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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT80 Gene

protein-coding   GIFtS: 51
GCID: GC12M052562

keratin 80

 Explore 5 diseases affiliated with
KRT80 via our new
 Human Malady Compendium 
Biological research products
for KRT80
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Keratin 801 2     Keratin B202
KB201 2 3 5     Keratin, Type II Cytoskeletal 802
Type-II Keratin Kb202 3     Keratin-803
CK-802 3     Type II Keratin2
K802 3     Cytokeratin-803
Cytokeratin-803     Keratin-803

External Ids:    HGNC: 270561   Entrez Gene: 1445012   Ensembl: ENSG000001677677   OMIM: 6111615   UniProtKB: Q6KB663   

Export aliases for KRT80 gene to outside databases

Previous GC identifers: GC12M050850 GC12M049596


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT80:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II
epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is
involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then
dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a
region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found
for this gene.(provided by RefSeq, Oct 2010)

Gene Wiki entry for KRT80


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT80 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   GR-beta   E2F-2   CBF-A   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT80 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT80

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT80 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052562:  view genomic region     (about GC identifiers)

Start:
52,562,780 bp from pter      End:
52,585,784 bp from pter
Size:
23,005 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K2C80_HUMAN, Q6KB66 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 80  
Size: 452 amino acids; 50525 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)
(40-55 and 56-70 kDa, respectively)
Secondary accessions: Q6P1A5 Q7Z3Q0
Alternative splicing: 3 isoforms:  Q6KB66-1   Q6KB66-2   Q6KB66-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT80: NX_Q6KB66

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6KB66

  • KRT80 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001074961.1  NP_872313.2  

    ENSEMBL proteins: 
     ENSP00000369361   ENSP00000378292  

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    Uscn Proteins for KRT80

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045095keratin filament IEA--


    KRT80 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KRT80 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q6KB66

    ProtoNet protein and cluster: Q6KB66

    3 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C80_HUMAN, Q6KB66
    Similarity: Belongs to the intermediate filament family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    miRTarBase miRNAs that target KRT80:
    hsa-mir-155 (MIRT005257)

    OriGene 3'-UTR Clone (see all 2): KRT80
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT80
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT80 (see all 23):
    hsa-miR-623 hsa-miR-1321 hsa-miR-429 hsa-miR-330-5p hsa-miR-3942-5p hsa-miR-298 hsa-miR-326 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidKRT80 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT80

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--


    KRT80 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT80

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/13 Interacting proteins for KRT80 (Q6KB663 ENSP000003782924) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    ATG12O948173I2D: score=1 
    C12orf44Q9BSB43I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GOSR1O952493I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT80
    Search CenterWatch for drugs/clinical trials and news about KRT80 / K2C80 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT80 gene (2 alternative transcripts): 
    NM_001081492.1  NM_182507.2  

    Unigene Cluster for KRT80:

    Keratin 80
    Hs.140978  [show with all ESTs]
    Unigene Representative Sequence: BC065180
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313234(uc001rzy.3) ENST00000394815(uc001rzw.3 uc001rzx.3)
    ENST00000466011

    miRNA
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    OriGene 3'-UTR Clone (see all 2): KRT80
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT80 (see all 23):
    hsa-miR-623 hsa-miR-1321 hsa-miR-429 hsa-miR-330-5p hsa-miR-3942-5p hsa-miR-298 hsa-miR-326 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidKRT80 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AJ717743.1 AL162069.1 BC033114.1 BC047308.1 BC065180.1 

    9 DOTS entries:

    DT.91680653  DT.97858078  DT.101986265  DT.100044463  DT.100738875  DT.121117310  DT.121118505  DT.422219 
    DT.121117904 

    24/109 AceView cDNA sequences (see all 109):

    BG742161 BQ956720 CK818919 BG874400 BQ895790 BQ890197 BQ949255 BQ955144 
    BU151185 BU754036 R63727 BQ688514 AA172302 AW591182 BU527047 BQ960355 
    AW732390 BQ919890 BQ101170 AL556079 AI433717 BG824850 AI621365 BM126903 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT80    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                                                                  
    SP2:                                                  -               
    SP3:                                                  -               


    ECgene alternative splicing isoforms for KRT80

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT80 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGTACAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    KRT80 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KRT80 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT80

    SOURCE GeneReport for Unigene cluster: Hs.140978

    UniProtKB/Swiss-Prot: K2C80_HUMAN, Q6KB66
    Tissue specificity: Weakly expressed in tongue, but not skin or in any other tissues or organs examined

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KRT80 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KRT801 keratin 80 63.1(n)
    51.99(a)
      431302  XM_428853.3  XP_428853.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    KRT806
    (see all 3)
    --

    52(a)
    (see all 3)
    possible ortholog
    1 ↔ 1
    (see all 3)
    AAWZ02039762(4434-6932)
    2(95942479-95980050)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1369306
    wu:fb15e046
    (see all 3)
    wu:fb15e04
    (see all 3)
    18(a)
    15(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    2(32498013-32508762)
    21(24464941-24474821)
    worm
    (Caenorhabditis elegans)
    Secernentea ifp-16
    ifc-26
    (see all 12)
    Intermediate filament protein ifc-2
    (see all 12)
    7(a)
    5(a)
    (see all 12)
    possible ortholog
    possible ortholog
    (see all 12)
    X(9675786-9680111)
    X(642160-654902)


    ENSEMBL Gene Tree for KRT80 (if available)
    TreeFam Gene Tree for KRT80 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/491 NCBI SNPs in KRT80 are shown (see all 491    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619152221,2
    C,--49596700(+) TCTTTC/TCAGAT 2 -- ut311Minor allele frequency- T:0.50NA 2
    rs37591961,2
    C,F,H,--49596806(-) AGTGGG/TGATAC 2 -- ut31 ese35Minor allele frequency- T:0.03EA NS NA 512
    rs1145082441,2
    C,F,--49597046(+) GAGGTG/AAGGCA 2 -- ut311Minor allele frequency- A:0.02WA 118
    rs171263551,2
    C,F,H,--49597142(+) TCAGCA/GTTGAG 2 -- ut31 ese39Minor allele frequency- G:0.07NA NS EA CSA WA 682
    rs1132763931,2
    F,--49597847(+) TCTGGA/GGCCTA 2 -- ut313Minor allele frequency- G:0.40CSA 5
    rs753808711,2
    C,--49598523(+) GATTTA/TGATCA 3 K * ut31 stg10--------
    rs118306701,2
    C,F,H,--49599666(+) CCTGAA/GGAGGC 2 -- int15Minor allele frequency- G:0.01NS EA NA 398
    rs790242171,2
    F,--49599723(+) TGTCCC/TGGCTG 2 -- int14Minor allele frequency- T:0.13CSA WA 124
    rs22773871,2
    C,F,H,--49600375(-) GGAAGG/CGGGAG 2 -- int1 trp37Minor allele frequency- C:0.16EA NS NA CSA WA 1961
    rs563293171,2
    C--49600403(+) GCCTCC/-TCCTG 2 -- int13Minor allele frequency- -:0.00NA CSA 8

    HapMap Linkage Disequilibrium report for KRT80 (52562780 - 52585784 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KRT80
         1 CNV: 3889

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KRT80 for disorders           About GeneDecksing

    OMIM gene information: 611161    OMIM disorders: --

    5 diseases for KRT80:    About MalaCards
    cervix uteri carcinoma in situ    hepatocellular carcinoma    pharyngitis    carcinoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for KRT80:
    Cervix uteri carcinoma in situ

    Export disorders for KRT80 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT80 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with KRT80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
    3. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia. (PubMed id 20843789)1 Langbein L....Schweizer J. (2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 144501 HGNC: 27056 AceView: LOC144501 Ensembl:ENSG00000167767 euGenes: HUgn144501
    ECgene: KRT80 H-InvDB: KRT80

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT80 gene:
    Search GeneIP for patents involving KRT80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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