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Aliases for KRT81 Gene

Aliases for KRT81 Gene

  • Keratin 81, Type II 2 3
  • Keratin, Hair, Basic, 1 2 3 4
  • Metastatic Lymph Node 137 Gene Protein 3 4
  • Type II Hair Keratin Hb1 3 4
  • Type-II Keratin Kb21 3 4
  • Hair Keratin K2.9 3 4
  • Keratin-81 3 4
  • MLN 137 3 4
  • KRTHB1 3 4
  • GhHkb1 3 4
  • MLN137 3 4
  • GhHb1 3 4
  • K81 3 4
  • Hard Keratin, Type II, 1 3
  • Hard Keratin Type II 1 2
  • Keratin 81 2
  • HHAKB2-1 3
  • Hb-1 3
  • Hb1 3

External Ids for KRT81 Gene

Previous HGNC Symbols for KRT81 Gene

  • KRTHB1

Previous GeneCards Identifiers for KRT81 Gene

  • GC12M050966
  • GC12M052679
  • GC12M049713

Summaries for KRT81 Gene

Entrez Gene Summary for KRT81 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT81 Gene

KRT81 (Keratin 81, Type II) is a Protein Coding gene. Diseases associated with KRT81 include long qt syndrome-3 and brugada syndrome 1. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT81 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT81 Gene

Genomics for KRT81 Gene

Regulatory Elements for KRT81 Gene

Genomic Location for KRT81 Gene

52,285,913 bp from pter
52,308,410 bp from pter
22,498 bases
Minus strand

Genomic View for KRT81 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT81 Gene

Proteins for KRT81 Gene

  • Protein details for KRT81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cuticular Hb1
    Protein Accession:
    Secondary Accessions:
    • Q14846
    • Q16274
    • Q17R48
    • Q8WU52
    • Q9BR74

    Protein attributes for KRT81 Gene

    505 amino acids
    Molecular mass:
    54928 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)

neXtProt entry for KRT81 Gene

Proteomics data for KRT81 Gene at MOPED

Post-translational modifications for KRT81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT81 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT81 Gene

Domains & Families for KRT81 Gene

Gene Families for KRT81 Gene

Protein Domains for KRT81 Gene

Suggested Antigen Peptide Sequences for KRT81 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT81: view

Function for KRT81 Gene

Gene Ontology (GO) - Molecular Function for KRT81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KRT81: view
genes like me logo Genes that share phenotypes with KRT81: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT81 Gene

Localization for KRT81 Gene

Subcellular locations from

Jensen Localization Image for KRT81 Gene COMPARTMENTS Subcellular localization image for KRT81 gene
Compartment Confidence
extracellular 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KRT81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRT81: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT81 Gene

Pathways & Interactions for KRT81 Gene

SuperPathways for KRT81 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT81 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT81 Gene

Drugs & Compounds for KRT81 Gene

No Compound Related Data Available

Transcripts for KRT81 Gene

mRNA/cDNA for KRT81 Gene

Unigene Clusters for KRT81 Gene

Keratin 81:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT81 Gene

No ASD Table

Relevant External Links for KRT81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT81 Gene

mRNA expression in normal human tissues for KRT81 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT81 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x44.0) and Skin - Sun Exposed (Lower leg) (x5.9).

Protein differential expression in normal tissues from HIPED for KRT81 Gene

This gene is overexpressed in Bone (53.3) and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT81 Gene

SOURCE GeneReport for Unigene cluster for KRT81 Gene Hs.658118

mRNA Expression by UniProt/SwissProt for KRT81 Gene

Tissue specificity: Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue.
genes like me logo Genes that share expression patterns with KRT81: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for KRT81 Gene

Orthologs for KRT81 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT81 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT81 35
  • 88.87 (n)
  • 90.2 (a)
-- 36
  • 84 (a)
(Canis familiaris)
Mammalia LOC486529 35
  • 90.83 (n)
  • 91.87 (a)
-- 36
  • 89 (a)
(Mus musculus)
Mammalia Krt81 35
  • 87.08 (n)
  • 88.98 (a)
Krt81 16
Krt83 36
  • 81 (a)
(Pan troglodytes)
Mammalia KRT81 35
  • 98.75 (n)
  • 99.41 (a)
KRT81 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt81 35
  • 88.21 (n)
  • 90.25 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
-- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
-- 36
  • 83 (a)
-- 36
  • 82 (a)
-- 36
  • 80 (a)
Species with no ortholog for KRT81:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT81 Gene

Gene Tree for KRT81 (if available)
Gene Tree for KRT81 (if available)

Paralogs for KRT81 Gene

genes like me logo Genes that share paralogs with KRT81: view

Variants for KRT81 Gene

Sequence variations from dbSNP and Humsavar for KRT81 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs870081 -- 52,309,739(-) GCCAT(C/G)AAGGC upstream-variant-2KB
rs1540092 -- 52,310,383(+) AAGCA(G/T)CCCCT upstream-variant-2KB
rs11428095 -- 52,310,095(+) CCTCA(-/G)GATTC upstream-variant-2KB
rs58810524 -- 52,309,824(+) GAGAT(G/T)GGACA upstream-variant-2KB
rs61915664 -- 52,310,241(+) TGGCC(A/G)GGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT81 Gene

Variant ID Type Subtype PubMed ID
dgv511e1 CNV Complex 17122850
nsv899087 CNV Loss 21882294
nsv7230 OTHER Inversion 18451855
nsv899088 CNV Loss 21882294
nsv899089 CNV Loss 21882294
essv22726 CNV CNV 17122850
dgv70e55 CNV Gain 17911159
nsv516938 CNV Gain+Loss 19592680
esv29967 CNV Gain 17803354
nsv826377 CNV Loss 20364138
esv27319 CNV Gain+Loss 19812545

Variation tolerance for KRT81 Gene

Gene Damage Index Score: 9.98; 89.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT81 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT81 Gene

Disorders for KRT81 Gene

MalaCards: The human disease database

(12) MalaCards diseases for KRT81 Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
long qt syndrome-3
  • long qt syndrome 3
brugada syndrome 1
  • brugada syndrome
heart block, progressive, type ia
  • cardiac conduction defect
ventricular fibrillation, familial, 1
  • paroxysmal familial ventricular fibrillation 1
sick sinus syndrome 1
  • sick sinus syndrome 1, autosomal recessive
- elite association
Search KRT81 in MalaCards View complete list of genes associated with diseases


  • Monilethrix (MNLIX) [MIM:158000]: A disorder clinically characterized by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. {ECO:0000269 PubMed:25557232, ECO:0000269 PubMed:9402962, ECO:0000269 PubMed:9665406}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT81

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT81: view

No data available for Genatlas for KRT81 Gene

Publications for KRT81 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 67
  2. Expression of type I hair keratins in follicular tumours. (PMID: 11359384) Cribier B. … Grosshans E. (Br. J. Dermatol. 2001) 23 67
  3. Expression of human hair keratin basic 1 in pilomatrixoma. A study of 128 cases. (PMID: 10233308) Cribier B. … Grosshans E. (Br. J. Dermatol. 1999) 23 67
  4. Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PMID: 9457912) Bowden P.E. … Hodgins M.B. (J. Invest. Dermatol. 1998) 23 67
  5. Expression pattern of human hair keratin basic 1 (hHb1) in hair follicle and pilomatricoma. (PMID: 9209890) RAcgnier C.H. … Rio M.C. (Exp. Dermatol. 1997) 23 67

Products for KRT81 Gene

Sources for KRT81 Gene

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