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Aliases for KRT8 Gene

Aliases for KRT8 Gene

  • Keratin 8, Type II 2 3
  • Type-II Keratin Kb8 3 4
  • Cytokeratin-8 3 4
  • CK-8 3 4
  • CYK8 3 4
  • K8 3 4
  • Keratin, Type II Cytoskeletal 8 3
  • Cytokeratin 8 3
  • Keratin 8 2
  • Keratin-8 4
  • CARD2 3
  • K2C8 3
  • CK8 3
  • KO 3

External Ids for KRT8 Gene

Previous GeneCards Identifiers for KRT8 Gene

  • GC12P053389
  • GC12P053619
  • GC12M053007
  • GC12M051577
  • GC12M053290
  • GC12M050334

Summaries for KRT8 Gene

Entrez Gene Summary for KRT8 Gene

  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for KRT8 Gene

KRT8 (Keratin 8, Type II) is a Protein Coding gene. Diseases associated with KRT8 include cirrhosis, cryptogenic and keratinizing squamous cell carcinoma. Among its related pathways are Cytoskeletal Signaling and EGFR1 Signaling Pathway. GO annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT8 Gene

  • Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Wiki entry for KRT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT8 Gene

Genomics for KRT8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRT8 Gene

Start:
52,897,187 bp from pter
End:
52,949,954 bp from pter
Size:
52,768 bases
Orientation:
Minus strand

Genomic View for KRT8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT8 Gene

Proteins for KRT8 Gene

  • Protein details for KRT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05787-K2C8_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 8
    Protein Accession:
    P05787
    Secondary Accessions:
    • A8K4H3
    • B0AZN5
    • F8VXB4
    • Q14099
    • Q14716
    • Q14717
    • Q53GJ0
    • Q6DHW5
    • Q6GMY0
    • Q6P4C7
    • Q96J60

    Protein attributes for KRT8 Gene

    Size:
    483 amino acids
    Molecular mass:
    53704 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Interacts with GPER1.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)

    Alternative splice isoforms for KRT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT8 Gene

Proteomics data for KRT8 Gene at MOPED

Post-translational modifications for KRT8 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner
  • O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation
  • Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
  • Ubiquitination at Lys11, Lys101, Lys108, Lys117, Lys122, Lys130, Lys178, Lys207, Lys295, Lys325, Lys352, and Lys393
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KRT8 (K8)

No data available for DME Specific Peptides for KRT8 Gene

Domains for KRT8 Gene

Gene Families for KRT8 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05787

UniProtKB/Swiss-Prot:

K2C8_HUMAN :
  • P05787
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT8: view

Function for KRT8 Gene

Molecular function for KRT8 Gene

GENATLAS Biochemistry:
keratin 8,type II,early embryonic,dimerizing with KRT18
UniProtKB/Swiss-Prot Function:
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Ontology (GO) - Molecular Function for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 10852826
GO:0032403 protein complex binding IEA --
GO:0097110 scaffold protein binding IPI 10852826
genes like me logo Genes that share ontologies with KRT8: view
genes like me logo Genes that share phenotypes with KRT8: view

Animal Models for KRT8 Gene

MGI Knock Outs for KRT8:

miRNA for KRT8 Gene

miRTarBase miRNAs that target KRT8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KRT8 Gene

Localization for KRT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT8 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT8 Gene COMPARTMENTS Subcellular localization image for KRT8 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IDA 15846844
GO:0005882 intermediate filament IDA 10852826
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with KRT8: view

Pathways for KRT8 Gene

genes like me logo Genes that share pathways with KRT8: view

Pathways by source for KRT8 Gene

1 Cell Signaling Technology pathway for KRT8 Gene
1 GeneGo (Thomson Reuters) pathway for KRT8 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
GO:0045214 sarcomere organization IEA --
GO:0051599 response to hydrostatic pressure IEA --
GO:0051707 response to other organism IEA --
genes like me logo Genes that share ontologies with KRT8: view

Compounds for KRT8 Gene

(1) Drugbank Compounds for KRT8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tenecteplase
  • t- PA
191588-94-0 target

(54) Novoseek inferred chemical compound relationships for KRT8 Gene

Compound -log(P) Hits PubMed IDs
griseofulvin 58.2 1
diethyl dithiocarbamate 43.4 2
n-acetylglucosamine 37 5
paraffin 31.7 1
matrigel 30.2 2
genes like me logo Genes that share compounds with KRT8: view

Transcripts for KRT8 Gene

Unigene Clusters for KRT8 Gene

Keratin 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT8 Gene

No ASD Table

Relevant External Links for KRT8 Gene

GeneLoc Exon Structure for
KRT8
ECgene alternative splicing isoforms for
KRT8

Expression for KRT8 Gene

mRNA expression in normal human tissues for KRT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT8 Gene

This gene is overexpressed in Colon - Transverse (11.7), Small Intestine - Terminal Ileum (4.9), and Pancreas (4.9).

Protein differential expression in normal tissues for KRT8 Gene

This gene is overexpressed in Liver, secretome (14.1), Stomach (6.8), Salivary gland (6.7), and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT8 Gene

SOURCE GeneReport for Unigene cluster for KRT8 Gene Hs.533782

mRNA Expression by UniProt/SwissProt for KRT8 Gene

P05787-K2C8_HUMAN
Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
genes like me logo Genes that share expressions with KRT8: view

Expression partners for KRT8 Gene

In Situ Assay Products

Orthologs for KRT8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT8 35
  • 88.89 (n)
  • 90.23 (a)
-- 36
  • 87 (a)
OneToMany
KRT8 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KRT8 35
  • 88.38 (n)
  • 88.59 (a)
-- 36
  • 72 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krt8 35
  • 85.02 (n)
  • 87.78 (a)
Krt8 16
Krt8 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC464613 35
  • 92.32 (n)
  • 88.27 (a)
KRT8 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt8 35
  • 84.61 (n)
  • 87.16 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KRT8 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves KRT8 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT8 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krt8 35
  • 69.72 (n)
  • 71.46 (a)
Str.8042 35
African clawed frog
(Xenopus laevis)
Amphibia krt8-prov 35
zebrafish
(Danio rerio)
Actinopterygii krt4 35
krt5 35
  • 71.51 (n)
  • 75 (a)
krt8 36
  • 61 (a)
ManyToMany
zgc:158846 36
  • 58 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.40 35
Species with no ortholog for KRT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT8 Gene

ENSEMBL:
Gene Tree for KRT8 (if available)
TreeFam:
Gene Tree for KRT8 (if available)

Paralogs for KRT8 Gene

genes like me logo Genes that share paralogs with KRT8: view

Variants for KRT8 Gene

Sequence variations from dbSNP and Humsavar for KRT8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7750 -- 52,898,882(-) GAGGC(C/T)GCCAT reference, synonymous-codon, nc-transcript-variant
rs8608 untested 52,900,597(-) CAGCT(A/G)TATGA reference, synonymous-codon, nc-transcript-variant
rs1055085 -- 52,946,723(-) GGTAA(A/G)AGGTT intron-variant
rs1065306 -- 52,904,985(-) GCCTC(C/T)ACCAT synonymous-codon, reference, utr-variant-5-prime, nc-transcript-variant
rs1065311 -- 52,899,832(-) ATCTC(A/T)GAGAT synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT8 Gene

Variant ID Type Subtype PubMed ID
nsv832416 CNV Loss 17160897
dgv1426n71 CNV Loss 21882294
nsv819337 CNV Loss 19587683

Relevant External Links for KRT8 Gene

HapMap Linkage Disequilibrium report
KRT8
Human Gene Mutation Database (HGMD)
KRT8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT8 Gene

Disorders for KRT8 Gene

(1) OMIM Diseases for KRT8 Gene (148060)

UniProtKB/Swiss-Prot

K2C8_HUMAN
  • Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269 PubMed:12724528}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for KRT8 Gene

(97) Novoseek inferred disease relationships for KRT8 Gene

Disease -log(P) Hits PubMed IDs
carcinoma 63.1 45
tumors 60.6 93
carcinoma squamous cell 49 9
breast carcinoma 48.5 7
ductal breast carcinoma 48.4 5

Relevant External Links for KRT8

Genetic Association Database (GAD)
KRT8
Human Genome Epidemiology (HuGE) Navigator
KRT8
genes like me logo Genes that share disorders with KRT8: view

No data available for Genatlas for KRT8 Gene

Publications for KRT8 Gene

  1. Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PMID: 1705144) Waseem A. … Lane E.B. (New Biol. 1990) 2 3 4 23
  2. Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431. (PMID: 9054461) Ku N.-O. … Omary M.B. (J. Biol. Chem. 1997) 3 4 23
  3. Organization and sequence of the human gene encoding cytokeratin 8. (PMID: 1691124) Krauss S. … Franke W.W. (Gene 1990) 3 4 23
  4. Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. (PMID: 11788583) Ku N.O. … Omary M.B. (J. Biol. Chem. 2002) 3 4 23
  5. Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. (PMID: 12724528) Ku N.-O. … Omary M.B. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23

Products for KRT8 Gene

  • Addgene plasmids for KRT8

Sources for KRT8 Gene

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