KRT77 Gene
protein-coding GIFtS: 45
GCID: GC12M053083
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|
keratin 77(Previous name: keratin 1B )
(Previous symbol: KRT1B)
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Aliases
for KRT77 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 771 2 | | K1B2 5 | | KRT1B1 2 3 | | Cytokeratin-1B3 | | Keratin 1B1 2 | | Keratin, Type II Cytoskeletal 1b2 | | Type-II Keratin Kb392 3 | | Keratin-773 | | CK-1B2 3 | | Cytokeratin-1B3 | | K772 3 | | Keratin-773 |
Export aliases for KRT77 gene to outside databasesPrevious GC identifers: GC12M051370 GC12M050127 |
Summaries
for KRT77 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT77:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and aresubdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed inthe skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.(provided byRefSeq, Jun 2009)
|
Genomic Views
for KRT77 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT77 gene promoter:
PPAR-alpha CREB AML1a p53 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT77
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT77 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13KRT77 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M053083: view genomic region
(about GC identifiers)
Start:
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53,083,410 bp from pter |
End:
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53,097,247 bp from pter |
Size:
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13,838 bases |
Orientation:
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minus strand |
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Proteins
for KRT77 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K2C1B_HUMAN, Q7Z794 (See
protein sequence)Recommended Name: Keratin, type II cytoskeletal 1b Size: 578 amino acids; 61901 Da
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral tobasic; 56-70 kDa)
Sequence caution: Sequence=DAA00402.1; Type=Erroneous gene model prediction;
Secondary accessions: Q7RTS8Explore the universe of human proteins at neXtProt for KRT77: NX_Q7Z794
Post-translational modifications:
Undergoes deimination of some arginine residues (citrullination) (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z794
KRT77 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778253.2
ENSEMBL proteins: ENSP00000342710 ENSP00000448207 ENSP00000440803
Human Recombinant Protein Products for KRT77:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0045095 | keratin filament |
IEA | -- |
KRT77 for ontologies About GeneDecksing
KRT77 Antibody Products:
Assay Products for KRT77: |
Protein
Domains /
Families
for KRT77 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT77 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z794ProtoNet protein and cluster: Q7Z794 4 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature IPB011072 Protein kinase PKN/PRK1
UniProtKB/Swiss-Prot: K2C1B_HUMAN, Q7Z794Similarity: Belongs to the intermediate filament family |
Function
for KRT77 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005198 | structural molecule activity |
IEA | -- |
KRT77 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT77 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT77
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT77 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT77 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT77 |
|
Pathways & Interactions
for KRT77 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT77
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/12 Interacting proteins for KRT77 (Q7Z7943 ENSP000003427104) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
KRT77 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT77 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT77
Search CenterWatch for drugs/clinical trials and news about KRT77 / K2C1B
|
Transcripts
for KRT77 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT77 gene: NM_175078.2 Unigene Cluster for KRT77: Keratin 77 Hs.334989 [show with all ESTs]Unigene Representative Sequence: NM_1750784 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341809(uc001saw.3 uc009zmi.3) ENST00000553168 ENST00000550823
ENST00000537195
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT77 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT77
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT77 (NM_175078) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT77 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT77 |
Additional cDNA sequence: AJ564104.1 BC033366.1 BC118598.1 BC122558.1 4 DOTS entries: DT.109071 DT.100744145 DT.121118605 DT.75106279 5 AceView cDNA sequences: AI184458 AI093203 BC033366 AJ564104 NM_175078
GeneLoc Exon Structure
|
Expression
for KRT77 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT77 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGCCCAG
About this image
See KRT77 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT77
SOURCE GeneReport for Unigene cluster: Hs.334989
UniProtKB/Swiss-Prot: K2C1B_HUMAN, Q7Z794Tissue specificity: Expressed exclusively in skin
SABiosciences Custom PCR Arrays for KRT77
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT77
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT77 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT77 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT77 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT77 |
Orthologs
for KRT77 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT77 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for KRT77 (if available)
TreeFam Gene Tree for KRT77 (if available) |
Paralogs
for KRT77 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT77 gene
- KRT742 KRT6B2 KRT832 KRT762 KRT862 KRT32 KRT842 KRT82
- KRT812 KRT712 KRT8P112 KRT782 KRT72 ENSG000001704422 KRT792 KRT722
- KRT732 KRT52 KRT6C2 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/44 SIMAP similar genes for KRT77 using alignment to 4 protein entries: K2C1B_HUMAN (see all proteins)
(see all similar genes):KRT1B KRT79 KRT5 KRT7 KRT4 KRT6A
KRT6B KRTHB6 KRT1 KRT71 KRT8 KRT6C
KRT2 KRT76 KRT74 KRT121P KRT78 KRT75
KRT77 for paralogs About GeneDecksing
|
Genomic Variants
for KRT77 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT77 (53083410 - 53097247 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRT77
1 CNV: 66225
1 Indel: 49088 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT77 |
|
Disorders
/ Diseases
for KRT77 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT77 for disorders About GeneDecksing
OMIM gene information: 611158
OMIM disorders: --
2  diseases for KRT77: About MalaCardspharyngitis neuronitis
Export disorders for KRT77 gene to outside databases
|
Publications
for KRT77 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT77 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with KRT77) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2, 3 Hesse M.... Weber K. (2001)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
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External Searches for KRT77 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT77 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT77 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT77 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT77 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT77 gene:
Search GeneIP for patents involving KRT77
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT77 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT77 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT77 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT77 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT77 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT77 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT77 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KRT77 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT77 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT77 |
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