Aliases for KRT80 Gene
Aliases for KRT80 Gene
External Ids for KRT80 Gene
- HGNC: 27056
- Entrez Gene: 144501
- Ensembl: ENSG00000167767
- OMIM: 611161
- UniProtKB: Q6KB66
Previous GeneCards Identifiers for KRT80 Gene
- GC12M050850
- GC12M052562
- GC12M049596
Summaries for KRT80 Gene
-
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
GeneCards Summary for KRT80 Gene
KRT80 (Keratin 80) is a Protein Coding gene. Diseases associated with KRT80 include Cervix Uteri Carcinoma In Situ. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT80 Gene
Genomics for KRT80 Gene
GeneHancer (GH) Regulatory Elements for KRT80 Gene
Promoters and enhancers for KRT80 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KRT80 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KRT80 Gene
Genomic Locations for KRT80 Gene
- chr12:52,168,996-52,192,000
- (GRCh38/hg38)
- Size:
- 23,005 bases
- Orientation:
- Minus strand
- chr12:52,562,780-52,585,784
- (GRCh37/hg19)
Genomic View for KRT80 Gene
Genes around KRT80 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
KRT80 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRT80 Gene
Proteins for KRT80 Gene
-
Protein details for KRT80 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6KB66-K2C80_HUMAN
- Recommended name:
- Keratin, type II cytoskeletal 80
- Protein Accession:
- Q6KB66
- Q6P1A5
- Q7Z3Q0
Protein attributes for KRT80 Gene
- Size:
- 452 amino acids
- Molecular mass:
- 50525 Da
- Quaternary structure:
-
- Heterotetramer of two type I and two type II keratins.
- Miscellaneous:
-
- There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Protein Expression for KRT80 Gene
Post-translational modifications for KRT80 Gene
No Post-translational modifications
Other Protein References for KRT80 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KRT80
- Novus Biologicals Antibodies for KRT80
- Invitrogen Antibodies for KRT80
- Search GeneTex for Antibodies for KRT80
Protein Products
-
OriGene Purified Proteins for KRT80
- Search Origene for MassSpec and Protein Over-expression Lysates for KRT80
- Origene Custom Protein Services for KRT80
- antibodies-online: Search results for 3 available KRT80 Proteins ranked by validation data
- Compare Top KRT80 Proteins
-
Quality Products:
- Search GeneTex for Proteins for KRT80
Assay Products
No data available for DME Specific Peptides for KRT80 Gene
Domains & Families for KRT80 Gene
Gene Families for KRT80 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for KRT80 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KRT80 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6KB66- Family:
-
- Belongs to the intermediate filament family.
Function for KRT80 Gene
Phenotypes From GWAS Catalog for KRT80 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for KRT80 Gene
- GenomeRNAi human phenotypes for KRT80:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for KRT80 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for KRT80
- genomics-online: gRNA clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
- Applied Biological Materials CRISPR for KRT80
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT80
- GenScript: Design CRISPR guide RNA sequences for KRT80
miRNA for KRT80 Gene
- miRTarBase miRNAs that target KRT80
-
- hsa-mir-155-5p (MIRT005257)
- hsa-mir-7-5p (MIRT025643)
- hsa-mir-6165 (MIRT489786)
- hsa-mir-4709-3p (MIRT489787)
- hsa-mir-4316 (MIRT489788)
- hsa-mir-4710 (MIRT489789)
- hsa-mir-486-3p (MIRT489790)
- hsa-mir-6721-5p (MIRT489791)
- hsa-mir-6883-5p (MIRT489792)
- hsa-mir-6785-5p (MIRT489793)
- hsa-mir-4763-3p (MIRT489794)
- hsa-mir-149-3p (MIRT489795)
- hsa-mir-1207-5p (MIRT489796)
- hsa-mir-6809-5p (MIRT489797)
- hsa-mir-6851-5p (MIRT489798)
- hsa-mir-3689d (MIRT489799)
- hsa-mir-7854-3p (MIRT489800)
- hsa-mir-1827 (MIRT489801)
- hsa-mir-6754-5p (MIRT489802)
- hsa-mir-4441 (MIRT489803)
- hsa-mir-4270 (MIRT489804)
- hsa-mir-6743-5p (MIRT489805)
- hsa-mir-4756-5p (MIRT489806)
- hsa-mir-4688 (MIRT489807)
- hsa-mir-4739 (MIRT489808)
- hsa-mir-1321 (MIRT489809)
- hsa-mir-3175 (MIRT569857)
- hsa-mir-4728-5p (MIRT569858)
- hsa-mir-8085 (MIRT569859)
- hsa-mir-6731-5p (MIRT569860)
- hsa-mir-6880-5p (MIRT694837)
- hsa-mir-139-3p (MIRT694838)
- hsa-mir-6134 (MIRT694839)
- hsa-mir-6823-3p (MIRT694840)
- hsa-mir-2114-3p (MIRT694841)
- hsa-mir-6846-3p (MIRT694842)
- hsa-mir-6859-3p (MIRT694843)
- hsa-mir-4750-3p (MIRT694844)
- hsa-mir-151b (MIRT694845)
- hsa-mir-151a-5p (MIRT694846)
- hsa-mir-4257 (MIRT694847)
- hsa-mir-6847-5p (MIRT694848)
- hsa-mir-548o-3p (MIRT694849)
- hsa-mir-1323 (MIRT694850)
- hsa-mir-5195-5p (MIRT694851)
- hsa-mir-548f-3p (MIRT694852)
- hsa-mir-548e-3p (MIRT694853)
- hsa-mir-548az-3p (MIRT694854)
- hsa-mir-548ar-3p (MIRT694855)
- hsa-mir-548a-3p (MIRT694856)
- hsa-mir-1249-5p (MIRT736439)
- hsa-mir-1252-5p (MIRT736517)
- hsa-mir-3150b-3p (MIRT740311)
- hsa-mir-3173-3p (MIRT740612)
- hsa-mir-4533 (MIRT746016)
- hsa-mir-4693-3p (MIRT747146)
- hsa-mir-4747-5p (MIRT748245)
- hsa-mir-4779 (MIRT748740)
- hsa-mir-4784 (MIRT748828)
- hsa-mir-5192 (MIRT749945)
- hsa-mir-5196-5p (MIRT750029)
- hsa-mir-5586-3p (MIRT750990)
- hsa-mir-6797-5p (MIRT756199)
- hsa-mir-6891-5p (MIRT758670)
- hsa-mir-9500 (MIRT760887)
miRNA Products
- Search ViGene Biosciences for KRT80
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KRT80
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- genomics-online: shRNA clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KRT80 gene
Clone Products
- Sino Biological Human cDNA Clone for KRT80
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- VectorBuilder custom plasmid, inducible vectors for KRT80
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KRT80
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KRT80
-
ViGene Biosciences adenoviral particle packaged cDNA for KRT80 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KRT80 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KRT80 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT80 Gene
Localization for KRT80 Gene
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| nucleus | 2 |
| extracellular | 1 |
- Intermediate filaments (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
| GO:0045095 | keratin filament | IEA | -- |
| GO:0045111 | intermediate filament cytoskeleton | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT80 Gene
Pathways & Interactions for KRT80 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
| 2 | Keratinization |
.33
|
|
Pathways by source for KRT80 Gene
2 Reactome pathways for KRT80 Gene
Interacting Proteins for KRT80 Gene
Selected Interacting proteins:
Q6KB66-K2C80_HUMAN
ENSP00000378292
for KRT80 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031424 | keratinization | TAS | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for KRT80 Gene
Transcripts for KRT80 Gene
mRNA/cDNA for KRT80 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (109) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for KRT80
- genomics-online: gRNA clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
- Applied Biological Materials CRISPR for KRT80
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT80
- GenScript: Design CRISPR guide RNA sequences for KRT80
miRNA Products
- Search ViGene Biosciences for KRT80
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KRT80
- Browse OriGene Inhibitory RNA Products For KRT80
- genomics-online: shRNA clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KRT80 gene
Clone Products
- Sino Biological Human cDNA Clone for KRT80
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KRT80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRT80
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KRT80
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - |
Expression for KRT80 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- Epidermis (Integumentary System)
- Hair
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for KRT80 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.1), Skin - Not Sun Exposed (Suprapubic) (x17.3), and Esophagus - Mucosa (x4.7).
This gene is overexpressed in Cervix (35.6), Saliva (8.2), Brain (7.1), and Nasal epithelium (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT80 Gene
NURSA nuclear receptor signaling pathways regulating expression of KRT80 Gene:
KRT80SOURCE GeneReport for Unigene cluster for KRT80 Gene:
Hs.140978mRNA Expression by UniProt/SwissProt for KRT80 Gene:
Q6KB66-K2C80_HUMAN
Tissue specificity:
Weakly expressed in tongue, but not skin or in any other tissues or organs examined.
Evidence on tissue expression from TISSUES for KRT80 Gene
- Skin(4.5)
Primer Products
-
OriGene qPCR primer pairs for KRT80
-
OriGene qPCR primer pairs and template standards for KRT80
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT80 Gene
Orthologs for KRT80 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KRT80 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | KRT80 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KRT80 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Krt80 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Krt80 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KRT80 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KRT80 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | KRT80 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | KRT80 34 |
|
OneToOne |
- Species where no ortholog for KRT80 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KRT80 Gene
(41) SIMAP similar genes for KRT80 Gene using alignment to 1 proteins:
No data available for Paralogs for KRT80 Gene
Variants for KRT80 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021514 | -- | 52,181,571(-) | G/A | intron_variant | |
| rs1000122956 | -- | 52,186,607(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000154114 | -- | 52,186,902(-) | C/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000182835 | -- | 52,190,095(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000328087 | -- | 52,192,022(-) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759899 | CNV | gain | 17122850 |
| esv3581594 | CNV | gain | 25503493 |
| nsv1038149 | CNV | gain | 25217958 |
| nsv832409 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.75;
57.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRT80 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT80 Gene
Disorders for KRT80 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cervix uteri carcinoma in situ |
|
|
Search KRT80 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KRT80
No data available for UniProtKB/Swiss-Prot and Genatlas for KRT80 Gene
Publications for KRT80 Gene
- New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
- Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers MA … Schweizer J (The Journal of investigative dermatology 2005) 3 4 58
- Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan JT … Howley PM (Journal of proteome research 2015) 3 58
- Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D … Clayton PE (Journal of molecular endocrinology 2014) 3 58
- hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R … Pardo OE (Nucleic acids research 2014) 3 58
Products for KRT80 Gene
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- Invitrogen Antibodies for KRT80
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- VectorBuilder custom plasmid, inducible vectors for KRT80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRT80
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 34 available KRT80 Antibodies ranked by validation data
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- antibodies-online: Search results for available KRT80 related products ranked by validation data
- antibodies-online: Search results for 3 available KRT80 Proteins ranked by validation data
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- Quality Products:
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- ViGene Biosciences adenoviral particle packaged cDNA for KRT80 gene
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- Search ViGene Biosciences for KRT80
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- genomics-online: cdna clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
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- Overview of 94 available KRT80 gene related products
- genomics-online: gRNA clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
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- Overview of 94 available KRT80 gene related products
- genomics-online: shRNA clones - Search results for 94 available KRT80 gene related products
- Overview of 94 available KRT80 gene related products
Sources for KRT80 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
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