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Aliases for KRTAP10-10 Gene

Aliases for KRTAP10-10 Gene

  • Keratin Associated Protein 10-10 2 3
  • High Sulfur Keratin-Associated Protein 10.10 3 4
  • Keratin-Associated Protein 18-10 3 4
  • KRTAP18.10 3 4
  • KAP10.10 3 4
  • Keratin-Associated Protein 10-10 3
  • Keratin-Associated Protein 10.10 4
  • Keratin-Associated Protein 18.10 4
  • KRTAP18-10 3
  • KRTAP10.10 4
  • KRTAP18-1 4
  • KAP18.10 3
  • KAP18-10 4

External Ids for KRTAP10-10 Gene

Summaries for KRTAP10-10 Gene

GeneCards Summary for KRTAP10-10 Gene

KRTAP10-10 (Keratin Associated Protein 10-10) is a Protein Coding gene. An important paralog of this gene is KRTAP10-2.

UniProtKB/Swiss-Prot for KRTAP10-10 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP10-10 Gene

Genomics for KRTAP10-10 Gene

Genomic Location for KRTAP10-10 Gene

44,637,356 bp from pter
44,638,455 bp from pter
1,100 bases
Plus strand

Genomic View for KRTAP10-10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP10-10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP10-10 Gene

Regulatory Elements for KRTAP10-10 Gene

Proteins for KRTAP10-10 Gene

  • Protein details for KRTAP10-10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin-associated protein 10-10
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KRTAP10-10 Gene

    251 amino acids
    Molecular mass:
    25571 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP10-10 Gene

Proteomics data for KRTAP10-10 Gene at MOPED

Post-translational modifications for KRTAP10-10 Gene

No Post-translational modifications

Other Protein References for KRTAP10-10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP10-10 Gene

Domains for KRTAP10-10 Gene

Gene Families for KRTAP10-10 Gene

  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP10-10 Gene



  • Belongs to the KRTAP type 10 family.:
    • P60014
genes like me logo Genes that share domains with KRTAP10-10: view

Function for KRTAP10-10 Gene

Molecular function for KRTAP10-10 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP10-10 Gene

Localization for KRTAP10-10 Gene

Subcellular locations from

Jensen Localization Image for KRTAP10-10 Gene COMPARTMENTS Subcellular localization image for KRTAP10-10 gene
Compartment Confidence
extracellular 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KRTAP10-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP10-10: view

Pathways for KRTAP10-10 Gene

SuperPathways for KRTAP10-10 Gene

No Data Available

Interacting Proteins for KRTAP10-10 Gene

Gene Ontology (GO) - Biological Process for KRTAP10-10 Gene


No data available for Pathways by source for KRTAP10-10 Gene

Transcripts for KRTAP10-10 Gene

mRNA/cDNA for KRTAP10-10 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP10-10 Gene

No ASD Table

Relevant External Links for KRTAP10-10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRTAP10-10 Gene

mRNA expression in normal human tissues for KRTAP10-10 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP10-10 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (45.1) and Skin - Sun Exposed (Lower leg) (7.1).

SOURCE GeneReport for Unigene cluster for KRTAP10-10 Gene Hs.474001

mRNA Expression by UniProt/SwissProt for KRTAP10-10 Gene

Tissue specificity: Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.
genes like me logo Genes that share expressions with KRTAP10-10: view

Orthologs for KRTAP10-10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP10-10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRTAP10-10 36
  • 97.34 (n)
  • 95.62 (a)
(Bos Taurus)
Mammalia -- 37
  • 55 (a)
(Canis familiaris)
Mammalia -- 37
  • 45 (a)
(Mus musculus)
Mammalia Gm9507 37
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 46 (a)
-- 37
  • 28 (a)
Species with no ortholog for KRTAP10-10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP10-10 Gene

Gene Tree for KRTAP10-10 (if available)
Gene Tree for KRTAP10-10 (if available)

Paralogs for KRTAP10-10 Gene

Selected SIMAP similar genes for KRTAP10-10 Gene using alignment to 1 proteins: Pseudogenes for KRTAP10-10 Gene

genes like me logo Genes that share paralogs with KRTAP10-10: view

Variants for KRTAP10-10 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRTAP10-10 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913946 CNV Gain 21882294
nsv913950 CNV Gain 21882294
esv8518 OTHER Inversion 19470904
esv2723675 CNV Deletion 23290073
nsv913954 CNV Loss 21882294

Relevant External Links for KRTAP10-10 Gene

HapMap Linkage Disequilibrium report

No data available for Sequence variations from dbSNP and Humsavar for KRTAP10-10 Gene

Disorders for KRTAP10-10 Gene

No disorders were found for KRTAP10-10 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP10-10 Gene

Publications for KRTAP10-10 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  2. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. (PMID: 14962103) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2004) 3 4
  3. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. (PMID: 15028290) Shibuya K. … Shimizu N. (Genomics 2004) 3 4

Products for KRTAP10-10 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP10-10
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP10-10
    • Block miRNA regulation of KRTAP10-10 using miScript Target Protectors

    Sources for KRTAP10-10 Gene

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