Aliases for KRT81 Gene
External Ids for KRT81 Gene
Previous HGNC Symbols for KRT81 Gene
Previous GeneCards Identifiers for KRT81 Gene
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT81 Gene
KRT81 (Keratin 81, Type II) is a Protein Coding gene. Diseases associated with KRT81 include long qt syndrome-3 and brugada syndrome 1. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.