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Aliases for KRT79 Gene

Aliases for KRT79 Gene

  • Keratin 79, Type II 2 3
  • KRT6L 3 4 6
  • K6L 3 4 6
  • Type-II Keratin Kb38 3 4
  • Cytokeratin-79 3 4
  • Keratin-6L 3 4
  • Keratin-79 3 4
  • CK-79 3 4
  • K79 3 4
  • Keratin, Type II Cytoskeletal 79 3
  • Keratin 6-Like 2
  • Keratin-6-Like 4
  • Keratin 79 2
  • Keratin 6L 3
  • KB38 4

External Ids for KRT79 Gene

Previous GeneCards Identifiers for KRT79 Gene

  • GC12M051502
  • GC12M053215
  • GC12M050259

Summaries for KRT79 Gene

Entrez Gene Summary for KRT79 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT79 Gene

KRT79 (Keratin 79, Type II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

Gene Wiki entry for KRT79 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT79 Gene

Genomics for KRT79 Gene

Regulatory Elements for KRT79 Gene

Genomic Location for KRT79 Gene

52,821,410 bp from pter
52,834,295 bp from pter
12,886 bases
Minus strand

Genomic View for KRT79 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT79 Gene

Proteins for KRT79 Gene

  • Protein details for KRT79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 79
    Protein Accession:
    Secondary Accessions:
    • Q6P465
    • Q7Z793

    Protein attributes for KRT79 Gene

    535 amino acids
    Molecular mass:
    57836 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)

neXtProt entry for KRT79 Gene

Proteomics data for KRT79 Gene at MOPED

Post-translational modifications for KRT79 Gene

  • Ubiquitination at Lys152 and Lys159
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT79 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT79 Gene

Domains for KRT79 Gene

Gene Families for KRT79 Gene

Protein Domains for KRT79 Gene

Suggested Antigen Peptide Sequences for KRT79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT79: view

Function for KRT79 Gene

Gene Ontology (GO) - Molecular Function for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0004871 signal transducer activity --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with KRT79: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT79

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT79 Gene

Localization for KRT79 Gene

Subcellular locations from

Jensen Localization Image for KRT79 Gene COMPARTMENTS Subcellular localization image for KRT79 gene
Compartment Confidence
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT79: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT79 Gene

Pathways for KRT79 Gene

SuperPathways for KRT79 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with KRT79: view

No data available for Pathways by source for KRT79 Gene

Transcripts for KRT79 Gene

mRNA/cDNA for KRT79 Gene

Unigene Clusters for KRT79 Gene

Keratin 79:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT79

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT79 Gene

No ASD Table

Relevant External Links for KRT79 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT79 Gene

mRNA expression in normal human tissues for KRT79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT79 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (34.7) and Skin - Sun Exposed (Lower leg) (15.1).

Protein differential expression in normal tissues for KRT79 Gene

This gene is overexpressed in Saliva (54.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT79 Gene

SOURCE GeneReport for Unigene cluster for KRT79 Gene Hs.711471

mRNA Expression by UniProt/SwissProt for KRT79 Gene

Tissue specificity: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined.
genes like me logo Genes that share expressions with KRT79: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Expression partners for KRT79 Gene

Orthologs for KRT79 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT79 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT79 35
  • 87.35 (n)
  • 87.1 (a)
KRT79 36
  • 87 (a)
(Canis familiaris)
Mammalia KRT79 35
  • 88.47 (n)
  • 89.35 (a)
KRT79 36
  • 89 (a)
(Mus musculus)
Mammalia Krt79 35
  • 82.61 (n)
  • 83.43 (a)
Krt79 16
Krt79 36
  • 83 (a)
(Pan troglodytes)
Mammalia KRT79 35
  • 98.82 (n)
  • 97.94 (a)
KRT79 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Krt79 35
  • 82.35 (n)
  • 81.97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
-- 36
  • 67 (a)
(Gallus gallus)
Aves KRT5 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt1 35
  • 61.95 (n)
  • 60.9 (a)
Species with no ortholog for KRT79:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT79 Gene

Gene Tree for KRT79 (if available)
Gene Tree for KRT79 (if available)

Paralogs for KRT79 Gene Pseudogenes for KRT79 Gene

genes like me logo Genes that share paralogs with KRT79: view

Variants for KRT79 Gene

Sequence variations from dbSNP and Humsavar for KRT79 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs876407 -- 52,821,139(+) AACAA(A/G)GCATG downstream-variant-500B
rs2256838 -- 52,825,142(+) CCCAC(A/G)TGGGG intron-variant
rs2363622 -- 52,822,560(+) GAAAG(G/T)GCAGA intron-variant
rs2638496 -- 52,835,096(-) AGAGG(C/G)TCAGG upstream-variant-2KB
rs2638497 - 52,834,019(-) CTTGT(C/T)GGGGC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for KRT79 Gene

Variant ID Type Subtype PubMed ID
nsv832416 CNV Loss 17160897
nsv470293 CNV Loss 18288195
esv272248 CNV Insertion 20981092

Relevant External Links for KRT79 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT79 Gene

Disorders for KRT79 Gene

No disorders were found for KRT79 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRT79 Gene

Publications for KRT79 Gene

  1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M. … Weber K. (J. Cell Sci. 2001) 2 3 4
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  4. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for KRT79 Gene

Sources for KRT79 Gene

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