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Aliases for KRTAP12-3 Gene

Aliases for KRTAP12-3 Gene

  • Keratin Associated Protein 12-3 2 3
  • High Sulfur Keratin-Associated Protein 12.3 3 4
  • Keratin-Associated Protein 12.3 3 4
  • KRTAP12.3 3 4
  • Keratin-Associated Protein 12-3 3
  • KAP12.3 4

External Ids for KRTAP12-3 Gene

Previous GeneCards Identifiers for KRTAP12-3 Gene

  • GC00U914012
  • GC21P044934
  • GC21P044882
  • GC21P044902
  • GC21P046067
  • GC21P031452
  • GC21P046077

Summaries for KRTAP12-3 Gene

GeneCards Summary for KRTAP12-3 Gene

KRTAP12-3 (Keratin Associated Protein 12-3) is a Protein Coding gene. An important paralog of this gene is KRTAP12-2.

UniProtKB/Swiss-Prot for KRTAP12-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP12-3 Gene

Genomics for KRTAP12-3 Gene

Regulatory Elements for KRTAP12-3 Gene

Genomic Location for KRTAP12-3 Gene

Start:
44,646,657 bp from pter
End:
44,658,341 bp from pter
Size:
11,685 bases
Orientation:
Plus strand

Genomic View for KRTAP12-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP12-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP12-3 Gene

Proteins for KRTAP12-3 Gene

  • Protein details for KRTAP12-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60328-KR123_HUMAN
    Recommended name:
    Keratin-associated protein 12-3
    Protein Accession:
    P60328
    Secondary Accessions:

    Protein attributes for KRTAP12-3 Gene

    Size:
    96 amino acids
    Molecular mass:
    9947 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP12-3 Gene

Proteomics data for KRTAP12-3 Gene at MOPED

Post-translational modifications for KRTAP12-3 Gene

No Post-translational modifications

Other Protein References for KRTAP12-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP12-3 Gene

Domains for KRTAP12-3 Gene

Gene Families for KRTAP12-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP12-3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP12-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60328

UniProtKB/Swiss-Prot:

KR123_HUMAN :
  • P60328
Family:
  • Belongs to the KRTAP type 12 family.
genes like me logo Genes that share domains with KRTAP12-3: view

Function for KRTAP12-3 Gene

Molecular function for KRTAP12-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Phenotypes for KRTAP12-3 Gene

GenomeRNAi human phenotypes for KRTAP12-3:
genes like me logo Genes that share phenotypes with KRTAP12-3: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP12-3
    • Block miRNA regulation of KRTAP12-3 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP12-3

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP12-3 Gene

    Localization for KRTAP12-3 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP12-3 Gene COMPARTMENTS Subcellular localization image for KRTAP12-3 gene
    Compartment Confidence
    extracellular 3
    cytoskeleton 2
    cytosol 1
    endoplasmic reticulum 1
    mitochondrion 1
    nucleus 1
    peroxisome 1

    Gene Ontology (GO) - Cellular Components for KRTAP12-3 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0045095 keratin filament IEA --
    genes like me logo Genes that share ontologies with KRTAP12-3: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP12-3 Gene

    Pathways for KRTAP12-3 Gene

    SuperPathways for KRTAP12-3 Gene

    No Data Available

    Interacting Proteins for KRTAP12-3 Gene

    Gene Ontology (GO) - Biological Process for KRTAP12-3 Gene

    None

    No data available for Pathways by source for KRTAP12-3 Gene

    Transcripts for KRTAP12-3 Gene

    mRNA/cDNA for KRTAP12-3 Gene

    (2) Selected AceView cDNA sequences:
    (1) REFSEQ mRNAs :
    (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP12-3
      • Block miRNA regulation of KRTAP12-3 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP12-3

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP12-3
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP12-3 Gene

      No ASD Table

      Relevant External Links for KRTAP12-3 Gene

      GeneLoc Exon Structure for
      KRTAP12-3
      ECgene alternative splicing isoforms for
      KRTAP12-3

      Expression for KRTAP12-3 Gene

      mRNA expression in normal human tissues for KRTAP12-3 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP12-3 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.7) and Skin - Sun Exposed (Lower leg) (4.5).

      SOURCE GeneReport for Unigene cluster for KRTAP12-3 Gene Hs.528023

      mRNA Expression by UniProt/SwissProt for KRTAP12-3 Gene

      P60328-KR123_HUMAN
      Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.
      genes like me logo Genes that share expressions with KRTAP12-3: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP12-3 Gene

      Orthologs for KRTAP12-3 Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for KRTAP12-3 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia KRTAP12-3 36
      • 96 (a)
      OneToOne
      LOC100612403 35
      • 98.26 (n)
      • 95.83 (a)
      cow
      (Bos Taurus)
      Mammalia -- 36
      • 34 (a)
      ManyToMany
      KRTAP12-2 36
      • 42 (a)
      ManyToMany
      dog
      (Canis familiaris)
      Mammalia -- 36
      • 53 (a)
      ManyToMany
      -- 36
      • 63 (a)
      ManyToMany
      -- 36
      • 37 (a)
      ManyToMany
      mouse
      (Mus musculus)
      Mammalia Gm10100 36
      • 48 (a)
      ManyToMany
      Gm10272 36
      • 54 (a)
      ManyToMany
      Krtap12-1 36
      • 45 (a)
      ManyToMany
      Species with no ortholog for KRTAP12-3:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP12-3 Gene

      ENSEMBL:
      Gene Tree for KRTAP12-3 (if available)
      TreeFam:
      Gene Tree for KRTAP12-3 (if available)

      Paralogs for KRTAP12-3 Gene

      Paralogs for KRTAP12-3 Gene

      Selected SIMAP similar genes for KRTAP12-3 Gene using alignment to 1 proteins:

      genes like me logo Genes that share paralogs with KRTAP12-3: view

      Variants for KRTAP12-3 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP12-3 Gene

      SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
      VAR_017592 -

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP12-3 Gene

      Variant ID Type Subtype PubMed ID
      nsv913950 CNV Gain 21882294
      esv2723675 CNV Deletion 23290073
      nsv913954 CNV Loss 21882294
      nsv913955 CNV Loss 21882294

      Relevant External Links for KRTAP12-3 Gene

      HapMap Linkage Disequilibrium report
      KRTAP12-3

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP12-3 Gene

      Disorders for KRTAP12-3 Gene

      No disorders were found for KRTAP12-3 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP12-3 Gene

      Publications for KRTAP12-3 Gene

      1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
      2. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3 4
      3. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PMID: 14962103) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2004) 4

      Products for KRTAP12-3 Gene

      Sources for KRTAP12-3 Gene

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