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KRT77 Gene

protein-coding   GIFtS: 48
GCID: GC12M053083

Keratin 77

(Previous name: keratin 1B)
(Previous symbol: KRT1B)
  Search for KRT77
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 771 2     K1B2 5
KRT1B1 2 3     cytokeratin-1B2
Keratin 1B1 2     Keratin, Type II Cytoskeletal 1b2
Type-II Keratin Kb392 3     keratin-772
CK-1B2 3     Cytokeratin-1B3
K772 3     Keratin-773

External Ids:    HGNC: 204111   Entrez Gene: 3744542   Ensembl: ENSG000001891827   OMIM: 6111585   UniProtKB: Q7Z7943   

Export aliases for KRT77 gene to outside databases

Previous GC identifers: GC12M051370 GC12M050127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT77 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed
in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome
12q13.(provided by RefSeq, Jun 2009)

GeneCards Summary for KRT77 Gene:
KRT77 (keratin 77) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT77 gene promoter:
         PPAR-alpha   CREB   AML1a   p53   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT77 promoter sequence
   Search Chromatin IP Primers for KRT77

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT77


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT77 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT77 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053083:  view genomic region     (about GC identifiers)

Start:
53,083,410 bp from pter      End:
53,097,247 bp from pter
Size:
13,838 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C1B_HUMAN, Q7Z794 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 1b  
Size: 578 amino acids; 61901 Da
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Sequence caution: Sequence=DAA00402.1; Type=Erroneous gene model prediction;
Secondary accessions: Q7RTS8

Explore the universe of human proteins at neXtProt for KRT77: NX_Q7Z794

Explore proteomics data for KRT77 at MOPED

Post-translational modifications: 

  • Undergoes deimination of some arginine residues (citrullination) (By similarity)1
  • Ubiquitination2 at Lys181, Lys253
  • Modification sites at PhosphoSitePlus

  • See KRT77 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778253.2  
    ENSEMBL proteins: 
     ENSP00000342710   ENSP00000448207   ENSP00000440803  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II
     IPR018159 Spectrin/alpha-actinin

    Graphical View of Domain Structure for InterPro Entry Q7Z794

    ProtoNet protein and cluster: Q7Z794

    4 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: K2C1B_HUMAN, Q7Z794
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT77           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with KRT77           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT77
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    miRNA
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    miRTarBase miRNAs that target KRT77:
    hsa-mir-30a-5p (MIRT028485)

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    3 qRT-PCR Assays for microRNAs that regulate KRT77:
    hsa-miR-877* hsa-miR-513b hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidKRT77 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--

    Find genes that share ontologies with KRT77           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT77
    Interactions:

        Search GeneGlobe Interaction Network for KRT77

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for KRT77 (Q7Z7943 ENSP000003427104) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206440Q9UBC13, ENSP000003831424I2D: score=1 STRING: ENSP00000383142
    ENSG00000227565Q9UBC13I2D: score=1 
    ENSG00000234530Q9UBC13I2D: score=1 
    ENSG00000235125Q9UBC13I2D: score=1 
    ENSG00000236196Q9UBC13I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with KRT77           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT77 (K2C1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT77 gene: 
    NM_175078.2  

    Unigene Cluster for KRT77:

    Keratin 77
    Hs.334989  [show with all ESTs]
    Unigene Representative Sequence: NM_175078
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341809(uc001saw.3 uc009zmi.3) ENST00000553168 ENST00000550823
    ENST00000537195
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate KRT77:
    hsa-miR-877* hsa-miR-513b hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidKRT77 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat KRT77

    Additional mRNA sequence: 

    AJ564104.1 BC033366.1 BC118598.1 BC122558.1 

    4 DOTS entries:

    DT.109071  DT.100744145  DT.121118605  DT.75106279 

    5 AceView cDNA sequences:

    AI184458 BC033366 AJ564104 AI093203 NM_175078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT77 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGCCCAG
    KRT77 Expression
    About this image

    KRT77 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT77 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334989

    UniProtKB/Swiss-Prot: K2C1B_HUMAN, Q7Z794
    Tissue specificity: Expressed exclusively in skin

        Custom PCR Arrays for KRT77
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT77

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT77 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt771 , 5 keratin 771, 5 81.07(n)1
    78.96(a)1
      15 (57.08 cM)5
    4062201  NM_001003667.11  NP_001003667.11 
     1018587325 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    2(95440022-95458665)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia krt5.41 keratin 5, gene 4 63.96(n)
    62.16(a)
      448361  NM_001006715.1  NP_001006716.1 


    ENSEMBL Gene Tree for KRT77 (if available)
    TreeFam Gene Tree for KRT77 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT77 gene
    KRT742  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  KRT82  
    KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT77 using alignment to 4 protein entries:     K2C1B_HUMAN (see all proteins) (see all similar genes):
    KRT1B    KRT79    KRT5    KRT7    KRT4    KRT6A
    KRT6B    KRTHB6    KRT8    KRT1    KRT71    KRT6C
    KRT2    KRT76    KRT74    KRT121P    KRT78    KRT75

    Find genes that share paralogs with KRT77           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT77 (see all 438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431356191,2
    --52917480(+) AAGGTA/GGGAGG 1 -- ds50010--------
    rs562465451,2
    C,F--52917620(+) AGAAGA/GAGGAG 1 -- ds50012Minor allele frequency- G:0.14NA EA 240
    rs1998208781,2
    C--52917631(+) GGAGG-/GAGAGGAG 1 -- ds50010--------
    rs1926837031,2
    --52917778(+) AAAGGA/GGAAGA 1 -- ds50010--------
    rs730946661,2
    C,F--52917786(+) AGAAGG/AAGAAG 1 -- ds50012Minor allele frequency- A:0.14NA EA 240
    rs1511507041,2
    C--52917923(+) AAGAAC/TAGCCT 1 -- ut310--------
    rs740937791,2
    C,F--52918056(+) TCAAGG/ACCTGA 1 -- ut313Minor allele frequency- A:0.21WA CSA 122
    rs125783871,2
    C,F,H--52918123(+) AATTAA/GGAGTC 1 -- ut31 ese36Minor allele frequency- G:0.00NS EA NA 568
    rs1401807451,2
    --52918257(+) AACCCC/TTCCAA 1 -- ut310--------
    rs1850216551,2
    --52918265(+) CAAGAA/CCCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT77 (53083410 - 53097247 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for KRT77:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745893CNV Deletion23290073
    esv2659959CNV Deletion23128226
    nsv516955CNV Loss19592680
    esv24797CNV Loss19812545
    nsv832415CNV Loss17160897
    nsv524563CNV Loss19592680
    nsv899092CNV Gain21882294
    nsv428281CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611158    OMIM disorders: --


    Find genes that share disorders with KRT77           About GenesLikeMe

    Genetic Association Database (GAD): KRT77

    Export disorders for KRT77 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT77 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KRT77)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2, 3 Hesse M.... Weber K. (J. Cell Sci. 2001)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (J. Invest. Dermatol. 2005)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374454 HGNC: 20411 AceView: KRT1B Ensembl:ENSG00000189182 euGenes: HUgn374454
    ECgene: KRT77 H-InvDB: KRT77

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT77 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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