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Aliases for KRT82 Gene

Aliases for KRT82 Gene

  • Keratin 82 2 3 5
  • Type II Hair Keratin Hb2 3 4
  • Keratin, Hair, Basic, 2 2 3
  • Type-II Keratin Kb22 3 4
  • Keratin 82, Type II 2 3
  • KRTHB2 3 4
  • K82 3 4
  • Keratin, Type II Cuticular Hb2 3
  • Hard Keratin, Type II, 2 3
  • Hard Keratin Type II 2 2
  • Keratin-82 4
  • Hb-2 3
  • HB2 3

External Ids for KRT82 Gene

Previous HGNC Symbols for KRT82 Gene

  • KRTHB2

Previous GeneCards Identifiers for KRT82 Gene

  • GC12M051075
  • GC12M052787
  • GC12M049831

Summaries for KRT82 Gene

Entrez Gene Summary for KRT82 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT82 Gene

KRT82 (Keratin 82) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT84.

Additional gene information for KRT82 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT82 Gene

Genomics for KRT82 Gene

GeneHancer (GH) Regulatory Elements for KRT82 Gene

Promoters and enhancers for KRT82 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I052406 Promoter 0.5 EPDnew 550.8 +0.1 106 0.1 ENSG00000257500 KRT82 KRT84 GC12M052334 GC12M052373
GH12I052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -496.5 -496536 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 ATF7 LOC100652999 EIF4B ENSG00000257808
GH12I052491 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -88.2 -88165 6.4 CTCF STAT1 KLF17 CEBPB SIN3A EBF1 ZIC2 SP1 JUND GLIS1 KRT6A KRT6C KRT5 KRT71 KRT82 KRT84 KRT87P KRT86 KRT2 KRT78
GH12I052515 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 9.7 -114.7 -114652 11.4 PKNOX1 ZNF133 GLIS2 SCRT2 RCOR1 FOS DEK ZNF398 MAFF GLIS1 KRT5 GC12M052518 KRT6A KRT6C KRT71 KRT74 KRT84 KRT2 KRT4 KRT82
GH12I052968 Enhancer 1.3 Ensembl ENCODE dbSUPER 10 -564.8 -564757 4.7 HDGF PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A FEZF1 ZBTB7B E2F8 ZNF207 KRT18 KRT79 KRT82 KRT84 KRT71 KRT4 KRT86 KRT8 LOC283335 SOAT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT82 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT82 gene promoter:

Genomic Locations for KRT82 Gene

Genomic Locations for KRT82 Gene
12,462 bases
Minus strand

Genomic View for KRT82 Gene

Genes around KRT82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT82 Gene

Proteins for KRT82 Gene

  • Protein details for KRT82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cuticular Hb2
    Protein Accession:

    Protein attributes for KRT82 Gene

    513 amino acids
    Molecular mass:
    56653 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT82 Gene

Post-translational modifications for KRT82 Gene

No Post-translational modifications

Other Protein References for KRT82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT82 Gene

Domains & Families for KRT82 Gene

Gene Families for KRT82 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT82 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT82: view

Function for KRT82 Gene

Phenotypes From GWAS Catalog for KRT82 Gene

Gene Ontology (GO) - Molecular Function for KRT82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030280 structural constituent of epidermis NAS 10692104
genes like me logo Genes that share ontologies with KRT82: view

Phenotypes for KRT82 Gene

genes like me logo Genes that share phenotypes with KRT82: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT82 Gene

Localization for KRT82 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT82 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IDA 10692104
genes like me logo Genes that share ontologies with KRT82: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT82 Gene

Pathways & Interactions for KRT82 Gene

SuperPathways for KRT82 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT82: view

Pathways by source for KRT82 Gene

2 Reactome pathways for KRT82 Gene

Gene Ontology (GO) - Biological Process for KRT82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT82: view

No data available for SIGNOR curated interactions for KRT82 Gene

Drugs & Compounds for KRT82 Gene

No Compound Related Data Available

Transcripts for KRT82 Gene

mRNA/cDNA for KRT82 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT82 Gene

Keratin 82:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT82 Gene

No ASD Table

Relevant External Links for KRT82 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT82 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x39.9) and Skin - Sun Exposed (Lower leg) (x9.0).

Protein differential expression in normal tissues from HIPED for KRT82 Gene

This gene is overexpressed in Urine (30.2), Brain (9.9), Heart (8.9), Bone marrow mesenchymal stem cell (7.3), and Plasma (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT82 Gene

Protein tissue co-expression partners for KRT82 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT82 Gene:


SOURCE GeneReport for Unigene cluster for KRT82 Gene:

genes like me logo Genes that share expression patterns with KRT82: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT82 Gene

Orthologs for KRT82 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT82 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT82 33 34
  • 98.96 (n)
(Canis familiaris)
Mammalia KRT82 33 34
  • 87.91 (n)
(Mus musculus)
Mammalia Krt82 33 16 34
  • 86.05 (n)
(Bos Taurus)
Mammalia KRT82 33 34
  • 85.82 (n)
(Rattus norvegicus)
Mammalia Krt82 33
  • 85.6 (n)
(Ornithorhynchus anatinus)
Mammalia KRT82 34
  • 78 (a)
Species where no ortholog for KRT82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT82 Gene

Gene Tree for KRT82 (if available)
Gene Tree for KRT82 (if available)

Paralogs for KRT82 Gene

genes like me logo Genes that share paralogs with KRT82: view

Variants for KRT82 Gene

Sequence variations from dbSNP and Humsavar for KRT82 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs483352762 uncertain-significance, not provided 52,401,340(-) C/G coding_sequence_variant, missense_variant
rs1000055205 -- 52,397,095(-) G/A intron_variant
rs1000446589 -- 52,394,704(-) G/C 3_prime_UTR_variant
rs1000455529 -- 52,405,829(-) G/A intron_variant
rs1000648058 -- 52,398,444(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT82 Gene

Variant ID Type Subtype PubMed ID
dgv1503n100 CNV gain 25217958
dgv200n27 CNV gain 19166990
dgv2630n54 CNV gain 21841781
dgv70e55 CNV gain 17911159
nsv516938 CNV gain+loss 19592680
nsv558928 CNV loss 21841781
nsv832410 CNV gain 17160897
nsv832411 CNV loss 17160897
nsv832412 CNV loss 17160897

Variation tolerance for KRT82 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT82 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT82 Gene

Disorders for KRT82 Gene

Additional Disease Information for KRT82

No disorders were found for KRT82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT82 Gene

Publications for KRT82 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  2. Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. (PMID: 10692104) Rogers MA … Schweizer J (The Journal of investigative dermatology 2000) 3 4 58
  3. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid HW … Franke WW (Differentiation; research in biological diversity 1986) 2 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner BL … Wichterle H (PloS one 2015) 3 58

Products for KRT82 Gene

Sources for KRT82 Gene

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