KRT80 Gene
protein-coding GIFtS : 51
GCID: GC12 M052562
keratin 80
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Aliasesfor KRT80 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Keratin 80 1 2 Keratin B202 KB201 2 3 5 Keratin, Type II Cytoskeletal 802 Type-II Keratin Kb202 3 Keratin-803 CK-802 3 Type II Keratin2 K802 3 Cytokeratin-803 Cytokeratin-803 Keratin-803
Export aliases for KRT80 gene to outside databases Previous GC identifers: GC12M050850 GC12M049596
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Summariesfor KRT80 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KRT80 : Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.(provided by RefSeq, Oct 2010) Gene Wiki entry for KRT80
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Genomic Viewsfor KRT80 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KRT80 gene promoter: GR E2F-4 E2F-3a E2F-5 GR-beta E2F-2 CBF-A E2F E2F-1 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for KRT80 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT80
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13 KRT80 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M052562: view genomic region
(about GC identifiers )
Start:
52,562,780 bp from pter
End:
52,585,784 bp from pter
Size:
23,005 bases
Orientation:
minus strand
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Proteinsfor KRT80 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: K2C80_HUMAN, Q6KB66 (See
protein sequence )Recommended Name: Keratin, type II cytoskeletal 80 Size : 452 amino acids; 50525 Da
Subunit : Heterotetramer of two type I and two type II keratins
Miscellaneous : There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)(40-55 and 56-70 kDa, respectively)
Secondary accessions : Q6P1A5 Q7Z3Q0Alternative splicing : 3 isoforms : Q6KB66-1 Q6KB66-2 Q6KB66-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KRT80: NX_Q6KB66 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6KB66 KRT80 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001074961.1 NP_872313.2 ENSEMBL proteins: ENSP00000369361 ENSP00000378292 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0045095 keratin filament
IEA --
KRT80 for ontologies About GeneDecksing KRT80 Antibody Products: Assay Products for KRT80:
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Protein
Domains / Familiesfor KRT80 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KRT80 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6KB66 ProtoNet protein and cluster: Q6KB66
3 Blocks protein families : IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature UniProtKB/Swiss-Prot: K2C80_HUMAN, Q6KB66 Similarity : Belongs to the intermediate filament family
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Functionfor KRT80 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT80 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT80 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): KRT80 (NM_001081492 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT80 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT80
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT80
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005198 structural molecule activity
IEA --
KRT80 for ontologies About GeneDecksing
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Pathways & Interactionsfor KRT80 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT80 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)5/13 Interacting proteins for KRT80 (Q6KB66 3 ENSP00000378292 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 13 )About this table
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Drugs & Compoundsfor KRT80 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KRT80 Search CenterWatch for drugs/clinical trials and news about KRT80 / K2C80
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Transcriptsfor KRT80 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KRT80 gene (2 alternative transcripts): NM_001081492.1 NM_182507.2 Unigene Cluster for KRT80:
Keratin 80 Hs.140978 [show with all ESTs ] Unigene Representative Sequence: BC065180 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000313234 (uc001rzy.3 ) ENST00000394815 (uc001rzw.3 uc001rzx.3 )ENST00000466011 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT80 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT80 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): KRT80 (NM_001081492 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT80 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT80
Additional cDNA sequence: AJ717743.1 AL162069.1 BC033114.1 BC047308.1 BC065180.1
9 DOTS entries : DT.91680653 DT.97858078
DT.101986265 DT.100044463 DT.100738875 DT.121117310 DT.121118505 DT.422219 DT.121117904 24/109 AceView cDNA sequences (see all 109 ):
BG742161 BQ956720 CK818919 BG874400 BQ895790 BQ890197 BQ949255 BQ955144 BU151185 BU754036 R63727 BQ688514 AA172302 AW591182 BU527047 BQ960355 AW732390 BQ919890 BQ101170 AL556079 AI433717 BG824850 AI621365 BM126903 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for KRT80 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c SP1 :                       SP2 :                 -       SP3 :                 -      
ECgene alternative splicing isoforms for KRT80
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Expression for KRT80 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KRT80 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCAGTACAGC
About this image KRT80 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KRT80 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KRT80 SOURCE GeneReport for Unigene cluster: Hs.140978 UniProtKB/Swiss-Prot: K2C80_HUMAN, Q6KB66 Tissue specificity : Weakly expressed in tongue, but not skin or in any other tissues or organs examined SABiosciences Custom PCR Arrays for KRT80 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KRT80Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KRT80 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KRT80 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KRT80 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT80
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Orthologsfor KRT80 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KRT80 gene from 4/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for KRT80 (if available)TreeFam Gene Tree for KRT80 (if available)
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Paralogsfor KRT80 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor KRT80 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KRT80 (52562780 - 52585784 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for KRT80 1 CNV : 3889
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KRT80
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Disorders
/ Diseasesfor KRT80 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KRT80 for disorders About GeneDecksing
OMIM gene information: 611161
OMIM disorders : --5 diseases for KRT80 : About MalaCards cervix uteri carcinoma in situ hepatocellular carcinoma pharyngitis carcinoma neuronitis 1 disease from the University of Copenhagen DISEASES database for KRT80 :Cervix uteri carcinoma in situ Export disorders for KRT80 gene to outside databases
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Publicationsfor KRT80 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KRT80 gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with KRT80) Utopia : connect your pdf to the dynamic world of online information
New consensus nomenclature for mammalian keratins. (PubMed id 16831889) 1 , 3 Schweizer J....Wright M.W. (2006) Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194) 1 , 2 Rogers M.A....Schweizer J. (2005) The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051) 1 Fang Y....Shen X. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572) 1 Lee K.A....Doedens J.R. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia. (PubMed id 20843789) 1 Langbein L....Schweizer J. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 2 Daub H.... Mann M. (2008)
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External Searches for KRT80 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KRT80 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KRT80 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KRT80 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KRT80 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KRT80 gene: Search GeneIP for patents involving KRT80 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KRT80 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KRT80 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KRT80 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KRT80 OriGene Protein Over-expression Lysate for KRT80 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KRT80 OriGene 3'-UTR Clone for KRT80 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KRT80 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KRT80 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KRT80 OriGene Custom Protein Services for KRT80 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT80 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KRT80 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT80 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KRT80 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KRT80 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KRT80
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KRT80 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT80
ThermoFisher Antibodies for KRT80
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KRT80
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Aliases for KRT80
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Expression for KRT80
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