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Aliases for KRT86 Gene

Aliases for KRT86 Gene

  • Keratin 86 2 3 5
  • Keratin, Hair, Basic, 6 (Monilethrix) 2 3
  • Type II Hair Keratin Hb6 3 4
  • Type-II Keratin Kb26 3 4
  • Keratin 86, Type II 2 3
  • Hair Keratin K2.11 3 4
  • KRTHB6 3 4
  • K86 3 4
  • Keratin, Type II Cuticular Hb6 3
  • Hard Keratin, Type II, 6 3
  • Hard Keratin Type II 6 2
  • Keratin Protein HB6 3
  • Keratin-86 4
  • KRTHB1 3
  • HB6 3
  • HB1 3
  • MNX 3

External Ids for KRT86 Gene

Previous HGNC Symbols for KRT86 Gene

  • KRTHB6

Previous GeneCards Identifiers for KRT86 Gene

  • GC12P050982
  • GC12P052695
  • GC12P049730
  • GC12P052643
  • GC12P052668

Summaries for KRT86 Gene

Entrez Gene Summary for KRT86 Gene

  • This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. [provided by RefSeq, Feb 2016]

GeneCards Summary for KRT86 Gene

KRT86 (Keratin 86) is a Protein Coding gene. Diseases associated with KRT86 include Monilethrix and Hair Disease. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT81.

Gene Wiki entry for KRT86 Gene

Additional gene information for KRT86 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT86 Gene

Genomics for KRT86 Gene

Regulatory Elements for KRT86 Gene

Enhancers for KRT86 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H052277 2 FANTOM5 Ensembl ENCODE dbSUPER 27.9 +32.6 32593 9.2 PKNOX1 FOXA2 ATF1 SIN3A FEZF1 BRCA1 GLIS2 ELK1 ZNF143 FOS KRT86 ZNF740 KRT80 KRT7 HNRNPA3P10 CSAD KRT87P KRT83 ENSG00000257808 NR4A1
GH12H052307 1.1 Ensembl ENCODE 32.2 +59.1 59141 1.2 CTCF MXI1 SUZ12 ZIC2 E2F1 ZFHX2 CTBP1 GLIS2 ZNF600 EGR2 KRT86 KRT87P KRT7 KRT81 KRT83
GH12H052196 2 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -41.4 -41368 22.5 HDGF PKNOX1 SIN3A ZBTB7B ZNF207 ZNF143 ZNF548 FOS DEK REST ZNF740 KRT7 HNRNPA3P10 KRT86 KRT87P KRT81 POU6F1 KRT83 LOC283335 KRT7-AS
GH12H052163 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -84.3 -84284 2.9 SIN3A ZNF2 ZBTB7B ZNF143 ATF7 DEK SP3 YY2 TSHZ1 REST KRT80 KRT81 KRT7 KRT86 KRT87P KRT83 KRT84 ACVR1B NR4A1 LINC00592
GH12H052118 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -130.1 -130068 2.4 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF143 ATF7 RUNX3 SP5 ENSG00000257989 KRT80 KRT87P KRT86 KRT7 KRT83 KRT84 NR4A1 LOC105369771 GC12P052156
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT86 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRT86 Gene

Genomic Locations for KRT86 Gene
59,864 bases
Plus strand

Genomic View for KRT86 Gene

Genes around KRT86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT86 Gene

Proteins for KRT86 Gene

  • Protein details for KRT86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cuticular Hb6
    Protein Accession:
    Secondary Accessions:
    • P78387

    Protein attributes for KRT86 Gene

    486 amino acids
    Molecular mass:
    53501 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT86 Gene

Post-translational modifications for KRT86 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT86 Gene

No data available for DME Specific Peptides for KRT86 Gene

Domains & Families for KRT86 Gene

Gene Families for KRT86 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT86: view

Function for KRT86 Gene

Phenotypes From GWAS Catalog for KRT86 Gene

Gene Ontology (GO) - Molecular Function for KRT86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT86: view
genes like me logo Genes that share phenotypes with KRT86: view

Human Phenotype Ontology for KRT86 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT86 Gene

Localization for KRT86 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT86 gene
Compartment Confidence
cytosol 4
mitochondrion 2
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KRT86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with KRT86: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT86 Gene

Pathways & Interactions for KRT86 Gene

SuperPathways for KRT86 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT86: view

Pathways by source for KRT86 Gene

2 Reactome pathways for KRT86 Gene

Interacting Proteins for KRT86 Gene

Gene Ontology (GO) - Biological Process for KRT86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT86: view

No data available for SIGNOR curated interactions for KRT86 Gene

Drugs & Compounds for KRT86 Gene

(1) Drugs for KRT86 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for KRT86 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT86: view

Transcripts for KRT86 Gene

Unigene Clusters for KRT86 Gene

Keratin 86:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT86 Gene

No ASD Table

Relevant External Links for KRT86 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT86 Gene

mRNA differential expression in normal tissues according to GTEx for KRT86 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.9) and Skin - Sun Exposed (Lower leg) (x5.1).

Protein differential expression in normal tissues from HIPED for KRT86 Gene

This gene is overexpressed in Heart (22.3), Kidney (16.7), Urine (13.2), and Plasma (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT86 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT86 Gene:


SOURCE GeneReport for Unigene cluster for KRT86 Gene:


mRNA Expression by UniProt/SwissProt for KRT86 Gene:

Tissue specificity: Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.

Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT86 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • integumentary
  • nervous
  • skeleton
Head and neck:
  • brain
  • face
  • forehead
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • skull
  • tooth
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
  • hair
  • skin
genes like me logo Genes that share expression patterns with KRT86: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Evidence on tissue expression from TISSUES for KRT86 Gene

Orthologs for KRT86 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT86 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT86 33 34
  • 98.9 (n)
(Canis familiaris)
Mammalia KRT86 33
  • 91.27 (n)
-- 34
  • 72 (a)
(Bos Taurus)
Mammalia KRT86 33 34
  • 89.09 (n)
(Rattus norvegicus)
Mammalia Krt86 33
  • 87.79 (n)
(Mus musculus)
Mammalia Krt86 33 16 34
  • 87.17 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
-- 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
-- 34
  • 79 (a)
-- 34
  • 78 (a)
-- 34
  • 78 (a)
Species where no ortholog for KRT86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT86 Gene

Gene Tree for KRT86 (if available)
Gene Tree for KRT86 (if available)

Paralogs for KRT86 Gene

Paralogs for KRT86 Gene Pseudogenes for KRT86 Gene

genes like me logo Genes that share paralogs with KRT86: view

Variants for KRT86 Gene

Sequence variations from dbSNP and Humsavar for KRT86 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121909129 Pathogenic, Monilethrix (MNLIX) [MIM:158000] 52,306,270(+) AGGGC(A/G)AGGAG reference, missense
rs121909130 Pathogenic, Monilethrix (MNLIX) [MIM:158000] 52,306,272(+) GGCGA(G/T)GAGCA reference, missense
rs28939669 Monilethrix (MNLIX) [MIM:158000]
rs60687604 Pathogenic, Monilethrix (MNLIX) [MIM:158000] 52,306,237(+) ACATC(A/C/G)AGATC reference, missense
rs61091894 Pathogenic, Monilethrix (MNLIX) [MIM:158000], Monilethrix (MNLIX) [MIM:158000] 52,302,256(+) CCCTC(A/C/G)ACAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT86 Gene

Variant ID Type Subtype PubMed ID
nsv976616 CNV duplication 23825009
nsv826378 CNV loss 20364138
nsv818917 CNV gain 17921354
nsv7230 OTHER inversion 18451855
nsv558904 CNV gain 21841781
nsv558900 CNV loss 21841781
nsv516938 CNV gain+loss 19592680
esv3892201 CNV loss 25118596
esv29967 CNV gain 17803354
esv2760832 CNV gain 21179565
esv2759899 CNV gain 17122850
esv27319 CNV gain+loss 19812545
dgv9e209 CNV duplication 24192839
dgv70e55 CNV gain 17911159
dgv487e212 CNV gain 25503493
dgv29e180 CNV gain 20482838
dgv2630n54 CNV gain 21841781
dgv200n27 CNV gain 19166990
dgv1503n100 CNV gain 25217958
dgv1502n100 CNV gain 25217958

Variation tolerance for KRT86 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT86 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT86 Gene

Disorders for KRT86 Gene

MalaCards: The human disease database

(8) MalaCards diseases for KRT86 Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • nodose hair
hair disease
  • abnormality of the hair
cardiomyopathy, hypertrophic, 20
  • hypertrophic cardiomyopathy 20
white sponge nevus 1
  • hereditary mucosal leukokeratosis
- elite association - COSMIC cancer census association via MalaCards
Search KRT86 in MalaCards View complete list of genes associated with diseases


  • Monilethrix (MNLIX) [MIM:158000]: A disorder clinically characterized by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. {ECO:0000269 PubMed:10469314, ECO:0000269 PubMed:10504448, ECO:0000269 PubMed:10594761, ECO:0000269 PubMed:25557232, ECO:0000269 PubMed:9402962}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT86

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT86: view

No data available for Genatlas for KRT86 Gene

Publications for KRT86 Gene

  1. Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6. (PMID: 10469314) Winter H … Schweizer J (The Journal of investigative dermatology 1999) 3 4 22 60
  2. Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype. (PMID: 10504448) Korge BP … Munro CS (The Journal of investigative dermatology 1999) 3 4 22 60
  3. Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix. (PMID: 10594761) Pearce EG … Bowden PE (The Journal of investigative dermatology 1999) 3 4 22 60
  4. Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PMID: 9457912) Bowden PE … Hodgins MB (The Journal of investigative dermatology 1998) 3 4 22 60
  5. Sequences and differential expression of three novel human type-II hair keratins. (PMID: 9084137) Rogers MA … Schweizer J (Differentiation; research in biological diversity 1997) 3 4 22 60

Products for KRT86 Gene

Sources for KRT86 Gene

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