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Aliases for KRTAP1-3 Gene

Aliases for KRTAP1-3 Gene

  • Keratin Associated Protein 1-3 2 3
  • KAP1.2 3 4 6
  • KAP1.3 3 4 6
  • KAP1.9 3 4 6
  • Keratin-Associated Protein 1.8 3 4
  • Keratin-Associated Protein 1.9 3 4
  • Keratin Associated Protein 1.6 3
  • Keratin-Associated Protein 1-3 3
  • KRTAP1.3 3
  • KRATP1.9 4
  • KRTAP1.8 4
  • KAP1.8A 3
  • KAP1.8B 3
  • KAP1.6 3
  • KAP1.8 4
  • B2B 4

External Ids for KRTAP1-3 Gene

Previous GeneCards Identifiers for KRTAP1-3 Gene

  • GC17M038690
  • GC17M041366
  • GC17M039098
  • GC17M039563
  • GC17M036444
  • GC17P9W0088
  • GC17M039190
  • GC17M034984

Summaries for KRTAP1-3 Gene

Entrez Gene Summary for KRTAP1-3 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRTAP1-3 Gene

KRTAP1-3 (Keratin Associated Protein 1-3) is a Protein Coding gene. Diseases associated with KRTAP1-3 include choroid cancer. GO annotations related to this gene include structural constituent of epidermis. An important paralog of this gene is KRTAP1-5.

UniProtKB/Swiss-Prot for KRTAP1-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP1-3 Gene

Genomics for KRTAP1-3 Gene

Regulatory Elements for KRTAP1-3 Gene

Genomic Location for KRTAP1-3 Gene

Start:
41,033,884 bp from pter
End:
41,034,855 bp from pter
Size:
972 bases
Orientation:
Minus strand

Genomic View for KRTAP1-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP1-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP1-3 Gene

Proteins for KRTAP1-3 Gene

  • Protein details for KRTAP1-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUG1-KRA13_HUMAN
    Recommended name:
    Keratin-associated protein 1-3
    Protein Accession:
    Q8IUG1
    Secondary Accessions:
    • Q07628
    • Q8IUG0
    • Q9BYS2

    Protein attributes for KRTAP1-3 Gene

    Size:
    177 amino acids
    Molecular mass:
    18184 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP1-3 Gene

Proteomics data for KRTAP1-3 Gene at MOPED

Post-translational modifications for KRTAP1-3 Gene

No Post-translational modifications

Other Protein References for KRTAP1-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP1-3 Gene

Domains for KRTAP1-3 Gene

Gene Families for KRTAP1-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP1-3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP1-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUG1

UniProtKB/Swiss-Prot:

KRA13_HUMAN :
  • Q8IUG1
Family:
  • Belongs to the KRTAP type 1 family.
genes like me logo Genes that share domains with KRTAP1-3: view

Function for KRTAP1-3 Gene

Molecular function for KRTAP1-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP1-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030280 structural constituent of epidermis NAS 1279380
genes like me logo Genes that share ontologies with KRTAP1-3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP1-3 Gene

Localization for KRTAP1-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP1-3 Gene COMPARTMENTS Subcellular localization image for KRTAP1-3 gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP1-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP1-3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP1-3 Gene

Pathways for KRTAP1-3 Gene

SuperPathways for KRTAP1-3 Gene

No Data Available

Interacting Proteins for KRTAP1-3 Gene

Gene Ontology (GO) - Biological Process for KRTAP1-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRTAP1-3: view

No data available for Pathways by source for KRTAP1-3 Gene

Transcripts for KRTAP1-3 Gene

mRNA/cDNA for KRTAP1-3 Gene

(4) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP1-3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP1-3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP1-3 Gene

No ASD Table

Relevant External Links for KRTAP1-3 Gene

GeneLoc Exon Structure for
KRTAP1-3
ECgene alternative splicing isoforms for
KRTAP1-3

Expression for KRTAP1-3 Gene

mRNA expression in normal human tissues for KRTAP1-3 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP1-3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (48.7) and Skin - Sun Exposed (Lower leg) (4.1).

SOURCE GeneReport for Unigene cluster for KRTAP1-3 Gene Hs.534495

mRNA Expression by UniProt/SwissProt for KRTAP1-3 Gene

Q8IUG1-KRA13_HUMAN
Tissue specificity: Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
genes like me logo Genes that share expressions with KRTAP1-3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP1-3 Gene

Orthologs for KRTAP1-3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP1-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP1-3 36
  • 97 (a)
OneToOne
LOC743364 35
  • 99 (n)
  • 98.8 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
ManyToMany
KRTAP1-1 36
  • 69 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Krtap1-5 36
  • 82 (a)
ManyToMany
Krtap9-3 35
  • 86.51 (n)
  • 82.44 (a)
Krtap9-3 36
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
Species with no ortholog for KRTAP1-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP1-3 Gene

ENSEMBL:
Gene Tree for KRTAP1-3 (if available)
TreeFam:
Gene Tree for KRTAP1-3 (if available)

Paralogs for KRTAP1-3 Gene

Paralogs for KRTAP1-3 Gene

Selected SIMAP similar genes for KRTAP1-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP1-3: view

Variants for KRTAP1-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP1-3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2872967 -- 41,035,230(+) CTCAC(A/G)TGACA upstream-variant-2KB
rs2872968 -- 41,035,430(+) CATGT(A/G)TCAAT upstream-variant-2KB
rs4442876 -- 41,036,545(+) ATATG(A/T)TTCTT upstream-variant-2KB
rs7503378 -- 41,035,720(+) CTTTC(C/T)TTCTT upstream-variant-2KB
rs7504050 -- 41,035,802(+) TCCTT(C/T)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP1-3 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
dgv3167n71 CNV Loss 21882294
nsv908232 CNV Loss 21882294
esv2659091 CNV Deletion 23128226

Relevant External Links for KRTAP1-3 Gene

HapMap Linkage Disequilibrium report
KRTAP1-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP1-3 Gene

Disorders for KRTAP1-3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KRTAP1-3 Gene including...

Search for KRTAP1-3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for KRTAP1-3 Gene

Relevant External Links for KRTAP1-3

Genetic Association Database (GAD)
KRTAP1-3
genes like me logo Genes that share disorders with KRTAP1-3: view

No data available for UniProtKB/Swiss-Prot for KRTAP1-3 Gene

Publications for KRTAP1-3 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4
  2. Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family. (PMID: 12228244) Shimomura Y. … Ito M. (J. Biol. Chem. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP1-3 Gene

Sources for KRTAP1-3 Gene

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