KRT84 Gene
protein-coding GIFtS: 47
GCID: GC12M052771
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keratin 84(Previous names: keratin, hair, basic, 4 )
(Previous symbol: KRTHB4)
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Aliases
for KRT84 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 841 2 | | HB42 | | KRTHB41 2 3 | | Hard Keratin, Type II, 42 | | Keratin, Hair, Basic, 41 2 | | Keratin, Type II Cuticular Hb42 | | Type II Hair Keratin Hb42 3 | | Keratin-843 | | Type-II Keratin Kb242 3 | | Type II Hair Keratin 42 | | K842 3 | | Keratin-843 | | Hb-41 | | |
Export aliases for KRT84 gene to outside databasesPrevious GC identifers: GC12M051058 GC12M049815 |
Summaries
for KRT84 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT84:
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basicprotein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered ina region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. Onesubfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includesKRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is containedprimarily in the filiform tongue papilla, among other hair keratins. (provided by RefSeq, Jul 2008)
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Genomic Views
for KRT84 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT84 gene promoter:
STAT5B CRE-BP1 p53 ATF-2 Hand1 RelA NF-kappaB1 NF-kappaB LCR-F1 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT84
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT84 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13KRT84 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M052771: view genomic region
(about GC identifiers)
Start:
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52,771,596 bp from pter |
End:
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52,779,436 bp from pter |
Size:
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7,841 bases |
Orientation:
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minus strand |
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Proteins
for KRT84 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRT84_HUMAN, Q9NSB2 (See
protein sequence)Recommended Name: Keratin, type II cuticular Hb4 Size: 600 amino acids; 64842 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: B2RA43 Q6ISB0 Q701L6Explore the universe of human proteins at neXtProt for KRT84: NX_Q9NSB2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NSB2
KRT84 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149034.2
ENSEMBL proteins: ENSP00000257951
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KRT84 for ontologies About GeneDecksing
KRT84 Antibody Products:
Assay Products for KRT84: |
Protein
Domains /
Families
for KRT84 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT84 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NSB2ProtoNet protein and cluster: Q9NSB2 3 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: KRT84_HUMAN, Q9NSB2Similarity: Belongs to the intermediate filament family |
Function
for KRT84 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT84 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT84
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KRT84 (NM_033045) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT84 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT84 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT84 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005200 | structural constituent of cytoskeleton |
NAS | 10692104 | | GO:0030280 | structural constituent of epidermis |
NAS | -- |
KRT84 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRT84 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT84
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/6 Interacting proteins for KRT84 (Q9NSB23 ENSP000002579514) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
KRT84 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT84 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT84
Search CenterWatch for drugs/clinical trials and news about KRT84
|
Transcripts
for KRT84 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT84 gene: NM_033045.3 Unigene Cluster for KRT84: Keratin 84 Hs.272336 [show with all ESTs]Unigene Representative Sequence: BC0696471 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000257951(uc001sah.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT84 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT84
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT84 (NM_033045) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT84 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT84 |
Additional cDNA sequence: AJ628420.1 AK314030.1 BC069647.1 2 DOTS entries: DT.99950980 DT.121119174 3 AceView cDNA sequences: BC069647 NM_033045 AJ628420
GeneLoc Exon Structure
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Expression
for KRT84 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT84 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGATGCTCC
About this image
See KRT84 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT84
SOURCE GeneReport for Unigene cluster: Hs.272336
UniProtKB/Swiss-Prot: KRT84_HUMAN, Q9NSB2Tissue specificity: Expressed in the hair follicles
SABiosciences Custom PCR Arrays for KRT84
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT84
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT84 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT84 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT84 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT84 |
Orthologs
for KRT84 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT84 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for KRT84 (if available)
TreeFam Gene Tree for KRT84 (if available) |
Paralogs
for KRT84 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT84 gene
- KRT742 KRT772 KRT6B2 KRT832 KRT762 KRT862 KRT32 KRT82
- KRT812 KRT712 KRT8P112 KRT782 KRT72 ENSG000001704422 KRT792 KRT722
- KRT732 KRT52 KRT6C2 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/33 SIMAP similar genes for KRT84 using alignment to 1 protein entry: KRT84_HUMAN(see all similar genes):KRT121P KRT7 KRT5 KRT82 KRT83 KRT85
KRT86 KRTHB2 KRT8 KRT81 KRT6A KRT6B
KRT6C KRT71 KRT1B KRT4 KRT72 KRT73
KRT84 for paralogs About GeneDecksing
|
Genomic Variants
for KRT84 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT84 (52771596 - 52779436 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for KRT84
8 CNVs: 4778 9695 66223 30601 23297 53570 2984 8730 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT84 |
|
Disorders
/ Diseases
for KRT84 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT84 for disorders About GeneDecksing
OMIM gene information: 602766
OMIM disorders: --
2  diseases for KRT84: About MalaCardspharyngitis neuronitis
Export disorders for KRT84 gene to outside databases
|
Publications
for KRT84 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT84 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KRT84) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of a 300 kbp region of human DNA containing the type II hair keratin. (PubMed id 10692104)1, 2 Rogers M.A.... Schweizer J. (2000)
- The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PubMed id 2431943)1, 3 Heid H.W....Franke W.W. (1986)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
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External Searches for KRT84 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KRT84 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT84 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT84 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT84 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KRT84 gene:
Search GeneIP for patents involving KRT84
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT84 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT84 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT84 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT84 | | | OriGene Protein Over-expression Lysate for KRT84 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT84 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT84 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT84 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KRT84 | | OriGene Custom Protein Services for KRT84 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT84 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT84 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT84 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT84 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT84 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT84 |
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| | | | Search Tocris compounds for KRT84 |
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 | | | KRT84 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT84 |
|  |  |  | | | | ThermoFisher Antibody for KRT84 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT84 |
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