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Aliases for KRT77 Gene

Aliases for KRT77 Gene

  • Keratin 77, Type II 2 3
  • Type-II Keratin Kb39 3 4
  • Cytokeratin-1B 3 4
  • Keratin 1B 2 3
  • Keratin-77 3 4
  • KRT1B 3 4
  • CK-1B 3 4
  • K1B 3 6
  • K77 3 4
  • Keratin, Type II Cytoskeletal 1b 3
  • Keratin 77 2

External Ids for KRT77 Gene

Previous HGNC Symbols for KRT77 Gene

  • KRT1B

Previous GeneCards Identifiers for KRT77 Gene

  • GC12M051370
  • GC12M053083
  • GC12M050127

Summaries for KRT77 Gene

Entrez Gene Summary for KRT77 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT77 Gene

KRT77 (Keratin 77, Type II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT77 Gene

Genomics for KRT77 Gene

Regulatory Elements for KRT77 Gene

Genomic Location for KRT77 Gene

Start:
52,689,612 bp from pter
End:
52,703,463 bp from pter
Size:
13,852 bases
Orientation:
Minus strand

Genomic View for KRT77 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT77 Gene

Proteins for KRT77 Gene

  • Protein details for KRT77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z794-K2C1B_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 1b
    Protein Accession:
    Q7Z794
    Secondary Accessions:
    • Q7RTS8

    Protein attributes for KRT77 Gene

    Size:
    578 amino acids
    Molecular mass:
    61901 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)
    SequenceCaution:
    • Sequence=DAA00402.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KRT77 Gene

Proteomics data for KRT77 Gene at MOPED

Post-translational modifications for KRT77 Gene

  • Undergoes deimination of some arginine residues (citrullination).
  • Ubiquitination at Lys181 and Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT77 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT77 Gene

Domains for KRT77 Gene

Gene Families for KRT77 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT77 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z794

UniProtKB/Swiss-Prot:

K2C1B_HUMAN :
  • Q7Z794
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT77: view

Function for KRT77 Gene

Gene Ontology (GO) - Molecular Function for KRT77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT77: view

Animal Model Products

miRNA for KRT77 Gene

miRTarBase miRNAs that target KRT77

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRT77 Gene

Localization for KRT77 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT77 Gene COMPARTMENTS Subcellular localization image for KRT77 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IDA 16117782
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT77: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT77 Gene

Pathways for KRT77 Gene

SuperPathways for KRT77 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRT77: view

No data available for Pathways by source for KRT77 Gene

Transcripts for KRT77 Gene

mRNA/cDNA for KRT77 Gene

(5) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT77 Gene

Keratin 77:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT77

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT77

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT77 Gene

No ASD Table

Relevant External Links for KRT77 Gene

GeneLoc Exon Structure for
KRT77
ECgene alternative splicing isoforms for
KRT77

Expression for KRT77 Gene

mRNA expression in normal human tissues for KRT77 Gene

mRNA differential expression in normal tissues according to GTEx for KRT77 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (33.5) and Skin - Sun Exposed (Lower leg) (19.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT77 Gene

SOURCE GeneReport for Unigene cluster for KRT77 Gene Hs.334989

mRNA Expression by UniProt/SwissProt for KRT77 Gene

Q7Z794-K2C1B_HUMAN
Tissue specificity: Expressed exclusively in skin.
genes like me logo Genes that share expressions with KRT77: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRT77 Gene

Orthologs for KRT77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT77 35
  • 98.27 (n)
  • 96.71 (a)
KRT77 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT77 35
  • 83.09 (n)
  • 80.08 (a)
KRT77 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT77 35
  • 83.69 (n)
  • 81.47 (a)
mouse
(Mus musculus)
Mammalia Krt77 35
  • 81.07 (n)
  • 78.96 (a)
Krt77 16
Krt77 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt77 35
  • 80.71 (n)
  • 81.25 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia krt5.4 35
  • 63.96 (n)
  • 62.16 (a)
Species with no ortholog for KRT77:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT77 Gene

ENSEMBL:
Gene Tree for KRT77 (if available)
TreeFam:
Gene Tree for KRT77 (if available)

Paralogs for KRT77 Gene

genes like me logo Genes that share paralogs with KRT77: view

Variants for KRT77 Gene

Sequence variations from dbSNP and Humsavar for KRT77 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs582143 -- 52,700,545(-) CACCA(G/T)CATCC intron-variant
rs585664 -- 52,694,741(-) CCTGT(C/T)CATGG reference, missense
rs588706 -- 52,696,284(-) GACAA(C/T)GGCAG intron-variant
rs601072 -- 52,693,627(-) AAGGG(C/T)GTGGC intron-variant
rs624444 -- 52,701,524(-) CCCAC(A/G)GGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT77 Gene

Variant ID Type Subtype PubMed ID
nsv832415 CNV Loss 17160897
nsv428281 CNV Gain 18775914
nsv899092 CNV Gain 21882294
nsv524563 CNV Loss 19592680
esv2659959 CNV Deletion 23128226
esv2745893 CNV Deletion 23290073
esv24797 CNV Loss 19812545
nsv516955 CNV Loss 19592680

Relevant External Links for KRT77 Gene

HapMap Linkage Disequilibrium report
KRT77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT77 Gene

Disorders for KRT77 Gene

Relevant External Links for KRT77

Genetic Association Database (GAD)
KRT77
genes like me logo Genes that share disorders with KRT77: view

No data available for UniProtKB/Swiss-Prot for KRT77 Gene

Publications for KRT77 Gene

  1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M. … Weber K. (J. Cell Sci. 2001) 2 3 4
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  4. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for KRT77 Gene

Sources for KRT77 Gene

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