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Aliases for KRT82 Gene

Aliases for KRT82 Gene

  • Keratin 82, Type II 2 3
  • KRTHB2 3 4 6
  • Type II Hair Keratin Hb2 3 4
  • Keratin, Hair, Basic, 2 2 3
  • Type-II Keratin Kb22 3 4
  • Keratin-82 3 4
  • HB2 3 6
  • K82 3 4
  • Keratin, Type II Cuticular Hb2 3
  • Hard Keratin, Type II, 2 3
  • Hard Keratin Type II 2 2
  • Keratin 82 2
  • Hb-2 3

External Ids for KRT82 Gene

Previous HGNC Symbols for KRT82 Gene

  • KRTHB2

Previous GeneCards Identifiers for KRT82 Gene

  • GC12M051075
  • GC12M052787
  • GC12M049831

Summaries for KRT82 Gene

Entrez Gene Summary for KRT82 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT82 Gene

KRT82 (Keratin 82, Type II) is a Protein Coding gene. GO annotations related to this gene include structural constituent of epidermis. An important paralog of this gene is KRT73.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT82 Gene

Genomics for KRT82 Gene

Regulatory Elements for KRT82 Gene

Genomic Location for KRT82 Gene

52,393,931 bp from pter
52,406,392 bp from pter
12,462 bases
Minus strand

Genomic View for KRT82 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT82 Gene

Proteins for KRT82 Gene

  • Protein details for KRT82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cuticular Hb2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KRT82 Gene

    513 amino acids
    Molecular mass:
    56653 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT82 Gene

Proteomics data for KRT82 Gene at MOPED

Post-translational modifications for KRT82 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT82 Gene

Domains for KRT82 Gene

Gene Families for KRT82 Gene

  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NSB4
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT82: view

Function for KRT82 Gene

Gene Ontology (GO) - Molecular Function for KRT82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0030280 structural constituent of epidermis NAS 10692104
genes like me logo Genes that share ontologies with KRT82: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT82

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT82 Gene

Localization for KRT82 Gene

Subcellular locations from

Jensen Localization Image for KRT82 Gene COMPARTMENTS Subcellular localization image for KRT82 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament --
GO:0045095 keratin filament IDA 10692104
genes like me logo Genes that share ontologies with KRT82: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT82 Gene

Pathways for KRT82 Gene

SuperPathways for KRT82 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRT82: view

No data available for Pathways by source for KRT82 Gene

Transcripts for KRT82 Gene

mRNA/cDNA for KRT82 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT82 Gene

Keratin 82:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT82

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT82 Gene

No ASD Table

Relevant External Links for KRT82 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT82 Gene

mRNA expression in normal human tissues for KRT82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT82 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (39.9) and Skin - Sun Exposed (Lower leg) (9.0).

Protein differential expression in normal tissues for KRT82 Gene

This gene is overexpressed in Urine (30.2), Brain (9.9), Heart (8.9), Bone marrow mesenchymal stem cell (7.3), and Plasma (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT82 Gene

SOURCE GeneReport for Unigene cluster for KRT82 Gene Hs.134640

genes like me logo Genes that share expressions with KRT82: view

Expression partners for KRT82 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KRT82 Gene

Orthologs for KRT82 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT82 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT82 35
  • 85.82 (n)
  • 83.14 (a)
KRT82 36
  • 82 (a)
(Canis familiaris)
Mammalia KRT82 35
  • 87.91 (n)
  • 88.63 (a)
KRT82 36
  • 87 (a)
(Mus musculus)
Mammalia Krt82 35
  • 86.05 (n)
  • 86.64 (a)
Krt82 16
Krt82 36
  • 85 (a)
(Pan troglodytes)
Mammalia KRT82 35
  • 98.96 (n)
  • 99.03 (a)
KRT82 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt82 35
  • 85.6 (n)
  • 88.48 (a)
(Ornithorhynchus anatinus)
Mammalia KRT82 36
  • 78 (a)
Species with no ortholog for KRT82:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT82 Gene

Gene Tree for KRT82 (if available)
Gene Tree for KRT82 (if available)

Paralogs for KRT82 Gene

genes like me logo Genes that share paralogs with KRT82: view

Variants for KRT82 Gene

Sequence variations from dbSNP and Humsavar for KRT82 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs916161 -- 52,400,858(-) TGAGA(C/T)GCTGC intron-variant
rs928993 -- 52,404,580(-) GACCA(C/T)GTTCC intron-variant
rs928994 -- 52,407,512(-) AACTA(C/T)CTCAT upstream-variant-2KB
rs928995 -- 52,407,126(-) CTGGG(C/T)TGGGC upstream-variant-2KB
rs1395341 -- 52,405,431(+) GGAAA(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT82 Gene

Variant ID Type Subtype PubMed ID
dgv70e55 CNV Gain 17911159
nsv516938 CNV Gain+Loss 19592680
dgv200n27 CNV Gain 19166990
nsv832410 CNV Gain 17160897
nsv832411 CNV Loss 17160897
nsv832412 CNV Loss 17160897

Relevant External Links for KRT82 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT82 Gene

Disorders for KRT82 Gene

Relevant External Links for KRT82

Genetic Association Database (GAD)

No disorders were found for KRT82 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KRT82 Gene

Publications for KRT82 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  2. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid H.W. … Franke W.W. (Differentiation 1986) 2 3
  3. Characterization of a 300 kbp region of human DNA containing the type II hair keratin. (PMID: 10692104) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2000) 3 4
  4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for KRT82 Gene

Sources for KRT82 Gene

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