KRT78 Gene
protein-coding GIFtS: 46
GCID: GC12M053232
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|
keratin 78
| |
Aliases
for KRT78 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 781 2 | | Keratin, Type II Cytoskeletal 782 | | K5B1 2 3 5 | | Keratin-5b3 | | Type-II Keratin Kb402 3 | | Keratin-783 | | CK-782 3 | | Cytokeratin-783 | | K782 3 | | KB403 | | Kb402 | | Keratin-5b3 | | Cytokeratin-783 | | Keratin-783 | | Keratin 5b2 | | |
Export aliases for KRT78 gene to outside databasesPrevious GC identifers: GC12M051518 GC12M050276 |
Summaries
for KRT78 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT78:
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain.Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wideintermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanicalstresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of thisgene family have been identified. (provided by RefSeq, Jul 2008)
Gene Wiki entry for KRT78
|
Genomic Views
for KRT78 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT78 gene promoter:
GR RP58 AML1a Tal-1beta E47 C/EBPalpha HEN1 CHOP-10 GR-alpha Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT78
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT78 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13KRT78 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M053232: view genomic region
(about GC identifiers)
Start:
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53,231,588 bp from pter |
End:
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53,242,876 bp from pter |
Size:
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11,289 bases |
Orientation:
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minus strand |
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Proteins
for KRT78 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K2C78_HUMAN, Q8N1N4 (See
protein sequence)Recommended Name: Keratin, type II cytoskeletal 78 Size: 520 amino acids; 56866 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)(40-55 and 56-70 kDa, respectively)
Sequence caution: Sequence=DAA00377.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K4D6 Q5HYM7 Q7RTT2Alternative splicing: 2 isoforms: Q8N1N4-1 Q8N1N4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KRT78: NX_Q8N1N4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N1N4
KRT78 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775487.2
ENSEMBL proteins: ENSP00000352479 ENSP00000306261 ENSP00000448562 ENSP00000447817
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045095 | keratin filament |
IEA | -- |
KRT78 for ontologies About GeneDecksing
KRT78 Antibody Products:
Assay Products for KRT78: |
Protein
Domains /
Families
for KRT78 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT78 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N1N4ProtoNet protein and cluster: Q8N1N4 3 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: K2C78_HUMAN, Q8N1N4Similarity: Belongs to the intermediate filament family |
Function
for KRT78 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT78 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT78
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KRT78 (NM_173352) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT78 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT78 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT78 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT78 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT78:
|
Pathways & Interactions
for KRT78 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT78
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/31 Interacting proteins for KRT78 (Q8N1N43 ENSP000003062614) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
|
Drugs & Compounds
for KRT78 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT78
Search CenterWatch for drugs/clinical trials and news about KRT78 / K2C78
|
Transcripts
for KRT78 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT78 gene: NM_173352.2 Unigene Cluster for KRT78: Keratin 78 Hs.665267 [show with all ESTs]Unigene Representative Sequence: BX6470955 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359499 ENST00000304620(uc001sbc.1) ENST00000547920 ENST00000547110
ENST00000551581
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT78 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT78
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT78 (NM_173352) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT78 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT78 |
Additional cDNA sequence: AK290901.1 AK298636.1 BX647095.1 2 DOTS entries: DT.99997715 DT.101976768 24/251 AceView cDNA sequences (see all 251): NM_175834 BP371899 BQ027522 AK130156 C00570 AJ564105 BE742142 BM697307 BE735977 BM715509 AU077018 BF830977 AW265613 AW082111 BC039148 AA629199 BG741384 BG698586 BG697394 AK098110 BG741061 BG695944 BU742578 BG741716
GeneLoc Exon Structure
|
Expression
for KRT78 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT78 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KRT78 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT78
SOURCE GeneReport for Unigene cluster: Hs.665267
UniProtKB/Swiss-Prot: K2C78_HUMAN, Q8N1N4Tissue specificity: Expressed in tongue, but not in skin or in any other tissues or organs examined
SABiosciences Custom PCR Arrays for KRT78
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT78
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT78 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT78 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT78 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT78 |
Orthologs
for KRT78 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT78 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for KRT78 (if available)
TreeFam Gene Tree for KRT78 (if available) |
Paralogs
for KRT78 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT78 gene
- KRT742 KRT772 KRT6B2 KRT832 KRT762 KRT862 KRT32 KRT842
- KRT82 KRT812 KRT712 KRT8P112 KRT72 ENSG000001704422 KRT792 KRT722
- KRT732 KRT52 KRT6C2 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/37 SIMAP similar genes for KRT78 using alignment to 3 protein entries: K2C78_HUMAN (see all proteins)
(see all similar genes):KRT7 KRT79 KRT121P KRT1 KRTHB6 KRT3
KRT4 KRT75 KRT72 KRT6C KRT74 KRT8
KRT2 KRT73 KRT5 KRT76 KRT1B KRT6A
KRT78 for paralogs About GeneDecksing
|
Genomic Variants
for KRT78 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT78 (53231588 - 53242876 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT78: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT78 |
|
Disorders
/ Diseases
for KRT78 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT78 for disorders About GeneDecksing
OMIM gene information: 611159
OMIM disorders: --
4  diseases for KRT78: About MalaCardshepatocellular carcinoma pharyngitis carcinoma neuronitis
Export disorders for KRT78 gene to outside databases
|
Publications
for KRT78 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT78 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with KRT78) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2 Hesse M.... Weber K. (2001)
- The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for KRT78 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT78 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT78 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT78 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT78 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT78 gene:
Search GeneIP for patents involving KRT78
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT78 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT78 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT78 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT78 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT78 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT78 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT78 |
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 | | | KRT78 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT78 |
|  |  |  | | | | ThermoFisher Antibodies for KRT78 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT78 |
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