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Aliases for KRTAP13-1 Gene

Aliases for KRTAP13-1 Gene

  • Keratin Associated Protein 13-1 2 3 5
  • High Sulfur Keratin-Associated Protein 13.1 3 4
  • KRTAP13.1 3 4
  • KAP13.1 3 4
  • High Sulfur Keratin Associated Protein 13.1 3

External Ids for KRTAP13-1 Gene

Previous GeneCards Identifiers for KRTAP13-1 Gene

  • GC21P028428
  • GC21P030688
  • GC21P030690
  • GC21P031768
  • GC21P017177

Summaries for KRTAP13-1 Gene

Entrez Gene Summary for KRTAP13-1 Gene

  • Hair keratins and hair keratin-associated proteins (KAPs), such as KRTAP13-1, are the main structural proteins of hair fibers (Rogers et al., 2002 [PubMed 12359730]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KRTAP13-1 Gene

KRTAP13-1 (Keratin Associated Protein 13-1) is a Protein Coding gene. An important paralog of this gene is KRTAP13-2.

UniProtKB/Swiss-Prot for KRTAP13-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP13-1 Gene

Genomics for KRTAP13-1 Gene

Regulatory Elements for KRTAP13-1 Gene

Genomic Location for KRTAP13-1 Gene

Chromosome:
21
Start:
30,396,074 bp from pter
End:
30,396,822 bp from pter
Size:
749 bases
Orientation:
Plus strand

Genomic View for KRTAP13-1 Gene

Genes around KRTAP13-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP13-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP13-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP13-1 Gene

Proteins for KRTAP13-1 Gene

  • Protein details for KRTAP13-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC0-KR131_HUMAN
    Recommended name:
    Keratin-associated protein 13-1
    Protein Accession:
    Q8IUC0
    Secondary Accessions:
    • Q14D20
    • Q3LI79

    Protein attributes for KRTAP13-1 Gene

    Size:
    172 amino acids
    Molecular mass:
    18320 Da
    Quaternary structure:
    • Interacts with hair keratins.
    SequenceCaution:
    • Sequence=AAI13537.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI13539.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KRTAP13-1 Gene

Proteomics data for KRTAP13-1 Gene at MOPED

Post-translational modifications for KRTAP13-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP13-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP13-1 Gene

Domains & Families for KRTAP13-1 Gene

Gene Families for KRTAP13-1 Gene

Protein Domains for KRTAP13-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP13-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUC0

UniProtKB/Swiss-Prot:

KR131_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP13-1: view

Function for KRTAP13-1 Gene

Molecular function for KRTAP13-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP13-1 Gene

genes like me logo Genes that share phenotypes with KRTAP13-1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP13-1 Gene

Localization for KRTAP13-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP13-1 Gene COMPARTMENTS Subcellular localization image for KRTAP13-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP13-1 Gene

Pathways & Interactions for KRTAP13-1 Gene

SuperPathways for KRTAP13-1 Gene

No Data Available

Interacting Proteins for KRTAP13-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP13-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP13-1 Gene

Drugs & Compounds for KRTAP13-1 Gene

No Compound Related Data Available

Transcripts for KRTAP13-1 Gene

mRNA/cDNA for KRTAP13-1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP13-1 Gene

No ASD Table

Relevant External Links for KRTAP13-1 Gene

GeneLoc Exon Structure for
KRTAP13-1
ECgene alternative splicing isoforms for
KRTAP13-1

Expression for KRTAP13-1 Gene

mRNA expression in normal human tissues for KRTAP13-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP13-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.9) and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for KRTAP13-1 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRTAP13-1 Gene



SOURCE GeneReport for Unigene cluster for KRTAP13-1 Gene Hs.407653

mRNA Expression by UniProt/SwissProt for KRTAP13-1 Gene

Q8IUC0-KR131_HUMAN
Tissue specificity: Weak expression seen in the late matrix and entire cortex area of the hair follicle.
genes like me logo Genes that share expression patterns with KRTAP13-1: view

Protein tissue co-expression partners for KRTAP13-1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTAP13-1 Gene

Orthologs for KRTAP13-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP13-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRTAP13-2 35
  • 79.33 (n)
  • 69.33 (a)
-- 36
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krtap13-1 35
  • 76.71 (n)
  • 65.66 (a)
Krtap13-1 16
2310061N02Rik 36
  • 56 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia KRTAP13-1 35
  • 99.22 (n)
  • 98.84 (a)
KRTAP13-1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100363184 35
  • 78.11 (n)
  • 68.07 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for KRTAP13-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP13-1 Gene

ENSEMBL:
Gene Tree for KRTAP13-1 (if available)
TreeFam:
Gene Tree for KRTAP13-1 (if available)

Paralogs for KRTAP13-1 Gene

Paralogs for KRTAP13-1 Gene

(4) SIMAP similar genes for KRTAP13-1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KRTAP13-1 Gene

genes like me logo Genes that share paralogs with KRTAP13-1: view

Variants for KRTAP13-1 Gene

Variation tolerance for KRTAP13-1 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP13-1 Gene

HapMap Linkage Disequilibrium report
KRTAP13-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for KRTAP13-1 Gene

Disorders for KRTAP13-1 Gene

Relevant External Links for KRTAP13-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP13-1

No disorders were found for KRTAP13-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP13-1 Gene

Publications for KRTAP13-1 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3

Products for KRTAP13-1 Gene

Sources for KRTAP13-1 Gene

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