13-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP13-3 Gene

Genomics for KRTAP13-3 Gene

Regulatory Elements for KRTAP13-3 Gene

Enhancers for KRTAP13-3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F030088 0.3 FANTOM5 8.4 +337.5 337527 0.4 KRTAP23-1 KRTAP19-7 KRTAP27-1 KRTAP15-1 KRTAP13-3 KRTAP25-1 KRTAP19-4 KRTAP19-2 KRTAP19-6 KRTAP13-4
GH21F030426 0.2 ENCODE 0.8 -0.7 -741 0.9 ZFHX2 ZSCAN16 TEAD4 EGR2 KRTAP13-3 KRTAP13-4
GH21F030408 0.2 ENCODE 0.3 +17.0 16951 0.2 SIX4 CTCF PKNOX1 MAX SIN3A RAD21 FOXK2 POLR2A SCRT2 SCRT1 KRTAP13-4 KRTAP13-1 KRTAP13-3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRTAP13-3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP13-3 Gene

Chromosome:
21
Start:
30,425,265 bp from pter
End:
30,425,968 bp from pter
Size:
704 bases
Orientation:
Minus strand

Genomic View for KRTAP13-3 Gene

Genes around KRTAP13-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP13-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP13-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP13-3 Gene

Proteins for KRTAP13-3 Gene

  • Protein details for KRTAP13-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY46-KR133_HUMAN
    Recommended name:
    Keratin-associated protein 13-3
    Protein Accession:
    Q3SY46
    Secondary Accessions:
    • Q3LI78

    Protein attributes for KRTAP13-3 Gene

    Size:
    172 amino acids
    Molecular mass:
    19236 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP13-3 Gene

Post-translational modifications for KRTAP13-3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP13-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP13-3 Gene

Domains & Families for KRTAP13-3 Gene

Gene Families for KRTAP13-3 Gene

Protein Domains for KRTAP13-3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP13-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SY46

UniProtKB/Swiss-Prot:

KR133_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP13-3: view

Function for KRTAP13-3 Gene

Molecular function for KRTAP13-3 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Gene Ontology (GO) - Molecular Function for KRTAP13-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP13-3: view

Phenotypes for KRTAP13-3 Gene

genes like me logo Genes that share phenotypes with KRTAP13-3: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP13-3 Gene

Localization for KRTAP13-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP13-3 Gene COMPARTMENTS Subcellular localization image for KRTAP13-3 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRTAP13-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP13-3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP13-3 Gene

Pathways & Interactions for KRTAP13-3 Gene

SuperPathways for KRTAP13-3 Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRTAP13-3: view

Pathways by source for KRTAP13-3 Gene

1 Reactome pathway for KRTAP13-3 Gene

Interacting Proteins for KRTAP13-3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000375109%0d%0a9606.ENSP00000354929%0d%0a
Selected Interacting proteins: ENSP00000375109 Q3SY46-KR133_HUMAN for KRTAP13-3 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for KRTAP13-3 Gene

None

No data available for SIGNOR curated interactions for KRTAP13-3 Gene

Transcripts for KRTAP13-3 Gene

mRNA/cDNA for KRTAP13-3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP13-3 Gene

No ASD Table

Relevant External Links for KRTAP13-3 Gene

GeneLoc Exon Structure for
KRTAP13-3
ECgene alternative splicing isoforms for
KRTAP13-3

Expression for KRTAP13-3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRTAP13-3 Gene

SOURCE GeneReport for Unigene cluster for KRTAP13-3 Gene:

Hs.553687
genes like me logo Genes that share expression patterns with KRTAP13-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KRTAP13-3 Gene

Orthologs for KRTAP13-3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP13-3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 67 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krtap13 35
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
Species where no ortholog for KRTAP13-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP13-3 Gene

ENSEMBL:
Gene Tree for KRTAP13-3 (if available)
TreeFam:
Gene Tree for KRTAP13-3 (if available)

Paralogs for KRTAP13-3 Gene

Paralogs for KRTAP13-3 Gene

(4) SIMAP similar genes for KRTAP13-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP13-3: view

Variants for KRTAP13-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP13-3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs112753283 -- 30,427,417(+) TGCTT(C/G)GTGTA intron-variant, upstream-variant-2KB
rs113734566 -- 30,426,902(+) AGTGG(C/G)ATATA intron-variant, upstream-variant-2KB
rs115780982 -- 30,426,923(+) GAAGA(A/C)AATTG intron-variant, upstream-variant-2KB
rs13049579 -- 30,424,976(+) TAGAC(A/C)ATGCT intron-variant, downstream-variant-500B
rs139668107 -- 30,425,976(+) TGGCA(G/T)CCTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP13-3 Gene

Variant ID Type Subtype PubMed ID
nsv1057467 CNV gain 25217958
nsv1060328 CNV loss 25217958
nsv587354 CNV gain 21841781
nsv587357 CNV loss 21841781

Variation tolerance for KRTAP13-3 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP13-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP13-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP13-3 Gene

Disorders for KRTAP13-3 Gene

Relevant External Links for KRTAP13-3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP13-3

No disorders were found for KRTAP13-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP13-3 Gene

Publications for KRTAP13-3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for KRTAP13-3 Gene

Sources for KRTAP13-3 Gene

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