Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT8 Gene

Aliases for KRT8 Gene

  • Keratin 8 2 3
  • Keratin 8, Type II 2 3 5
  • Type-II Keratin Kb8 3 4
  • Cytokeratin-8 3 4
  • CK-8 3 4
  • CYK8 3 4
  • K8 3 4
  • Keratin-8 4
  • CARD2 3
  • K2C8 3
  • CK8 3
  • KO 3

External Ids for KRT8 Gene

Previous GeneCards Identifiers for KRT8 Gene

  • GC12P053389
  • GC12P053619
  • GC12M053007
  • GC12M051577
  • GC12M053290
  • GC12M050334

Summaries for KRT8 Gene

Entrez Gene Summary for KRT8 Gene

  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for KRT8 Gene

KRT8 (Keratin 8) is a Protein Coding gene. Diseases associated with KRT8 include Cirrhosis, Cryptogenic and Mammary Paget's Disease. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and EGFR1 Signaling Pathway. GO annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT73.

UniProtKB/Swiss-Prot for KRT8 Gene

  • Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Wiki entry for KRT8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT8 Gene

Genomics for KRT8 Gene

Regulatory Elements for KRT8 Gene

Enhancers for KRT8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT8 on UCSC Golden Path with GeneCards custom track

Promoters for KRT8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KRT8 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT8 Gene

52,897,187 bp from pter
52,949,954 bp from pter
52,768 bases
Minus strand

Genomic View for KRT8 Gene

Genes around KRT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT8 Gene

Proteins for KRT8 Gene

  • Protein details for KRT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 8
    Protein Accession:
    Secondary Accessions:
    • A8K4H3
    • B0AZN5
    • F8VXB4
    • Q14099
    • Q14716
    • Q14717
    • Q53GJ0
    • Q6DHW5
    • Q6GMY0
    • Q6P4C7
    • Q96J60

    Protein attributes for KRT8 Gene

    483 amino acids
    Molecular mass:
    53704 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Interacts with GPER1.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Alternative splice isoforms for KRT8 Gene


neXtProt entry for KRT8 Gene

Proteomics data for KRT8 Gene at MOPED

Post-translational modifications for KRT8 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
  • Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
  • Ubiquitination at Lys 11, Lys 117, Lys 122, Lys 130, Lys 207, Lys 295, and Lys 325
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KRT8 Gene

Domains & Families for KRT8 Gene

Gene Families for KRT8 Gene

Suggested Antigen Peptide Sequences for KRT8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT8: view

Function for KRT8 Gene

Molecular function for KRT8 Gene

GENATLAS Biochemistry:
keratin 8,type II,early embryonic,dimerizing with KRT18
UniProtKB/Swiss-Prot Function:
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
genes like me logo Genes that share phenotypes with KRT8: view

Human Phenotype Ontology for KRT8 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KRT8 Gene

MGI Knock Outs for KRT8:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for KRT8 Gene

Localization for KRT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT8 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Subcellular locations from

Jensen Localization Image for KRT8 Gene COMPARTMENTS Subcellular localization image for KRT8 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 3
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15846844
GO:0005882 intermediate filament IEA,IDA 10852826
GO:0005911 cell-cell junction IEA --
GO:0016010 dystrophin-associated glycoprotein complex IEA --
GO:0043034 costamere IEA --
genes like me logo Genes that share ontologies with KRT8: view

Pathways & Interactions for KRT8 Gene

genes like me logo Genes that share pathways with KRT8: view

Pathways by source for KRT8 Gene

1 Cell Signaling Technology pathway for KRT8 Gene
1 GeneGo (Thomson Reuters) pathway for KRT8 Gene

SIGNOR curated interactions for KRT8 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
GO:0051707 response to other organism IEA --
GO:0097284 hepatocyte apoptotic process IEA --
genes like me logo Genes that share ontologies with KRT8: view

Drugs & Compounds for KRT8 Gene

(27) Drugs for KRT8 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tenecteplase Approved Pharma Target 40

(28) Additional Compounds for KRT8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT8: view

Transcripts for KRT8 Gene

Unigene Clusters for KRT8 Gene

Keratin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT8 Gene

No ASD Table

Relevant External Links for KRT8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT8 Gene

mRNA expression in normal human tissues for KRT8 Gene

mRNA differential expression in normal tissues according to GTEx for KRT8 Gene

This gene is overexpressed in Colon - Transverse (x11.7), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.9).

Protein differential expression in normal tissues from HIPED for KRT8 Gene

This gene is overexpressed in Liver, secretome (14.1), Stomach (6.8), Salivary gland (6.7), and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT8 Gene

SOURCE GeneReport for Unigene cluster for KRT8 Gene Hs.533782

mRNA Expression by UniProt/SwissProt for KRT8 Gene

Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
genes like me logo Genes that share expression patterns with KRT8: view

Protein tissue co-expression partners for KRT8 Gene

- Elite partner

Primer Products

Orthologs for KRT8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT8 35
  • 88.89 (n)
  • 90.23 (a)
-- 36
  • 87 (a)
KRT8 36
  • 86 (a)
(Canis familiaris)
Mammalia KRT8 35
  • 88.38 (n)
  • 88.59 (a)
-- 36
  • 72 (a)
-- 36
  • 72 (a)
-- 36
  • 77 (a)
-- 36
  • 86 (a)
(Mus musculus)
Mammalia Krt8 35
  • 85.02 (n)
  • 87.78 (a)
Krt8 16
Krt8 36
  • 90 (a)
(Pan troglodytes)
Mammalia LOC464613 35
  • 92.32 (n)
  • 88.27 (a)
KRT8 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Krt8 35
  • 84.61 (n)
  • 87.16 (a)
(Ornithorhynchus anatinus)
Mammalia KRT8 36
  • 69 (a)
(Gallus gallus)
Aves KRT8 36
  • 76 (a)
(Anolis carolinensis)
Reptilia KRT8 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt8 35
  • 69.72 (n)
  • 71.46 (a)
Str.8042 35
African clawed frog
(Xenopus laevis)
Amphibia krt8-prov 35
(Danio rerio)
Actinopterygii krt4 35
krt5 35
  • 71.51 (n)
  • 75 (a)
krt8 36
  • 61 (a)
zgc:158846 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.40 35
Species with no ortholog for KRT8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT8 Gene

Gene Tree for KRT8 (if available)
Gene Tree for KRT8 (if available)

Paralogs for KRT8 Gene

genes like me logo Genes that share paralogs with KRT8: view

Variants for KRT8 Gene

Sequence variations from dbSNP and Humsavar for KRT8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs61710484 Cirrhosis (CIRRH) 52,904,824(-) CGGCG(A/G/T)CTATG nc-transcript-variant, reference, missense
VAR_023059 Cirrhosis (CIRRH)
rs11554495 Cirrhosis (CIRRH) 52,904,798(-) TGGGA(G/T)GCATC nc-transcript-variant, reference, missense
rs59536457 - 52,904,795(-) GAGGC(A/G)TCACC nc-transcript-variant, reference, missense
rs2277330 - 52,898,680(+) CCACC(A/G)GCTCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT8 Gene

Variant ID Type Subtype PubMed ID
nsv832416 CNV Loss 17160897
dgv1426n71 CNV Loss 21882294
nsv819337 CNV Loss 19587683

Variation tolerance for KRT8 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT8 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT8 Gene

Disorders for KRT8 Gene

MalaCards: The human disease database

(46) MalaCards diseases for KRT8 Gene - From: OMIM, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cirrhosis, cryptogenic
  • cirrhosis, noncryptogenic
mammary paget's disease
  • mammary paget disease
breast osteosarcoma
  • osteogenic sarcoma of breast
idiopathic corneal edema
cervical clear cell adenocarcinoma
  • clear cell carcinoma of the cervix uteri
- elite association - COSMIC cancer census association via MalaCards
Search KRT8 in MalaCards View complete list of genes associated with diseases


  • Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269 PubMed:12724528}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT8: view

No data available for Genatlas for KRT8 Gene

Publications for KRT8 Gene

  1. Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PMID: 1705144) Waseem A. … Lane E.B. (New Biol. 1990) 2 3 4 23 67
  2. Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18. (PMID: 9988531) Kralovich K.R. … Gonias S.L. (J. Protein Chem. 1998) 3 23 25
  3. Insights into the mechanical properties of epithelial cells: the effects of shear stress on the assembly and remodeling of keratin intermediate filaments. (PMID: 19246484) Flitney E.W. … Goldman R.D. (FASEB J. 2009) 3 23
  4. Alkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimens. (PMID: 19419944) Serpil O. … Ziya A. (Folia Histochem. Cytobiol. 2009) 3 23
  5. Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus. (PMID: 19755983) Makino T. … Doki Y. (Br. J. Cancer 2009) 3 23

Products for KRT8 Gene

Sources for KRT8 Gene