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Aliases for KRTAP10-11 Gene

Aliases for KRTAP10-11 Gene

  • Keratin Associated Protein 10-11 2 3 5
  • High Sulfur Keratin-Associated Protein 10.11 3 4
  • Keratin-Associated Protein 10.11 3 4
  • Keratin-Associated Protein 18.11 3 4
  • KRTAP18-11 3 4
  • KRTAP18.11 3 4
  • KAP10.11 3 4
  • Keratin Associated Protein 18-11 3
  • Keratin-Associated Protein 10-11 3
  • Keratin-Associated Protein 18-11 4
  • KRTAP10.11 4
  • KAP18.11 3
  • KAP18-11 4

External Ids for KRTAP10-11 Gene

Previous HGNC Symbols for KRTAP10-11 Gene

  • KRTAP18-11

Previous GeneCards Identifiers for KRTAP10-11 Gene

  • GC21P044890
  • GC21P044883
  • GC21P046066
  • GC21P031440

Summaries for KRTAP10-11 Gene

GeneCards Summary for KRTAP10-11 Gene

KRTAP10-11 (Keratin Associated Protein 10-11) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is KRTAP10-9.

UniProtKB/Swiss-Prot for KRTAP10-11 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP10-11 Gene

Genomics for KRTAP10-11 Gene

Regulatory Elements for KRTAP10-11 Gene

Enhancers for KRTAP10-11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G044876 2 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +234.4 234393 8.0 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B DMAP1 YY1 PTTG1IP SUMO3 LINC01424 UBE2G2 ENSG00000215447 KRTAP10-6 KRTAP12-2 KRTAP10-11 KRTAP12-1 ITGB2
GH21G044618 0.9 Ensembl ENCODE 11.9 -27.3 -27328 2.0 CTCF CBX3 L3MBTL2 RAD21 CBX1 ZFHX2 CBX5 EGR1 FOS TRIM28 KRTAP10-11 KRTAP12-3 IMMTP1 KRTAP12-1 KRTAP10-2 KRTAP10-1 TSPEAR-AS1 KRTAP10-6 KRTAP10-9 KRTAP10-8
GH21G044263 0.9 FANTOM5 ENCODE 2.4 -382.8 -382761 0.9 ZFHX2 NR2F1 GLIS1 PATZ1 PRDM10 ZIC2 PRDM1 EGR2 ICOSLG AIRE ENSG00000184441 DNMT3L KRTAP12-2 KRTAP10-6 KRTAP12-4 KRTAP12-1 KRTAP10-11 KRTAP10-12
GH21G045132 0.9 FANTOM5 Ensembl dbSUPER 1.5 +486.7 486687 0.6 ZNF10 ZEB2 ADARB1 SSR4P1 LINC00334 ITGB2 KRTAP12-2 KRTAP12-1 KRTAP10-11 LOC105372835 GC21M045391
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRTAP10-11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP10-11 Gene

Chromosome:
21
Start:
44,646,414 bp from pter
End:
44,647,650 bp from pter
Size:
1,237 bases
Orientation:
Plus strand

Genomic View for KRTAP10-11 Gene

Genes around KRTAP10-11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP10-11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP10-11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP10-11 Gene

Proteins for KRTAP10-11 Gene

  • Protein details for KRTAP10-11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60412-KR10B_HUMAN
    Recommended name:
    Keratin-associated protein 10-11
    Protein Accession:
    P60412
    Secondary Accessions:
    • A2RRF9

    Protein attributes for KRTAP10-11 Gene

    Size:
    298 amino acids
    Molecular mass:
    30243 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP10-11 Gene

Post-translational modifications for KRTAP10-11 Gene

No Post-translational modifications

Other Protein References for KRTAP10-11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP10-11 Gene

Domains & Families for KRTAP10-11 Gene

Gene Families for KRTAP10-11 Gene

Protein Domains for KRTAP10-11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP10-11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60412

UniProtKB/Swiss-Prot:

KR10B_HUMAN :
  • Belongs to the KRTAP type 10 family.
Family:
  • Belongs to the KRTAP type 10 family.
genes like me logo Genes that share domains with KRTAP10-11: view

Function for KRTAP10-11 Gene

Molecular function for KRTAP10-11 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Gene Ontology (GO) - Molecular Function for KRTAP10-11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP10-11: view

Phenotypes for KRTAP10-11 Gene

GenomeRNAi human phenotypes for KRTAP10-11:
genes like me logo Genes that share phenotypes with KRTAP10-11: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP10-11 Gene

Localization for KRTAP10-11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP10-11 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KRTAP10-11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP10-11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP10-11 Gene

Pathways & Interactions for KRTAP10-11 Gene

SuperPathways for KRTAP10-11 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP10-11: view

Pathways by source for KRTAP10-11 Gene

2 Reactome pathways for KRTAP10-11 Gene

Gene Ontology (GO) - Biological Process for KRTAP10-11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP10-11: view

No data available for SIGNOR curated interactions for KRTAP10-11 Gene

Drugs & Compounds for KRTAP10-11 Gene

No Compound Related Data Available

Transcripts for KRTAP10-11 Gene

mRNA/cDNA for KRTAP10-11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP10-11 Gene

Keratin associated protein 10-11:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP10-11 Gene

No ASD Table

Relevant External Links for KRTAP10-11 Gene

GeneLoc Exon Structure for
KRTAP10-11
ECgene alternative splicing isoforms for
KRTAP10-11

Expression for KRTAP10-11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP10-11 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP10-11 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x46.8) and Skin - Sun Exposed (Lower leg) (x5.5).

SOURCE GeneReport for Unigene cluster for KRTAP10-11 Gene:

Hs.58076

mRNA Expression by UniProt/SwissProt for KRTAP10-11 Gene:

P60412-KR10B_HUMAN
Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.

Evidence on tissue expression from TISSUES for KRTAP10-11 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with KRTAP10-11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP10-11 Gene

Orthologs for KRTAP10-11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP10-11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP10-11 34 35
  • 98.32 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krtap10-10 35
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
Species where no ortholog for KRTAP10-11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP10-11 Gene

ENSEMBL:
Gene Tree for KRTAP10-11 (if available)
TreeFam:
Gene Tree for KRTAP10-11 (if available)

Paralogs for KRTAP10-11 Gene

genes like me logo Genes that share paralogs with KRTAP10-11: view

Variants for KRTAP10-11 Gene

Sequence variations from dbSNP and Humsavar for KRTAP10-11 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000952779 -- 44,647,970(+) GTCGG(C/G)AAGAA intron-variant
rs1001453725 -- 44,645,215(+) CCAGA(G/T)TGCAG intron-variant, upstream-variant-2KB
rs1004394366 -- 44,644,645(+) GACTA(A/T)CTGAT intron-variant, upstream-variant-2KB
rs1005369576 -- 44,647,898(+) GTGGG(C/T)TCGGC intron-variant
rs1006076242 -- 44,645,315(+) GAGCA(C/T)TCTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP10-11 Gene

Variant ID Type Subtype PubMed ID
esv2723675 CNV deletion 23290073
esv2760705 CNV gain 21179565
esv33817 CNV loss 17666407

Variation tolerance for KRTAP10-11 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP10-11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP10-11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP10-11 Gene

Disorders for KRTAP10-11 Gene

Relevant External Links for KRTAP10-11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP10-11

No disorders were found for KRTAP10-11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP10-11 Gene

Publications for KRTAP10-11 Gene

  1. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3 4 64
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PMID: 14962103) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for KRTAP10-11 Gene

Sources for KRTAP10-11 Gene

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