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Aliases for KRTAP10-12 Gene

Aliases for KRTAP10-12 Gene

  • Keratin Associated Protein 10-12 2 3
  • High Sulfur Keratin-Associated Protein 10.12 3 4
  • Keratin-Associated Protein 18-12 3 4
  • KRTAP18-12 3 4
  • KRTAP18.12 3 4
  • KAP10.12 3 4
  • Keratin Associated Protein 18-12 2
  • Keratin-Associated Protein 10.12 4
  • Keratin-Associated Protein 18.12 4
  • KRTAP10.12 4
  • KAP18-12 4

External Ids for KRTAP10-12 Gene

Previous HGNC Symbols for KRTAP10-12 Gene

  • KRTAP18-12

Previous GeneCards Identifiers for KRTAP10-12 Gene

  • GC21P044942
  • GC21P046117
  • GC21P031491

Summaries for KRTAP10-12 Gene

GeneCards Summary for KRTAP10-12 Gene

KRTAP10-12 (Keratin Associated Protein 10-12) is a Protein Coding gene. An important paralog of this gene is KRTAP10-2.

UniProtKB/Swiss-Prot for KRTAP10-12 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP10-12 Gene

Genomics for KRTAP10-12 Gene

Regulatory Elements for KRTAP10-12 Gene

Genomic Location for KRTAP10-12 Gene

Chromosome:
21
Start:
44,697,172 bp from pter
End:
44,698,044 bp from pter
Size:
873 bases
Orientation:
Plus strand

Genomic View for KRTAP10-12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP10-12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP10-12 Gene

Proteins for KRTAP10-12 Gene

  • Protein details for KRTAP10-12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60413-KR10C_HUMAN
    Recommended name:
    Keratin-associated protein 10-12
    Protein Accession:
    P60413
    Secondary Accessions:
    • B2RPA3

    Protein attributes for KRTAP10-12 Gene

    Size:
    245 amino acids
    Molecular mass:
    25107 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP10-12 Gene

Proteomics data for KRTAP10-12 Gene at MOPED

Post-translational modifications for KRTAP10-12 Gene

No Post-translational modifications

Other Protein References for KRTAP10-12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP10-12 Gene

Domains & Families for KRTAP10-12 Gene

Gene Families for KRTAP10-12 Gene

Protein Domains for KRTAP10-12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP10-12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60413

UniProtKB/Swiss-Prot:

KR10C_HUMAN :
  • Belongs to the KRTAP type 10 family.
Family:
  • Belongs to the KRTAP type 10 family.
genes like me logo Genes that share domains with KRTAP10-12: view

Function for KRTAP10-12 Gene

Molecular function for KRTAP10-12 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Phenotypes for KRTAP10-12 Gene

GenomeRNAi human phenotypes for KRTAP10-12:
genes like me logo Genes that share phenotypes with KRTAP10-12: view

Animal Model Products

CRISPR Products

miRNA for KRTAP10-12 Gene

miRTarBase miRNAs that target KRTAP10-12

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP10-12
    • Block miRNA regulation of KRTAP10-12 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP10-12

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for KRTAP10-12 Gene

    Localization for KRTAP10-12 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP10-12 Gene COMPARTMENTS Subcellular localization image for KRTAP10-12 gene
    Compartment Confidence
    cytoskeleton 2

    Gene Ontology (GO) - Cellular Components for KRTAP10-12 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0045095 keratin filament IEA --
    genes like me logo Genes that share ontologies with KRTAP10-12: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP10-12 Gene

    Pathways & Interactions for KRTAP10-12 Gene

    SuperPathways for KRTAP10-12 Gene

    No Data Available

    Interacting Proteins for KRTAP10-12 Gene

    Gene Ontology (GO) - Biological Process for KRTAP10-12 Gene

    None

    No data available for Pathways by source and SIGNOR curated interactions for KRTAP10-12 Gene

    Drugs & Compounds for KRTAP10-12 Gene

    No Compound Related Data Available

    Transcripts for KRTAP10-12 Gene

    mRNA/cDNA for KRTAP10-12 Gene

    (1) REFSEQ mRNAs :
    (3) Additional mRNA sequences :
    (6) Selected AceView cDNA sequences:
    (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for KRTAP10-12 Gene

    Keratin associated protein 10-12:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP10-12
      • Block miRNA regulation of KRTAP10-12 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP10-12

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP10-12 Gene

      No ASD Table

      Relevant External Links for KRTAP10-12 Gene

      GeneLoc Exon Structure for
      KRTAP10-12
      ECgene alternative splicing isoforms for
      KRTAP10-12

      Expression for KRTAP10-12 Gene

      mRNA expression in normal human tissues for KRTAP10-12 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP10-12 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x45.1) and Skin - Sun Exposed (Lower leg) (x6.9).

      SOURCE GeneReport for Unigene cluster for KRTAP10-12 Gene Hs.297526

      mRNA Expression by UniProt/SwissProt for KRTAP10-12 Gene

      P60413-KR10C_HUMAN
      Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.
      genes like me logo Genes that share expression patterns with KRTAP10-12: view

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRTAP10-12 Gene

      Orthologs for KRTAP10-12 Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for KRTAP10-12 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia KRTAP10-12 35
      • 97.01 (n)
      • 95.51 (a)
      KRTAP10-12 36
      • 86 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Gm9508 16
      Gm7137 36
      • 53 (a)
      ManyToMany
      cow
      (Bos Taurus)
      Mammalia KRTAP10-8 36
      • 50 (a)
      ManyToMany
      dog
      (Canis familiaris)
      Mammalia -- 36
      • 51 (a)
      ManyToMany
      platypus
      (Ornithorhynchus anatinus)
      Mammalia -- 36
      • 48 (a)
      ManyToMany
      -- 36
      • 35 (a)
      ManyToMany
      Species with no ortholog for KRTAP10-12:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP10-12 Gene

      ENSEMBL:
      Gene Tree for KRTAP10-12 (if available)
      TreeFam:
      Gene Tree for KRTAP10-12 (if available)

      Paralogs for KRTAP10-12 Gene

      (10) SIMAP similar genes for KRTAP10-12 Gene using alignment to 1 proteins:

      genes like me logo Genes that share paralogs with KRTAP10-12: view

      Variants for KRTAP10-12 Gene

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP10-12 Gene

      Variant ID Type Subtype PubMed ID
      nsv913950 CNV Gain 21882294
      esv2723675 CNV Deletion 23290073
      dgv4775n71 CNV Loss 21882294
      nsv913957 CNV Loss 21882294
      nsv913958 CNV Loss 21882294
      nsv913959 CNV Loss 21882294
      esv2723677 CNV Deletion 23290073

      Variation tolerance for KRTAP10-12 Gene

      Residual Variation Intolerance Score: 89.19% of all genes are more intolerant (likely to be disease-causing)
      Gene Damage Index Score: 9.44; 88.63% of all genes are more intolerant (likely to be disease-causing)

      Relevant External Links for KRTAP10-12 Gene

      HapMap Linkage Disequilibrium report
      KRTAP10-12

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KRTAP10-12 Gene

      Disorders for KRTAP10-12 Gene

      Relevant External Links for KRTAP10-12

      Atlas of Genetics and Cytogenetics in Oncology and Haematology:
      KRTAP10-12
      genes like me logo Genes that share disorders with KRTAP10-12: view

      No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP10-12 Gene

      Publications for KRTAP10-12 Gene

      1. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 67
      2. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PMID: 14962103) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2004) 67
      3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
      4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67
      5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 67

      Products for KRTAP10-12 Gene

      Sources for KRTAP10-12 Gene

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