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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT81 Gene

protein-coding   GIFtS: 51
GCID: GC12M052679

keratin 81

(Previous names: keratin, hair, basic, 1 )
(Previous symbol: KRTHB1)
 Explore 18 diseases affiliated with
KRT81 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KRT81    

Aliases
for KRT81 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratin 811 2     GhHb11
KRTHB11 2 3 5     MLN 1372 3
Keratin, Hair, Basic, 11 2 3     HB12 5
Hb-11 2     GhHkb11
Hair Keratin K2.92 3     HHAKB2-11
Metastatic Lymph Node 137 Gene Protein2 3     Hard Keratin, Type II, 12
Type II Hair Keratin Hb12 3     Keratin, Type II Cuticular Hb12
Type-II Keratin Kb212 3     Keratin-813
K812 3     Keratin-813
MLN1372 3     GhHKb11

External Ids:    HGNC: 64581   Entrez Gene: 38872   Ensembl: ENSG000002054267   OMIM: 6021535   UniProtKB: Q145333   

Export aliases for KRT81 gene to outside databases

Previous GC identifers: GC12M050966 GC12M049713


Summaries
for KRT81 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KRT81:
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic
protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in
a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One
subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes
KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3
and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients
with a rare dominant hair disease, monilethrix. (provided by RefSeq, Jul 2008)

Gene Wiki entry for KRT81


Genomic Views
for KRT81 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT81 gene promoter:
         AhR   c-Fos   HEN1   AP-1   HSF1short   HSF1 (long)   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT81 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT81

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

KRT81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT81 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052679:  view genomic region     (about GC identifiers)

Start:
 52,679,697 bp from pter      End:
 52,685,318 bp from pter
Size:
 5,622 bases      Orientation:
 minus strand

Proteins
for KRT81 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533 (See protein sequence)
Recommended Name: Keratin, type II cuticular Hb1  
Size: 505 amino acids; 54928 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: Q14846 Q16274 Q17R48 Q8WU52 Q9BR74

Explore the universe of human proteins at neXtProt for KRT81: NX_Q14533

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14533

    • KRT81 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002272.2  
    ENSEMBL proteins: 
     ENSP00000369349  

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    Novus Biologicals KRT81 Protein
    Novus Biologicals KRT81 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KRT81

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045095keratin filament IEA--


    KRT81 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KRT81

    Protein Domains /
    Families
    for KRT81 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KRT81 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q14533

    ProtoNet protein and cluster: Q14533

    2 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533
    Similarity: Belongs to the intermediate filament family


    Function
    for KRT81 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: KRT81
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT81
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT81 (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-222 hsa-miR-221 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: KRT81 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT81
    OriGene shRNA RFP: KRT81
    OriGene siRNA: KRT81
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT81

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for KRT81

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KRT81

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI--


    KRT81 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KRT81:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for KRT81 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT81

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for KRT81 (Q145331, 2, 3 ENSP000003693494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-68081 I2D: score=5 STRING: ENSP00000254043
    SKILP127572, 3MINT-61647 I2D: score=3 
    KXD1Q9BQD31, 2, 3, ENSP000002223074EBI-739648,EBI-739657 MINT-66033 I2D: score=5 STRING: ENSP00000222307
    USP15Q9Y4E83, ENSP000002581234I2D: score=2 STRING: ENSP00000258123
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    About this table

    Drugs & Compounds
    for KRT81 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT81
    Search CenterWatch for drugs/clinical trials and news about KRT81 

    Transcripts
    for KRT81 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KRT81 gene: 
    NM_002281.3  

    Unigene Cluster for KRT81:

    Keratin 81
    Hs.658118  [show with all ESTs]
    Unigene Representative Sequence: NM_002281
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327741(uc001sab.3 uc001sac.3)

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT81 (see all 11):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-222 hsa-miR-221 hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: KRT81 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT81
    OriGene shRNA RFP: KRT81
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT81
    Clone
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    GenScript: all cDNA clones in your preferred vector: KRT81 (NM_002281)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT81

    Additional cDNA sequence: 

    BC006452.1 BC021241.2 BC031978.1 BC117465.1 BC117467.1 X80197.1 X81420.1 

    9 DOTS entries:

    DT.95069074  DT.95155856  DT.111776  DT.100044835  DT.95069067  DT.40271285  DT.405699  DT.95069075 
    DT.97770268 

    24/117 AceView cDNA sequences (see all 117):

    CB158604 AK057905 BQ689978 BI828482 BQ686286 BQ690728 BQ926065 X80197 
    BQ689754 BG490944 BQ691199 BQ689237 BU168431 BU162974 BQ687594 BU191398 
    BQ949708 BQ919324 BC021241 NM_002281 X81420 BU158516 BU149796 BC031978 

    GeneLoc Exon Structure


    Expression
    for KRT81 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT81 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTGCCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KRT81 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KRT81 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT81

    SOURCE GeneReport for Unigene cluster: Hs.658118

    UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533
    Tissue specificity: Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is
    restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in
    malignant lymph node tissue in breast carcinoma tissue

        SABiosciences Custom PCR Arrays for KRT81
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    In Situ
    Assay Products:     
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    Orthologs
    for KRT81 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KRT81 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KRT86
    		 --
    		 34(a)
    		 possible ortholog
    		 E22C19W28_E50C23(508667-511528)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 6)    		 --
    46(a)
    (see all 6)    		 possible ortholog
    many ↔ many
    (see all 6)    		 AAWZ02039762(4434-6932)
    2(95805788-95817465)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1369306
    wu:fb15e046
    (see all 3)    		 wu:fb15e04
    (see all 3)    		 20(a)
    15(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(32498013-32508762)
    21(24464941-24474821)
    worm
    (Caenorhabditis elegans)    		 Secernentea ifp-16
    ifc-26
    (see all 12)    		 Intermediate filament protein ifc-2
    (see all 12)    		 7(a)
    6(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 X(9675786-9680111)
    X(642160-654902)


    ENSEMBL Gene Tree for KRT81 (if available)
    TreeFam Gene Tree for KRT81 (if available) 

    Paralogs
    for KRT81 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT81 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT862  KRT32  KRT842  
    KRT82  KRT712  KRT8P112  KRT782  KRT72  ENSG000001704422  KRT792  KRT722  
    KRT732  KRT52  KRT6C2  KRT6A2  KRT852  KRT22  KRT752  KRT12  
    KRT822  KRT42  
    18/48 SIMAP similar genes for KRT81 using alignment to 1 protein entry:     KRT81_HUMAN(see all similar genes):
    KRTHB6    KRTHB1    KRT121P    KRT86    KRT83    KRT85
    KRT7    KRT72    KRT8    KRT84    KRT78    KRT82
    KRTHB2    KRT5    KRT4    KRT1    KRT6A    KRT6B

    KRT81 for paralogs           About GeneDecksing



    Genomic Variants
    for KRT81 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 NCBI SNPs in KRT81 are shown (see all 177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs574195211,2
    		Cpathogenic49714625(-) AGGGCA/GAGGAG 2 K E mis10--------
    rs568213041,2
    		C,F,pathogenic49714658(-) ACATCA/C/GAGATC 3 K Q E mis12NA EU 5861
    rs128126691,2
    		C,F,A,untested52682141(+) AGCCCG/ACACCT 1 -- int16Minor allele frequency- A:0.29NA CSA EU 866
    rs1137438041,2
    		F--49713365(+) GACTTC/TGGGGA 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1121037021,2
    		F--49713413(+) ACACAG/CACAAG 1 -- ds50012Minor allele frequency- C:0.50CSA 4
    rs1113820151,2
    		F--49714635(+) TCCAGG/CAGGCG 2 /L syn12Minor allele frequency- C:0.50CSA 4
    rs1116355101,2
    		F--49715091(+) CCTTGG/CGCACA 1 -- int12Minor allele frequency- C:0.50CSA 4
    rs341879241,2
    		C,F--49715137(+) CGGCCG/ATCAGC 2 /T /M mis12Minor allele frequency- A:0.00NA 4552
    rs1118585671,2
    		--49716104(+) CCCTTC/TTGCCC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1129774811,2
    		--49716291(+) CCCCCG/ACAAGT 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for KRT81 (52679697 - 52685318 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for KRT81
         5 CNVs: 2984 8730 3889 66223 23297
    Human Gene Mutation Database (HGMD): KRT81

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT81
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT81

    Disorders / Diseases
    for KRT81 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KRT81 for disorders           About GeneDecksing

    OMIM gene information: 602153   
    OMIM disorders: 158000  
    UniProtKB/Swiss-Prot: KRT81_HUMAN, Q14533
  • Defects in KRT81 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hair
    • disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of
    normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is
    involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected

    18 diseases for KRT81:    About MalaCards
    monilethrix    hair disease    triple-a syndrome    congenital ichthyosiform erythroderma
    emphysematous cholecystitis    epidermolytic hyperkeratosis    epidermolysis bullosa simplex    pachyonychia congenita
    epidermolysis bullosa    pilomatrixoma    cholecystitis    keratosis
    alopecia    pharyngitis    breast carcinoma    lung cancer
    carcinoma    neuronitis

    5 diseases from the University of Copenhagen DISEASES database for KRT81:
    Monilethrix     Epidermolytic hyperkeratosis     Epidermolysis bullosa simplex     Emphysematous cholecystitis
    Pachyonychia congenita

    Export disorders for KRT81 gene to outside databases

    Publications
    for KRT81 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT81 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with KRT81)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PubMed id 7556444)1, 2, 3 Rogers M.A.... Schweizer J. (1995)
    2. Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PubMed id 9457912)1, 2, 9 Bowden P.E.... Hodgins M.B. (1998)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1. (PubMed id 9665406)1, 2 Winter H.... Schweizer J. (1998)
    6. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. (PubMed id 9402962)1, 2 Winter H....Schweizer J. (1997)
    7. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2 Tomasetto C.L.... Rio M.-C. (1995)
    8. Sequence and expression of human hair keratin genes. (PubMed id 7528047)1, 2 Bowden P.E.... Hodgins M.B. (1994)
    9. Impact of MiRSNPs on survival and progression in patie nts with multiple myeloma undergoing autologous stem cell transplantation. (PubMed id 22539802)1 de Larrea C.F....Blade J. (2012)
    10. A dual role for KRT81: a miR-SNP associated with recu rrence in non-small-cell lung cancer and a novel marker of squamous cell lung c arcinoma. (PubMed id 21799879)1 Campayo M....Monzo M. (2011)

    External Searches for KRT81 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing KRT81 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3887 HGNC: 6458 AceView: KRTHB1andKRTHBP4 Ensembl:ENSG00000205426 euGenes: HUgn3887
    ECgene: KRT81 H-InvDB: KRT81

    Other Databases showing KRT81 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KRT81 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT81 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT81

    Intellectual Property
    for KRT81 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KRT81 gene:
    Search GeneIP for patents involving KRT81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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