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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRTAP10-3 Gene

protein-coding   GIFtS: 32
GCID: GC21M045977

keratin associated protein 10-3


(Previous symbol: KRTAP18-3)
 Explore 1 disease affiliated with
KRTAP10-3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KRTAP10-3    

Aliases
for KRTAP10-3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratin Associated Protein 10-31 2     Keratin-Associated Protein 18-32 3
KAP10.31 2 3     Keratin-Associated Protein 18.32 3
KRTAP18-31 2 3     KAP18-32 3
KAP18.31 2     KRTAP10.32 3
High Sulfur Keratin-Associated Protein 10.32 3     KRTAP18.32 3
Keratin-Associated Protein 10.32 3     Keratin-Associated Protein 10-32

External Ids:    HGNC: 229681   Entrez Gene: 3866822   Ensembl: ENSG000002129357   UniProtKB: P603693   

Export aliases for KRTAP10-3 gene to outside databases

Previous GC identifers: GC21U900093 GC21M044802 GC21M031351


Summaries
for KRTAP10-3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KRTAP10-3:
This gene encodes a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin
intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique,
family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to
amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This gene encodes a
member of the high sulfur KAP family. It is localized to a cluster of intronless KAPs at 21q22.3 which are located
within the introns of the C21orf29 gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KR103_HUMAN, P60369
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,
consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant
hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The
matrix proteins include the high-sulfur and high-glycine-tyrosine keratins




Genomic Views
for KRTAP10-3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRTAP10-3 gene promoter:
         NF-1   NF-1/L   Pbx1a   Lmo2   Olf-1   HNF-4alpha1   E47   HEN1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP10-3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

KRTAP10-3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTAP10-3 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M045977:  view genomic region     (about GC identifiers)

Start:
 45,977,673 bp from pter      End:
 45,978,643 bp from pter
Size:
 971 bases      Orientation:
 minus strand

Proteins
for KRTAP10-3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KR103_HUMAN, P60369 (See protein sequence)
Recommended Name: Keratin-associated protein 10-3  
Size: 221 amino acids; 22348 Da
Subunit: Interacts with hair keratins
Secondary accessions: A3KN67 Q70LJ4

Explore the universe of human proteins at neXtProt for KRTAP10-3: NX_P60369

KRTAP10-3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_941969.2  
ENSEMBL proteins: 
 ENSP00000375478  

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Uscn Proteins for KRTAP10-3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045095keratin filament IEA--


KRTAP10-3 for ontologies           About GeneDecksing



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Protein Domains /
Families
for KRTAP10-3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
KRTAP10-3 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002494 Keratin-assoc

Graphical View of Domain Structure for InterPro Entry P60369

ProtoNet protein and cluster: P60369

UniProtKB/Swiss-Prot: KR103_HUMAN, P60369
Similarity: Belongs to the KRTAP type 10 family


Function
for KRTAP10-3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: KR103_HUMAN, P60369
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,
consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant
hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The
matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

miRNA
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In Situ Assay
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Pathways & Interactions
for KRTAP10-3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP10-3

Drugs & Compounds
for KRTAP10-3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for KRTAP10-3
Search CenterWatch for drugs/clinical trials and news about KRTAP10-3 / KR103 

Transcripts
for KRTAP10-3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section
REFSEQ mRNAs for KRTAP10-3 gene: 
NM_198696.2  

Unigene Cluster for KRTAP10-3:

Keratin associated protein 10-3
Hs.688630
Unigene Representative Sequence: NM_198696
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000391620(uc002zfj.1)

miRNA
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Primer
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Additional cDNA sequence: 

AB076350.1 AJ566383.1 BC133677.1 

1 DOTS entry:

DT.101979332 

3 AceView cDNA sequences:

NM_198696 AB076350 AJ566383 

GeneLoc Exon Structure


Expression
for KRTAP10-3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRTAP10-3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

KRTAP10-3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See KRTAP10-3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.688630

UniProtKB/Swiss-Prot: KR103_HUMAN, P60369
Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above
the apex of the dermal papilla of the hair root; not detected in any other tissues

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In Situ
Assay Products: 
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Orthologs
for KRTAP10-3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of eukaryotes.

Orthologs for KRTAP10-3 gene from 5/9 species (see all 9)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves --
 --
 8(a)
 possible ortholog
 25(1245309-1247390)
zebrafish
(Danio rerio)		 Actinopterygii CT573349.16
 --
 8(a)
 possible ortholog
 23(27159106-27160345)
fruit fly
(Drosophila melanogaster)		 Insecta CG427586
 --
 14(a)
 possible ortholog
 3L(14560540-14561233)
worm
(Caenorhabditis elegans)		 Secernentea pqn-26
abu-16
(see all 22)		 Prion-like-(Q/N-rich)-domain-bearing protein famil...
Activated in Blocked Unfolded protein response fam...
(see all 22)		 9(a)
9(a)
(see all 22)		 possible ortholog
possible ortholog
(see all 22)		 V(10382419-10383953)
V(10380316-10381800)
thale cress
(Arabidopsis thaliana)		 eudicotyledons AT5G206356
 uncharacterized protein
 8(a)
 possible ortholog
 5(6979213-6981935)


ENSEMBL Gene Tree for KRTAP10-3 (if available)
TreeFam Gene Tree for KRTAP10-3 (if available) 

Paralogs
for KRTAP10-3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KRTAP10-3 gene
KRTAP4-42  KRTAP10-22  KRTAP9-32  KRTAP10-112  KRTAP5-102  KRTAP9-62  KRTAP4-72  KRTAP1-12  
KRTAP5-42  KRTAP10-12  KRTAP1-42  KRTAP9-72  KRTAP4-12  KRTAP4-122  KRTAP9-92  KRTAP10-122  
KRTAP5-22  KRTAP2-22  KRTAP12-32  KRTAP5-72  KRTAP10-102  KRTAP10-82  KRTAP16-12  KRTAP9-22  
KRTAP12-42  KRTAP5-12  KRTAP4-16P2  KRTAP5-32  KRTAP1-52  KRTAP4-112  KRTAP2-42  KRTAP10-62  
KRTAP9-12  KRTAP1-32  KRTAP10-72  KRTAP4-52  KRTAP2-12  KRTAP4-22  KRTAP9-42  KRTAP4-92  
KRTAP5-52  KRTAP5-62  KRTAP12-22  KRTAP29-12  KRTAP5-112  KRTAP10-92  KRTAP5-92  KRTAP10-52  
KRTAP4-82  KRTAP12-12  KRTAP5-82  KRTAP2-32  KRTAP9-82  KRTAP4-62  KRTAP10-42  KRTAP4-32  
16 SIMAP similar genes for KRTAP10-3 using alignment to 1 protein entry:     KR103_HUMAN:
KRTAP10-12    KRTAP10-2    KRTAP10-6    KRTAP10-10    KRTAP10-7    KRTAP2.1B
KRTAP18.9s    KRTAP10-8    KRTAP10-1    KRTAP10-9    KRTAP10-4    KRTAP10-5
KRTAP10-11    KRTAP4-1    KRTAP12-2    KRTAP4-2

KRTAP10-3 for paralogs           About GeneDecksing



Genomic Variants
for KRTAP10-3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRTAP10-3
     2 CNVs: 90825 7327
SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for KRTAP10-3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
KRTAP10-3 for disorders           About GeneDecksing

1 disease for KRTAP10-3:    About MalaCards
fraser syndrome


Export disorders for KRTAP10-3 gene to outside databases

Publications
for KRTAP10-3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KRTAP10-3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRTAP10-3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PubMed id 14962103)1, 2 Rogers M.A....Schweizer J. (2004)
  2. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PubMed id 15028290)1, 2 Shibuya K....Shimizu N. (2004)
  3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PubMed id 12359730)1 Rogers M.A....Schweizer J. (2002)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for KRTAP10-3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing KRTAP10-3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 386682 HGNC: 22968 AceView: KRTAP10-3 Ensembl:ENSG00000212935 euGenes: HUgn386682
ECgene: KRTAP10-3 H-InvDB: KRTAP10-3

Other Databases showing KRTAP10-3 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing KRTAP10-3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KRTAP10-3 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for KRTAP10-3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KRTAP10-3 gene:
Search GeneIP for patents involving KRTAP10-3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for KRTAP10-3 gene

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About This Section

 
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