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Aliases for KRTAP10-5 Gene

Aliases for KRTAP10-5 Gene

  • Keratin Associated Protein 10-5 2 3
  • High Sulfur Keratin-Associated Protein 10.5 3 4
  • Keratin-Associated Protein 18.5 3 4
  • KRTAP18-5 3 4
  • KRTAP10.5 3 4
  • KRTAP18.5 3 4
  • KAP10.5 3 4
  • KAP18-5 3 4
  • Keratin-Associated Protein 10-5 3
  • Keratin-Associated Protein 10.5 4
  • Keratin-Associated Protein 18-5 4
  • KRTAP18.1 3
  • KAP18.5 3

External Ids for KRTAP10-5 Gene

Previous HGNC Symbols for KRTAP10-5 Gene

  • KRTAP18-5

Previous GeneCards Identifiers for KRTAP10-5 Gene

  • GC21U900092
  • GC21M044823
  • GC21M045999
  • GC21M031373

Summaries for KRTAP10-5 Gene

Entrez Gene Summary for KRTAP10-5 Gene

  • This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014]

GeneCards Summary for KRTAP10-5 Gene

KRTAP10-5 (Keratin Associated Protein 10-5) is a Protein Coding gene. An important paralog of this gene is KRTAP10-2.

UniProtKB/Swiss-Prot for KRTAP10-5 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP10-5 Gene

Genomics for KRTAP10-5 Gene

Regulatory Elements for KRTAP10-5 Gene

Transcription factor binding sites by QIAGEN in the KRTAP10-5 gene promoter:

Genomic Location for KRTAP10-5 Gene

Start:
44,579,455 bp from pter
End:
44,580,604 bp from pter
Size:
1,150 bases
Orientation:
Minus strand

Genomic View for KRTAP10-5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP10-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP10-5 Gene

Proteins for KRTAP10-5 Gene

  • Protein details for KRTAP10-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60370-KR105_HUMAN
    Recommended name:
    Keratin-associated protein 10-5
    Protein Accession:
    P60370
    Secondary Accessions:
    • Q0VAR7
    • Q0VAR8
    • Q70LJ3

    Protein attributes for KRTAP10-5 Gene

    Size:
    271 amino acids
    Molecular mass:
    27626 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP10-5 Gene

Proteomics data for KRTAP10-5 Gene at MOPED

Post-translational modifications for KRTAP10-5 Gene

No Post-translational modifications

Other Protein References for KRTAP10-5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP10-5 Gene

Domains for KRTAP10-5 Gene

Gene Families for KRTAP10-5 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP10-5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP10-5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60370

UniProtKB/Swiss-Prot:

KR105_HUMAN :
  • P60370
Family:
  • Belongs to the KRTAP type 10 family.
genes like me logo Genes that share domains with KRTAP10-5: view

Function for KRTAP10-5 Gene

Molecular function for KRTAP10-5 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP10-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP10-5: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP10-5
    • Block miRNA regulation of KRTAP10-5 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP10-5

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP10-5 Gene

    Localization for KRTAP10-5 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP10-5 Gene COMPARTMENTS Subcellular localization image for KRTAP10-5 gene
    Compartment Confidence
    cytoskeleton 2
    extracellular 2

    Gene Ontology (GO) - Cellular Components for KRTAP10-5 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0045095 keratin filament IEA --
    genes like me logo Genes that share ontologies with KRTAP10-5: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP10-5 Gene

    Pathways for KRTAP10-5 Gene

    SuperPathways for KRTAP10-5 Gene

    No Data Available

    Gene Ontology (GO) - Biological Process for KRTAP10-5 Gene

    None

    No data available for Pathways by source for KRTAP10-5 Gene

    Transcripts for KRTAP10-5 Gene

    mRNA/cDNA for KRTAP10-5 Gene

    (1) REFSEQ mRNAs :
    (3) Selected AceView cDNA sequences:
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP10-5
      • Block miRNA regulation of KRTAP10-5 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP10-5

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP10-5
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP10-5 Gene

      No ASD Table

      Relevant External Links for KRTAP10-5 Gene

      GeneLoc Exon Structure for
      KRTAP10-5
      ECgene alternative splicing isoforms for
      KRTAP10-5

      Expression for KRTAP10-5 Gene

      mRNA expression in normal human tissues for KRTAP10-5 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP10-5 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (46.6) and Skin - Sun Exposed (Lower leg) (5.8).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRTAP10-5 Gene

      SOURCE GeneReport for Unigene cluster for KRTAP10-5 Gene Hs.688629

      mRNA Expression by UniProt/SwissProt for KRTAP10-5 Gene

      P60370-KR105_HUMAN
      Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.
      genes like me logo Genes that share expressions with KRTAP10-5: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTAP10-5 Gene

      Orthologs for KRTAP10-5 Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for KRTAP10-5 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia -- 36
      • 74 (a)
      ManyToMany
      KRTAP10-5 35
      • 97.05 (n)
      • 94.83 (a)
      cow
      (Bos Taurus)
      Mammalia -- 36
      • 52 (a)
      OneToMany
      dog
      (Canis familiaris)
      Mammalia -- 36
      • 44 (a)
      ManyToMany
      mouse
      (Mus musculus)
      Mammalia Gm10318 36
      • 57 (a)
      ManyToMany
      platypus
      (Ornithorhynchus anatinus)
      Mammalia -- 36
      • 44 (a)
      ManyToMany
      -- 36
      • 28 (a)
      ManyToMany
      Species with no ortholog for KRTAP10-5:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP10-5 Gene

      ENSEMBL:
      Gene Tree for KRTAP10-5 (if available)
      TreeFam:
      Gene Tree for KRTAP10-5 (if available)

      Paralogs for KRTAP10-5 Gene

      genes like me logo Genes that share paralogs with KRTAP10-5: view

      Variants for KRTAP10-5 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP10-5 Gene

      SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
      VAR_017696 -
      VAR_017697 -
      VAR_047505 -
      VAR_047506 -
      VAR_047507 -

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP10-5 Gene

      Variant ID Type Subtype PubMed ID
      esv33817 CNV Loss 17666407
      esv2723638 CNV Deletion 23290073
      nsv913943 CNV Loss 21882294
      nsv913946 CNV Gain 21882294
      nsv913948 CNV Loss 21882294
      nsv913950 CNV Gain 21882294
      esv7169 OTHER Inversion 19470904
      nsv913951 CNV Loss 21882294
      nsv913952 CNV Loss 21882294
      esv2751931 CNV Loss 17911159
      esv2723674 CNV Deletion 23290073
      esv2660233 CNV Deletion 23128226

      Relevant External Links for KRTAP10-5 Gene

      HapMap Linkage Disequilibrium report
      KRTAP10-5

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP10-5 Gene

      Disorders for KRTAP10-5 Gene

      No disorders were found for KRTAP10-5 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP10-5 Gene

      Publications for KRTAP10-5 Gene

      1. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PMID: 14962103) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2004) 3 4
      2. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3 4
      3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
      4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
      5. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 3

      Products for KRTAP10-5 Gene

      Sources for KRTAP10-5 Gene

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