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Aliases for KRT78 Gene

Aliases for KRT78 Gene

  • Keratin 78, Type II 2 3
  • K5B 3 4 6
  • Type-II Keratin Kb40 3 4
  • Cytokeratin-78 3 4
  • Keratin-5b 3 4
  • CK-78 3 4
  • Kb40 3 4
  • K78 3 4
  • Keratin, Type II Cytoskeletal 78 3
  • Keratin 78 2
  • Keratin-78 4

External Ids for KRT78 Gene

Previous GeneCards Identifiers for KRT78 Gene

  • GC12M051518
  • GC12M053232
  • GC12M050276

Summaries for KRT78 Gene

Entrez Gene Summary for KRT78 Gene

  • This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT78 Gene

KRT78 (Keratin 78, Type II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT80.

Gene Wiki entry for KRT78 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT78 Gene

Genomics for KRT78 Gene

Regulatory Elements for KRT78 Gene

Genomic Location for KRT78 Gene

Start:
52,837,804 bp from pter
End:
52,849,092 bp from pter
Size:
11,289 bases
Orientation:
Minus strand

Genomic View for KRT78 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT78 Gene

Proteins for KRT78 Gene

  • Protein details for KRT78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1N4-K2C78_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 78
    Protein Accession:
    Q8N1N4
    Secondary Accessions:
    • A8K4D6
    • Q5HYM7
    • Q7RTT2

    Protein attributes for KRT78 Gene

    Size:
    520 amino acids
    Molecular mass:
    56866 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)
    SequenceCaution:
    • Sequence=DAA00377.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KRT78 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT78 Gene

Proteomics data for KRT78 Gene at MOPED

Post-translational modifications for KRT78 Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT78 Gene

No data available for DME Specific Peptides for KRT78 Gene

Domains for KRT78 Gene

Gene Families for KRT78 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT78 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1N4

UniProtKB/Swiss-Prot:

K2C78_HUMAN :
  • Q8N1N4
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT78: view

Function for KRT78 Gene

Gene Ontology (GO) - Molecular Function for KRT78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT78: view

Phenotypes for KRT78 Gene

GenomeRNAi human phenotypes for KRT78:
genes like me logo Genes that share phenotypes with KRT78: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT78 Gene

Localization for KRT78 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT78 Gene COMPARTMENTS Subcellular localization image for KRT78 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT78: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT78 Gene

Pathways for KRT78 Gene

SuperPathways for KRT78 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT78 Gene

None

No data available for Pathways by source for KRT78 Gene

Transcripts for KRT78 Gene

Unigene Clusters for KRT78 Gene

Keratin 78:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT78

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT78

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT78 Gene

No ASD Table

Relevant External Links for KRT78 Gene

GeneLoc Exon Structure for
KRT78
ECgene alternative splicing isoforms for
KRT78

Expression for KRT78 Gene

mRNA expression in normal human tissues for KRT78 Gene

mRNA differential expression in normal tissues according to GTEx for KRT78 Gene

This gene is overexpressed in Esophagus - Mucosa (29.3), Cervix - Ectocervix (7.0), Vagina (6.0), and Skin - Sun Exposed (Lower leg) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT78 Gene

SOURCE GeneReport for Unigene cluster for KRT78 Gene Hs.665267

mRNA Expression by UniProt/SwissProt for KRT78 Gene

Q8N1N4-K2C78_HUMAN
Tissue specificity: Expressed in tongue, but not in skin or in any other tissues or organs examined.
genes like me logo Genes that share expressions with KRT78: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRT78 Gene

Orthologs for KRT78 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT78 35
  • 98.72 (n)
  • 98.27 (a)
KRT78 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT78 35
  • 84.24 (n)
  • 78.21 (a)
KRT78 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT78 35
  • 82.2 (n)
  • 74.37 (a)
KRT78 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt78 35
  • 76.65 (n)
  • 67.65 (a)
Krt78 16
Krt78 36
  • 33 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRT78 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT78 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt78 35
  • 76.98 (n)
  • 68.52 (a)
chicken
(Gallus gallus)
Aves KRT78 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT78 36
  • 38 (a)
OneToOne
Species with no ortholog for KRT78:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT78 Gene

ENSEMBL:
Gene Tree for KRT78 (if available)
TreeFam:
Gene Tree for KRT78 (if available)

Paralogs for KRT78 Gene

Paralogs for KRT78 Gene

genes like me logo Genes that share paralogs with KRT78: view

Variants for KRT78 Gene

Sequence variations from dbSNP and Humsavar for KRT78 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2013335 - 52,848,656(+) TCAGC(A/G)GATTC upstream-variant-2KB, missense, reference, utr-variant-5-prime
rs2253798 -- 52,848,795(+) GCACC(C/T)CCCAA upstream-variant-2KB, missense, reference, splice-donor-variant
rs2253800 -- 52,848,901(+) AAGCC(C/T)CTCTG upstream-variant-2KB, synonymous-codon, reference, utr-variant-5-prime
rs2363623 -- 52,850,429(+) TTGGG(A/G)TTCCC upstream-variant-2KB
rs2638494 -- 52,846,746(+) GGAGC(A/G)CTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT78 Gene

Variant ID Type Subtype PubMed ID
nsv832416 CNV Loss 17160897
nsv711 CNV Insertion 18451855

Relevant External Links for KRT78 Gene

HapMap Linkage Disequilibrium report
KRT78

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT78 Gene

Disorders for KRT78 Gene

Relevant External Links for KRT78

Genetic Association Database (GAD)
KRT78
genes like me logo Genes that share disorders with KRT78: view

No data available for UniProtKB/Swiss-Prot for KRT78 Gene

Publications for KRT78 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  2. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M. … Weber K. (J. Cell Sci. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for KRT78 Gene

Sources for KRT78 Gene

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