Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KRT9 Gene

protein-coding   GIFtS: 53
GCID: GC17M039722

Keratin 9

  See KRT9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Keratin 91 2     Epidermolytic Palmoplantar Keratoderma1
Cytokeratin 91 2     cytokeratin-92
Type I Cytoskeletal 91 2     Keratin, Type I Cytoskeletal 92
CK-92 3     keratin-92
K92 3     Cytokeratin-93
EPPK2 5     Keratin-93

External Ids:    HGNC: 64471   Entrez Gene: 38572   Ensembl: ENSG000001714037   OMIM: 6076065   UniProtKB: P355273   

Export aliases for KRT9 gene to outside databases

Previous GC identifers: GC17M038843 GC17P041832 GC17M039630 GC17M040095 GC17M036975 GC17M035485


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KRT9 Gene:
This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally
differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma.
(provided by RefSeq, Jul 2008)

GeneCards Summary for KRT9 Gene:
KRT9 (keratin 9) is a protein-coding gene. Diseases associated with KRT9 include acral lentiginous melanoma, and palmoplantar keratoderma, epidermolytic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot: K1C9_HUMAN, P35527
Function: May serve an important special function either in the mature palmar and plantar skin tissue or in the
morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly

Gene Wiki entry for KRT9 (Keratin 9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT9 gene promoter:
         TBP   AP-2alpha isoform 3   AP-2alpha isoform 2   STAT3   AP-2alpha isoform 4   AP-2alpha   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT9 promoter sequence
   Search Chromatin IP Primers for KRT9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KRT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT9 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M039722:  view genomic region     (about GC identifiers)

Start:
39,722,093 bp from pter      End:
39,728,310 bp from pter
Size:
6,218 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: K1C9_HUMAN, P35527 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 9  
Size: 623 amino acids; 62064 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Caution: Was originally (PubMed:2140676) thought to be a 60 kDa chain of placental scatter protein
Secondary accessions: O00109 Q0IJ47 Q14665

Explore the universe of human proteins at neXtProt for KRT9: NX_P35527

Explore proteomics data for KRT9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000217.2  
    ENSEMBL proteins: 
     ENSP00000246662   ENSP00000467932  

    KRT9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KRT9
    OriGene Protein Over-expression Lysate for KRT9
    OriGene MassSpec for KRT9
    OriGene Custom Protein Services for KRT9
    GenScript Custom Purified and Recombinant Proteins Services for KRT9
    Novus Biologicals KRT9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT9

     
    Search eBioscience for Proteins for KRT9 

    KRT9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KRT9
    Novus Biologicals KRT9 Antibodies
    Abcam antibodies for KRT9
    Cloud-Clone Corp. Antibodies for KRT9
    ThermoFisher Antibody for KRT9
    LSBio Antibodies in human, mouse, rat for KRT9

    KRT9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KRT9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KRT9
    Cloud-Clone Corp. CLIAs for KRT9
    Search eBioscience for ELISAs for KRT9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IFF1: Intermediate filaments type I, keratins (acidic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I

    Graphical View of Domain Structure for InterPro Entry P35527

    ProtoNet protein and cluster: P35527

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C9_HUMAN, P35527
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K1C9_HUMAN, P35527
    Function: May serve an important special function either in the mature palmar and plantar skin tissue or in the
    morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly
    Induction: Induced by intrinsic regulatory mechanisms and by extrinsic signals from a subset of dermal
    palmoplantar fibroblasts

         Genatlas biochemistry entry for KRT9:
    keratin 9,type I,palm and sole skin,dimerizing either with KRT1 or KRT10

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS8647270
         
    Find genes that share ontologies with KRT9           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Krt9):
     behavior/neurological  cellular  growth/size/body  integument  limbs/digits/tail 
     pigmentation  tumorigenesis 

    Find genes that share phenotypes with KRT9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Krt9tm1(KOMP)Vlcg for KRT9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT9

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat KRT9 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT9:
    hsa-miR-1207-3p hsa-miR-3915 hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KRT9
    Predesigned siRNA for gene silencing in human, mouse, rat KRT9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KRT9

    Clone
    Products:
         
    OriGene clones in human, mouse for KRT9 (see all 5)
    OriGene ORF clones in mouse, rat for KRT9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT9 (NM_000226)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT9

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KRT9
    Browse ESI BIO Cell Lines and PureStem Progenitors for KRT9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005882intermediate filament IEA--
    GO:0070062extracellular vesicular exosome IDA11487543

    Find genes that share ontologies with KRT9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT9
    Interactions:

        Search GeneGlobe Interaction Network for KRT9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for KRT9 (P355272, 3 ENSP000002466624) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928442, 3, ENSP000002590754MINT-48255 I2D: score=2 STRING: ENSP00000259075
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis ----
    GO:0008544epidermis development TAS8647270
    GO:0043588skin development IDA7507869
    GO:0045109intermediate filament organization IMP10218578

    Find genes that share ontologies with KRT9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT9 (K1C9)

    5 Novoseek inferred chemical compound relationships for KRT9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 43.6 7 8647270 (1), 15605275 (1), 14517588 (1), 7532198 (1) (see all 6)
    leucine 27.9 3 15099359 (1), 9204965 (1), 17362238 (1)
    histidine 7.74 3 10233272 (1), 15115518 (1)
    polyacrylamide 5.82 1 16216052 (1)
    glutamine 4.32 2 8647270 (1)



    Find genes that share compounds with KRT9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KRT9 gene: 
    NM_000226.3  

    Unigene Cluster for KRT9:

    Keratin 9
    Hs.654569
    Unigene Representative Sequence: S69510
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246662(uc002hxe.4) ENST00000588431
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT9 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT9:
    hsa-miR-1207-3p hsa-miR-3915 hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmidKRT9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KRT9
    Predesigned siRNA for gene silencing in human, mouse, rat KRT9
    Clone
    Products:
         
    OriGene clones in human, mouse for KRT9 (see all 5)
    OriGene ORF clones in mouse, rat for KRT9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT9 (NM_000226)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT9
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT9
      QuantiTect SYBR Green Assays in human, mouse, rat KRT9
      QuantiFast Probe-based Assays in human, mouse, rat KRT9

    Additional mRNA sequence: 

    AB001594.1 BC121170.2 S69510.1 Z29074.1 

    1 DOTS entry:

    DT.205749 

    3 AceView cDNA sequences:

    Z29074 S69510 NM_000226 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KRT9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGGAAG
    KRT9 Expression
    About this image


    KRT9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Granular Keratinocytes Stratified Epidermis
     
     Epidermis (Integumentary System)
             Granular Keratinocytes Stratified Epidermis
    KRT9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654569

    UniProtKB/Swiss-Prot: K1C9_HUMAN, P35527
    Tissue specificity: Expressed in the terminally differentiated epidermis of palms and soles

        Custom PCR Arrays for KRT9
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT9
    QuantiTect SYBR Green Assays in human, mouse, rat KRT9
    QuantiFast Probe-based Assays in human, mouse, rat KRT9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT9 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt95 keratin 9   --   11 (63.43 cM) 100186781 
    chicken
    (Gallus gallus)
    Aves KRT96
    keratin 9
    37(a)
    1 ↔ 1
    27(4571268-4589501)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    46(a)
    43(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    6(70777029-70784816)
    6(70702069-70711380)


    ENSEMBL Gene Tree for KRT9 (if available)
    TreeFam Gene Tree for KRT9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KRT9 gene
    KRT342  KRT172  KRT162  KRT312  KRT252  KRT392  KRT402  KRT202  
    KRT372  KRT272  KRT322  KRT382  KRT362  KRT192  KRT282  KRT142  
    KRT132  KRT262  KRT102  KRT122  KRT352  KRT152  KRT242  KRT33B2  
    KRT33A2  
    Selected SIMAP similar genes for KRT9 using alignment to 2 protein entries:     K1C9_HUMAN (see all proteins) (see all similar genes):
    K14    JUP    KRT14    KRT17    KRT15    KRT33B
    KRT13    KRT33A    KRT19    KRT32    GUCA1B    KRT16
    KRT10    KRT31    KRT35    KRT12    keratin    KRT20

    Find genes that share paralogs with KRT9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KRT9 (see all 320)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs598781531,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515264(-) GGTGCA/CGGCTC 2 Q P mis10--------
    rs570197201,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515268(-) ATAAGA/GTGCAG 2 M V mis10--------
    rs611570951,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515276(-) TTACTC/TGGATA 2 S L mis10--------
    rs577582621,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515291(-) TTCTCA/C/GGCTGG 3 Q P R mis10--------
    rs596169211,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515292(-) ATTCTC/TGGCTG 2 R W mis10--------
    rs575363121,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515296(-) CTCAAA/TTCTCG 2 K N mis10--------
    rs567077681,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515297(-) ACTCAA/G/TTTCTC 3 N S I mis10--------
    rs592962731,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515298(-) AACTCA/C/TATTCT 3 N H Y mis10--------
    rs289408961,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515301(-) AGGAAC/G/TTCAAT 3 L V F mis1 ese30--------
    rs595105791,2,,4
    CKeratoderma, palmoplantar, epidermolytic (EPPK)4 pathogenic140515309(-) CACCAA/C/G/
            
    GCAGG
    4 K T R M mis10--------

    HapMap Linkage Disequilibrium report for KRT9 (39722093 - 39728310 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KRT9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2053CNV Insertion18451855
    nsv510711CNV Loss20534489
    esv34903CNV Gain17911159
    nsv827992CNV Gain20364138
    nsv9555CNV Gain18304495
    dgv962e1CNV Complex17122850
    dgv961e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): KRT9
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KRT9
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607606   
    OMIM disorders: 144200  
    UniProtKB/Swiss-Prot: K1C9_HUMAN, P35527
  • Keratoderma, palmoplantar, epidermolytic (EPPK) [MIM:144200]: A dermatological disorder characterized by
    diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous
    margins. Some patients may present knuckle pads, thick pads of skin appearing over the proximal phalangeal
    joints. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 11 diseases for KRT9:    
    About MalaCards
    acral lentiginous melanoma    palmoplantar keratoderma, epidermolytic    opisthorchiasis    bile duct carcinoma
    amebiasis    keratoderma    palmoplantar keratosis    epidermolytic hyperkeratosis
    hereditary mucosal leukokeratosis    pachyonychia congenita    monilethrix

    8 diseases from the University of Copenhagen DISEASES database for KRT9:
    Epidermolytic hyperkeratosis     Palmoplantar keratosis     Amebiasis     Epidermolysis bullosa simplex
    Pachyonychia congenita     Monilethrix     Hereditary mucosal leukokeratosis     Acral lentiginous melanoma

    Find genes that share disorders with KRT9           About GenesLikeMe

    9 Novoseek inferred disease relationships for KRT9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    palmoplantar keratoderma, epidermolytic 98.6 22 9204965 (2), 10632938 (2), 15099359 (1), 17074468 (1) (see all 19)
    keratoderma palmoplantar 89.5 9 12192490 (1), 8647270 (1), 10536990 (1), 17369150 (1)
    knuckle pads 89.3 2 17074468 (1), 12838553 (1)
    neppk 85.8 3 7544664 (1), 9833037 (1)
    hyperkeratosis 82.3 4 10201533 (1), 11346340 (1), 7512862 (1)
    keratoderma 80.2 3 18683133 (1), 7528239 (1), 17369150 (1)
    skin diseases 57.2 1 19106041 (1)
    acanthosis 52.9 2 10201533 (1), 11346340 (1)
    melanoma 0 1 10201533 (1)


    Export disorders for KRT9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KRT9 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with KRT9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). (PubMed id 7512862)1, 2, 3, 9 Reis A....Kuester W. (Nat. Genet. 1994)
    2. Mutations in the 1A domain of keratin 9 in patients with epidermolytic palmoplantar keratoderma. (PubMed id 7532199)1, 2, 9 Rothnagel J.A.... Roop D.R. (J. Invest. Dermatol. 1995)
    3. A novel mutation of a leucine residue in coil 1A of keratin 9 in epidermolytic palmoplantar keratoderma. (PubMed id 9204965)1, 2, 9 Endo H.... Shinkai H. (J. Invest. Dermatol. 1997)
    4. Keratin 9 point mutation in the pedigree of epidermolytic hereditary palmoplantar keratoderma perturbs keratin intermediate filament network formation. (PubMed id 8647270)1, 2, 9 Kobayashi S.... Imamura S. (FEBS Lett. 1996)
    5. Mutations of keratin 9 in two families with palmoplantar epidermolytic hyperkeratosis. (PubMed id 7523529)1, 2, 9 Bonifas J.M.... Epstein E.H. Jr. (J. Invest. Dermatol. 1994)
    6. Mutations in keratin K9 in kindreds with epidermolytic palmoplantar keratoderma and epidemiology in Northern Ireland. (PubMed id 9856842)1, 2, 9 Covello S.P.... McLean W.H.I. (J. Invest. Dermatol. 1998)
    7. Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer. (PubMed id 7511021)1, 2, 9 Torchard D....Feunteun J. (Nat. Genet. 1994)
    8. Keratin 9 gene mutations in five Korean families with epidermolytic palmoplantar keratoderma. (PubMed id 14675368)1, 2, 9 Lee J.-H.... Yang J.-M. (Exp. Dermatol. 2003)
    9. Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma. (PubMed id 7516304)1, 2, 9 Hennies H.-C.... Reis A. (Hum. Genet. 1994)
    10. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3857 HGNC: 6447 AceView: KRT9 Ensembl:ENSG00000171403 euGenes: HUgn3857
    ECgene: KRT9 H-InvDB: KRT9

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KRT9 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=KRT9[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KRT9 gene:
    Search GeneIP for patents involving KRT9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KRT9  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KRT9  
     OriGene MassSpec something-or-other for KRT9   OriGene clones in human, mouse for KRT9  
     OriGene qSTAR qPCR primer pairs in human, mouse for KRT9   OriGene Purified Protein for KRT9  
     OriGene ORF clones in mouse, rat for KRT9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT9   OriGene Custom Protein Services for KRT9  

     
     
     Block miRNA regulation of human, mouse, rat KRT9 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KRT9
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT9 Predesigned siRNA for gene silencing in human, mouse, rat KRT9
     QuantiFast Probe-based Assays in human, mouse, rat KRT9 QuantiTect SYBR Green Assays in human, mouse, rat KRT9
     Custom PCR Arrays for KRT9 Search Chromatin IP Primers for KRT9
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT9  Search GeneGlobe Interaction Network for KRT9
     Regulatory tfbs in KRT9 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KRT9 GenScript cDNA clones with any tag delivered in your preferred vector for KRT9
     GenScript Custom Assay Services for KRT9 GenScript Custom overexpressing Cell Line Services for KRT9
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KRT9 (K1C9)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KRT9 antibodies
     KRT9 lysates
     Antibodies for KRT9
     See all of Abcam's Antibodies, Kits and Proteins for KRT9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KRT9
     Antibodies for KRT9
     ELISAs for KRT9
     CLIAs for KRT9



     Browse ESI BIO Cell Lines and PureStem Progenitors for KRT9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT9
     SwitchGear 3'UTR luciferase reporter plasmids for KRT9
     SwitchGear Promoter luciferase reporter plasmids for KRT9
     ThermoFisher Antibody for KRT9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT9
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT9
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT9
     LSBio Antibodies in human, mouse, rat for KRT9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KRT9
      Search eBioscience for proteins for KRT9
      Search eBioscience for elisas for KRT9
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KRT9 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4