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Aliases for KRT81 Gene

Aliases for KRT81 Gene

  • Keratin 81, Type II 2 3
  • Keratin, Hair, Basic, 1 2 3 4
  • KRTHB1 3 4 6
  • Metastatic Lymph Node 137 Gene Protein 3 4
  • Type II Hair Keratin Hb1 3 4
  • Type-II Keratin Kb21 3 4
  • Hair Keratin K2.9 3 4
  • Keratin-81 3 4
  • MLN 137 3 4
  • GhHkb1 3 4
  • MLN137 3 4
  • GhHb1 3 4
  • Hb1 3 6
  • K81 3 4
  • Keratin, Type II Cuticular Hb1 3
  • Hard Keratin, Type II, 1 3
  • Hard Keratin Type II 1 2
  • Keratin 81 2
  • HHAKB2-1 3
  • Hb-1 3

External Ids for KRT81 Gene

Previous HGNC Symbols for KRT81 Gene

  • KRTHB1

Previous GeneCards Identifiers for KRT81 Gene

  • GC12M050966
  • GC12M052679
  • GC12M049713

Summaries for KRT81 Gene

Entrez Gene Summary for KRT81 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT81 Gene

KRT81 (Keratin 81, Type II) is a Protein Coding gene. Diseases associated with KRT81 include monilethrix and emphysematous cholecystitis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT81 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT81 Gene

Genomics for KRT81 Gene

Regulatory Elements for KRT81 Gene

Genomic Location for KRT81 Gene

Start:
52,285,913 bp from pter
End:
52,291,534 bp from pter
Size:
5,622 bases
Orientation:
Minus strand

Genomic View for KRT81 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT81 Gene

Proteins for KRT81 Gene

  • Protein details for KRT81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14533-KRT81_HUMAN
    Recommended name:
    Keratin, type II cuticular Hb1
    Protein Accession:
    Q14533
    Secondary Accessions:
    • Q14846
    • Q16274
    • Q17R48
    • Q8WU52
    • Q9BR74

    Protein attributes for KRT81 Gene

    Size:
    505 amino acids
    Molecular mass:
    54928 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT81 Gene

Proteomics data for KRT81 Gene at MOPED

Post-translational modifications for KRT81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT81 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT81 Gene

Domains for KRT81 Gene

Gene Families for KRT81 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Protein Domains for KRT81 Gene

Suggested Antigen Peptide Sequences for KRT81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14533

UniProtKB/Swiss-Prot:

KRT81_HUMAN :
  • Q14533
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT81: view

Function for KRT81 Gene

Gene Ontology (GO) - Molecular Function for KRT81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KRT81: view

Phenotypes for KRT81 Gene

GenomeRNAi human phenotypes for KRT81:
genes like me logo Genes that share phenotypes with KRT81: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT81 Gene

Localization for KRT81 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT81 Gene COMPARTMENTS Subcellular localization image for KRT81 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRT81: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT81 Gene

Pathways for KRT81 Gene

SuperPathways for KRT81 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT81 Gene

None

No data available for Pathways by source for KRT81 Gene

Transcripts for KRT81 Gene

mRNA/cDNA for KRT81 Gene

Unigene Clusters for KRT81 Gene

Keratin 81:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT81

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT81 Gene

No ASD Table

Relevant External Links for KRT81 Gene

GeneLoc Exon Structure for
KRT81
ECgene alternative splicing isoforms for
KRT81

Expression for KRT81 Gene

mRNA expression in normal human tissues for KRT81 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT81 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (44.0) and Skin - Sun Exposed (Lower leg) (5.9).

Protein differential expression in normal tissues for KRT81 Gene

This gene is overexpressed in Bone (53.3) and Urine (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT81 Gene

SOURCE GeneReport for Unigene cluster for KRT81 Gene Hs.658118

mRNA Expression by UniProt/SwissProt for KRT81 Gene

Q14533-KRT81_HUMAN
Tissue specificity: Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.
genes like me logo Genes that share expressions with KRT81: view

In Situ Assay Products

No data available for Expression partners for KRT81 Gene

Orthologs for KRT81 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT81 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT81 35
  • 88.87 (n)
  • 90.2 (a)
-- 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC486529 35
  • 90.83 (n)
  • 91.87 (a)
-- 36
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Krt81 35
  • 87.08 (n)
  • 88.98 (a)
Krt81 16
Krt83 36
  • 81 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia KRT81 35
  • 98.75 (n)
  • 99.41 (a)
KRT81 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt81 35
  • 88.21 (n)
  • 90.25 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
Species with no ortholog for KRT81:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT81 Gene

ENSEMBL:
Gene Tree for KRT81 (if available)
TreeFam:
Gene Tree for KRT81 (if available)

Paralogs for KRT81 Gene

genes like me logo Genes that share paralogs with KRT81: view

Variants for KRT81 Gene

Sequence variations from dbSNP and Humsavar for KRT81 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_018113 -
VAR_018114 -
VAR_018115 -
VAR_018116 Monilethrix (MLTRX)
VAR_018117 Monilethrix (MLTRX)

Structural Variations from Database of Genomic Variants (DGV) for KRT81 Gene

Variant ID Type Subtype PubMed ID
dgv511e1 CNV Complex 17122850
nsv899087 CNV Loss 21882294
nsv7230 OTHER Inversion 18451855
nsv899088 CNV Loss 21882294
nsv899089 CNV Loss 21882294
essv22726 CNV CNV 17122850
dgv70e55 CNV Gain 17911159
nsv516938 CNV Gain+Loss 19592680
esv29967 CNV Gain 17803354
nsv826377 CNV Loss 20364138
esv27319 CNV Gain+Loss 19812545

Relevant External Links for KRT81 Gene

HapMap Linkage Disequilibrium report
KRT81
Human Gene Mutation Database (HGMD)
KRT81

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT81 Gene

Disorders for KRT81 Gene

(1) OMIM Diseases for KRT81 Gene (602153)

UniProtKB/Swiss-Prot

KRT81_HUMAN
  • Monilethrix (MNLIX) [MIM:158000]: A disorder clinically characterized by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. {ECO:0000269 PubMed:25557232, ECO:0000269 PubMed:9402962, ECO:0000269 PubMed:9665406}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with KRT81: view

No data available for Novoseek inferred disease relationships , Genatlas and External Links for KRT81 Gene

Publications for KRT81 Gene

  1. Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PMID: 7556444) Rogers M.A. … Schweizer J. (Exp. Cell Res. 1995) 2 3 4
  2. Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PMID: 9457912) Bowden P.E. … Hodgins M.B. (J. Invest. Dermatol. 1998) 3 4 23
  3. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PMID: 7490069) Tomasetto C.L. … Rio M.-C. (Genomics 1995) 3 4
  4. Sequence and expression of human hair keratin genes. (PMID: 7528047) Bowden P.E. … Hodgins M.B. (J. Dermatol. Sci. 1994) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KRT81 Gene

Sources for KRT81 Gene

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