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Aliases for KRT76 Gene

Aliases for KRT76 Gene

  • Keratin 76 2 3 5
  • Keratin 76, Type II 2 3
  • Type-II Keratin Kb9 3 4
  • Cytokeratin-2P 3 4
  • CK-2P 3 4
  • KRT2B 3 4
  • KRT2P 3 4
  • K2P 3 4
  • K76 3 4
  • Keratin, Type II Cytoskeletal 2 Oral 3
  • Cytokeratin 2 3
  • Keratin 2p 3
  • Keratin-76 4
  • HUMCYT2A 3

External Ids for KRT76 Gene

Previous GeneCards Identifiers for KRT76 Gene

  • GC12M051450
  • GC12M053161
  • GC12M050205

Summaries for KRT76 Gene

Entrez Gene Summary for KRT76 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009]

GeneCards Summary for KRT76 Gene

KRT76 (Keratin 76) is a Protein Coding gene. Among its related pathways are Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT3.

UniProtKB/Swiss-Prot for KRT76 Gene

  • Probably contributes to terminal cornification.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT76 Gene

Genomics for KRT76 Gene

Regulatory Elements for KRT76 Gene

Enhancers for KRT76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F052859 1.2 FANTOM5 Ensembl ENCODE 10.4 -83.1 -83075 1.8 ZNF687 RFX1 CEBPB MNT DPF2 CEBPG RFX5 SREBF1 CTBP1 KLF9 KRT79 KRT4 KRT76 KRT1 KRT2 KRT83 KRT71 KRT6A RARG KRT5
GH12F052644 1.1 Ensembl ENCODE 10.3 +131.4 131416 3.1 HDGF CTCF KLF1 ARNT CREB3L1 YBX1 RAD21 ZNF121 ZFHX2 POLR2A KRT1 KRT77 KRT79 KRT76 KRT4 KRT84 ENSG00000257700 KRT2 KRT128P
GH12F052713 0.4 Ensembl 10.1 +63.0 63002 1.6 SUZ12 L3MBTL2 TEAD4 MAX ZIC2 HIC1 ZNF121 ZFHX2 POLR2A ZNF341 KRT1 KRT76 KRT71 KRT77 ENSG00000272724 AAAS KRT126P
GH12F052609 1 Ensembl ENCODE 10.1 +167.0 167037 2.2 CTCF PKNOX1 SIN3A ZNF335 ZNF316 ADNP TRIM24 MAFK RFX1 CEBPB KRT72 MAP3K12 KRT2 KRT71 KRT78 KRT76 KRT79 KRT73 GC12P052616
GH12F052579 1.4 FANTOM5 Ensembl ENCODE 9.5 +195.8 195814 3.9 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF207 FOS DEK ZNF263 SP5 KRT72 KRT1 KRT71 KRT78 KRT79 KRT2 KRT84 KRT4 KRT6C KRT76
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KRT76 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT76 Gene

52,768,155 bp from pter
52,777,345 bp from pter
9,191 bases
Minus strand

Genomic View for KRT76 Gene

Genes around KRT76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT76 Gene

Proteins for KRT76 Gene

  • Protein details for KRT76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 2 oral
    Protein Accession:
    Secondary Accessions:
    • B4DRR3
    • Q7Z795

    Protein attributes for KRT76 Gene

    638 amino acids
    Molecular mass:
    65841 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    • Sequence=BAG61375.1; Type=Erroneous termination; Positions=267; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for KRT76 Gene

Post-translational modifications for KRT76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT76 Gene

Domains & Families for KRT76 Gene

Gene Families for KRT76 Gene

Suggested Antigen Peptide Sequences for KRT76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT76: view

Function for KRT76 Gene

Molecular function for KRT76 Gene

UniProtKB/Swiss-Prot Function:
Probably contributes to terminal cornification.

Gene Ontology (GO) - Molecular Function for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT76: view
genes like me logo Genes that share phenotypes with KRT76: view

Animal Models for KRT76 Gene

MGI Knock Outs for KRT76:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KRT76 Gene

Localization for KRT76 Gene

Subcellular locations from

Jensen Localization Image for KRT76 Gene COMPARTMENTS Subcellular localization image for KRT76 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005882 intermediate filament NAS 1282112
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT76: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT76 Gene

Pathways & Interactions for KRT76 Gene

SuperPathways for KRT76 Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRT76: view

Pathways by source for KRT76 Gene

1 Reactome pathway for KRT76 Gene

Gene Ontology (GO) - Biological Process for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 1282112
GO:0008544 epidermis development IEA --
GO:0048733 sebaceous gland development IEA --
genes like me logo Genes that share ontologies with KRT76: view

No data available for SIGNOR curated interactions for KRT76 Gene

Transcripts for KRT76 Gene

mRNA/cDNA for KRT76 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(251) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT76 Gene

Keratin 76:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT76 Gene

No ASD Table

Relevant External Links for KRT76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT76 Gene

mRNA differential expression in normal tissues according to GTEx for KRT76 Gene

This gene is overexpressed in Minor Salivary Gland (x32.4), Skin - Not Sun Exposed (Suprapubic) (x4.9), and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for KRT76 Gene

This gene is overexpressed in Saliva (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT76 Gene

Protein tissue co-expression partners for KRT76 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT76 Gene:


SOURCE GeneReport for Unigene cluster for KRT76 Gene:

genes like me logo Genes that share expression patterns with KRT76: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRT76 Gene

Orthologs for KRT76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT76 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT76 34 35
  • 99.17 (n)
(Mus musculus)
Mammalia Krt76 34 16 35
  • 88.08 (n)
(Rattus norvegicus)
Mammalia Krt76 34
  • 86.96 (n)
(Bos Taurus)
Mammalia LOC100336907 34
  • 85.17 (n)
-- 35
  • 71 (a)
(Canis familiaris)
Mammalia LOC100683401 34
  • 84.94 (n)
KRT76 35
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
(Gallus gallus)
Aves -- 35
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
Species where no ortholog for KRT76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT76 Gene

Gene Tree for KRT76 (if available)
Gene Tree for KRT76 (if available)

Paralogs for KRT76 Gene Pseudogenes for KRT76 Gene

genes like me logo Genes that share paralogs with KRT76: view

Variants for KRT76 Gene

Sequence variations from dbSNP and Humsavar for KRT76 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036368 A breast cancer sample
rs10876339 -- 52,767,984(+) CCTGG(A/G)CAGAC downstream-variant-500B
rs10876340 -- 52,769,683(+) GCCCC(A/C)CTAGG intron-variant
rs10876341 -- 52,774,378(+) TGTGC(G/T)CTCAT intron-variant
rs10876342 -- 52,774,959(+) TGGAC(C/G)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT76 Gene

Variant ID Type Subtype PubMed ID
esv3306574 CNV mobile element insertion 20981092
esv3424879 CNV insertion 20981092
esv3629524 CNV gain 21293372
nsv528616 CNV loss 19592680
nsv558964 CNV loss 21841781
nsv976622 CNV duplication 23825009

Variation tolerance for KRT76 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.51; 96.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT76 Gene

Disorders for KRT76 Gene

Relevant External Links for KRT76

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRT76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT76 Gene

Publications for KRT76 Gene

  1. Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. (PMID: 1282112) Collin C. … Franke W.W. (Differentiation 1992) 2 3 4 22 64
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3 64
  3. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64

Products for KRT76 Gene

Sources for KRT76 Gene

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