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KRT8 Gene

protein-coding GIFtS: 66

GC12M051577

keratin 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CARD2 ^¹, ²
CK-8 ^³
CK8 ^¹, ²
CYK8 ^¹, ², ³
Cytokeratin-8 ^³
K2C8 ^¹, ²
K8 ^¹, ², ³
KO ^¹, ²
Keratin-8 ^³

Descriptions
cytokeratin 8 ^²
keratin 8 ^²
keratin, type II cytoskeletal 8 ^²

External Ids
HGNC: 6446¹
Entrez Gene: 3856²
UniProtKB: P05787³
Ensembl: ENSG00000170421⁷

Search outside databases for aliases for KRT8 gene

Previous GC identifers: GC12P053389 GC12P053619 GC12M053007

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KRT8:

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12.

Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm

of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an

intermediate filament in simple single-layered epithelial cells. This protein plays a role in

maintaining cellular structural integrity and also functions in signal transduction and cellular

differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq]

UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787

Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the

costameres of striated muscle

Gene Wiki entry for KRT8 (Keratin_8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KRT8 gene

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13

KRT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M051577: (about GC identifiers)

Start:	51,577,238 bp from pter
End:	51,585,127 bp from pter
Size:	7,890 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787 (See protein sequence)

Recommended Name: Keratin, type II cytoskeletal 8

Size: 483 amino acids; 53704 Da

Subunit: Heterotetramer of two type I and two type II keratins. keratin-8 associates with

keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with

KRT19, interacts with DMD. Interacts with TCHP

Subcellular location: Cytoplasm

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55

kDa) and II (neutral to basic; 56-70 kDa)

Secondary accessions: Q14099 Q14716 Q14717 Q53GJ0 Q6DHW5 Q6GMY0 Q6P4C7 Q96J60

Post-translational modifications:

Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74

phosphorylation plays an important role in keratin filament reorganization¹

O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002264.1

ENSEMBL proteins:

ENSP00000293308

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cytokeratin 5 + 6 + 8 + 18, Cytokeratin 8 + 18 + 19, Cytokeratin 4 + 5 + 6 + 8 + 10 + 13 + 18, Cytokeratin 5 + 8, Cytokeratin 8, Cytokeratin 1 - 8, Cytokeratin 8+18, Cytokeratin)
	Human Recombinant Proteins from Abnova (KRT8)

OriGene Purified Recombinant Human Protein: KRT8

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0030018	Z disc	IEA	--
GO:0042383	sarcolemma	IEA	--
GO:0045095	keratin filament	IEA	--

About this table

Antibodies for KRT8:

	Invitrogen Antibodies for KRT8
	Millipore Mono- and Polyclonal Antibodies for the study of KRT8
	Sigma-Aldrich Antibody Arrays and Antibodies for KRT8
	R&D Systems Antibodies for KRT8 (Cytokeratin 8)
	Antibodies from Abcam (Cytokeratin 5 + 6 + 8 + 18, Cytokeratin 8 + 18 + 19, Cytokeratin 4 + 5 + 6 + 8 + 10 + 13 + 18, Cytokeratin 5 + 8, Cytokeratin 8, Cytokeratin 1 - 8, Cytokeratin 8+18, Cytokeratin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KRT8)
	Novus Biologicals Antibodies for KRT8

Assays for KRT8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05787

ProtoNet protein and cluster: P05787

4 Blocks protein families:

IPB000873 AMP-binding signature

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

IPB003054 Type II keratin signature

UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787

Similarity: Belongs to the intermediate filament family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KRT8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002273

Applied Biosystems Silencer® siRNAs for KRT8

Sigma-Aldrich siRNA for KRT8

Sigma-Aldrich shRNA Panels and shRNA for KRT8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KRT8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002273
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002273
untagged cDNA clones in CMV expression vector (see all 3): BC008200

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002273

UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787

Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the

costameres of striated muscle

Genatlas biochemistry entry for KRT8:

keratin 8,type II,early embryonic,dimerizing with KRT18

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Krt8):

	digestive/alimentary	embryogenesis	growth/size	hematopoietic system
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	--
GO:0005515	protein binding	IPI	10954706 11684708 16608857

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KRT8

5/38 Interacting proteins for KRT8 (P05787^{1, 2} ENSP00000293308³) via UniProtKB, MINT, and/or STRING (see all 38 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLN5	O75503¹	EBI-297852, EBI-1043514
HSPA4L	O95757¹	EBI-297852, EBI-358652
KRT18	P05783¹	EBI-297852, EBI-297888
MDM2	Q00987¹	EBI-297852, EBI-389668
GRB2	P62993²	MINT-61555

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0007010	cytoskeleton organization	NAS	--
GO:0033209	tumor necrosis factor-mediated signaling pathway	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--
GO:0051707	response to other organism	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KRT8
10/29 Novoseek chemical compound relationships for KRT8 gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetylglucosamine	38.33	6	1371281 (3), 16825119 (1), 7510249 (1)
matrigel	32.34	2	17299793 (1), 11506501 (1)
hematoxylin	30.50	5	18305433 (1), 11041235 (1), 18626977 (1), 10193935 (1)
okadaic acid	27.09	4	16343483 (1), 7540986 (1), 11788583 (1)
progesterone	26.98	7	18715613 (1), 7544088 (1), 15010880 (1), 17144530 (1) (see all 5)
b 723	23.50	2	10757396 (1), 12508174 (1)
2-naphthol	21.61	1	1707525 (1)
percoll	6.82	1	1999856 (1)
oligonucleotide	5.40	1	15900602 (1)
calcium	3.68	4	18603402 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KRT8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002273

Sigma-Aldrich siRNA for KRT8

Sigma-Aldrich shRNA Panels and shRNA for KRT8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002273

REFSEQ mRNAs for KRT8 gene:

NM_002273.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002273

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002273
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002273
                                 untagged cDNA clones in CMV expression vector (see all 3): BC008200

Additional cDNA sequence:

D28446.1 Z36777.1

24/154 DOTS entries (see all 154 ):

DT.95363496 DT.91723246 DT.453659 DT.91776011 DT.91776017 DT.100699511 DT.100856806 DT.100850363

DT.91677886 DT.100765608 DT.97848181 DT.100870033 DT.121118086 DT.100852320 DT.100872833 DT.95070270

DT.92033258 DT.91998325 DT.91896377 DT.91652435 DT.100699527 DT.92064411 DT.95333919 DT.100868211

24/120 AceView cDNA sequences (see all 120 ):

CR620184 CR607818 CR600505 CR598939 CR599921 CR624959 CR592000 CR619053

CR596245 CR606768 CR604045 CR603822 CR605272 CR591747 CR607028 CR624626

CR608394 CR626613 CR601787 CR593206 CR607281 CR602560 CR625900 CR595443

highest scoring ESTs for KRT8:

BC000654 BC008200 BC063513 BG979488 U76549 X74929 AA069860 AA070375 AA100020 AA121116

Unigene Clusters for KRT8:

Keratin 8

Hs.533782 [show with all ESTs], Hs.708445 [show with all ESTs]

Unigene Representative Sequences: CR607281, BG323224

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000293308

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KRT8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KRT8

¹ / ² / ³

5 probe-sets matching KRT8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88178_at²^{, 3}	U95-E	2	1.00	0.72	0.06	0.97	AI380786	0.20	0.50	0.38	1
49888_f_at²^{, 3}	U95-B	17	0.88	0.36	0.97	1.08	AI357616	0.20	0.12	0.17	2
33824_at²^{, 3}	U95-A	21	0.62	0.23	0.88	0.96	M34482	0.20	1.00	0.72	1
209008_x_at²^{, 3}	U133-A	31	1.00	0.23	--	--	U76549	0.80	1.00	0.91	1
209008_x_at²	U133Plus2	31	1.00	0.23	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCCAGCTA

SOURCE GeneReport for Unigene clusters: Hs.533782 Hs.708445
Expression variation in blood from EXPOLDB for KRT8
UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787
Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the
sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival
mucosa and hard palate of the oral cavity

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KRT8 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KRT8¹	--	keratin 8	88.3(n) 88.45(a)	486513 XM_543639.2 XP_543639.2
chimpanzee (Pan troglodytes)	KRT8¹	--	keratin 8	97.52(n) 95.65(a)	743020 XM_001158862.1 XP_001158862.1
cow (Bos taurus)	KRT8¹	--	keratin 8	88.89(n) 90.23(a)	281269 NM_001033610.1 NP_001028782.1
rat (Rattus norvegicus)	Krt8¹	--	keratin 8	87.52(n) 91(a)	25626 NM_199370.1 NP_955402.1
mouse (Mus musculus)	Krt8^{1, 5}	15 (58.86 cM)⁵	keratin 8^{1, 5}	87.99(n)¹ 91.67(a)¹	16691¹ NM_031170.2¹ NP_112447.2¹ AA960620⁵ AK077597⁵ (see all 38)

About this table Species with no ortholog for KRT8

ENSEMBL Gene Tree for KRT8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KRT8 gene

KRT7² KRT79²

Pseudogenes

31 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/103 NCBI SNPs in KRT8 are shown (see all 103 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2070910^1,2	A,C,F,H	51585102(-)	`CCAAGA/CAGCAG`	1	--	ut5¹		11		EU EA WA MN NA	3334
	rs12580050^1,2	A,C,F,H	51586470(+)	`GCTTTA/TCCCAG`	1	--	ng3¹		6		NA EU EA	426
--	rs1065306^1,2	A,C,F	51585036(-)	`GCCTCT/CACCAT`	1	--	ut5¹ ese³		2		EA MN	1282
	rs17120212^1,2	C,F,H	51585344(+)	`AGTTCA/GGTGAA`	1	--	ng3¹		9		NA MN EA EU WA	1812
	rs2277330^1,2	C,F,H	51578731(+)	`CCACCG/AGCTCT`	1	W/R	mis¹		9		EA EU WA	2338
--	rs11554280^1,2	H	51580002(-)	`ACGAGG/TATATT`	1	D/Y	mis¹ ese³		4		EU EA WA	406
--	rs10431541^1,2	A	51585927(+)	`atcacA/Gaggtc`	1	--	ng3¹		0	--	--	--	--
--	rs10431540^1,2	A	51585867(+)	`AggccA/Gggcac`	1	--	ng3¹		0	--	--	--	--
--	rs11554500^1,2	H	51577507(+)	`ACTCAG/AACACC`	1	F/S	mis¹ ese³		4		EU EA WA	406
	rs3814773^1,2	H	51587063(+)	`cacacA/CcCCCA`	1	--	ng3¹ tfbs³		2		EU WA	228

About this table

HapMap Linkage Disequilibrium images for KRT8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 148060

UniProtKB/Swiss-Prot: K2C8_HUMAN, P05787

Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600]

10/97 Novoseek disease relationships for KRT8 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma	63.57	69	16540085 (3), 7536188 (2), 11689350 (2), 1719006 (2) (see all 36)
tumors	60.89	109	7544088 (3), 12367790 (3), 18603673 (2), 8625158 (2) (see all 76)
ductal breast carcinoma	49.76	6	14660278 (2), 16825119 (2), 10941333 (1)
epithelial tumor	49.22	1	9355978 (1)
breast carcinoma	48.92	7	14974217 (2), 18715613 (1), 14660278 (1), 7544088 (1) (see all 5)
carcinoma squamous cell	48.35	8	7686975 (3), 7527618 (1), 8634660 (1), 12142616 (1) (see all 6)
carcinoma ductal	48.22	3	10941333 (1), 19201736 (1)
metastasis	47.60	18	9568504 (2), 18715613 (1), 14974217 (1), 10555744 (1) (see all 15)
liver diseases	46.46	26	16911694 (5), 11372009 (3), 16575832 (2), 16365160 (2) (see all 11)
carcinoma medullary	45.50	1	14534746 (1)

About this table

Human Gene Mutation Database: KRT8
Genetic Association Database: KRT8
Human Genome Epidemiology Navigator: KRT8 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/615 PubMed articles for KRT8 gene (see all 615 ):

Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PubMed id 1705144)^{1, 2, 3, 4} Waseem A....Lane E.B. (1990)
Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ. (PubMed id 2434381)^{2, 3, 4} Leube R.E....Franke W.W. (1986)
Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431. (PubMed id 9054461)^{1, 3, 4} Ku N.-O. and Omary M.B. (1997)
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. (PubMed id 11788583)^{1, 3, 4} Ku N.O.... Omary M.B. (2002)
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. (PubMed id 11781324)^{1, 3, 4} He T.... Eriksson J.E. (2002)
Keratins as susceptibility genes for end-stage liver disease. (PubMed id 16143128)^{1, 3, 6} Ku N.O....Omary M.B. (2005)
Organization and sequence of the human gene encoding cytokeratin 8. (PubMed id 1691124)^{1, 3, 4} Krauss S. and Franke W.W. (1990)
Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. (PubMed id 12724528)^{1, 3, 4} Ku N.-O.... Omary M.B. (2003)
Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19. (PubMed id 16000376)^{1, 3, 4} Stone M.R.... Bloch R.J. (2005)
Keratin 8 mutations are not associated with familial, sporadic and alcoholic pancreatitis in a population from the United States. (PubMed id 16327287)^{1, 3, 6} Schneider A....Whitcomb D.C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3856	HGNC: 6446	AceView: KRT8	Ensembl:ENSG00000170421	euGenes: HUgn3856
ECgene: KRT8	H-InvDB: KRT8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Human Intermediate Filament Mutation Database	http://www.interfil.org

Licensable Technologies for KRT8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KRT8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KRT8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KRT8		Antibodies for KRT8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KRT8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KRT8)
	Antibodies (KRT8)
	Chimera RNAi (KRT8)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Cytokeratin 5 + 6 + 8 + 18, Cytokeratin 8 + 18 + 19, Cytokeratin 4 + 5 + 6 + 8 + 10 + 13 + 18, Cytokeratin 5 + 8, Cytokeratin 8, Cytokeratin 1 - 8, Cytokeratin 8+18, Cytokeratin)
	Antibodies (Cytokeratin 5 + 6 + 8 + 18, Cytokeratin 8 + 18 + 19, Cytokeratin 4 + 5 + 6 + 8 + 10 + 13 + 18, Cytokeratin 5 + 8, Cytokeratin 8, Cytokeratin 1 - 8, Cytokeratin 8+18, Cytokeratin)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for KRT8

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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KRT8 Gene at Home site.
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KRT8 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for KRT8

Summaries
for KRT8

Genomic Location
for KRT8

Proteins
for KRT8

Protein Domains/
Families
for KRT8

Gene Function
for KRT8

Pathways & Interactions
for KRT8

Drugs & Compounds
for KRT8

Transcripts
for KRT8

Expression
for KRT8

Orthologs
for KRT8

Paralogs
for KRT8

SNPs/Variants
for KRT8

Disorders & Mutations
for KRT8

Medical News
for KRT8

Publications
for KRT8

Search for KRT8

Genome Databases showing KRT8

Other Databases showing KRT8

Specialized Databases showing KRT8

Licensable Technologies
for KRT8

Services
for KRT8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KRT8 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor KRT8

Summariesfor KRT8

Genomic Locationfor KRT8

Proteinsfor KRT8

Protein Domains/Familiesfor KRT8

Gene Functionfor KRT8

Pathways & Interactionsfor KRT8

Drugs & Compoundsfor KRT8

Transcriptsfor KRT8

Expression for KRT8

Orthologsfor KRT8

Paralogsfor KRT8

SNPs/Variantsfor KRT8

Disorders & Mutationsfor KRT8

Medical Newsfor KRT8

Publicationsfor KRT8

Search for KRT8

Genome Databases showing KRT8

Other Databases showing KRT8

Specialized Databases showing KRT8

Licensable Technologiesfor KRT8

Servicesfor KRT8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KRT8

Summaries
for KRT8

Genomic Location
for KRT8

Proteins
for KRT8

Protein Domains/
Families
for KRT8

Gene Function
for KRT8

Pathways & Interactions
for KRT8

Drugs & Compounds
for KRT8

Transcripts
for KRT8

Expression
for KRT8

Orthologs
for KRT8

Paralogs
for KRT8

SNPs/Variants
for KRT8

Disorders & Mutations
for KRT8

Medical News
for KRT8

Publications
for KRT8

Licensable Technologies
for KRT8

Services
for KRT8