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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT79 Gene

protein-coding   GIFtS: 47
GCID: GC12M053215

keratin 79
 Explore 2 diseases affiliated with
KRT79 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KRT79    

Aliases
for KRT79 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Keratin 791 2     Keratin, Type II Cytoskeletal 792
K6L1 2 3 5     Keratin-6L3
KRT6L1 2 3 5     Keratin-793
Type-II Keratin Kb382 3     Cytokeratin-793
CK-792 3     KB383
K792 3     Keratin-6-Like1
Cytokeratin-793     Keratin-6L3
Keratin 6L2     Keratin-793

External Ids:    HGNC: 289301   Entrez Gene: 3387852   Ensembl: ENSG000001856407   OMIM: 6111605   UniProtKB: Q5XKE53   

Export aliases for KRT79 gene to outside databases

Previous GC identifers: GC12M051502 GC12M050259


Summaries
for KRT79 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KRT79:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in
skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.(provided by
RefSeq, Jun 2009)

Gene Wiki entry for KRT79


Genomic Views
for KRT79 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT79 gene promoter:
         GR   RP58   AML1a   p300   C/EBPalpha   HNF-4alpha1   CHOP-10   HEN1   Zic1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT79 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT79

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT79


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT79 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT79 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053215:  view genomic region     (about GC identifiers)

Start:
 53,215,194 bp from pter      End:
 53,228,079 bp from pter
Size:
 12,886 bases      Orientation:
 minus strand

Proteins
for KRT79 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 79  
Size: 535 amino acids; 57836 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)
(40-55 and 56-70 kDa, respectively)
Secondary accessions: Q6P465 Q7Z793

Explore the universe of human proteins at neXtProt for KRT79: NX_Q5XKE5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5XKE5

    • KRT79 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_787028.1  
    ENSEMBL proteins: 
     ENSP00000328358   ENSP00000449159  

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    Novus Biologicals KRT79 Protein
    Novus Biologicals KRT79 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KRT79

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045095keratin filament IEA--


    KRT79 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KRT79

    Protein Domains /
    Families
    for KRT79 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KRT79 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q5XKE5

    ProtoNet protein and cluster: Q5XKE5

    2 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5
    Similarity: Belongs to the intermediate filament family


    Function
    for KRT79 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT79
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT79:
    hsa-miR-3132 hsa-miR-2116* hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmid: KRT79 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: KRT79
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--


    KRT79 for ontologies           About GeneDecksing



    Pathways & Interactions
    for KRT79 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT79

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for KRT79 (Q5XKE53 ENSP000003283584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    WIPI2Q9Y4P83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for KRT79 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT79
    Search CenterWatch for drugs/clinical trials and news about KRT79 / K2C79 

    Transcripts
    for KRT79 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KRT79 gene: 
    NM_175834.2  

    Unigene Cluster for KRT79:

    Keratin 79
    Hs.711471  [show with all ESTs]
    Unigene Representative Sequence: BC039148
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546453(uc001sba.3) ENST00000330553(uc001sbb.3) ENST00000549255


    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate KRT79:
    hsa-miR-3132 hsa-miR-2116* hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmid: KRT79 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT79 (see all 4)
    OriGene shRNA RFP: KRT79
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT79
    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT79

    Additional cDNA sequence: 

    AJ564105.1 AK130156.1 BC039148.1 BC063648.1 

    4 DOTS entries:

    DT.101981719  DT.101981718  DT.91759228  DT.92470158 

    24/251 AceView cDNA sequences (see all 251):

    BP371899 BF830977 BC039148 BE742142 BG741384 AK130156 AW265613 BE735977 
    AJ564105 AA629199 AW082111 AU077018 C00570 NM_175834 BQ027522 BM697307 
    BM715509 BG741716 BG674413 BG742783 BQ352789 BG698825 BU727784 BG743809 

    GeneLoc Exon Structure


    Expression
    for KRT79 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT79 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAACAACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KRT79 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KRT79 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT79

    SOURCE GeneReport for Unigene cluster: Hs.711471

    UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5
    Tissue specificity: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined

        SABiosciences Custom PCR Arrays for KRT79
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT79

    Orthologs
    for KRT79 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KRT79 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q6PVZ5_CHICK6
    --
    (see all 3)    		 --
    		 54(a)
    45(a)
    (see all 3)    		 possible ortholog
    1 ↔ 1
    (see all 3)    		 E22C19W28_E50C23(642021-648330)
    E22C19W28_E50C23(541402-545250)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    51(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 AAWZ02039762(4434-6932)
    2(95689880-95702695)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1369306
    wu:fb15e046
    (see all 3)    		 wu:fb15e04
    (see all 3)    		 23(a)
    19(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(32498013-32508762)
    21(24464941-24474821)
    worm
    (Caenorhabditis elegans)    		 Secernentea ifp-16
    ifc-26
    (see all 12)    		 Intermediate filament protein ifc-2
    (see all 12)    		 7(a)
    6(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 X(9675786-9680111)
    X(642160-654902)


    ENSEMBL Gene Tree for KRT79 (if available)
    TreeFam Gene Tree for KRT79 (if available) 

    Paralogs
    for KRT79 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT79 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT862  KRT32  KRT842  
    KRT82  KRT812  KRT712  KRT8P112  KRT782  KRT72  ENSG000001704422  KRT722  
    KRT732  KRT52  KRT6C2  KRT6A2  KRT852  KRT22  KRT752  KRT12  
    KRT822  KRT42  
    18/41 SIMAP similar genes for KRT79 using alignment to 2 protein entries:     K2C79_HUMAN (see all proteins) (see all similar genes):
    KRTHB6    KRT1B    KRT75    KRT6C    KRT77    KRT121P
    KRT72    KRT74    KRT5    KRT7    KRT2    KRT78
    KRT4    KRT6A    KRT6B    KRT71    GFAP    KRT3

    KRT79 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRT79
    PGOHUM00000239460


    Genomic Variants
    for KRT79 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/356 NCBI SNPs in KRT79 are shown (see all 356)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs740966411,2
    		C,--50259219(+) AGGACG/AGACTG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs733058051,2
    		C,--50260327(+) TGTGCC/TCAGGT 1 -- int12Minor allele frequency- T:0.04WA 120
    rs23636221,2
    		C,--50260356(+) GAAAGG/TGCAGA 1 -- int15Minor allele frequency- T:0.01NA 140
    rs755727071,2
    		--50260395(+) CCTCCC/TCTTTT 1 -- int12Minor allele frequency- T:0.07CSA WA 120
    rs1121642021,2
    		C,--50260532(+) GTGGAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1129879301,2
    		--50260597(+) CCTACC/AGGGCT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs796455871,2
    		F,--50260606(+) CTGTCA/GGCCAC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs750553101,2
    		F,--50261195(+) AAGCAG/AGATCA 1 -- int11Minor allele frequency- A:0.07EA 120
    rs1143349911,2
    		C,F,--50261357(+) TAGCCG/TTTCTA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs731044991,2
    		C,F,--50261448(+) GATCAG/ATTTCC 1 -- int12Minor allele frequency- A:0.03WA NA 238

    HapMap Linkage Disequilibrium report for KRT79 (53215194 - 53228079 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KRT79: --

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    Disorders / Diseases
    for KRT79 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KRT79 for disorders           About GeneDecksing

    OMIM gene information: 611160    OMIM disorders: --

    2 diseases for KRT79:    About MalaCards
    pharyngitis    neuronitis


    Export disorders for KRT79 gene to outside databases

    Publications
    for KRT79 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT79 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with KRT79)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2, 3 Hesse M.... Weber K. (2001)
    2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    6. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    7. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for KRT79 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing KRT79 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338785 HGNC: 28930 AceView: KRT4andHUMCYT2AandKRT3andK5BandKRT6L Ensembl:ENSG00000185640 euGenes: HUgn338785
    ECgene: KRT79 H-InvDB: KRT79

    Other Databases showing KRT79 gene

    (According to HUGE)
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    Specialized Databases showing KRT79 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT79 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KRT79 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KRT79 gene:
    Search GeneIP for patents involving KRT79

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