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Aliases for KRT84 Gene

Aliases for KRT84 Gene

  • Keratin 84 2 3 5
  • Type II Hair Keratin Hb4 3 4
  • Keratin, Hair, Basic, 4 2 3
  • Type-II Keratin Kb24 3 4
  • Keratin 84, Type II 2 3
  • KRTHB4 3 4
  • K84 3 4
  • Keratin, Type II Cuticular Hb4 3
  • Hard Keratin, Type II, 4 3
  • Hard Keratin Type II 4 2
  • Type II Hair Keratin 4 3
  • Keratin-84 4
  • HB4 3

External Ids for KRT84 Gene

Previous HGNC Symbols for KRT84 Gene

  • KRTHB4

Previous GeneCards Identifiers for KRT84 Gene

  • GC12M051058
  • GC12M052771
  • GC12M049815

Summaries for KRT84 Gene

Entrez Gene Summary for KRT84 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT84 Gene

KRT84 (Keratin 84) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT85.

Additional gene information for KRT84 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT84 Gene

Genomics for KRT84 Gene

GeneHancer (GH) Regulatory Elements for KRT84 Gene

Promoters and enhancers for KRT84 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I052385 Promoter 0.5 EPDnew 550.8 +1.2 1234 0.1 KRT84 ENSG00000258253 GC12M052334 GC12M052373
GH12I052869 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -486.4 -486419 7.1 HDGF PKNOX1 SMAD1 NEUROD1 SIN3A ZBTB7B POLR2B ZNF766 CBX5 ZNF207 KRT2 PCBP2 EIF4B AAAS SP1 ZNF740 ATF7 KRT84 LOC100652999 PFDN5
GH12I052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -516.0 -516022 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 ATF7 LOC100652999 EIF4B ENSG00000257808
GH12I052491 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -107.7 -107651 6.4 CTCF STAT1 KLF17 CEBPB SIN3A EBF1 ZIC2 SP1 JUND GLIS1 KRT6A KRT6C KRT5 KRT71 KRT82 KRT84 KRT87P KRT86 KRT2 KRT78
GH12I052923 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 9.7 -539.9 -539941 6.2 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A YY1 ZNF207 ZNF143 KRT8 KRT18 PFDN5 CSAD ZNF740 KRT84 GC12M052900
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT84 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT84 gene promoter:

Genomic Locations for KRT84 Gene

Genomic Locations for KRT84 Gene
9,095 bases
Minus strand

Genomic View for KRT84 Gene

Genes around KRT84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT84 Gene

Proteins for KRT84 Gene

  • Protein details for KRT84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cuticular Hb4
    Protein Accession:
    Secondary Accessions:
    • B2RA43
    • Q6ISB0
    • Q701L6

    Protein attributes for KRT84 Gene

    600 amino acids
    Molecular mass:
    64842 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT84 Gene

Post-translational modifications for KRT84 Gene

No Post-translational modifications

Other Protein References for KRT84 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT84 Gene

Domains & Families for KRT84 Gene

Gene Families for KRT84 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT84: view

Function for KRT84 Gene

Phenotypes From GWAS Catalog for KRT84 Gene

Gene Ontology (GO) - Molecular Function for KRT84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005200 structural constituent of cytoskeleton NAS 10692104
GO:0030280 structural constituent of epidermis IEA --
genes like me logo Genes that share ontologies with KRT84: view
genes like me logo Genes that share phenotypes with KRT84: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT84 Gene

Localization for KRT84 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT84 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IDA 10692104
GO:0045111 intermediate filament cytoskeleton IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with KRT84: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT84 Gene

Pathways & Interactions for KRT84 Gene

SuperPathways for KRT84 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT84: view

Pathways by source for KRT84 Gene

2 Reactome pathways for KRT84 Gene

Gene Ontology (GO) - Biological Process for KRT84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development NAS 10692104
GO:0007010 cytoskeleton organization IEA --
GO:0031424 keratinization TAS --
GO:0035878 nail development NAS 10692104
GO:0045616 regulation of keratinocyte differentiation IEA --
genes like me logo Genes that share ontologies with KRT84: view

No data available for SIGNOR curated interactions for KRT84 Gene

Drugs & Compounds for KRT84 Gene

No Compound Related Data Available

Transcripts for KRT84 Gene

mRNA/cDNA for KRT84 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT84 Gene

Keratin 84:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT84 Gene

No ASD Table

Relevant External Links for KRT84 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT84 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x38.9) and Skin - Sun Exposed (Lower leg) (x7.1).

Protein differential expression in normal tissues from HIPED for KRT84 Gene

This gene is overexpressed in Adipocyte (41.4), Bone marrow mesenchymal stem cell (13.1), and Stomach (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT84 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT84 Gene:


SOURCE GeneReport for Unigene cluster for KRT84 Gene:


mRNA Expression by UniProt/SwissProt for KRT84 Gene:

Tissue specificity: Expressed in the hair follicles.

Evidence on tissue expression from TISSUES for KRT84 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with KRT84: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT84 Gene

Orthologs for KRT84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT84 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT84 33 34
  • 98.94 (n)
(Canis familiaris)
Mammalia KRT84 33 34
  • 86.39 (n)
(Bos Taurus)
Mammalia KRT84 33 34
  • 84.12 (n)
(Rattus norvegicus)
Mammalia Krt84 33
  • 83.92 (n)
(Mus musculus)
Mammalia Krt84 33 16 34
  • 82.85 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
-- 34
  • 49 (a)
-- 34
  • 49 (a)
-- 34
  • 48 (a)
(Danio rerio)
Actinopterygii si:dkey-222f2.1 33
  • 62.45 (n)
krt8 34
  • 49 (a)
zgc:158846 34
  • 44 (a)
Species where no ortholog for KRT84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT84 Gene

Gene Tree for KRT84 (if available)
Gene Tree for KRT84 (if available)

Paralogs for KRT84 Gene

genes like me logo Genes that share paralogs with KRT84: view

Variants for KRT84 Gene

Sequence variations from dbSNP and Humsavar for KRT84 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000421639 -- 52,379,415(-) T/A intron_variant
rs1001134522 -- 52,379,676(-) C/A intron_variant
rs1001315457 -- 52,380,224(-) C/A intron_variant
rs1001688382 -- 52,380,753(-) TGGGGTAGGGCATTG/TG intron_variant
rs1002026991 -- 52,379,588(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT84 Gene

Variant ID Type Subtype PubMed ID
dgv1503n100 CNV gain 25217958
dgv200n27 CNV gain 19166990
dgv2630n54 CNV gain 21841781
dgv29e180 CNV gain 20482838
dgv487e212 CNV gain 25503493
dgv70e55 CNV gain 17911159
dgv9e209 CNV duplication 24192839
esv27319 CNV gain+loss 19812545
esv2759899 CNV gain 17122850
esv2760832 CNV gain 21179565
esv29967 CNV gain 17803354
esv3629516 CNV loss 21293372
nsv516938 CNV gain+loss 19592680
nsv818917 CNV gain 17921354
nsv832410 CNV gain 17160897
nsv832411 CNV loss 17160897
nsv8972 CNV gain 18304495

Variation tolerance for KRT84 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.54; 97.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT84 Gene

Disorders for KRT84 Gene

Additional Disease Information for KRT84

No disorders were found for KRT84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT84 Gene

Publications for KRT84 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers MA … Schweizer J (The Journal of investigative dermatology 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. (PMID: 10692104) Rogers MA … Schweizer J (The Journal of investigative dermatology 2000) 3 4 58
  5. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid HW … Franke WW (Differentiation; research in biological diversity 1986) 2 3 58

Products for KRT84 Gene

Sources for KRT84 Gene

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