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Aliases for KRTAP1-4 Gene

Aliases for KRTAP1-4 Gene

  • Keratin Associated Protein 1-4 2 3
  • KAP1.4 3 4 6
  • High Sulfur Keratin-Associated Protein 1.4 3 4
  • Keratin-Associated Protein 1.4 3 4
  • KRTAP1.4 3 4
  • Keratin-Associated Protein 1-4 3

External Ids for KRTAP1-4 Gene

Previous GeneCards Identifiers for KRTAP1-4 Gene

  • GC17U990281
  • GC17M036447
  • GC17M039187

Summaries for KRTAP1-4 Gene

Entrez Gene Summary for KRTAP1-4 Gene

  • The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]).[supplied by OMIM, Jan 2009]

GeneCards Summary for KRTAP1-4 Gene

KRTAP1-4 (Keratin Associated Protein 1-4) is a Protein Coding gene. An important paralog of this gene is KRTAP1-5.

UniProtKB/Swiss-Prot for KRTAP1-4 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP1-4 Gene

Genomics for KRTAP1-4 Gene

Regulatory Elements for KRTAP1-4 Gene

Genomic Location for KRTAP1-4 Gene

41,029,677 bp from pter
41,030,125 bp from pter
449 bases
Minus strand

Genomic View for KRTAP1-4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP1-4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP1-4 Gene

Proteins for KRTAP1-4 Gene

  • Protein details for KRTAP1-4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin-associated protein 1-4
    Protein Accession:
    Secondary Accessions:
    • A6NJ92

    Protein attributes for KRTAP1-4 Gene

    121 amino acids
    Molecular mass:
    12324 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP1-4 Gene

Proteomics data for KRTAP1-4 Gene at MOPED

Post-translational modifications for KRTAP1-4 Gene

No Post-translational modifications

Other Protein References for KRTAP1-4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP1-4 Gene

Domains for KRTAP1-4 Gene

Gene Families for KRTAP1-4 Gene

  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP1-4 Gene


Suggested Antigen Peptide Sequences for KRTAP1-4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P0C5Y4
  • Belongs to the KRTAP type 1 family.
genes like me logo Genes that share domains with KRTAP1-4: view

Function for KRTAP1-4 Gene

Molecular function for KRTAP1-4 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP1-4 Gene

Localization for KRTAP1-4 Gene

Subcellular locations from

Jensen Localization Image for KRTAP1-4 Gene COMPARTMENTS Subcellular localization image for KRTAP1-4 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP1-4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP1-4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP1-4 Gene

Pathways for KRTAP1-4 Gene

SuperPathways for KRTAP1-4 Gene

No Data Available

Interacting Proteins for KRTAP1-4 Gene

Gene Ontology (GO) - Biological Process for KRTAP1-4 Gene


No data available for Pathways by source for KRTAP1-4 Gene

Transcripts for KRTAP1-4 Gene

mRNA/cDNA for KRTAP1-4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP1-4 Gene

No ASD Table

Relevant External Links for KRTAP1-4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRTAP1-4 Gene

mRNA expression in normal human tissues for KRTAP1-4 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP1-4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (46.6) and Skin - Sun Exposed (Lower leg) (5.1).

SOURCE GeneReport for Unigene cluster for KRTAP1-4 Gene Hs.744827

mRNA Expression by UniProt/SwissProt for KRTAP1-4 Gene

Tissue specificity: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
genes like me logo Genes that share expressions with KRTAP1-4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP1-4 Gene

Orthologs for KRTAP1-4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP1-4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRTAP1-4 35
  • 98.9 (n)
  • 97.52 (a)
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
KRTAP1-1 36
  • 56 (a)
(Mus musculus)
Mammalia Krtap1-5 36
  • 74 (a)
Krtap9-3 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
Species with no ortholog for KRTAP1-4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP1-4 Gene

Gene Tree for KRTAP1-4 (if available)
Gene Tree for KRTAP1-4 (if available)

Paralogs for KRTAP1-4 Gene

Paralogs for KRTAP1-4 Gene

Selected SIMAP similar genes for KRTAP1-4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP1-4: view

Variants for KRTAP1-4 Gene

Sequence variations from dbSNP and Humsavar for KRTAP1-4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8072687 -- 41,029,546(+) AGTAA(A/G)TGAAT downstream-variant-500B
rs8073323 -- 41,029,968(+) CAGCC(A/G)GTTCC reference, synonymous-codon
rs8074117 -- 41,029,779(+) TAGGA(C/T)GGGCG synonymous-codon, reference
rs8074887 -- 41,029,916(+) CACAG(A/C)TCCAC missense, reference
rs8077277 -- 41,030,130(+) TTTGG(A/G)CTGTA upstream-variant-2KB

Relevant External Links for KRTAP1-4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRTAP1-4 Gene

Disorders for KRTAP1-4 Gene

No disorders were found for KRTAP1-4 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP1-4 Gene

Publications for KRTAP1-4 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  3. Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family. (PMID: 12228244) Shimomura Y. … Ito M. (J. Biol. Chem. 2002) 3

Products for KRTAP1-4 Gene

Sources for KRTAP1-4 Gene

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