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Aliases for KRT82 Gene

Aliases for KRT82 Gene

  • Keratin 82 2 3
  • Keratin 82, Type II 2 3 5
  • Type II Hair Keratin Hb2 3 4
  • Keratin, Hair, Basic, 2 2 3
  • Type-II Keratin Kb22 3 4
  • Keratin-82 3 4
  • KRTHB2 3 4
  • K82 3 4
  • Hard Keratin, Type II, 2 3
  • Hard Keratin Type II 2 2
  • Hb-2 3
  • HB2 3

External Ids for KRT82 Gene

Previous HGNC Symbols for KRT82 Gene

  • KRTHB2

Previous GeneCards Identifiers for KRT82 Gene

  • GC12M051075
  • GC12M052787
  • GC12M049831

Summaries for KRT82 Gene

Entrez Gene Summary for KRT82 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT82 Gene

KRT82 (Keratin 82) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT86.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT82 Gene

Genomics for KRT82 Gene

Regulatory Elements for KRT82 Gene

Enhancers for KRT82 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT82 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT82 Gene

52,393,931 bp from pter
52,406,392 bp from pter
12,462 bases
Minus strand

Genomic View for KRT82 Gene

Genes around KRT82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT82 Gene

Proteins for KRT82 Gene

  • Protein details for KRT82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cuticular Hb2
    Protein Accession:

    Protein attributes for KRT82 Gene

    513 amino acids
    Molecular mass:
    56653 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT82 Gene

Proteomics data for KRT82 Gene at MOPED

Post-translational modifications for KRT82 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT82 Gene

Domains & Families for KRT82 Gene

Gene Families for KRT82 Gene

Suggested Antigen Peptide Sequences for KRT82 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT82: view

Function for KRT82 Gene

Phenotypes for KRT82 Gene

genes like me logo Genes that share phenotypes with KRT82: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT82 Gene

Localization for KRT82 Gene

Subcellular locations from

Jensen Localization Image for KRT82 Gene COMPARTMENTS Subcellular localization image for KRT82 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRT82 Gene

Pathways & Interactions for KRT82 Gene

SuperPathways for KRT82 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT82 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT82 Gene

Drugs & Compounds for KRT82 Gene

No Compound Related Data Available

Transcripts for KRT82 Gene

mRNA/cDNA for KRT82 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT82 Gene

Keratin 82:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT82 Gene

No ASD Table

Relevant External Links for KRT82 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT82 Gene

mRNA expression in normal human tissues for KRT82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT82 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x39.9) and Skin - Sun Exposed (Lower leg) (x9.0).

Protein differential expression in normal tissues from HIPED for KRT82 Gene

This gene is overexpressed in Urine (30.2), Brain (9.9), Heart (8.9), Bone marrow mesenchymal stem cell (7.3), and Plasma (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT82 Gene

SOURCE GeneReport for Unigene cluster for KRT82 Gene Hs.134640

genes like me logo Genes that share expression patterns with KRT82: view

Protein tissue co-expression partners for KRT82 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KRT82 Gene

Orthologs for KRT82 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT82 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT82 35
  • 85.82 (n)
  • 83.14 (a)
KRT82 36
  • 82 (a)
(Canis familiaris)
Mammalia KRT82 35
  • 87.91 (n)
  • 88.63 (a)
KRT82 36
  • 87 (a)
(Mus musculus)
Mammalia Krt82 35
  • 86.05 (n)
  • 86.64 (a)
Krt82 16
Krt82 36
  • 85 (a)
(Pan troglodytes)
Mammalia KRT82 35
  • 98.96 (n)
  • 99.03 (a)
KRT82 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt82 35
  • 85.6 (n)
  • 88.48 (a)
(Ornithorhynchus anatinus)
Mammalia KRT82 36
  • 78 (a)
Species with no ortholog for KRT82:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT82 Gene

Gene Tree for KRT82 (if available)
Gene Tree for KRT82 (if available)

Paralogs for KRT82 Gene

Paralogs for KRT82 Gene

genes like me logo Genes that share paralogs with KRT82: view

Variants for KRT82 Gene

Sequence variations from dbSNP and Humsavar for KRT82 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2658658 - 52,395,144(+) CAGGC(A/G)TGCTG reference, missense
rs1791634 - 52,401,315(+) GTGTT(C/G/T)AGAAT reference, missense
rs1732263 - 52,395,161(+) CATGG(C/G)TCGTA reference, missense
rs2001036 -- 52,393,794(-) CAAAT(G/T)GCCTG downstream-variant-500B
rs2001037 -- 52,393,679(-) CAGGC(A/C)TCCTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRT82 Gene

Variant ID Type Subtype PubMed ID
dgv70e55 CNV Gain 17911159
nsv516938 CNV Gain+Loss 19592680
dgv200n27 CNV Gain 19166990
nsv832410 CNV Gain 17160897
nsv832411 CNV Loss 17160897
nsv832412 CNV Loss 17160897

Variation tolerance for KRT82 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT82 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT82 Gene

Disorders for KRT82 Gene

Relevant External Links for KRT82

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT82 Gene

Publications for KRT82 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 67
  2. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid H.W. … Franke W.W. (Differentiation 1986) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for KRT82 Gene

Sources for KRT82 Gene