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Aliases for KRT79 Gene

Aliases for KRT79 Gene

  • Keratin 79 2 3 5
  • Type-II Keratin Kb38 3 4
  • Keratin 79, Type II 2 3
  • Cytokeratin-79 3 4
  • CK-79 3 4
  • KRT6L 3 4
  • K6L 3 4
  • K79 3 4
  • Keratin, Type II Cytoskeletal 79 3
  • Keratin 6-Like 2
  • Keratin-6-Like 4
  • Keratin 6L 3
  • Keratin-6L 4
  • Keratin-79 4
  • KB38 4

External Ids for KRT79 Gene

Previous GeneCards Identifiers for KRT79 Gene

  • GC12M051502
  • GC12M053215
  • GC12M050259

Summaries for KRT79 Gene

Entrez Gene Summary for KRT79 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT79 Gene

KRT79 (Keratin 79) is a Protein Coding gene. Among its related pathways are Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is KRT3.

Gene Wiki entry for KRT79 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT79 Gene

Genomics for KRT79 Gene

Regulatory Elements for KRT79 Gene

Enhancers for KRT79 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F052869 1.8 FANTOM5 Ensembl ENCODE 10.5 -39.0 -39031 7.1 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 KRT2 IGFBP6 MAP3K12 AAAS KRT84 ZNF740 PFDN5 KRT79 ENSG00000259884 KRT4
GH12F052894 1.8 FANTOM5 Ensembl ENCODE 10.1 -68.7 -68744 16.3 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC AAAS ZNF740 SP1 PFDN5 IGFBP6 LOC100652999 KRT18 ENSG00000257500 LOC105378250 MAP3K12
GH12F052579 1.5 FANTOM5 Ensembl ENCODE 10.4 +252.8 252764 3.9 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF207 FOS DEK ZNF263 SP5 KRT72 KRT1 KRT71 KRT78 KRT79 KRT2 KRT84 KRT4 KRT6C KRT76
GH12F052859 1.2 FANTOM5 Ensembl ENCODE 11.1 -26.1 -26125 1.8 ZNF687 RFX1 CEBPB MNT DPF2 CEBPG RFX5 SREBF1 CTBP1 KLF9 KRT79 KRT4 KRT76 KRT1 KRT2 KRT83 KRT71 KRT6A RARG KRT5
GH12F052968 1.3 Ensembl ENCODE 10.1 -136.9 -136854 4.7 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF766 CBX5 ZNF207 FOS DEK KRT18 MAP3K12 ZNF740 KRT79 KRT82 KRT84 KRT71 KRT4 KRT86 KRT8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT79 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT79 Gene

52,821,410 bp from pter
52,834,295 bp from pter
12,886 bases
Minus strand

Genomic View for KRT79 Gene

Genes around KRT79 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT79 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT79 Gene

Proteins for KRT79 Gene

  • Protein details for KRT79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 79
    Protein Accession:
    Secondary Accessions:
    • Q6P465
    • Q7Z793

    Protein attributes for KRT79 Gene

    535 amino acids
    Molecular mass:
    57836 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

neXtProt entry for KRT79 Gene

Post-translational modifications for KRT79 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT79 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT79 Gene

Domains & Families for KRT79 Gene

Gene Families for KRT79 Gene

Suggested Antigen Peptide Sequences for KRT79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT79: view

Function for KRT79 Gene

Gene Ontology (GO) - Molecular Function for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with KRT79: view
genes like me logo Genes that share phenotypes with KRT79: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT79 Gene

Localization for KRT79 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT79 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT79: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT79 Gene

Pathways & Interactions for KRT79 Gene

SuperPathways for KRT79 Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRT79: view

Pathways by source for KRT79 Gene

1 Reactome pathway for KRT79 Gene

Gene Ontology (GO) - Biological Process for KRT79 Gene


No data available for SIGNOR curated interactions for KRT79 Gene

Transcripts for KRT79 Gene

mRNA/cDNA for KRT79 Gene

Unigene Clusters for KRT79 Gene

Keratin 79:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT79 Gene

No ASD Table

Relevant External Links for KRT79 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT79 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT79 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x34.7) and Skin - Sun Exposed (Lower leg) (x15.1).

Protein differential expression in normal tissues from HIPED for KRT79 Gene

This gene is overexpressed in Saliva (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT79 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT79 Gene:


SOURCE GeneReport for Unigene cluster for KRT79 Gene:


mRNA Expression by UniProt/SwissProt for KRT79 Gene:

Tissue specificity: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined.
genes like me logo Genes that share expression patterns with KRT79: view

Primer Products

No data available for Protein tissue co-expression partners for KRT79 Gene

Orthologs for KRT79 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT79 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT79 34 35
  • 98.82 (n)
(Canis familiaris)
Mammalia KRT79 34 35
  • 88.47 (n)
(Bos Taurus)
Mammalia KRT79 34 35
  • 87.35 (n)
(Mus musculus)
Mammalia Krt79 34 16 35
  • 82.61 (n)
(Rattus norvegicus)
Mammalia Krt79 34
  • 82.35 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
-- 35
  • 67 (a)
(Gallus gallus)
Aves KRT5 35
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt1 34
  • 61.95 (n)
Species where no ortholog for KRT79 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT79 Gene

Gene Tree for KRT79 (if available)
Gene Tree for KRT79 (if available)

Paralogs for KRT79 Gene Pseudogenes for KRT79 Gene

genes like me logo Genes that share paralogs with KRT79: view

Variants for KRT79 Gene

Sequence variations from dbSNP and Humsavar for KRT79 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10783542 -- 52,826,382(+) GTGAC(A/G)TGCGC intron-variant
rs10876353 -- 52,823,272(+) CCTCC(A/G)GGGTC intron-variant
rs10876354 -- 52,823,917(+) CCCTG(A/C)AGCCT reference, synonymous-codon
rs10876355 -- 52,836,118(+) GTGGG(C/T)CCTAG upstream-variant-2KB
rs111335374 -- 52,835,427(+) GGGCC(A/G)AGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT79 Gene

Variant ID Type Subtype PubMed ID
esv3307974 CNV mobile element insertion 20981092
esv3432030 CNV insertion 20981092
esv3629524 CNV gain 21293372
nsv1048816 CNV gain 25217958
nsv470293 CNV loss 18288195
nsv832416 CNV loss 17160897

Variation tolerance for KRT79 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.10; 80.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT79 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT79 Gene

Disorders for KRT79 Gene

Relevant External Links for KRT79

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT79 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT79 Gene

Publications for KRT79 Gene

  1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M. … Weber K. (J. Cell Sci. 2001) 2 3 4 64
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3 64

Products for KRT79 Gene

Sources for KRT79 Gene

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