Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRTAP10-9 Gene

Aliases for KRTAP10-9 Gene

  • Keratin Associated Protein 10-9 2 3 5
  • High Sulfur Keratin-Associated Protein 10.9 3 4
  • Keratin-Associated Protein 10.9 3 4
  • Keratin-Associated Protein 18-9 3 4
  • Keratin-Associated Protein 18.9 3 4
  • KRTAP18-9 3 4
  • KAP10.9 3 4
  • Keratin Associated Protein 18-9 3
  • KRTAP10.9 4
  • KRTAP18.9 4
  • KAP18.9 3
  • KAP18-9 4

External Ids for KRTAP10-9 Gene

Previous HGNC Symbols for KRTAP10-9 Gene

  • KRTAP18-9

Previous GeneCards Identifiers for KRTAP10-9 Gene

  • GC21U900090
  • GC21P044871
  • GC21P046047
  • GC21P031421

Summaries for KRTAP10-9 Gene

GeneCards Summary for KRTAP10-9 Gene

KRTAP10-9 (Keratin Associated Protein 10-9) is a Protein Coding gene. An important paralog of this gene is KRTAP10-2.

UniProtKB/Swiss-Prot for KRTAP10-9 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP10-9 Gene

Genomics for KRTAP10-9 Gene

Regulatory Elements for KRTAP10-9 Gene

Enhancers for KRTAP10-9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRTAP10-9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP10-9 Gene

Chromosome:
21
Start:
44,627,123 bp from pter
End:
44,628,378 bp from pter
Size:
1,256 bases
Orientation:
Plus strand

Genomic View for KRTAP10-9 Gene

Genes around KRTAP10-9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP10-9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP10-9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP10-9 Gene

Proteins for KRTAP10-9 Gene

  • Protein details for KRTAP10-9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60411-KR109_HUMAN
    Recommended name:
    Keratin-associated protein 10-9
    Protein Accession:
    P60411
    Secondary Accessions:
    • A2RRG1
    • A6NIR9
    • Q70LJ1

    Protein attributes for KRTAP10-9 Gene

    Size:
    292 amino acids
    Molecular mass:
    30037 Da
    Quaternary structure:
    • Interacts with hair keratins.

    Alternative splice isoforms for KRTAP10-9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRTAP10-9 Gene

Proteomics data for KRTAP10-9 Gene at MOPED

Post-translational modifications for KRTAP10-9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP10-9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP10-9 Gene

Domains & Families for KRTAP10-9 Gene

Gene Families for KRTAP10-9 Gene

Protein Domains for KRTAP10-9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP10-9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60411

UniProtKB/Swiss-Prot:

KR109_HUMAN :
  • Belongs to the KRTAP type 10 family.
Family:
  • Belongs to the KRTAP type 10 family.
genes like me logo Genes that share domains with KRTAP10-9: view

Function for KRTAP10-9 Gene

Molecular function for KRTAP10-9 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP10-9 Gene

GenomeRNAi human phenotypes for KRTAP10-9:
genes like me logo Genes that share phenotypes with KRTAP10-9: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP10-9 Gene

Localization for KRTAP10-9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP10-9 Gene COMPARTMENTS Subcellular localization image for KRTAP10-9 gene
Compartment Confidence
cytoskeleton 2
extracellular 2
plasma membrane 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP10-9 Gene

Pathways & Interactions for KRTAP10-9 Gene

SuperPathways for KRTAP10-9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP10-9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP10-9 Gene

Drugs & Compounds for KRTAP10-9 Gene

No Compound Related Data Available

Transcripts for KRTAP10-9 Gene

mRNA/cDNA for KRTAP10-9 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP10-9 Gene

No ASD Table

Relevant External Links for KRTAP10-9 Gene

GeneLoc Exon Structure for
KRTAP10-9
ECgene alternative splicing isoforms for
KRTAP10-9

Expression for KRTAP10-9 Gene

mRNA expression in normal human tissues for KRTAP10-9 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP10-9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x45.9) and Skin - Sun Exposed (Lower leg) (x6.4).

SOURCE GeneReport for Unigene cluster for KRTAP10-9 Gene Hs.474000

mRNA Expression by UniProt/SwissProt for KRTAP10-9 Gene

P60411-KR109_HUMAN
Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.
genes like me logo Genes that share expression patterns with KRTAP10-9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRTAP10-9 Gene

Orthologs for KRTAP10-9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP10-9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC783535 35
  • 78.01 (n)
  • 74.23 (a)
-- 36
  • 58 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KRTAP10-9 35
  • 98.29 (n)
  • 97.26 (a)
KRTAP10-9 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm3250 36
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for KRTAP10-9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP10-9 Gene

ENSEMBL:
Gene Tree for KRTAP10-9 (if available)
TreeFam:
Gene Tree for KRTAP10-9 (if available)

Paralogs for KRTAP10-9 Gene

(12) SIMAP similar genes for KRTAP10-9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP10-9: view

Variants for KRTAP10-9 Gene

Sequence variations from dbSNP and Humsavar for KRTAP10-9 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_017739 -
VAR_060052 -

Structural Variations from Database of Genomic Variants (DGV) for KRTAP10-9 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913946 CNV Gain 21882294
nsv913948 CNV Loss 21882294
nsv913950 CNV Gain 21882294
esv7169 OTHER Inversion 19470904
esv2751931 CNV Loss 17911159
esv8518 OTHER Inversion 19470904
esv2723675 CNV Deletion 23290073
nsv913954 CNV Loss 21882294

Variation tolerance for KRTAP10-9 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.28; 85.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRTAP10-9 Gene

Disorders for KRTAP10-9 Gene

Relevant External Links for KRTAP10-9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP10-9

No disorders were found for KRTAP10-9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP10-9 Gene

Publications for KRTAP10-9 Gene

  1. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PMID: 14962103) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3

Products for KRTAP10-9 Gene

Sources for KRTAP10-9 Gene

Content