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Aliases for KRT85 Gene

Aliases for KRT85 Gene

  • Keratin 85, Type II 2 3
  • KRTHB5 3 4 6
  • Type II Hair Keratin Hb5 3 4
  • Keratin, Hair, Basic, 5 2 3
  • Type-II Keratin Kb25 3 4
  • Hair Keratin K2.12 3 4
  • Keratin-85 3 4
  • ECTD4 3 6
  • HB5 3 6
  • K85 3 4
  • Keratin, Type II Cuticular Hb5 3
  • Hard Keratin, Type II, 5 3
  • Hard Keratin Type II 2
  • Keratin 85 2
  • Hb-5 3
  • HHb5 3

External Ids for KRT85 Gene

Previous Symbols for KRT85 Gene

  • KRTHB5

Summaries for KRT85 Gene

Entrez Gene Summary for KRT85 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT85 Gene

KRT85 (Keratin 85, Type II) is a Protein Coding gene. Diseases associated with KRT85 include ectodermal dysplasia 4, hair/nail type. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT85 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT85 Gene

Genomics for KRT85 Gene

Genomic Location for KRT85 Gene

Start:
52,360,006 bp from pter
End:
52,367,525 bp from pter
Size:
7,520 bases
Orientation:
Minus strand

Genomic View for KRT85 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT85 Gene

Regulatory Elements for KRT85 Gene

Proteins for KRT85 Gene

  • Protein details for KRT85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78386-KRT85_HUMAN
    Recommended name:
    Keratin, type II cuticular Hb5
    Protein Accession:
    P78386
    Secondary Accessions:
    • Q9NSB1

    Protein attributes for KRT85 Gene

    Size:
    507 amino acids
    Molecular mass:
    55802 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT85 Gene

Proteomics data for KRT85 Gene at MOPED

Post-translational modifications for KRT85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT85 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT85 Gene

Domains for KRT85 Gene

Gene Families for KRT85 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Protein Domains for KRT85 Gene

UniProtKB/Swiss-Prot:

KRT85_HUMAN
Family:
  • Belongs to the intermediate filament family.:
    • P78386
genes like me logo Genes that share domains with KRT85: view

Function for KRT85 Gene

Gene Ontology (GO) - Molecular Function for KRT85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT85: view

miRNA for KRT85 Gene

miRTarBase miRNAs that target KRT85

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRT85 Gene

Localization for KRT85 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT85 Gene COMPARTMENTS Subcellular localization image for KRT85 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRT85: view

Pathways for KRT85 Gene

SuperPathways for KRT85 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 9084137
genes like me logo Genes that share ontologies with KRT85: view

No data available for Pathways by source for KRT85 Gene

Transcripts for KRT85 Gene

mRNA/cDNA for KRT85 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT85 Gene

Keratin 85:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT85 Gene

No ASD Table

Relevant External Links for KRT85 Gene

GeneLoc Exon Structure for
KRT85
ECgene alternative splicing isoforms for
KRT85

Expression for KRT85 Gene

mRNA expression in normal human tissues for KRT85 Gene

mRNA differential expression in normal tissues according to GTEx for KRT85 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (41.5) and Skin - Sun Exposed (Lower leg) (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT85 Gene

SOURCE GeneReport for Unigene cluster for KRT85 Gene Hs.182507

mRNA Expression by UniProt/SwissProt for KRT85 Gene

P78386-KRT85_HUMAN
Tissue specificity: Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft.
genes like me logo Genes that share expressions with KRT85: view

Orthologs for KRT85 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT85 36
  • 99.34 (n)
  • 99.41 (a)
KRT85 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT85 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT85 36
  • 91.72 (n)
  • 94.28 (a)
KRT85 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5430421N21Rik 37
  • 82 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KRT85 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt85 36
  • 89.15 (n)
  • 93.07 (a)
Species with no ortholog for KRT85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT85 Gene

ENSEMBL:
Gene Tree for KRT85 (if available)
TreeFam:
Gene Tree for KRT85 (if available)

Paralogs for KRT85 Gene

Pseudogenes.org Pseudogenes for KRT85 Gene

genes like me logo Genes that share paralogs with KRT85: view

Variants for KRT85 Gene

Sequence variations from dbSNP and Humsavar for KRT85 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15667 -- 52,360,077(-) TTCTT(A/G)TGACT utr-variant-3-prime, downstream-variant-500B
rs1059837 -- 52,360,551(-) AGGGA(C/T)AAGAC utr-variant-3-prime, downstream-variant-500B
rs1395340 -- 52,368,981(+) AACTG(C/G)GTTTG upstream-variant-2KB
rs1506566 -- 52,368,175(+) ATGGC(C/T)ACTTG upstream-variant-2KB
rs1621938 -- 52,362,881(-) CTGAC(A/G)GCCGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for KRT85 Gene

Variant ID Type Subtype PubMed ID
dgv511e1 CNV Complex 17122850
nsv899089 CNV Loss 21882294
essv22726 CNV CNV 17122850
dgv70e55 CNV Gain 17911159
nsv516938 CNV Gain+Loss 19592680
esv29967 CNV Gain 17803354
esv27319 CNV Gain+Loss 19812545
dgv29e180 CNV Gain 20482838
nsv818917 CNV Gain 17921354
dgv200n27 CNV Gain 19166990
nsv832410 CNV Gain 17160897
nsv832411 CNV Loss 17160897

Relevant External Links for KRT85 Gene

HapMap Linkage Disequilibrium report
KRT85
Human Gene Mutation Database (HGMD)
KRT85

Disorders for KRT85 Gene

(1) OMIM Diseases for KRT85 Gene (602767)

UniProtKB/Swiss-Prot

KRT85_HUMAN
  • Ectodermal dysplasia 4, hair/nail type (ECTD4) [MIM:602032]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD4 is characterized by complete alopecia, hypotricosis and nail dystrophy in all digits. There is no evidence of any other abnormality. Inheritance can be autosomal dominant or recessive. {ECO:0000269 PubMed:16525032}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT85

Genetic Association Database (GAD)
KRT85
genes like me logo Genes that share disorders with KRT85: view

Publications for KRT85 Gene

  1. Sequences and differential expression of three novel human type-II hair keratins. (PMID: 9084137) Rogers M.A. … Schweizer J. (Differentiation 1997) 2 3 4 23
  2. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. (PMID: 10727209) Tang K. … Honn K.V. (Biochemistry 2000) 3 23
  3. Characterization of a 300 kbp region of human DNA containing the type II hair keratin. (PMID: 10692104) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2000) 3 4
  4. A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type. (PMID: 16525032) Naeem M. … Ahmad W. (J. Med. Genet. 2006) 3 4
  5. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3

Products for KRT85 Gene

Sources for KRT85 Gene

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