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Aliases for KRTAP12-4 Gene

Aliases for KRTAP12-4 Gene

  • Keratin Associated Protein 12-4 2 3
  • High Sulfur Keratin-Associated Protein 12.4 3 4
  • KRTAP12.4 3 4
  • Keratin-Associated Protein 12-4 3
  • Keratin-Associated Protein 12.4 4
  • KAP12.4 4

External Ids for KRTAP12-4 Gene

Previous GeneCards Identifiers for KRTAP12-4 Gene

  • GC00U914013
  • GC21M044930
  • GC21M044898
  • GC21M046075
  • GC21M031448
  • GC21M046164
  • GC21M046387
  • GC21M046546
  • GC21M046733

Summaries for KRTAP12-4 Gene

GeneCards Summary for KRTAP12-4 Gene

KRTAP12-4 (Keratin Associated Protein 12-4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP12-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP12-4 Gene

Genomics for KRTAP12-4 Gene

Regulatory Elements for KRTAP12-4 Gene

Genomic Location for KRTAP12-4 Gene

Start:
44,654,213 bp from pter
End:
44,654,659 bp from pter
Size:
447 bases
Orientation:
Minus strand

Genomic View for KRTAP12-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP12-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP12-4 Gene

Proteins for KRTAP12-4 Gene

  • Protein details for KRTAP12-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60329-KR124_HUMAN
    Recommended name:
    Keratin-associated protein 12-4
    Protein Accession:
    P60329
    Secondary Accessions:
    • Q08AF5

    Protein attributes for KRTAP12-4 Gene

    Size:
    112 amino acids
    Molecular mass:
    11433 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP12-4 Gene

Proteomics data for KRTAP12-4 Gene at MOPED

Post-translational modifications for KRTAP12-4 Gene

No Post-translational modifications

Other Protein References for KRTAP12-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP12-4 Gene

Domains for KRTAP12-4 Gene

Gene Families for KRTAP12-4 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP12-4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP12-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60329

UniProtKB/Swiss-Prot:

KR124_HUMAN :
  • P60329
Family:
  • Belongs to the KRTAP type 12 family.
genes like me logo Genes that share domains with KRTAP12-4: view

Function for KRTAP12-4 Gene

Molecular function for KRTAP12-4 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP12-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP12-4: view

Phenotypes for KRTAP12-4 Gene

genes like me logo Genes that share phenotypes with KRTAP12-4: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP12-4
    • Block miRNA regulation of KRTAP12-4 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP12-4

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP12-4 Gene

    Localization for KRTAP12-4 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP12-4 Gene COMPARTMENTS Subcellular localization image for KRTAP12-4 gene
    Compartment Confidence
    extracellular 3
    cytoskeleton 2

    Gene Ontology (GO) - Cellular Components for KRTAP12-4 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0045095 keratin filament IEA --
    genes like me logo Genes that share ontologies with KRTAP12-4: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP12-4 Gene

    Pathways for KRTAP12-4 Gene

    SuperPathways for KRTAP12-4 Gene

    No Data Available

    Gene Ontology (GO) - Biological Process for KRTAP12-4 Gene

    None

    No data available for Pathways by source for KRTAP12-4 Gene

    Transcripts for KRTAP12-4 Gene

    mRNA/cDNA for KRTAP12-4 Gene

    (2) Selected AceView cDNA sequences:
    (1) REFSEQ mRNAs :
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP12-4
      • Block miRNA regulation of KRTAP12-4 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP12-4

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP12-4
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP12-4 Gene

      No ASD Table

      Relevant External Links for KRTAP12-4 Gene

      GeneLoc Exon Structure for
      KRTAP12-4
      ECgene alternative splicing isoforms for
      KRTAP12-4

      Expression for KRTAP12-4 Gene

      mRNA expression in normal human tissues for KRTAP12-4 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP12-4 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (48.2).

      SOURCE GeneReport for Unigene cluster for KRTAP12-4 Gene Hs.689664

      mRNA Expression by UniProt/SwissProt for KRTAP12-4 Gene

      P60329-KR124_HUMAN
      Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.
      genes like me logo Genes that share expressions with KRTAP12-4: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP12-4 Gene

      Orthologs for KRTAP12-4 Gene

      This gene was present in the common ancestor of human and chimp.

      Orthologs for KRTAP12-4 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia KRTAP12-4 35
      • 98.51 (n)
      • 97.32 (a)
      KRTAP12-4 36
      • 78 (a)
      OneToOne
      Species with no ortholog for KRTAP12-4:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • mouse (Mus musculus)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP12-4 Gene

      ENSEMBL:
      Gene Tree for KRTAP12-4 (if available)
      TreeFam:
      Gene Tree for KRTAP12-4 (if available)

      Paralogs for KRTAP12-4 Gene

      Selected SIMAP similar genes for KRTAP12-4 Gene using alignment to 1 proteins:

      Pseudogenes.org Pseudogenes for KRTAP12-4 Gene

      genes like me logo Genes that share paralogs with KRTAP12-4: view

      No data available for Paralogs for KRTAP12-4 Gene

      Variants for KRTAP12-4 Gene

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP12-4 Gene

      Variant ID Type Subtype PubMed ID
      nsv913950 CNV Gain 21882294
      esv2723675 CNV Deletion 23290073
      nsv913954 CNV Loss 21882294
      nsv913955 CNV Loss 21882294

      Relevant External Links for KRTAP12-4 Gene

      HapMap Linkage Disequilibrium report
      KRTAP12-4

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KRTAP12-4 Gene

      Disorders for KRTAP12-4 Gene

      No disorders were found for KRTAP12-4 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP12-4 Gene

      Publications for KRTAP12-4 Gene

      1. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3 4
      2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
      3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
      4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
      5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

      Products for KRTAP12-4 Gene

      Sources for KRTAP12-4 Gene

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