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Aliases for KRTAP1-5 Gene

Aliases for KRTAP1-5 Gene

  • Keratin Associated Protein 1-5 2 3
  • KAP1.5 3 4 6
  • High Sulfur Keratin-Associated Protein 1.5 3 4
  • Keratin-Associated Protein 1.5 3 4
  • KRTAP1.5 3 4
  • Keratin Associated Protein 1.5 3
  • Keratin-Associated Protein 1-5 3
  • KRTAP-15 6

External Ids for KRTAP1-5 Gene

Summaries for KRTAP1-5 Gene

Entrez Gene Summary for KRTAP1-5 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRTAP1-5 Gene

KRTAP1-5 (Keratin Associated Protein 1-5) is a Protein Coding gene. An important paralog of this gene is KRTAP1-1.

UniProtKB/Swiss-Prot for KRTAP1-5 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP1-5 Gene

Genomics for KRTAP1-5 Gene

Genomic Location for KRTAP1-5 Gene

Start:
41,026,026 bp from pter
End:
41,027,202 bp from pter
Size:
1,177 bases
Orientation:
Minus strand

Genomic View for KRTAP1-5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP1-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP1-5 Gene

Regulatory Elements for KRTAP1-5 Gene

Proteins for KRTAP1-5 Gene

  • Protein details for KRTAP1-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYS1-KRA15_HUMAN
    Recommended name:
    Keratin-associated protein 1-5
    Protein Accession:
    Q9BYS1
    Secondary Accessions:
    • A6NJW6
    • A6NLZ6
    • B6ZDR1
    • Q52LP6

    Protein attributes for KRTAP1-5 Gene

    Size:
    174 amino acids
    Molecular mass:
    18010 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP1-5 Gene

Proteomics data for KRTAP1-5 Gene at MOPED

Post-translational modifications for KRTAP1-5 Gene

No Post-translational modifications

Other Protein References for KRTAP1-5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP1-5 Gene

Domains for KRTAP1-5 Gene

Gene Families for KRTAP1-5 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP1-5 Gene

UniProtKB/Swiss-Prot:

KRA15_HUMAN
Family:
  • Belongs to the KRTAP type 1 family.:
    • Q9BYS1
genes like me logo Genes that share domains with KRTAP1-5: view

Function for KRTAP1-5 Gene

Molecular function for KRTAP1-5 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with KRTAP1-5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP1-5 Gene

Localization for KRTAP1-5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP1-5 Gene COMPARTMENTS Subcellular localization image for KRTAP1-5 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP1-5: view

Pathways for KRTAP1-5 Gene

SuperPathways for KRTAP1-5 Gene

No Data Available

Interacting Proteins for KRTAP1-5 Gene

Gene Ontology (GO) - Biological Process for KRTAP1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRTAP1-5: view

No data available for Pathways by source for KRTAP1-5 Gene

Transcripts for KRTAP1-5 Gene

mRNA/cDNA for KRTAP1-5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP1-5 Gene

Keratin associated protein 1-5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP1-5 Gene

No ASD Table

Relevant External Links for KRTAP1-5 Gene

GeneLoc Exon Structure for
KRTAP1-5
ECgene alternative splicing isoforms for
KRTAP1-5

Expression for KRTAP1-5 Gene

mRNA expression in normal human tissues for KRTAP1-5 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP1-5 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP1-5 Gene

SOURCE GeneReport for Unigene cluster for KRTAP1-5 Gene Hs.534499

mRNA Expression by UniProt/SwissProt for KRTAP1-5 Gene

Q9BYS1-KRA15_HUMAN
Tissue specificity: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
genes like me logo Genes that share expressions with KRTAP1-5: view

Orthologs for KRTAP1-5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP1-5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP1-5 36
  • 97.15 (n)
  • 95.73 (a)
KRTAP1-5 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 64 (a)
ManyToMany
KRTAP1-1 37
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Krtap1-4 36
  • 76.91 (n)
  • 70.48 (a)
Krtap1-5 37
  • 77 (a)
ManyToMany
Krtap9-3 37
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Krtap1-1 36
  • 76.27 (n)
  • 71.76 (a)
Species with no ortholog for KRTAP1-5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP1-5 Gene

ENSEMBL:
Gene Tree for KRTAP1-5 (if available)
TreeFam:
Gene Tree for KRTAP1-5 (if available)

Paralogs for KRTAP1-5 Gene

Paralogs for KRTAP1-5 Gene

Selected SIMAP similar genes for KRTAP1-5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP1-5: view

Variants for KRTAP1-5 Gene

Sequence variations from dbSNP and Humsavar for KRTAP1-5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4890104 -- 41,025,704(+) CAGTA(A/G)CATGA downstream-variant-500B
rs6503575 -- 41,025,757(+) CTCCT(G/T)CCTCA downstream-variant-500B
rs7210324 -- 41,027,298(+) TTAAA(C/T)TTGTT upstream-variant-2KB
rs7210463 -- 41,027,382(+) TTTTA(C/T)AGTTT upstream-variant-2KB
rs9916638 -- 41,026,408(+) GCAAA(C/T)TGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTAP1-5 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
dgv3167n71 CNV Loss 21882294
nsv908232 CNV Loss 21882294

Relevant External Links for KRTAP1-5 Gene

HapMap Linkage Disequilibrium report
KRTAP1-5

Disorders for KRTAP1-5 Gene

No disorders were found for KRTAP1-5 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP1-5 Gene

Publications for KRTAP1-5 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family. (PMID: 12228244) Shimomura Y. … Ito M. (J. Biol. Chem. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP1-5 Gene

Sources for KRTAP1-5 Gene

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