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KRT79 Gene

protein-coding   GIFtS: 45
GCID: GC12M053215

Keratin 79

  Search for KRT79
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 791 2     Keratin, Type II Cytoskeletal 792
K6L2 3 5     keratin-6L2
KRT6L2 3 5     keratin-792
Type-II Keratin Kb382 3     Cytokeratin-793
CK-792 3     KB383
K792 3     Keratin-6-like3
Keratin 6-Like1     Keratin-6L3
cytokeratin-792     Keratin-793
Keratin 6L2     

External Ids:    HGNC: 289301   Entrez Gene: 3387852   Ensembl: ENSG000001856407   OMIM: 6111605   UniProtKB: Q5XKE53   

Export aliases for KRT79 gene to outside databases

Previous GC identifers: GC12M051502 GC12M050259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT79 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed
in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.(provided
by RefSeq, Jun 2009)

GeneCards Summary for KRT79 Gene:
KRT79 (keratin 79) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

Gene Wiki entry for KRT79 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KRT79 gene promoter:
         GR   RP58   AML1a   p300   C/EBPalpha   HNF-4alpha1   CHOP-10   HEN1   Zic1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT79 promoter sequence
   Search Chromatin IP Primers for KRT79

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT79


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT79 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT79 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053215:  view genomic region     (about GC identifiers)

Start:
53,215,194 bp from pter      End:
53,228,079 bp from pter
Size:
12,886 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 79  
Size: 535 amino acids; 57836 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Secondary accessions: Q6P465 Q7Z793

Explore the universe of human proteins at neXtProt for KRT79: NX_Q5XKE5

Explore proteomics data for KRT79 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys152, Lys159
  • Modification sites at PhosphoSitePlus

  • See KRT79 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787028.1  
    ENSEMBL proteins: 
     ENSP00000328358   ENSP00000449159  

    KRT79 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q5XKE5

    ProtoNet protein and cluster: Q5XKE5

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5
    Similarity: Belongs to the intermediate filament family


    KRT79 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0004871signal transducer activity ----
    GO:0005198structural molecule activity IEA--
         
    KRT79 for ontologies           About GeneDecksing


    Animal Models:
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    3 qRT-PCR Assays for microRNAs that regulate KRT79:
    hsa-miR-3132 hsa-miR-2116* hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidKRT79 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRT79

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    KRT79 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT79
    Interactions:

        Search GeneGlobe Interaction Network for KRT79

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for KRT79 (Q5XKE53 ENSP000003283584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    WIPI2Q9Y4P83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction ----

    KRT79 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT79 (K2C79)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRT79 gene: 
    NM_175834.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546453(uc001sba.3) ENST00000330553(uc001sbb.3) ENST00000549255

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT79 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT79:
    hsa-miR-3132 hsa-miR-2116* hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidKRT79 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KRT79
    Predesigned siRNA for gene silencing in human, mouse, rat KRT79
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      QuantiTect SYBR Green Assays in human, mouse, rat KRT79
      QuantiFast Probe-based Assays in human, mouse, rat KRT79

    Selected AceView cDNA sequences (see all 251):

    BP371899 AU077018 BE742142 AW082111 AK130156 BF830977 C00570 BQ027522 
    AW265613 BM697307 BM715509 BE735977 AA629199 BG741384 BC039148 AJ564105 
    NM_175834 BM955736 NM_057088 BC003630 BG680256 BP373464 BG696531 BQ045292 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT79 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAACAACC
    KRT79 Expression
    About this image


    KRT79 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
    KRT79 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT79 Protein Expression

    UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5
    Tissue specificity: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined

        Custom PCR Arrays for KRT79
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT79

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT79 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt791 , 5 keratin 791, 5 82.61(n)1
    83.43(a)1
      15 (57.14 cM)5
    2239171  NM_146063.11  NP_666175.11 
     1019293325 
    chicken
    (Gallus gallus)
    Aves KRT56
    Gallus gallus keratin 5 (KRT5), mRNA.
    56(a)
    many ↔ many
    LGE22C19W28_E50C23(667141-673450)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    2(95689544-95704356)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia krt11 keratin 1 61.95(n)
    60.9(a)
      100489309  XM_002935729.1  XP_002935775.1 


    ENSEMBL Gene Tree for KRT79 (if available)
    TreeFam Gene Tree for KRT79 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT79 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT72  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT79 using alignment to 2 protein entries:     K2C79_HUMAN (see all proteins) (see all similar genes):
    KRTHB6    KRT1B    KRT75    KRT6C    KRT77    KRT121P
    KRT7    KRT72    KRT74    KRT5    KRT2    KRT78
    KRT4    KRT6A    KRT6B    KRT71    KRT3    KRT73

    KRT79 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRT79
    PGOHUM00000239460


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT79 (see all 460)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161408501,2
    F--53049180(+) CTCTAT/AAAGCC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1932341031,2
    --53049266(+) TTGACC/TGAGGT 1 -- ds50010--------
    rs8764071,2
    C,F,A,H--53049352(+) AACAAA/GGCATG 1 -- ds500129Minor allele frequency- G:0.43EA NA NS WA 2918
    rs1512175981,2
    C--53049401(+) CACCA-/GGGGTG 1 -- ds50010--------
    rs778361181,2
    F--53049440(+) GTCTGG/ACCTTG 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1854549591,2
    --53049524(+) TCAAAC/TTAATG 1 -- ds50010--------
    rs1156868741,2
    F--53049582(+) GCTGTG/ATCAGG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs740966411,2
    C,F--53049636(+) AGGACG/AGACTG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1463678091,2
    --53049652(+) ACAGAC/GAGCTA 1 -- ds50010--------
    rs1457344241,2
    C--53049893(+) CCATCC/TTACTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT79 (53215194 - 53228079 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KRT79:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272248CNV Insertion20981092
    nsv832416CNV Loss17160897
    nsv470293CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT79
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT79

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611160    OMIM disorders: --


    KRT79 for disorders           About GeneDecksing


    Export disorders for KRT79 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT79 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with KRT79)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2, 3 Hesse M.... Weber K. (J. Cell Sci. 2001)
    2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (J. Invest. Dermatol. 2005)
    3. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    4. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. (PubMed id 24198274)1 Veniaminova N.A....Wong S.Y. (Development 2013)
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    6. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 338785 HGNC: 28930 AceView: KRT4andHUMCYT2AandKRT3andK5BandKRT6L Ensembl:ENSG00000185640 euGenes: HUgn338785
    ECgene: KRT79 H-InvDB: KRT79

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT79 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT79 gene:
    Search GeneIP for patents involving KRT79

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KRT79  
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     Block miRNA regulation of human, mouse, rat KRT79 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KRT79
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT79 Predesigned siRNA for gene silencing in human, mouse, rat KRT79
     QuantiFast Probe-based Assays in human, mouse, rat KRT79 QuantiTect SYBR Green Assays in human, mouse, rat KRT79
     Custom PCR Arrays for KRT79 Search Chromatin IP Primers for KRT79
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     Search Tocris compounds for KRT79 (K2C79)
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for KRT79
     Gene Synthesis
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     SwitchGear 3'UTR luciferase reporter plasmids for KRT79
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT79
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