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Aliases for KRT76 Gene

Aliases for KRT76 Gene

  • Keratin 76, Type II 2 3
  • Type-II Keratin Kb9 3 4
  • Cytokeratin-2P 3 4
  • Keratin-76 3 4
  • CK-2P 3 4
  • KRT2B 3 4
  • KRT2P 3 4
  • K2P 3 4
  • K76 3 4
  • Keratin, Type II Cytoskeletal 2 Oral 3
  • Cytokeratin 2 3
  • Keratin 76 2
  • Keratin 2p 3
  • HUMCYT2A 3

External Ids for KRT76 Gene

Previous GeneCards Identifiers for KRT76 Gene

  • GC12M051450
  • GC12M053161
  • GC12M050205

Summaries for KRT76 Gene

Entrez Gene Summary for KRT76 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009]

GeneCards Summary for KRT76 Gene

KRT76 (Keratin 76, Type II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT76 Gene

  • Probably contributes to terminal cornification.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT76 Gene

Genomics for KRT76 Gene

Regulatory Elements for KRT76 Gene

Genomic Location for KRT76 Gene

Start:
52,768,155 bp from pter
End:
52,777,345 bp from pter
Size:
9,191 bases
Orientation:
Minus strand

Genomic View for KRT76 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT76 Gene

Proteins for KRT76 Gene

  • Protein details for KRT76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01546-K22O_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 2 oral
    Protein Accession:
    Q01546
    Secondary Accessions:
    • B4DRR3
    • Q7Z795

    Protein attributes for KRT76 Gene

    Size:
    638 amino acids
    Molecular mass:
    65841 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)
    SequenceCaution:
    • Sequence=BAG61375.1; Type=Erroneous termination; Positions=267; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for KRT76 Gene

Proteomics data for KRT76 Gene at MOPED

Post-translational modifications for KRT76 Gene

  • Ubiquitination at Lys193, Lys200, and Lys272
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT76 Gene

Domains for KRT76 Gene

Gene Families for KRT76 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01546

UniProtKB/Swiss-Prot:

K22O_HUMAN :
  • Q01546
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT76: view

Function for KRT76 Gene

Molecular function for KRT76 Gene

UniProtKB/Swiss-Prot Function: Probably contributes to terminal cornification.

Gene Ontology (GO) - Molecular Function for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT76: view
genes like me logo Genes that share phenotypes with KRT76: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT76

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT76 Gene

Localization for KRT76 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT76 Gene COMPARTMENTS Subcellular localization image for KRT76 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005882 intermediate filament NAS 1282112
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT76: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT76 Gene

Pathways for KRT76 Gene

SuperPathways for KRT76 Gene

No Data Available

Interacting Proteins for KRT76 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330101%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000300574%0d%0a9606.ENSP00000356641%0d%0a9606.ENSP00000384109%0d%0a9606.ENSP00000364589%0d%0a
Selected Interacting proteins: ENSP00000330101 Q01546-K22O_HUMAN for KRT76 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 1282112
genes like me logo Genes that share ontologies with KRT76: view

No data available for Pathways by source for KRT76 Gene

Transcripts for KRT76 Gene

mRNA/cDNA for KRT76 Gene

(251) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT76 Gene

Keratin 76:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT76

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT76

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT76 Gene

No ASD Table

Relevant External Links for KRT76 Gene

GeneLoc Exon Structure for
KRT76
ECgene alternative splicing isoforms for
KRT76

Expression for KRT76 Gene

mRNA expression in normal human tissues for KRT76 Gene

mRNA differential expression in normal tissues according to GTEx for KRT76 Gene

This gene is overexpressed in Minor Salivary Gland (32.4), Skin - Not Sun Exposed (Suprapubic) (4.9), and Esophagus - Mucosa (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT76 Gene

SOURCE GeneReport for Unigene cluster for KRT76 Gene Hs.654392

genes like me logo Genes that share expressions with KRT76: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRT76 Gene

Orthologs for KRT76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT76 35
  • 99.17 (n)
  • 98.66 (a)
KRT76 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
ManyToMany
LOC100336907 35
  • 85.17 (n)
  • 81.36 (a)
dog
(Canis familiaris)
Mammalia KRT76 36
  • 83 (a)
OneToOne
LOC100683401 35
  • 84.94 (n)
  • 86.23 (a)
mouse
(Mus musculus)
Mammalia Krt76 35
  • 88.08 (n)
  • 88.27 (a)
Krt76 16
Krt76 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Krt76 35
  • 86.96 (n)
  • 87.71 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
Species with no ortholog for KRT76:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT76 Gene

ENSEMBL:
Gene Tree for KRT76 (if available)
TreeFam:
Gene Tree for KRT76 (if available)

Paralogs for KRT76 Gene

Pseudogenes.org Pseudogenes for KRT76 Gene

genes like me logo Genes that share paralogs with KRT76: view

Variants for KRT76 Gene

Sequence variations from dbSNP and Humsavar for KRT76 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1464423 -- 52,768,989(-) AGCAG(C/T)GGCTA synonymous-codon, reference
rs2280479 -- 52,768,854(-) ATCTC(C/T)GTGAG reference, synonymous-codon
rs2280480 - 52,768,744(-) GACCA(C/T)GAGCT reference, missense
rs2280481 -- 52,768,422(-) TGGCC(G/T)GTTCC utr-variant-3-prime
rs2280482 -- 52,768,398(-) CTCCC(A/T)TTCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRT76 Gene

Variant ID Type Subtype PubMed ID
nsv899093 CNV Gain 21882294
nsv528616 CNV Loss 19592680
nsv899094 CNV Gain 21882294
nsv899095 CNV Loss 21882294
esv270850 CNV Insertion 20981092

Relevant External Links for KRT76 Gene

HapMap Linkage Disequilibrium report
KRT76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT76 Gene

Disorders for KRT76 Gene

Relevant External Links for KRT76

Genetic Association Database (GAD)
KRT76
genes like me logo Genes that share disorders with KRT76: view

No data available for UniProtKB/Swiss-Prot for KRT76 Gene

Publications for KRT76 Gene

  1. Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. (PMID: 1282112) Collin C. … Franke W.W. (Differentiation 1992) 2 3 4 23
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2005) 3 4
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

Products for KRT76 Gene

Sources for KRT76 Gene

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