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Aliases for KRT77 Gene

Aliases for KRT77 Gene

  • Keratin 77 2 3 5
  • Type-II Keratin Kb39 3 4
  • Keratin 77, Type II 2 3
  • Cytokeratin-1B 3 4
  • Keratin 1B 2 3
  • KRT1B 3 4
  • CK-1B 3 4
  • K77 3 4
  • Keratin, Type II Cytoskeletal 1b 3
  • Keratin-77 4
  • K1B 3

External Ids for KRT77 Gene

Previous HGNC Symbols for KRT77 Gene

  • KRT1B

Previous GeneCards Identifiers for KRT77 Gene

  • GC12M051370
  • GC12M053083
  • GC12M050127

Summaries for KRT77 Gene

Entrez Gene Summary for KRT77 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT77 Gene

KRT77 (Keratin 77) is a Protein Coding gene. Diseases associated with KRT77 include Aggressive Digital Papillary Adenocarcinoma. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT77 Gene

Genomics for KRT77 Gene

Regulatory Elements for KRT77 Gene

Enhancers for KRT77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G052644 1.3 Ensembl ENCODE dbSUPER 11.2 +57.6 57605 3.1 HDGF CREB3L1 ARNT YBX1 RAD21 ZNF121 ZNF766 GATA2 EGR2 PAF1 KRT1 KRT77 KRT79 KRT76 KRT4 KRT84 ENSG00000257700 KRT2 KRT128P
GH12G052229 0.7 ENCODE dbSUPER 5 +475.0 474983 0.2 GATA3 FOS CUX1 KRT77 KRT7 C12orf80
GH12G052225 0.4 dbSUPER 4.7 +477.7 477708 0.8 GLIS1 ZIC2 KRT80 KRT86 KRT87P KRT83 KRT7 KRT81 KRT77 C12orf80
GH12G052867 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -164.2 -164207 1.4 ZNF664 USF1 NFYB KRT2 KRT74 KRT79 KRT4 KRT84 KRT8 KRT1 KRT77 KRT78 RPL7P41
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT77 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT77 Gene

Chromosome:
12
Start:
52,689,612 bp from pter
End:
52,703,534 bp from pter
Size:
13,923 bases
Orientation:
Minus strand

Genomic View for KRT77 Gene

Genes around KRT77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT77 Gene

Proteins for KRT77 Gene

  • Protein details for KRT77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z794-K2C1B_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 1b
    Protein Accession:
    Q7Z794
    Secondary Accessions:
    • Q7RTS8

    Protein attributes for KRT77 Gene

    Size:
    578 amino acids
    Molecular mass:
    61901 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    SequenceCaution:
    • Sequence=DAA00402.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KRT77 Gene

Post-translational modifications for KRT77 Gene

  • Undergoes deimination of some arginine residues (citrullination).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT77 Gene

No data available for DME Specific Peptides for KRT77 Gene

Domains & Families for KRT77 Gene

Gene Families for KRT77 Gene

Suggested Antigen Peptide Sequences for KRT77 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z794

UniProtKB/Swiss-Prot:

K2C1B_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT77: view

Function for KRT77 Gene

Gene Ontology (GO) - Molecular Function for KRT77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT77: view
genes like me logo Genes that share phenotypes with KRT77: view

Animal Model Products

miRNA for KRT77 Gene

miRTarBase miRNAs that target KRT77

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT77 Gene

Localization for KRT77 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT77 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IDA 16117782
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT77: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT77 Gene

Pathways & Interactions for KRT77 Gene

SuperPathways for KRT77 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT77: view

Pathways by source for KRT77 Gene

2 Reactome pathways for KRT77 Gene

Gene Ontology (GO) - Biological Process for KRT77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT77: view

No data available for SIGNOR curated interactions for KRT77 Gene

Drugs & Compounds for KRT77 Gene

No Compound Related Data Available

Transcripts for KRT77 Gene

mRNA/cDNA for KRT77 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT77 Gene

Keratin 77:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT77 Gene

No ASD Table

Relevant External Links for KRT77 Gene

GeneLoc Exon Structure for
KRT77
ECgene alternative splicing isoforms for
KRT77

Expression for KRT77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT77 Gene

mRNA differential expression in normal tissues according to GTEx for KRT77 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x33.5) and Skin - Sun Exposed (Lower leg) (x19.0).

Protein differential expression in normal tissues from HIPED for KRT77 Gene

This gene is overexpressed in Brain (17.1), Skin (16.9), and Serum (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT77 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT77 Gene:

KRT77

SOURCE GeneReport for Unigene cluster for KRT77 Gene:

Hs.334989

mRNA Expression by UniProt/SwissProt for KRT77 Gene:

Q7Z794-K2C1B_HUMAN
Tissue specificity: Expressed exclusively in skin.

Evidence on tissue expression from TISSUES for KRT77 Gene

  • Skin(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT77: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT77 Gene

Orthologs for KRT77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT77 34 35
  • 98.27 (n)
dog
(Canis familiaris)
Mammalia KRT77 34
  • 83.69 (n)
cow
(Bos Taurus)
Mammalia KRT77 34 35
  • 83.09 (n)
mouse
(Mus musculus)
Mammalia Krt77 34 16 35
  • 81.07 (n)
rat
(Rattus norvegicus)
Mammalia Krt77 34
  • 80.71 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia krt5.4 34
  • 63.96 (n)
Species where no ortholog for KRT77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT77 Gene

ENSEMBL:
Gene Tree for KRT77 (if available)
TreeFam:
Gene Tree for KRT77 (if available)

Paralogs for KRT77 Gene

Variants for KRT77 Gene

Sequence variations from dbSNP and Humsavar for KRT77 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000048299 -- 52,698,222(+) GTTTC(A/G)GAGCA intron-variant, utr-variant-5-prime
rs1000141410 -- 52,697,950(+) TCCCC(A/C)ATAAG intron-variant
rs1000999236 -- 52,692,107(+) AAGCC(A/G)GTGGG intron-variant
rs1001188245 -- 52,702,455(+) GTGGA(C/T)GGGTG intron-variant
rs1001862973 -- 52,693,757(+) AACAA(C/T)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT77 Gene

Variant ID Type Subtype PubMed ID
dgv2634n54 CNV loss 21841781
dgv2635n54 CNV loss 21841781
dgv2636n54 CNV loss 21841781
dgv2637n54 CNV loss 21841781
dgv2638n54 CNV loss 21841781
dgv2639n54 CNV loss 21841781
dgv2640n54 CNV loss 21841781
esv24797 CNV loss 19812545
esv2659959 CNV deletion 23128226
esv2745893 CNV deletion 23290073
esv3549223 CNV deletion 23714750
esv3629524 CNV gain 21293372
esv3629525 CNV loss 21293372
nsv428281 CNV gain 18775914
nsv516955 CNV loss 19592680
nsv524563 CNV loss 19592680
nsv832415 CNV loss 17160897

Variation tolerance for KRT77 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.29; 96.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT77 Gene

Disorders for KRT77 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT77 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aggressive digital papillary adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT77 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT77

Genetic Association Database (GAD)
KRT77
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT77
genes like me logo Genes that share disorders with KRT77: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT77 Gene

Publications for KRT77 Gene

  1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M. … Weber K. (J. Cell Sci. 2001) 2 3 4 64
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for KRT77 Gene

Sources for KRT77 Gene

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