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KRT81 Gene

protein-coding   GIFtS: 51
GCID: GC12M052679

Keratin 81

(Previous names: keratin, hair, basic, 1)
(Previous symbol: KRTHB1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 811 2     HB12 5
KRTHB11 2 3 5     Hard Keratin Type II 11
Keratin, Hair, Basic, 11 2 3     Hb-12
Hair Keratin K2.92 3     ghHkb12
Metastatic Lymph Node 137 Gene Protein2 3     hHAKB2-12
Type II Hair Keratin Hb12 3     Hard Keratin, Type II, 12
Type-II Keratin Kb212 3     Keratin, Type II Cuticular Hb12
K812 3     keratin-812
MLN1372 3     Keratin-813
ghHb12 3     ghHKb13
MLN 1372 3     

External Ids:    HGNC: 64581   Entrez Gene: 38872   Ensembl: ENSG000002054267   OMIM: 6021535   UniProtKB: Q145333   

Export aliases for KRT81 gene to outside databases

Previous GC identifers: GC12M050966 GC12M049713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT81 Gene:
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic
protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are
clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure
similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related
subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair
keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6
have been observed in patients with a rare dominant hair disease, monilethrix. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT81 Gene:
KRT81 (keratin 81) is a protein-coding gene. Diseases associated with KRT81 include emphysematous cholecystitis, and cholecystitis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

Gene Wiki entry for KRT81 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT81 gene promoter:
         AhR   c-Fos   HEN1   AP-1   HSF1short   HSF1 (long)   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT81 promoter sequence
   Search Chromatin IP Primers for KRT81

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

KRT81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT81 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052679:  view genomic region     (about GC identifiers)

Start:
52,679,697 bp from pter      End:
52,685,318 bp from pter
Size:
5,622 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533 (See protein sequence)
Recommended Name: Keratin, type II cuticular Hb1  
Size: 505 amino acids; 54928 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: Q14846 Q16274 Q17R48 Q8WU52 Q9BR74

Explore the universe of human proteins at neXtProt for KRT81: NX_Q14533

Explore proteomics data for KRT81 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRT81 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002272.2  
    ENSEMBL proteins: 
     ENSP00000369349  

    KRT81 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q14533

    ProtoNet protein and cluster: Q14533

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533
    Similarity: Belongs to the intermediate filament family


    KRT81 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI16189514
         
    KRT81 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT81:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT81
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    miRNA
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    Block miRNA regulation of human, mouse, rat KRT81 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KRT81 (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-222 hsa-miR-221 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidKRT81 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KRT81
    Predesigned siRNA for gene silencing in human, mouse, rat KRT81

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT81

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--

    KRT81 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT81
    Interactions:

        Search GeneGlobe Interaction Network for KRT81

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for KRT81 (Q145331, 2, 3 ENSP000003693494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-68081 I2D: score=5 STRING: ENSP00000254043
    SKILP127572, 3MINT-61647 I2D: score=3 
    KXD1Q9BQD31, 2, 3, ENSP000002223074EBI-739648,EBI-739657 MINT-66033 I2D: score=5 STRING: ENSP00000222307
    USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT81



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRT81 gene: 
    NM_002281.3  

    Unigene Cluster for KRT81:

    Keratin 81
    Hs.658118  [show with all ESTs]
    Unigene Representative Sequence: NM_002281
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327741(uc001sab.3 uc001sac.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat KRT81 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KRT81 (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-222 hsa-miR-221 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidKRT81 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRT81
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    GenScript: all cDNA clones in your preferred vector: KRT81 (NM_002281)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KRT81
      QuantiTect SYBR Green Assays in human, mouse, rat KRT81
      QuantiFast Probe-based Assays in human, mouse, rat KRT81

    Additional mRNA sequence: 

    BC006452.1 BC021241.2 BC031978.1 BC117465.1 BC117467.1 X80197.1 X81420.1 

    9 DOTS entries:

    DT.95069074  DT.95155856  DT.111776  DT.100044835  DT.95069067  DT.40271285  DT.405699  DT.95069075 
    DT.97770268 

    Selected AceView cDNA sequences (see all 117):

    CB158604 BQ686286 BQ689978 AK057905 BQ690728 BI828482 BQ924671 BC031978 
    BG489229 BU150206 BC006452 BQ687594 BQ690437 BQ217210 AW602601 BQ949858 
    BG488586 BQ217048 BQ944209 BM006611 BG330673 BU149796 BG436789 BQ689237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT81 expression in normal human tissues (normalized intensities)      KRT81 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGCCTGA
    KRT81 Expression
    About this image


    KRT81 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Epithelial Cells
             Fetal Cortex Cells Hair Shaft
     
     Hair (Integumentary System)
             Fetal Cortex Cells Hair Shaft
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    KRT81 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT81 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658118

    UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533
    Tissue specificity: Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is
    restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in
    malignant lymph node tissue in breast carcinoma tissue

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT81

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for KRT81 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt811 , 5 keratin 811, 5 87.08(n)1
    88.98(a)1
      15 (56.90 cM)5
    648181  NM_001166157.11  NP_001159629.11 
     1014590615 


    ENSEMBL Gene Tree for KRT81 (if available)
    TreeFam Gene Tree for KRT81 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT81 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT81 using alignment to 1 protein entry:     KRT81_HUMAN(see all similar genes):
    KRTHB6    KRTHB1    KRT121P    KRT86    KRT83    KRT85
    KRT7    KRT72    KRT8    KRT84    KRT78    KRT82
    KRTHB2    KRT5    KRT4    KRT1    KRT6A    KRT6B

    KRT81 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT81 (see all 222)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs574195211,2,,4
    CMonilethrix (MLTRX)4 pathogenic152515104(-) AGGGCA/GAGGAG 2 K E mis10--------
    rs568213041,2,,4
    C,FMonilethrix (MLTRX)4 pathogenic152515137(-) ACATCA/C/GAGATC 2 K E mis12NA EU 5861
    rs128126691,2
    C,F,Auntested152516349(+) AGCCCG/ACACCT 1 -- int16Minor allele frequency- A:0.29NA CSA EU 866
    rs1460068681,2
    --49721031(+) GAAGAC/TGGGCA 1 -- us2k10--------
    rs1449715181,2
    --52513463(+) TCTTCC/TCTACC 1 -- ds50010--------
    rs1467955121,2
    --52513473(+) CAAAGC/GAATGG 1 -- ds50010--------
    rs1406092221,2
    --52513540(+) TTTGCA/GGATAT 1 -- ds50010--------
    rs1504183031,2
    --52513777(+) CTTCTA/GTGAGG 1 -- ds50010--------
    rs107358411,2
    C,F,A,H--52513785(+) AGGCGA/GGGGAT 1 -- ds500114Minor allele frequency- G:0.16NA WA CSA EA 380
    rs1137438041,2
    F--52513844(+) GACTTC/TGGGGA 1 -- ds50012Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for KRT81 (52679697 - 52685318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KRT81 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv826377CNV Loss20364138
    nsv899089CNV Loss21882294
    nsv899088CNV Loss21882294
    nsv899087CNV Loss21882294
    esv29967CNV Gain17803354
    dgv70e55CNV Gain17911159
    nsv516938CNV Gain+Loss19592680
    esv27319CNV Gain+Loss19812545
    essv22726CNV CNV17122850
    dgv511e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): KRT81
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT81
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT81

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602153   
    OMIM disorders: 158000  
    UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533
  • Monilethrix (MLTRX) [MIM:158000]: Autosomal dominant hair disorder characterized clinically by alopecia
    and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent
    constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe
    forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 16 diseases for KRT81:    About MalaCards
    emphysematous cholecystitis    cholecystitis    hair disease    pilomatrixoma
    monilethrix    triple-a syndrome    epidermolytic hyperkeratosis    pachyonychia congenita
    congenital ichthyosiform erythroderma    epidermolysis bullosa simplex    epidermolysis bullosa    multiple myeloma
    keratosis    alopecia    myeloma    lung cancer

    5 diseases from the University of Copenhagen DISEASES database for KRT81:
    Monilethrix     Epidermolytic hyperkeratosis     Epidermolysis bullosa simplex     Emphysematous cholecystitis
    Pachyonychia congenita

    KRT81 for disorders           About GeneDecksing


    Export disorders for KRT81 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT81 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with KRT81)
        Utopia: connect your pdf to the dynamic
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    1. Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PubMed id 7556444)1, 2, 3 Rogers M.A.... Schweizer J. (Exp. Cell Res. 1995)
    2. Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PubMed id 9457912)1, 2, 9 Bowden P.E.... Hodgins M.B. (J. Invest. Dermatol. 1998)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1. (PubMed id 9665406)1, 2 Winter H.... Schweizer J. (J. Invest. Dermatol. 1998)
    6. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. (PubMed id 9402962)1, 2 Winter H....Schweizer J. (Hum. Genet. 1997)
    7. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2 Tomasetto C.L.... Rio M.-C. (Genomics 1995)
    8. Sequence and expression of human hair keratin genes. (PubMed id 7528047)1, 2 Bowden P.E.... Hodgins M.B. (J. Dermatol. Sci. 1994)
    9. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    10. Protein interactions of the transcription factor Hoxa1. (PubMed id 23088713)1 Lambert B....Rezsohazy R. (BMC Dev. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3887 HGNC: 6458 AceView: KRTHB1andKRTHBP4 Ensembl:ENSG00000205426 euGenes: HUgn3887
    ECgene: KRT81 H-InvDB: KRT81

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT81 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=KRT81[genesymbol]

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT81 gene:
    Search GeneIP for patents involving KRT81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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