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Aliases for KRT84 Gene

Aliases for KRT84 Gene

  • Keratin 84, Type II 2 3
  • KRTHB4 3 4 6
  • Type II Hair Keratin Hb4 3 4
  • Keratin, Hair, Basic, 4 2 3
  • Type-II Keratin Kb24 3 4
  • Keratin-84 3 4
  • HB4 3 6
  • K84 3 4
  • Keratin, Type II Cuticular Hb4 3
  • Hard Keratin, Type II, 4 3
  • Hard Keratin Type II 4 2
  • Type II Hair Keratin 4 3
  • Keratin 84 2

External Ids for KRT84 Gene

Previous HGNC Symbols for KRT84 Gene

  • KRTHB4

Previous GeneCards Identifiers for KRT84 Gene

  • GC12M051058
  • GC12M052771
  • GC12M049815

Summaries for KRT84 Gene

Entrez Gene Summary for KRT84 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT84 Gene

KRT84 (Keratin 84, Type II) is a Protein Coding gene. Diseases associated with KRT84 include petroclival meningioma. GO annotations related to this gene include structural constituent of cytoskeleton and structural constituent of epidermis. An important paralog of this gene is KRT82.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT84 Gene

Genomics for KRT84 Gene

Regulatory Elements for KRT84 Gene

Genomic Location for KRT84 Gene

Start:
52,377,812 bp from pter
End:
52,385,652 bp from pter
Size:
7,841 bases
Orientation:
Minus strand

Genomic View for KRT84 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT84 Gene

Proteins for KRT84 Gene

  • Protein details for KRT84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSB2-KRT84_HUMAN
    Recommended name:
    Keratin, type II cuticular Hb4
    Protein Accession:
    Q9NSB2
    Secondary Accessions:
    • B2RA43
    • Q6ISB0
    • Q701L6

    Protein attributes for KRT84 Gene

    Size:
    600 amino acids
    Molecular mass:
    64842 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT84 Gene

Proteomics data for KRT84 Gene at MOPED

Post-translational modifications for KRT84 Gene

  • Ubiquitination at Lys175 and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT84 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT84 Gene

Domains for KRT84 Gene

Gene Families for KRT84 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSB2

UniProtKB/Swiss-Prot:

KRT84_HUMAN :
  • Q9NSB2
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT84: view

Function for KRT84 Gene

Gene Ontology (GO) - Molecular Function for KRT84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton NAS 10692104
GO:0030280 structural constituent of epidermis IEA --
genes like me logo Genes that share ontologies with KRT84: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT84

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT84 Gene

Localization for KRT84 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT84 Gene COMPARTMENTS Subcellular localization image for KRT84 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament --
GO:0045095 keratin filament IDA 10692104
GO:0045111 intermediate filament cytoskeleton --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT84: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT84 Gene

Pathways for KRT84 Gene

SuperPathways for KRT84 Gene

No Data Available

Interacting Proteins for KRT84 Gene

Gene Ontology (GO) - Biological Process for KRT84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development NAS 10692104
GO:0035878 nail development NAS 10692104
GO:0045616 regulation of keratinocyte differentiation IEA --
genes like me logo Genes that share ontologies with KRT84: view

No data available for Pathways by source for KRT84 Gene

Transcripts for KRT84 Gene

mRNA/cDNA for KRT84 Gene

(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT84 Gene

Keratin 84:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT84

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT84

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT84 Gene

No ASD Table

Relevant External Links for KRT84 Gene

GeneLoc Exon Structure for
KRT84
ECgene alternative splicing isoforms for
KRT84

Expression for KRT84 Gene

mRNA expression in normal human tissues for KRT84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT84 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (38.9) and Skin - Sun Exposed (Lower leg) (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT84 Gene

SOURCE GeneReport for Unigene cluster for KRT84 Gene Hs.272336

mRNA Expression by UniProt/SwissProt for KRT84 Gene

Q9NSB2-KRT84_HUMAN
Tissue specificity: Expressed in the hair follicles.
genes like me logo Genes that share expressions with KRT84: view

In Situ Assay Products

Orthologs for KRT84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT84 35
  • 98.94 (n)
  • 98.83 (a)
KRT84 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT84 35
  • 84.12 (n)
  • 80.68 (a)
KRT84 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT84 35
  • 86.39 (n)
  • 83.88 (a)
KRT84 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt84 35
  • 82.85 (n)
  • 82.57 (a)
Krt84 16
Krt84 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt84 35
  • 83.92 (n)
  • 85.98 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii krt8 36
  • 49 (a)
ManyToMany
si:dkey-222f2.1 35
  • 62.45 (n)
  • 59.37 (a)
zgc:158846 36
  • 44 (a)
ManyToMany
Species with no ortholog for KRT84:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT84 Gene

ENSEMBL:
Gene Tree for KRT84 (if available)
TreeFam:
Gene Tree for KRT84 (if available)

Paralogs for KRT84 Gene

genes like me logo Genes that share paralogs with KRT84: view

Variants for KRT84 Gene

Sequence variations from dbSNP and Humsavar for KRT84 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs883709 -- 52,381,278(+) GGGGC(C/T)TCAAA intron-variant
rs883710 -- 52,381,611(+) TGGTG(C/T)CAGGG intron-variant
rs883711 -- 52,381,692(+) TCTGA(A/G/T)AACCA intron-variant
rs883712 -- 52,381,209(+) TACTG(C/G/T)GGAGA intron-variant
rs906139 -- 52,384,479(+) TCCCT(A/G)CAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT84 Gene

Variant ID Type Subtype PubMed ID
dgv511e1 CNV Complex 17122850
nsv899089 CNV Loss 21882294
essv22726 CNV CNV 17122850
dgv70e55 CNV Gain 17911159
nsv516938 CNV Gain+Loss 19592680
esv29967 CNV Gain 17803354
esv27319 CNV Gain+Loss 19812545
dgv29e180 CNV Gain 20482838
nsv818917 CNV Gain 17921354
dgv200n27 CNV Gain 19166990
nsv832410 CNV Gain 17160897
nsv832411 CNV Loss 17160897
nsv8972 CNV Gain 18304495

Relevant External Links for KRT84 Gene

HapMap Linkage Disequilibrium report
KRT84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT84 Gene

Disorders for KRT84 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KRT84 Gene including...

Search for KRT84 Gene in MalaCards »

(2) University of Copenhagen DISEASES for KRT84 Gene

genes like me logo Genes that share disorders with KRT84: view

No data available for UniProtKB/Swiss-Prot for KRT84 Gene

Publications for KRT84 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  4. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid H.W. … Franke W.W. (Differentiation 1986) 2 3
  5. Characterization of a 300 kbp region of human DNA containing the type II hair keratin. (PMID: 10692104) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2000) 3 4

Products for KRT84 Gene

Sources for KRT84 Gene

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