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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT8 Gene

protein-coding   GIFtS: 67
GCID: GC12M053290

keratin 8
 Explore 129 diseases affiliated with
KRT8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KRT8    

Aliases
for KRT8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratin 81 2     Type-II Keratin Kb82 3
CYK81 2 3     CK-82 3
K81 2 3     Cytokeratin 82
CARD21 2     Cytokeratin-83
CK81 2     Keratin, Type II Cytoskeletal 82
K2C81 2     Cytokeratin-83
KO1 2     Keratin-83

External Ids:    HGNC: 64461   Entrez Gene: 38562   Ensembl: ENSG000001704217   OMIM: 1480605   UniProtKB: P057873   

Export aliases for KRT8 gene to outside databases

Previous GC identifers: GC12P053389 GC12P053619 GC12M053007 GC12M051577 GC12M050334


Summaries
for KRT8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KRT8:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II
keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of
this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial
cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal
transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787
Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated
muscle

Gene Wiki entry for KRT8 (Keratin 8)


Genomic Views
for KRT8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT8 gene promoter:
         COUP-TF1   AP-1   COUP   Nkx2-5   HNF-4alpha2   C/EBPalpha   HNF-4alpha1   PPAR-gamma1   COUP-TF   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT8 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053290:  view genomic region     (about GC identifiers)

Start:
 53,290,971 bp from pter      End:
 53,343,738 bp from pter
Size:
 52,768 bases      Orientation:
 minus strand

Proteins
for KRT8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 8  
Size: 483 amino acids; 53704 Da
Subunit: Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20.
Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
Interacts with APEX1
Subcellular location: Cytoplasm. Nucleus, nucleoplasm (By similarity). Nucleus matrix (By similarity)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to
basic; 56-70 kDa)
Secondary accessions: A8K4H3 B0AZN5 F8VXB4 Q14099 Q14716 Q14717 Q53GJ0 Q6DHW5 Q6GMY0 Q6P4C7 Q96J60
Alternative splicing: 2 isoforms:  P05787-1   P05787-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT8: NX_P05787

Post-translational modifications:

  • Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an
    • important role in keratin filament reorganization1
  • O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal
    • degradation1
  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05787

    • KRT8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243211.1  NP_001243222.1  NP_002264.1  

    ENSEMBL proteins: 
     ENSP00000449640   ENSP00000447566   ENSP00000293308   ENSP00000448048   ENSP00000447402  
     ENSP00000449404   ENSP00000447881   ENSP00000449010   ENSP00000447040   ENSP00000450340  
     ENSP00000448681   ENSP00000450228  

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    ProSpec Recombinant Protein for KRT8
    Uscn Proteins for KRT8

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IDA19188445
    GO:0005882intermediate filament NAS--
    GO:0016363nuclear matrix IEA--
    GO:0045095keratin filament IEA--


    KRT8 for ontologies           About GeneDecksing



    KRT8 Antibody Products: 
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    R&D Systems Antibodies for KRT8 (Cytokeratin 8)
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    Uscn ELISAs and CLIAs for KRT8

    Protein Domains /
    Families
    for KRT8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KRT8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P05787

    ProtoNet protein and cluster: P05787

    4 Blocks protein families:
    IPB000873 AMP-binding signature
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787
    Similarity: Belongs to the intermediate filament family


    Function
    for KRT8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787
    Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated
    muscle

         Genatlas biochemistry entry for KRT8:
    keratin 8,type II,early embryonic,dimerizing with KRT18

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: KRT8 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: KRT8
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KRT8

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for KRT8

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS--
    GO:0005515protein binding IPI--
    GO:0097110scaffold protein binding IPI10852826


    KRT8 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KRT8:
     Increased S DNA content 

    Animal Models:
         Mouse knock-out Krt8tm1Rgo for KRT8
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Krt8):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size  hematopoietic system 
     immune system  liver/biliary system  mortality/aging  reproductive system 

    KRT8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KRT8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Keratin filaments
    		Cytoskeleton remodeling Keratin filaments1.00
    		Cytoskeleton remodeling_Keratin filaments0.91
    2Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    3EGFR1 Signaling Pathway
    		EGFR1 Signaling Pathway1.00
    4Signaling mediated by p38-alpha and p38-beta
    		Signaling mediated by p38-alpha and p38-beta1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KRT8
        Cytoskeleton remodeling Keratin filaments


    1 Cell Signaling Technology (CST) Pathway for KRT8
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for KRT8
        Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for KRT8 
        EGFR1 Signaling Pathway
    Signaling mediated by p38-alpha and p38-beta



    KRT8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for KRT8 (P057871, 2, 3 ENSP000002933084) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT18P057831, 2, 3, ENSP000003734874EBI-297852,EBI-297888 MINT-7899812 I2D: score=3 STRING: ENSP00000373487
    KRT17Q046952, 3, ENSP000003084524MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000308452
    TJP1Q071572, 3, ENSP000002815374MINT-2984733 I2D: score=3 STRING: ENSP00000281537
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    GRB2P629931, 2, 3, ENSP000003390074EBI-297852,EBI-401755 MINT-61555 I2D: score=4 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS--
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    KRT8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KRT8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT8

    1 DrugBank Compound for KRT8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tenecteplaset- PA (see all 4)191588-94-0target--9988531 8760360 8810346

    10/54 Novoseek chemical compound relationships for KRT8 gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    griseofulvin 58.2 1 18603402 (1)
    diethyl dithiocarbamate 43.4 2 16365160 (1), 18603402 (1)
    n-acetylglucosamine 37 6 1371281 (3), 16825119 (1), 7510249 (1)
    paraffin 31.7 1 16365828 (1)
    matrigel 30.2 2 17299793 (1), 11506501 (1)
    estrogen 28.5 11 8913869 (2), 18715613 (1), 20340005 (1), 7544088 (1) (see all 7)
    hematoxylin 28.4 5 18305433 (1), 11041235 (1), 18626977 (1), 10193935 (1)
    progesterone 26.8 8 18715613 (1), 20340005 (1), 7544088 (1), 15010880 (1) (see all 6)
    retinoic acid 26.5 16 1691021 (2), 8708944 (1), 8641545 (1), 8647816 (1) (see all 7)
    okadaic acid 25.9 4 16343483 (1), 7540986 (1), 11788583 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT8 / K2C8 

    Transcripts
    for KRT8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KRT8 gene (3 alternative transcripts): 
    NM_001256282.1  NM_001256293.1  NM_002273.3  

    Unigene Cluster for KRT8:

    Keratin 8
    Hs.533782  [show with all ESTs]
    Unigene Representative Sequence: NR_045962
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000548138 ENST00000552551(uc009zmk.1 uc009zml.1 uc009zmm.1)
    ENST00000293308(uc001sbd.2) ENST00000546583 ENST00000550170 ENST00000547916
    ENST00000546897 ENST00000552150 ENST00000547031 ENST00000549176 ENST00000546826
    ENST00000547176 ENST00000548998 ENST00000546900 ENST00000547413 ENST00000546542
    ENST00000549198 ENST00000552877

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK222941.1 AK290938.1 AK310257.1 AK315826.1 BC000654.2 BC008200.1 BC011373.1 BC063513.1 
    BC073760.1 BC075839.1 D28446.1 M34225.1 M77025.1 NR_045962.1 U76549.1 X12882.1 
    X74929.1 X98614.1 Z36777.1 

    24/156 DOTS entries (see all 156):

    DT.95363496  DT.91723246  DT.453659  DT.91776011  DT.91776017  DT.100856806  DT.100699511  DT.97848181 
    DT.100850363  DT.100872833  DT.95070270  DT.100765608  DT.91652435  DT.100852320  DT.121118086  DT.92033258 
    DT.100870033  DT.91677886  DT.91998325  DT.100699527  DT.91896377  DT.95333919  DT.92064411  DT.100868211 

    24/120 AceView cDNA sequences (see all 120):

    CR616496 CR595210 CR625900 CR605272 CR600505 CR625711 CR611843 CR621999 
    CR610938 CR617220 CR611761 CR617849 CR602866 CR607818 CR591747 CR611683 
    CR606810 CR590770 CR620184 CR624027 CR626613 CR611937 CR592661 CR623630 

    GeneLoc Exon Structure


    Expression
    for KRT8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCCAGCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KRT8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Immature hepatocytes (Functional, immature...)
    Extraembryonic endoderm-like cells (Generation of extrae...)

    See KRT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT8

    SOURCE GeneReport for Unigene cluster: Hs.533782

    UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787
    Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in
    structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity

        SABiosciences Expression via Pathway-Focused PCR Arrays including KRT8: 
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              Breast Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat
              Hepatotoxicity in human mouse rat

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    In Situ
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    Orthologs
    for KRT8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KRT8 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KRT86
    		 --
    		 69(a)
    		 possible ortholog
    		 E22C19W28_E50C23(508667-511528)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    KRT8P116
    (see all 4)    		 --
    71(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 AAWZ02039762(4434-6932)
    GL343250.1(1763676-1781619)
    African clawed frog
    (Xenopus laevis)    		 Amphibia krt8-prov2 keratin 8 77.71(n)    BC044116.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii krt42 keratin 4 80.89(n)   58021  AF134850.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ifp-16
    ifc-26
    (see all 12)    		 Intermediate filament protein ifc-2
    (see all 12)    		 8(a)
    6(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 X(9675786-9680111)
    X(642160-654902)


    ENSEMBL Gene Tree for KRT8 (if available)
    TreeFam Gene Tree for KRT8 (if available) 

    Paralogs
    for KRT8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT8 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT862  KRT32  KRT842  
    KRT812  KRT712  KRT8P112  KRT782  KRT72  ENSG000001704422  KRT792  KRT722  
    KRT732  KRT52  KRT6C2  KRT6A2  KRT852  KRT22  KRT752  KRT12  
    KRT822  KRT42  
    18/53 SIMAP similar genes for KRT8 using alignment to 10 protein entries:     K2C8_HUMAN (see all proteins) (see all similar genes):
    KRT7    KRT121P    KRT5    KRT1B    KRT72    KRT1
    KRT4    KRT3    KRT2    KRT76    KRT77    KRT85
    KRT75    KRT78    KRT6A    KRT6B    KRT71    KRT86

    KRT8 for paralogs           About GeneDecksing


    5/47 Pseudogenes.org Pseudogenes for KRT8 (see all 47)
    PGOHUM00000261079 PGOHUM00000261099 PGOHUM00000261105 PGOHUM00000261118 PGOHUM00000261120


    Genomic Variants
    for KRT8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/510 NCBI SNPs in KRT8 are shown (see all 510)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs115544951,2
    		C,F,pathogenic50342225(-) TGGGAG/TGCATC 7 G C mis1 ese35Minor allele frequency- T:0.01NA NS EU 5109
    rs577497751,2
    		C,F,pathogenic50342249(-) GCGGCT/CATGGT 7 /H /Y nc-transcript-variantmis12Minor allele frequency- C:0.01NS NA 3444
    rs2019420021,2
    		C,Funtested50334902(+) CTGCCG/ACAGCT 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.01EU 575
    rs2015070311,2
    		Cuntested50334970(+) ATCTTA/CTTCAC 7 K N mis10--------
    rs585736141,2
    		C,untested50335062(-) GCCCCA/GGCCTC 7 S G nc-transcript-variantmis10--------
    rs1896906621,2
    		C,untested50336115(+) CCAGGA/TCCCAG 4 -- int10--------
    rs569975211,2
    		C,F,untested50336225(-) TGAACG/ATCAAG 7 /I /V mis12Minor allele frequency- A:0.00NA EU 5873
    rs616161741,2
    		C,F,,untested50336235(-) CAGGAG/ACTGAT 7 /E nc-transcript-variantsyn11Minor allele frequency- A:0.00NA 4548
    rs574224271,2
    		C,F,untested50336341(-) GCAGCG/ATGGAG 7 /H /R nc-transcript-variantmis12Minor allele frequency- A:0.02NA EU 5663
    rs1440441151,2
    		Cuntested50336347(+) GCTGCT/GCGGCA 7 /E /A mis11Minor allele frequency- G:0.00NA 4248

    HapMap Linkage Disequilibrium report for KRT8 (53290971 - 53343738 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KRT8
         1 Indel: 58577
    Human Gene Mutation Database (HGMD): KRT8

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT8
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT8

    Disorders / Diseases
    for KRT8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KRT8 for disorders           About GeneDecksing

    OMIM gene information: 148060   
    OMIM disorders: 215600  
    UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787
  • Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600]

    • 20/129 diseases for KRT8 (see all 129):    About MalaCards
    brooke-spiegler syndrome    von hippel-lindau disease    calcifying epithelial odontogenic tumor    cirrhosis, noncryptogenic
    cirrhosis, cryptogenic    cervical intraepithelial neoplasia    hidradenitis suppurativa    keratinizing squamous cell carcinoma
    pulmonary large cell neuroendocrine carcinoma    sweat gland carcinoma    idiopathic corneal edema    carcinoma
    cervical squamous cell carcinoma    bile duct carcinoma    mammary paget's disease    primitive neuroectodermal tumor
    squamous cell carcinoma    chromophobe renal cell carcinoma    soft tissue sarcoma    hidradenitis

    4 diseases from the University of Copenhagen DISEASES database for KRT8:
    Carcinoma     Breast cancer     Idiopathic corneal edema     Ductal carcinoma in situ

    10/97 Novoseek disease relationships for KRT8 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 63.1 69 16540085 (3), 7536188 (2), 11689350 (2), 1719006 (2) (see all 36)
    tumors 60.6 116 7544088 (3), 12367790 (3), 18603673 (2), 19845941 (2) (see all 79)
    carcinoma squamous cell 49 9 7686975 (3), 19755983 (1), 7527618 (1), 8634660 (1) (see all 7)
    breast carcinoma 48.5 8 14974217 (2), 18715613 (1), 14660278 (1), 7544088 (1) (see all 6)
    ductal breast carcinoma 48.4 6 14660278 (2), 16825119 (2), 10941333 (1)
    epithelial tumor 47.7 1 9355978 (1)
    liver diseases 47.5 28 16911694 (5), 11372009 (3), 16575832 (2), 16143128 (2) (see all 12)
    metastasis 47.4 19 9568504 (2), 18715613 (1), 14974217 (1), 10555744 (1) (see all 16)
    carcinoma ductal 46.5 3 10941333 (1), 19201736 (1)
    metaplasia 45.4 1 17652797 (1)

    Genetic Association Database (GAD): KRT8
    Human Genome Epidemiology (HuGE) Navigator: KRT8 (8 documents)

    Export disorders for KRT8 gene to outside databases

    Publications
    for KRT8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT8 gene, integrated from 9 sources (see all 693):
    (articles sorted by number of sources associating them with KRT8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PubMed id 1705144)1, 2, 3, 9 Waseem A.... Lane E.B. (1990)
    2. Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ. (PubMed id 2434381)1, 2, 3 Leube R.E....Franke W.W. (1986)
    3. Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431. (PubMed id 9054461)1, 2, 9 Ku N.-O. and Omary M.B. (1997)
    4. Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. (PubMed id 11788583)1, 2, 9 Ku N.O.... Omary M.B. (2002)
    5. The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. (PubMed id 11781324)1, 2, 9 He T.... Eriksson J.E. (2002)
    6. Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18. (PubMed id 9988531)1, 7, 9 Kralovich K.R....Gonias S.L. (1998)
    7. Keratins as susceptibility genes for end-stage liver disease. (PubMed id 16143128)1, 4, 9 Ku N.O....Omary M.B. (2005)
    8. Organization and sequence of the human gene encoding cytokeratin 8. (PubMed id 1691124)1, 2, 9 Krauss S. and Franke W.W. (1990)
    9. Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. (PubMed id 12724528)1, 2, 9 Ku N.-O.... Omary M.B. (2003)
    10. Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19. (PubMed id 16000376)1, 2, 9 Stone M.R.... Bloch R.J. (2005)

    External Searches for KRT8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing KRT8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3856 HGNC: 6446 AceView: KRT8 Ensembl:ENSG00000170421 euGenes: HUgn3856
    ECgene: KRT8 H-InvDB: KRT8

    Other Databases showing KRT8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KRT8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT8 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org

    Intellectual Property
    for KRT8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KRT8 gene:
    Search GeneIP for patents involving KRT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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