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Aliases for KRT80 Gene

Aliases for KRT80 Gene

  • Keratin 80 2 3
  • Keratin 80, Type II 2 3 5
  • Type-II Keratin Kb20 3 4
  • Cytokeratin-80 3 4
  • Keratin-80 3 4
  • CK-80 3 4
  • KB20 3 4
  • K80 3 4
  • Type II Keratin 3
  • Keratin B20 3

External Ids for KRT80 Gene

Previous GeneCards Identifiers for KRT80 Gene

  • GC12M050850
  • GC12M052562
  • GC12M049596

Summaries for KRT80 Gene

Entrez Gene Summary for KRT80 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for KRT80 Gene

KRT80 (Keratin 80) is a Protein Coding gene. Diseases associated with KRT80 include cervix uteri carcinoma in situ. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT80 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT80 Gene

Genomics for KRT80 Gene

Regulatory Elements for KRT80 Gene

Promoters for KRT80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KRT80 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT80 Gene

Chromosome:
12
Start:
52,168,996 bp from pter
End:
52,192,000 bp from pter
Size:
23,005 bases
Orientation:
Minus strand

Genomic View for KRT80 Gene

Genes around KRT80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT80 Gene

Proteins for KRT80 Gene

  • Protein details for KRT80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6KB66-K2C80_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 80
    Protein Accession:
    Q6KB66
    Secondary Accessions:
    • Q6P1A5
    • Q7Z3Q0

    Protein attributes for KRT80 Gene

    Size:
    452 amino acids
    Molecular mass:
    50525 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Alternative splice isoforms for KRT80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT80 Gene

Proteomics data for KRT80 Gene at MOPED

Post-translational modifications for KRT80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT80 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT80 Gene

Domains & Families for KRT80 Gene

Gene Families for KRT80 Gene

Protein Domains for KRT80 Gene

Suggested Antigen Peptide Sequences for KRT80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6KB66

UniProtKB/Swiss-Prot:

K2C80_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT80: view

Function for KRT80 Gene

Gene Ontology (GO) - Molecular Function for KRT80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT80: view
genes like me logo Genes that share phenotypes with KRT80: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT80 Gene

Localization for KRT80 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT80 Gene COMPARTMENTS Subcellular localization image for KRT80 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KRT80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20843789
GO:0030057 NOT desmosome IDA 20843789
genes like me logo Genes that share ontologies with KRT80: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT80 Gene

Pathways & Interactions for KRT80 Gene

SuperPathways for KRT80 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT80 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRT80 Gene

Drugs & Compounds for KRT80 Gene

No Compound Related Data Available

Transcripts for KRT80 Gene

Unigene Clusters for KRT80 Gene

Keratin 80:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT80 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: -
SP3: -

Relevant External Links for KRT80 Gene

GeneLoc Exon Structure for
KRT80
ECgene alternative splicing isoforms for
KRT80

Expression for KRT80 Gene

mRNA expression in normal human tissues for KRT80 Gene

mRNA differential expression in normal tissues according to GTEx for KRT80 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.1), Skin - Not Sun Exposed (Suprapubic) (x17.3), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for KRT80 Gene

This gene is overexpressed in Cervix (35.6), Saliva (8.2), Brain (7.1), and Nasal epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT80 Gene



SOURCE GeneReport for Unigene cluster for KRT80 Gene Hs.140978

mRNA Expression by UniProt/SwissProt for KRT80 Gene

Q6KB66-K2C80_HUMAN
Tissue specificity: Weakly expressed in tongue, but not skin or in any other tissues or organs examined.
genes like me logo Genes that share expression patterns with KRT80: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for KRT80 Gene

Orthologs for KRT80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT80 36
  • 98 (a)
OneToOne
KRT80 35
  • 99.11 (n)
  • 99.28 (a)
cow
(Bos Taurus)
Mammalia KRT80 36
  • 87 (a)
OneToOne
KRT80 35
  • 88.81 (n)
  • 88.65 (a)
dog
(Canis familiaris)
Mammalia KRT80 35
  • 88.42 (n)
  • 86.28 (a)
KRT80 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt80 16
Krt80 36
  • 86 (a)
OneToOne
Krt80 35
  • 85.32 (n)
  • 85.62 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KRT80 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt80 35
  • 85.55 (n)
  • 85.84 (a)
chicken
(Gallus gallus)
Aves KRT80 35
  • 64.13 (n)
  • 53.28 (a)
KRT80 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT80 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KRT80 36
  • 41 (a)
OneToOne
Species with no ortholog for KRT80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT80 Gene

ENSEMBL:
Gene Tree for KRT80 (if available)
TreeFam:
Gene Tree for KRT80 (if available)

Paralogs for KRT80 Gene

Paralogs for KRT80 Gene

genes like me logo Genes that share paralogs with KRT80: view

Variants for KRT80 Gene

Sequence variations from dbSNP and Humsavar for KRT80 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35725856 - 52,173,719(+) GCCGA(A/C/T)GGTCA reference, missense
rs2360653 -- 52,193,089(+) ACTCT(C/T)CCACC upstream-variant-2KB
rs2360654 -- 52,193,204(+) CTCAA(C/T)CCTGC upstream-variant-2KB
rs2076875 -- 52,193,594(-) CCATT(A/C)GGATG upstream-variant-2KB
rs2085502 -- 52,188,003(-) ATGCC(C/T)TCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT80 Gene

Variant ID Type Subtype PubMed ID
nsv832409 CNV Loss 17160897
dgv511e1 CNV Complex 17122850
nsv899086 CNV Loss 21882294

Variation tolerance for KRT80 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT80 Gene

HapMap Linkage Disequilibrium report
KRT80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT80 Gene

Disorders for KRT80 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT80 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervix uteri carcinoma in situ
  • carcinoma in situ of cervix
- elite association - COSMIC cancer census association via MalaCards
Search KRT80 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT80

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT80
genes like me logo Genes that share disorders with KRT80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT80 Gene

Publications for KRT80 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 67
  2. A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. (PMID: 24465473) Liu Y. … Shi Y. (PLoS ONE 2014) 3
  3. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  4. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KRT80 Gene

Sources for KRT80 Gene

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