Aliases for KRT81 Gene
External Ids for KRT81 Gene
Previous HGNC Symbols for KRT81 Gene
Previous GeneCards Identifiers for KRT81 Gene
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT81 Gene
KRT81 (Keratin 81) is a Protein Coding gene. Diseases associated with KRT81 include monilethrix and sudden infant death syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.