Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT80 Gene

Aliases for KRT80 Gene

  • Keratin 80 2 3 5
  • Type-II Keratin Kb20 3 4
  • Keratin 80, Type II 2 3
  • Cytokeratin-80 3 4
  • CK-80 3 4
  • KB20 3 4
  • K80 3 4
  • Keratin, Type II Cytoskeletal 80 3
  • Type II Keratin 3
  • Keratin B20 3
  • Keratin-80 4

External Ids for KRT80 Gene

Previous GeneCards Identifiers for KRT80 Gene

  • GC12M050850
  • GC12M052562
  • GC12M049596

Summaries for KRT80 Gene

Entrez Gene Summary for KRT80 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for KRT80 Gene

KRT80 (Keratin 80) is a Protein Coding gene. Diseases associated with KRT80 include Cervix Uteri Carcinoma In Situ. Among its related pathways are Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT80 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT80 Gene

Genomics for KRT80 Gene

Regulatory Elements for KRT80 Gene

Enhancers for KRT80 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F052180 1.7 FANTOM5 Ensembl ENCODE 27.4 +3.5 3536 15.1 PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 ELK1 ZNF416 FOS ZNF263 SP3 KRT80 KRT7 ZNF740 C12orf80 NR4A1 FIGNL2 ACVRL1 ATG101 GRASP ACVR1B
GH12F052228 1.5 FANTOM5 Ensembl ENCODE 16.2 -42.5 -42522 11.5 TBP PKNOX1 SREBF2 SIN3A ZBTB40 RAD21 RFX5 ZNF766 SMARCC2 RCOR1 KRT7 ZNF740 KRT80 HNRNPA3P10 KRT83 KRT81 LINC00592 METTL7AP1 ENSG00000257671
GH12F052277 1.7 FANTOM5 Ensembl ENCODE 13.3 -89.9 -89893 9.2 PKNOX1 ATF1 SIN3A FEZF1 ZNF48 BRCA1 GLIS2 ELK1 ZNF143 FOS KRT86 KRT80 KRT7 KRT87P ZNF740 KRT83 NR4A1 ATG101 KRT5 KRT6A
GH12F052163 1.5 FANTOM5 Ensembl ENCODE 12.5 +27.1 27071 3.1 SIN3A ZNF48 ZNF2 ZNF143 DEK ZNF263 SP3 YY2 TSHZ1 REST KRT80 KRT81 KRT7 KRT86 KRT87P KRT83 KRT84 ACVR1B NR4A1 GC12M052162
GH12F052118 1.6 FANTOM5 Ensembl ENCODE 11.1 +71.7 71695 4.5 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 ZNF2 GLIS2 ZNF143 FOS ENSG00000257989 OR7E47P KRT80 KRT86 KRT87P KRT7 KRT83 KRT84 KRT6C NR4A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT80 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT80 Gene

Chromosome:
12
Start:
52,168,996 bp from pter
End:
52,192,000 bp from pter
Size:
23,005 bases
Orientation:
Minus strand

Genomic View for KRT80 Gene

Genes around KRT80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT80 Gene

Proteins for KRT80 Gene

  • Protein details for KRT80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6KB66-K2C80_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 80
    Protein Accession:
    Q6KB66
    Secondary Accessions:
    • Q6P1A5
    • Q7Z3Q0

    Protein attributes for KRT80 Gene

    Size:
    452 amino acids
    Molecular mass:
    50525 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Alternative splice isoforms for KRT80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT80 Gene

Post-translational modifications for KRT80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT80 Gene

No data available for DME Specific Peptides for KRT80 Gene

Domains & Families for KRT80 Gene

Gene Families for KRT80 Gene

Suggested Antigen Peptide Sequences for KRT80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6KB66

UniProtKB/Swiss-Prot:

K2C80_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT80: view

Function for KRT80 Gene

Gene Ontology (GO) - Molecular Function for KRT80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT80: view
genes like me logo Genes that share phenotypes with KRT80: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT80 Gene

Localization for KRT80 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT80 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KRT80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRT80: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT80 Gene

Pathways & Interactions for KRT80 Gene

SuperPathways for KRT80 Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRT80: view

Pathways by source for KRT80 Gene

1 Reactome pathway for KRT80 Gene

Gene Ontology (GO) - Biological Process for KRT80 Gene

None

No data available for SIGNOR curated interactions for KRT80 Gene

Transcripts for KRT80 Gene

Unigene Clusters for KRT80 Gene

Keratin 80:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT80 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: -
SP3: -

Relevant External Links for KRT80 Gene

GeneLoc Exon Structure for
KRT80
ECgene alternative splicing isoforms for
KRT80

Expression for KRT80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT80 Gene

mRNA differential expression in normal tissues according to GTEx for KRT80 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.1), Skin - Not Sun Exposed (Suprapubic) (x17.3), and Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for KRT80 Gene

This gene is overexpressed in Cervix (35.6), Saliva (8.2), Brain (7.1), and Nasal epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT80 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT80 Gene:

KRT80

SOURCE GeneReport for Unigene cluster for KRT80 Gene:

Hs.140978

mRNA Expression by UniProt/SwissProt for KRT80 Gene:

Q6KB66-K2C80_HUMAN
Tissue specificity: Weakly expressed in tongue, but not skin or in any other tissues or organs examined.
genes like me logo Genes that share expression patterns with KRT80: view

Primer Products

No data available for Protein tissue co-expression partners for KRT80 Gene

Orthologs for KRT80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT80 34 35
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia KRT80 34 35
  • 88.81 (n)
dog
(Canis familiaris)
Mammalia KRT80 34 35
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Krt80 34
  • 85.55 (n)
mouse
(Mus musculus)
Mammalia Krt80 34 16 35
  • 85.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KRT80 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves KRT80 34 35
  • 64.13 (n)
lizard
(Anolis carolinensis)
Reptilia KRT80 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KRT80 35
  • 41 (a)
OneToOne
Species where no ortholog for KRT80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT80 Gene

ENSEMBL:
Gene Tree for KRT80 (if available)
TreeFam:
Gene Tree for KRT80 (if available)

Paralogs for KRT80 Gene

Paralogs for KRT80 Gene

genes like me logo Genes that share paralogs with KRT80: view

Variants for KRT80 Gene

Sequence variations from dbSNP and Humsavar for KRT80 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10444538 -- 52,183,701(+) TAGAA(C/T)TTCCA intron-variant
rs10735840 -- 52,190,723(+) CATAG(G/T)AAGCA intron-variant
rs10747627 -- 52,190,993(+) GGAAG(A/G)CCCAA intron-variant
rs10783493 -- 52,174,692(+) GCCCC(A/G)GAGCC intron-variant
rs10783494 -- 52,182,903(+) GTCTG(C/G)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT80 Gene

Variant ID Type Subtype PubMed ID
esv2759899 CNV gain 17122850
esv3581594 CNV gain 25503493
nsv1038149 CNV gain 25217958
nsv832409 CNV loss 17160897

Variation tolerance for KRT80 Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT80 Gene

Disorders for KRT80 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT80 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervix uteri carcinoma in situ
  • carcinoma in situ of cervix
- elite association - COSMIC cancer census association via MalaCards
Search KRT80 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT80

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT80
genes like me logo Genes that share disorders with KRT80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT80 Gene

Publications for KRT80 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4 64
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64
  4. A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese. (PMID: 24465473) Liu Y. … Shi Y. (PLoS ONE 2014) 3 64
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3 64

Products for KRT80 Gene

Sources for KRT80 Gene

Content
Loading form....