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Aliases for KRTAP10-4 Gene

Aliases for KRTAP10-4 Gene

  • Keratin Associated Protein 10-4 2 3
  • High Sulfur Keratin-Associated Protein 10.4 3 4
  • Keratin-Associated Protein 18.4 3 4
  • KRTAP18-4 3 4
  • KRTAP10.4 3 4
  • KRTAP18.4 3 4
  • KAP10.4 3 4
  • KAP18-4 3 4
  • Keratin Associated Protein 18-4 2
  • Keratin-Associated Protein 10-4 3
  • Keratin-Associated Protein 10.4 4
  • Keratin-Associated Protein 18-4 4

External Ids for KRTAP10-4 Gene

Previous Symbols for KRTAP10-4 Gene

  • KRTAP18-4

Summaries for KRTAP10-4 Gene

Entrez Gene Summary for KRTAP10-4 Gene

  • This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014]

GeneCards Summary for KRTAP10-4 Gene

KRTAP10-4 (Keratin Associated Protein 10-4) is a Protein Coding gene. An important paralog of this gene is KRTAP10-2.

UniProtKB/Swiss-Prot for KRTAP10-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP10-4 Gene

Genomics for KRTAP10-4 Gene

Genomic Location for KRTAP10-4 Gene

Start:
44,573,729 bp from pter
End:
44,575,371 bp from pter
Size:
1,643 bases
Orientation:
Plus strand

Genomic View for KRTAP10-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP10-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP10-4 Gene

Regulatory Elements for KRTAP10-4 Gene

Proteins for KRTAP10-4 Gene

  • Protein details for KRTAP10-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60372-KR104_HUMAN
    Recommended name:
    Keratin-associated protein 10-4
    Protein Accession:
    P60372
    Secondary Accessions:
    • Q08AS0

    Protein attributes for KRTAP10-4 Gene

    Size:
    401 amino acids
    Molecular mass:
    40429 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP10-4 Gene

Proteomics data for KRTAP10-4 Gene at MOPED

Post-translational modifications for KRTAP10-4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP10-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP10-4 Gene

Domains for KRTAP10-4 Gene

Gene Families for KRTAP10-4 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP10-4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP10-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60372

UniProtKB/Swiss-Prot:

KR104_HUMAN
Family:
  • Belongs to the KRTAP type 10 family.:
    • P60372
genes like me logo Genes that share domains with KRTAP10-4: view

Function for KRTAP10-4 Gene

Molecular function for KRTAP10-4 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP10-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP10-4: view

miRNA for KRTAP10-4 Gene

miRTarBase miRNAs that target KRTAP10-4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRTAP10-4 Gene

Localization for KRTAP10-4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP10-4 Gene COMPARTMENTS Subcellular localization image for KRTAP10-4 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP10-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP10-4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP10-4 Gene

Pathways for KRTAP10-4 Gene

SuperPathways for KRTAP10-4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP10-4 Gene

None

No data available for Pathways by source for KRTAP10-4 Gene

Transcripts for KRTAP10-4 Gene

mRNA/cDNA for KRTAP10-4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP10-4 Gene

Keratin associated protein 10-4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP10-4 Gene

No ASD Table

Relevant External Links for KRTAP10-4 Gene

GeneLoc Exon Structure for
KRTAP10-4
ECgene alternative splicing isoforms for
KRTAP10-4

Expression for KRTAP10-4 Gene

SOURCE GeneReport for Unigene cluster for KRTAP10-4 Gene Hs.567901

mRNA Expression by UniProt/SwissProt for KRTAP10-4 Gene

P60372-KR104_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for KRTAP10-4 Gene

Orthologs for KRTAP10-4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP10-4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm19402 36
  • 52 (a)
ManyToMany
Krtap4-6 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
Species with no ortholog for KRTAP10-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP10-4 Gene

ENSEMBL:
Gene Tree for KRTAP10-4 (if available)
TreeFam:
Gene Tree for KRTAP10-4 (if available)

Paralogs for KRTAP10-4 Gene

Selected SIMAP similar genes for KRTAP10-4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP10-4: view

Variants for KRTAP10-4 Gene

Sequence variations from dbSNP and Humsavar for KRTAP10-4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_017694 -
VAR_017695 -
VAR_062112 -

Structural Variations from Database of Genomic Variants (DGV) for KRTAP10-4 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
esv2723638 CNV Deletion 23290073
nsv913943 CNV Loss 21882294
nsv913946 CNV Gain 21882294
nsv913948 CNV Loss 21882294
nsv913950 CNV Gain 21882294
esv7169 OTHER Inversion 19470904
nsv913951 CNV Loss 21882294
nsv913952 CNV Loss 21882294
esv2751931 CNV Loss 17911159
esv2723674 CNV Deletion 23290073
esv2660233 CNV Deletion 23128226

Relevant External Links for KRTAP10-4 Gene

HapMap Linkage Disequilibrium report
KRTAP10-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP10-4 Gene

Disorders for KRTAP10-4 Gene

Relevant External Links for KRTAP10-4

Genetic Association Database (GAD)
KRTAP10-4
genes like me logo Genes that share disorders with KRTAP10-4: view

No data available for UniProtKB/Swiss-Prot for KRTAP10-4 Gene

Publications for KRTAP10-4 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  2. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 3

Products for KRTAP10-4 Gene

Sources for KRTAP10-4 Gene

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