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Aliases for KRT78 Gene

Aliases for KRT78 Gene

  • Keratin 78 2 3 5
  • Type-II Keratin Kb40 3 4
  • Keratin 78, Type II 2 3
  • Cytokeratin-78 3 4
  • Keratin-5b 3 4
  • CK-78 3 4
  • Kb40 3 4
  • K5B 3 4
  • K78 3 4
  • Keratin, Type II Cytoskeletal 78 3
  • Keratin-78 4

External Ids for KRT78 Gene

Previous GeneCards Identifiers for KRT78 Gene

  • GC12M051518
  • GC12M053232
  • GC12M050276

Summaries for KRT78 Gene

Entrez Gene Summary for KRT78 Gene

  • This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT78 Gene

KRT78 (Keratin 78) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT84.

Gene Wiki entry for KRT78 Gene

Additional gene information for KRT78 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT78 Gene

Genomics for KRT78 Gene

Regulatory Elements for KRT78 Gene

Enhancers for KRT78 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H052894 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -53.8 -53836 16.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D AAAS ZNF740 PCBP2 SP1 MAP3K12 LOC100652999 ATF7 CALCOCO1 EIF4B ENSG00000257808
GH12H052491 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +354.5 354536 6.4 STAT1 CEBPB KLF17 SIN3A EBF1 NR3C1 ZIC2 JUND GLIS1 SCRT2 KRT6C KRT5 KRT6A KRT71 KRT82 KRT84 KRT87P KRT86 KRT2 KRT78
GH12H052964 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -116.1 -116053 1.7 ZNF687 POLR2A WT1 ZBTB40 EZH2 KRT78 KRT79 KRT84 KRT86 KRT71 KRT4 KRT87P PCBP2 AMHR2 KRT18
GH12H052869 2 FANTOM5 Ensembl ENCODE dbSUPER 6.4 -24.2 -24234 7.1 HDGF PKNOX1 SIN3A ZBTB7B ZNF766 CBX5 ZNF207 ZNF143 FOS REST AAAS KRT2 LOC100652999 PCBP2 EIF4B SP1 ZNF740 ATF7 KRT84 PFDN5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT78 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRT78 Gene

Genomic Locations for KRT78 Gene
11,289 bases
Minus strand

Genomic View for KRT78 Gene

Genes around KRT78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT78 Gene

Proteins for KRT78 Gene

  • Protein details for KRT78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 78
    Protein Accession:
    Secondary Accessions:
    • A8K4D6
    • Q5HYM7
    • Q7RTT2

    Protein attributes for KRT78 Gene

    520 amino acids
    Molecular mass:
    56866 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
    • Sequence=DAA00377.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KRT78 Gene


neXtProt entry for KRT78 Gene

Post-translational modifications for KRT78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT78 Gene

No data available for DME Specific Peptides for KRT78 Gene

Domains & Families for KRT78 Gene

Gene Families for KRT78 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT78 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT78: view

Function for KRT78 Gene

Phenotypes From GWAS Catalog for KRT78 Gene

Gene Ontology (GO) - Molecular Function for KRT78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT78: view
genes like me logo Genes that share phenotypes with KRT78: view

Animal Model Products

CRISPR Products

miRNA for KRT78 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT78 Gene

Localization for KRT78 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT78 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT78: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT78 Gene

Pathways & Interactions for KRT78 Gene

SuperPathways for KRT78 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT78: view

Pathways by source for KRT78 Gene

2 Reactome pathways for KRT78 Gene

Interacting Proteins for KRT78 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000306261 Q8N1N4-K2C78_HUMAN for KRT78 Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for KRT78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT78: view

No data available for SIGNOR curated interactions for KRT78 Gene

Drugs & Compounds for KRT78 Gene

No Compound Related Data Available

Transcripts for KRT78 Gene

Unigene Clusters for KRT78 Gene

Keratin 78:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT78 Gene

No ASD Table

Relevant External Links for KRT78 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT78 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT78 Gene

mRNA differential expression in normal tissues according to GTEx for KRT78 Gene

This gene is overexpressed in Esophagus - Mucosa (x29.3), Cervix - Ectocervix (x7.0), Vagina (x6.0), and Skin - Sun Exposed (Lower leg) (x4.2).

Protein differential expression in normal tissues from HIPED for KRT78 Gene

This gene is overexpressed in Saliva (42.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT78 Gene

Protein tissue co-expression partners for KRT78 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT78 Gene:


SOURCE GeneReport for Unigene cluster for KRT78 Gene:


mRNA Expression by UniProt/SwissProt for KRT78 Gene:

Tissue specificity: In non-keratinising esophageal and vaginal epithelium, strongly expressed in the basal and parabasal/lower suprabasal cell layers with considerably decreased expression in the mid/upper suprabasal layers (at protein level) (PubMed:26340985). A similar gradient from basal to lower suprabasal layers is seen in the partially keratinised dorsal tongue epithelium, in the scalp and in the plantar epidermis (at protein level) (PubMed:26340985). Extension of expression into the suprabasal compartments is distinctly more pronounced in non-keratinising epithelia than in keratinising epithelia and epidermis (at protein level) (PubMed:26340985). In scalp sections, present in the interfollicular epidermis and infundibulum including the entire outer root sheath of the hair follicles and also in the sebocytes (at protein level) (PubMed:26340985). In sweat glands, expressed in peripheral and luminal cells of the lower duct and in peripheral cells of the middle/upper duct with no expression observed in luminal cells (at protein level) (PubMed:26340985). In embryos at the 14th week of pregnancy, detected in basal and parabasal layers but is absent from the uppermost epidermal layer (at protein level) (PubMed:26340985). Expressed in tongue epithelium (PubMed:15737194).
genes like me logo Genes that share expression patterns with KRT78: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT78 Gene

Orthologs for KRT78 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT78 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT78 33 34
  • 98.72 (n)
(Bos Taurus)
Mammalia KRT78 33 34
  • 84.24 (n)
(Canis familiaris)
Mammalia KRT78 33 34
  • 82.2 (n)
(Rattus norvegicus)
Mammalia Krt78 33
  • 76.98 (n)
(Mus musculus)
Mammalia Krt78 33 16 34
  • 76.65 (n)
(Monodelphis domestica)
Mammalia KRT78 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia KRT78 34
  • 39 (a)
(Gallus gallus)
Aves KRT78 34
  • 41 (a)
(Anolis carolinensis)
Reptilia KRT78 34
  • 38 (a)
Species where no ortholog for KRT78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT78 Gene

Gene Tree for KRT78 (if available)
Gene Tree for KRT78 (if available)

Paralogs for KRT78 Gene

Paralogs for KRT78 Gene

genes like me logo Genes that share paralogs with KRT78: view

Variants for KRT78 Gene

Sequence variations from dbSNP and Humsavar for KRT78 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000796199 -- 52,839,704(+) ACTGT(A/G)TTGGC intron-variant
rs1001068331 -- 52,844,126(+) TGCAG(C/T)CTCTG reference, synonymous-codon
rs1001113238 -- 52,837,746(+) GGGCC(A/G)AATCC downstream-variant-500B
rs1001373091 -- 52,850,118(+) CCCAG(A/C)ACTTT upstream-variant-2KB
rs1001397543 -- 52,845,490(+) TATCT(C/T)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT78 Gene

Variant ID Type Subtype PubMed ID
nsv1048816 CNV gain 25217958
nsv711 CNV insertion 18451855
nsv832416 CNV loss 17160897

Variation tolerance for KRT78 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.64; 93.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT78 Gene

Disorders for KRT78 Gene

Relevant External Links for KRT78

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT78 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT78 Gene

Publications for KRT78 Gene

  1. Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression. (PMID: 26340985) Langbein L … Schweizer J (Cell and tissue research 2016) 3 4 60
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 60
  3. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers MA … Schweizer J (The Journal of investigative dermatology 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M … Weber K (Journal of cell science 2001) 3 4 60

Products for KRT78 Gene

Sources for KRT78 Gene

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