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Aliases for KRTAP13-3 Gene

Aliases for KRTAP13-3 Gene

  • Keratin Associated Protein 13-3 2 3
  • KAP13.3 3 4
  • Keratin-Associated Protein 13-3 3

External Ids for KRTAP13-3 Gene

Summaries for KRTAP13-3 Gene

GeneCards Summary for KRTAP13-3 Gene

KRTAP13-3 (Keratin Associated Protein 13-3) is a Protein Coding gene. An important paralog of this gene is KRTAP13-2.

UniProtKB/Swiss-Prot for KRTAP13-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP13-3 Gene

Genomics for KRTAP13-3 Gene

Genomic Location for KRTAP13-3 Gene

Start:
30,425,265 bp from pter
End:
30,425,968 bp from pter
Size:
704 bases
Orientation:
Minus strand

Genomic View for KRTAP13-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP13-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP13-3 Gene

Regulatory Elements for KRTAP13-3 Gene

Proteins for KRTAP13-3 Gene

  • Protein details for KRTAP13-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY46-KR133_HUMAN
    Recommended name:
    Keratin-associated protein 13-3
    Protein Accession:
    Q3SY46
    Secondary Accessions:
    • Q3LI78

    Protein attributes for KRTAP13-3 Gene

    Size:
    172 amino acids
    Molecular mass:
    19236 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP13-3 Gene

Proteomics data for KRTAP13-3 Gene at MOPED

Post-translational modifications for KRTAP13-3 Gene

No Post-translational modifications

Other Protein References for KRTAP13-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP13-3 Gene

Domains for KRTAP13-3 Gene

Gene Families for KRTAP13-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP13-3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KR133_HUMAN
Family:
  • Belongs to the PMG family.:
    • Q3SY46
genes like me logo Genes that share domains with KRTAP13-3: view

Function for KRTAP13-3 Gene

Molecular function for KRTAP13-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Gene Ontology (GO) - Molecular Function for KRTAP13-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP13-3: view

Phenotypes for KRTAP13-3 Gene

GenomeRNAi human phenotypes for KRTAP13-3:
genes like me logo Genes that share phenotypes with KRTAP13-3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP13-3 Gene

Localization for KRTAP13-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP13-3 Gene COMPARTMENTS Subcellular localization image for KRTAP13-3 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRTAP13-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP13-3: view

Pathways for KRTAP13-3 Gene

SuperPathways for KRTAP13-3 Gene

No Data Available

Interacting Proteins for KRTAP13-3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000375109%0d%0a9606.ENSP00000354929%0d%0a
Selected Interacting proteins: ENSP00000375109 Q3SY46-KR133_HUMAN for KRTAP13-3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for KRTAP13-3 Gene

None

No data available for Pathways by source for KRTAP13-3 Gene

Transcripts for KRTAP13-3 Gene

mRNA/cDNA for KRTAP13-3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP13-3 Gene

No ASD Table

Relevant External Links for KRTAP13-3 Gene

GeneLoc Exon Structure for
KRTAP13-3
ECgene alternative splicing isoforms for
KRTAP13-3

Expression for KRTAP13-3 Gene

mRNA expression in normal human tissues for KRTAP13-3 Gene

SOURCE GeneReport for Unigene cluster for KRTAP13-3 Gene Hs.553687

genes like me logo Genes that share expressions with KRTAP13-3: view

Orthologs for KRTAP13-3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP13-3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krtap13 37
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
Species with no ortholog for KRTAP13-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP13-3 Gene

ENSEMBL:
Gene Tree for KRTAP13-3 (if available)
TreeFam:
Gene Tree for KRTAP13-3 (if available)

Paralogs for KRTAP13-3 Gene

Paralogs for KRTAP13-3 Gene

Selected SIMAP similar genes for KRTAP13-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP13-3: view

Variants for KRTAP13-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP13-3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1475870 -- 30,426,856(+) GGAAG(C/G)CTTGC upstream-variant-2KB
rs2014040 -- 30,427,517(+) TAATA(C/T)AAAAA upstream-variant-2KB
rs2226546 -- 30,427,834(+) TATTG(C/T)TTCTG upstream-variant-2KB
rs2226547 -- 30,427,849(+) ATCCT(C/G)TCATC upstream-variant-2KB
rs5843443 -- 30,427,597(+) AAAAA(-/A)TTATT upstream-variant-2KB

Relevant External Links for KRTAP13-3 Gene

HapMap Linkage Disequilibrium report
KRTAP13-3

No data available for Structural Variations from Database of Genomic Variants (DGV) for KRTAP13-3 Gene

Disorders for KRTAP13-3 Gene

No disorders were found for KRTAP13-3 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP13-3 Gene

Publications for KRTAP13-3 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP13-3 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP13-3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP13-3
    • Block miRNA regulation of KRTAP13-3 using miScript Target Protectors

    Sources for KRTAP13-3 Gene

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