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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT79 Gene

protein-coding   GIFtS: 47
GCID: GC12M053215

Keratin 79

  Search for KRT79
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 791 2     Keratin, Type II Cytoskeletal 792
K6L2 3 5     keratin-6L2
KRT6L2 3 5     keratin-792
Type-II Keratin Kb382 3     Cytokeratin-793
CK-792 3     KB383
K792 3     Keratin-6-like3
Keratin 6-Like1     Keratin-6L3
cytokeratin-792     Keratin-793
Keratin 6L2     

External Ids:    HGNC: 289301   Entrez Gene: 3387852   Ensembl: ENSG000001856407   OMIM: 6111605   UniProtKB: Q5XKE53   

Export aliases for KRT79 gene to outside databases

Previous GC identifers: GC12M051502 GC12M050259


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT79 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed
in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.(provided
by RefSeq, Jun 2009)

GeneCards Summary for KRT79 Gene: 
KRT79 (keratin 79) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

Gene Wiki entry for KRT79 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT79 gene promoter:
         GR   RP58   AML1a   p300   C/EBPalpha   HNF-4alpha1   CHOP-10   HEN1   Zic1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT79 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT79

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT79


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT79 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT79 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053215:  view genomic region     (about GC identifiers)

Start:
53,215,194 bp from pter      End:
53,228,079 bp from pter
Size:
12,886 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 79  
Size: 535 amino acids; 57836 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Secondary accessions: Q6P465 Q7Z793

Explore the universe of human proteins at neXtProt for KRT79: NX_Q5XKE5

Explore proteomics data for KRT79 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5XKE5

  • KRT79 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT79 Protein Expression
    REFSEQ proteins: NP_787028.1  
    ENSEMBL proteins: 
     ENSP00000328358   ENSP00000449159  

    Human Recombinant Protein Products for KRT79: 
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    Cloud-Clone Corp. Proteins for KRT79 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045095keratin filament IEA--

    KRT79 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF2: Intermediate filaments type II, keratins (basic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q5XKE5

    ProtoNet protein and cluster: Q5XKE5

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5
    Similarity: Belongs to the intermediate filament family


    KRT79 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0004871signal transducer activity ----
    GO:0005198structural molecule activity IEA--
         
    KRT79 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidKRT79 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT79

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for KRT79 (Q5XKE53 ENSP000003283584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    WIPI2Q9Y4P83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction ----

    KRT79 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT79 (K2C79)

    Search CenterWatch for drugs/clinical trials and news about KRT79 / K2C79

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT79 gene: 
    NM_175834.2  

    Unigene Cluster for KRT79:

    Keratin 79
    Hs.711471  [show with all ESTs]
    Unigene Representative Sequence: BC039148
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546453(uc001sba.3) ENST00000330553(uc001sbb.3) ENST00000549255

    miRNA
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    hsa-miR-3132 hsa-miR-2116* hsa-miR-3672
    SwitchGear 3'UTR luciferase reporter plasmidKRT79 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ564105.1 AK130156.1 BC039148.1 BC063648.1 

    17 DOTS entries:

    DT.101981719  DT.441275  DT.101981718  DT.121119199  DT.91759228  DT.100043393  DT.121117777  DT.121117799 
    DT.121118172  DT.121118870  DT.95160542  DT.121117313  DT.121117654  DT.121118370  DT.121118489  DT.121119049 
    DT.92470158 

    24/251 AceView cDNA sequences (see all 251):

    AW082111 BM715509 AJ564105 BG741384 BE742142 BF830977 AA629199 AW265613 
    BQ027522 BP371899 BC039148 AK130156 AU077018 NM_175834 BM697307 C00570 
    BE735977 BG741820 BG674899 BQ352789 BF155536 BE735578 BE272256 AW081796 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT79 expression in normal human tissues (normalized intensities)      KRT79 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAACAACC
    KRT79 Expression
    About this image


    KRT79 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node

     -- (Integumentary System)
             skin   

    See KRT79 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT79

    SOURCE GeneReport for Unigene cluster: Hs.711471

    UniProtKB/Swiss-Prot: K2C79_HUMAN, Q5XKE5
    Tissue specificity: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT79

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT79 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt791 , 5 keratin 791, 5 82.61(n)1
    83.43(a)1
      15 (57.14 cM)5
    2239171  NM_146063.11  NP_666175.11 
     1019293325 
    chicken
    (Gallus gallus)
    Aves --
    --
    54(a)
    possible ortholog
    LGE22C19W28_E50C23(558727-563179)


    ENSEMBL Gene Tree for KRT79 (if available)
    TreeFam Gene Tree for KRT79 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT79 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT72  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    18/41 SIMAP similar genes for KRT79 using alignment to 2 protein entries:     K2C79_HUMAN (see all proteins) (see all similar genes):
    KRTHB6    KRT1B    KRT75    KRT6C    KRT77    KRT121P
    KRT7    KRT72    KRT74    KRT5    KRT2    KRT78
    KRT4    DES    KRT6A    KRT6B    KRT71    KRT3

    KRT79 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRT79
    PGOHUM00000239460


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/460 SNPs in KRT79 are shown (see all 460)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1161408501,2
    F--53049180(+) CTCTAT/AAAGCC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1932341031,2
    --53049266(+) TTGACC/TGAGGT 1 -- ds50010--------
    rs8764071,2
    C,F,A,H--53049352(+) AACAAA/GGCATG 1 -- ds500129Minor allele frequency- G:0.43EA NA NS WA 2918
    rs1512175981,2
    C--53049401(+) CACCA-/GGGGTG 1 -- ds50010--------
    rs778361181,2
    F--53049440(+) GTCTGG/ACCTTG 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1854549591,2
    --53049524(+) TCAAAC/TTAATG 1 -- ds50010--------
    rs1156868741,2
    F--53049582(+) GCTGTG/ATCAGG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs740966411,2
    C,F--53049636(+) AGGACG/AGACTG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1463678091,2
    --53049652(+) ACAGAC/GAGCTA 1 -- ds50010--------
    rs1457344241,2
    C--53049893(+) CCATCC/TTACTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT79 (53215194 - 53228079 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KRT79:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272248CNV Insertion20981092
    nsv832416CNV Loss17160897
    nsv470293CNV Loss18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KRT79 for disorders           About MalaCards
    OMIM gene information: 611160    OMIM disorders: --


    KRT79 for disorders           About GeneDecksing


    Export disorders for KRT79 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT79 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with KRT79)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2, 3 Hesse M.... Weber K. (2001)
    2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
    3. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (2013)
    4. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338785 HGNC: 28930 AceView: KRT4andHUMCYT2AandKRT3andK5BandKRT6L Ensembl:ENSG00000185640 euGenes: HUgn338785
    ECgene: KRT79 H-InvDB: KRT79

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT79 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT79 gene:
    Search GeneIP for patents involving KRT79

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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