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Aliases for KRTAP13-2 Gene

Aliases for KRTAP13-2 Gene

  • Keratin Associated Protein 13-2 2 3 5
  • KAP13-2 3
  • KAP13.2 4

External Ids for KRTAP13-2 Gene

Previous GeneCards Identifiers for KRTAP13-2 Gene

  • GC00U906259
  • GC21U900096
  • GC21M030665
  • GC21M030666
  • GC21M031721
  • GC21M017152
  • GC21M031743

Summaries for KRTAP13-2 Gene

GeneCards Summary for KRTAP13-2 Gene

KRTAP13-2 (Keratin Associated Protein 13-2) is a Protein Coding gene. An important paralog of this gene is KRTAP15-1.

UniProtKB/Swiss-Prot for KRTAP13-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP13-2 Gene

Genomics for KRTAP13-2 Gene

Regulatory Elements for KRTAP13-2 Gene

Genomic Location for KRTAP13-2 Gene

Chromosome:
21
Start:
30,348,075 bp from pter
End:
30,425,912 bp from pter
Size:
77,838 bases
Orientation:
Minus strand

Genomic View for KRTAP13-2 Gene

Genes around KRTAP13-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP13-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP13-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP13-2 Gene

Proteins for KRTAP13-2 Gene

  • Protein details for KRTAP13-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LG2-KR132_HUMAN
    Recommended name:
    Keratin-associated protein 13-2
    Protein Accession:
    Q52LG2

    Protein attributes for KRTAP13-2 Gene

    Size:
    175 amino acids
    Molecular mass:
    18727 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP13-2 Gene

Proteomics data for KRTAP13-2 Gene at MOPED

Post-translational modifications for KRTAP13-2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP13-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP13-2 Gene

Domains & Families for KRTAP13-2 Gene

Gene Families for KRTAP13-2 Gene

Protein Domains for KRTAP13-2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP13-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q52LG2

UniProtKB/Swiss-Prot:

KR132_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP13-2: view

Function for KRTAP13-2 Gene

Molecular function for KRTAP13-2 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
genes like me logo Genes that share phenotypes with KRTAP13-2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRTAP13-2 Gene

Localization for KRTAP13-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP13-2 Gene COMPARTMENTS Subcellular localization image for KRTAP13-2 gene
Compartment Confidence
cytoskeleton 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP13-2 Gene

Pathways & Interactions for KRTAP13-2 Gene

SuperPathways for KRTAP13-2 Gene

No Data Available

Interacting Proteins for KRTAP13-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP13-2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP13-2 Gene

Drugs & Compounds for KRTAP13-2 Gene

No Compound Related Data Available

Transcripts for KRTAP13-2 Gene

mRNA/cDNA for KRTAP13-2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP13-2 Gene

Keratin associated protein 13-2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP13-2 Gene

No ASD Table

Relevant External Links for KRTAP13-2 Gene

GeneLoc Exon Structure for
KRTAP13-2
ECgene alternative splicing isoforms for
KRTAP13-2

Expression for KRTAP13-2 Gene

mRNA expression in normal human tissues for KRTAP13-2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTAP13-2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x42.9) and Skin - Sun Exposed (Lower leg) (x4.7).

Protein differential expression in normal tissues from HIPED for KRTAP13-2 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTAP13-2 Gene



SOURCE GeneReport for Unigene cluster for KRTAP13-2 Gene Hs.58152

genes like me logo Genes that share expression patterns with KRTAP13-2: view

Protein tissue co-expression partners for KRTAP13-2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KRTAP13-2 Gene

Orthologs for KRTAP13-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP13-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP13-2 35
  • 98.67 (n)
  • 97.71 (a)
KRTAP13-2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
OneToMany
KRTAP13-1 35
  • 81.84 (n)
  • 73.05 (a)
dog
(Canis familiaris)
Mammalia LOC100686265 35
  • 84.76 (n)
  • 78.86 (a)
-- 36
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krtap13-1 36
  • 63 (a)
ManyToMany
Krtap13 16
2310034C09Rik 35
  • 75.1 (n)
  • 63.79 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100363287 35
  • 78.64 (n)
  • 67.07 (a)
Species with no ortholog for KRTAP13-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP13-2 Gene

ENSEMBL:
Gene Tree for KRTAP13-2 (if available)
TreeFam:
Gene Tree for KRTAP13-2 (if available)

Paralogs for KRTAP13-2 Gene

Paralogs for KRTAP13-2 Gene

(4) SIMAP similar genes for KRTAP13-2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP13-2: view

Variants for KRTAP13-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP13-2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs16986753 - 30,372,138(+) GCCAC(A/G/T)TGAGG reference, missense
rs3804010 - 30,371,992(+) CAGGG(C/G)CTGGA reference, missense
rs2009546 -- 30,371,845(+) CTGGA(A/C/G)CCACA reference, synonymous-codon
rs877346 -- 30,371,809(-) AGCTG(A/C/T)GGCTT reference, stop-gained
rs914139 -- 30,370,919(+) cacac(A/T)GAATA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRTAP13-2 Gene

Variant ID Type Subtype PubMed ID
nsv834076 CNV Gain 17160897

Variation tolerance for KRTAP13-2 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.98; 79.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP13-2 Gene

HapMap Linkage Disequilibrium report
KRTAP13-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP13-2 Gene

Disorders for KRTAP13-2 Gene

Relevant External Links for KRTAP13-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP13-2

No disorders were found for KRTAP13-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP13-2 Gene

Publications for KRTAP13-2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  3. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PMID: 20494980) Warnatz H.J. … Yaspo M.L. (Nucleic Acids Res. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP13-2 Gene

Sources for KRTAP13-2 Gene

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