Aliases for KRT86 Gene
External Ids for KRT86 Gene
Previous HGNC Symbols for KRT86 Gene
Previous GeneCards Identifiers for KRT86 Gene
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT86 Gene
KRT86 (Keratin 86, Type II) is a Protein Coding gene. Diseases associated with KRT86 include monilethrix and hair disease. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.