KRT76 Gene
protein-coding GIFtS: 44
GCID: GC12M053161
|
|
keratin 76
| |
Aliases
for KRT76 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 761 2 | | Cytokeratin 22 | | KRT2B1 2 3 | | Cytokeratin-2P3 | | KRT2P1 2 3 | | Keratin 2p2 | | HUMCYT2A1 2 | | Keratin, Type II Cytoskeletal 2 Oral2 | | Type-II Keratin Kb92 3 | | Keratin-763 | | CK-2P2 3 | | Cytokeratin-2P3 | | K2P2 3 | | Keratin-763 | | K762 3 | | |
Export aliases for KRT76 gene to outside databasesPrevious GC identifers: GC12M051450 GC12M050205 |
Summaries
for KRT76 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT76:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and aresubdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome12q13. (provided by RefSeq, Jun 2009)
UniProtKB/Swiss-Prot: K22O_HUMAN, Q01546Function: Probably contributes to terminal cornification
|
Genomic Views
for KRT76 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT76 gene promoter:
AREB6 SREBP-1a AML1a p53 p300 COMP1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT76
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT76 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13KRT76 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M053161: view genomic region
(about GC identifiers)
Start:
|
53,161,939 bp from pter |
End:
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53,171,129 bp from pter |
Size:
|
9,191 bases |
Orientation:
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minus strand |
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Proteins
for KRT76 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K22O_HUMAN, Q01546 (See
protein sequence)Recommended Name: Keratin, type II cytoskeletal 2 oral Size: 638 amino acids; 65841 Da
Subunit: Heterotetramer of two type I and two type II keratins
Developmental stage: Synthesized during maturation of epidermal keratinocytes
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral tobasic; 56-70 kDa)
Sequence caution: Sequence=BAG61375.1; Type=Erroneous termination; Positions=267; Note=Translated as Glu;
Secondary accessions: B4DRR3 Q7Z795Explore the universe of human proteins at neXtProt for KRT76: NX_Q01546
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q01546
KRT76 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056932.2
ENSEMBL proteins: ENSP00000330101
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KRT76 for ontologies About GeneDecksing
KRT76 Antibody Products:
Assay Products for KRT76: |
Protein
Domains /
Families
for KRT76 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT76 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q01546ProtoNet protein and cluster: Q01546 4 Blocks protein families: IPB000873 AMP-binding signature IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: K22O_HUMAN, Q01546Similarity: Belongs to the intermediate filament family |
Function
for KRT76 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: K22O_HUMAN, Q01546Function: Probably contributes to terminal cornification
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT76
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT76 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT76 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT76 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
NAS | -- |
KRT76 for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Krt76):
KRT76 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KRT76 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT76
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/36 Interacting proteins for KRT76 (Q015463 ENSP000003301014) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007010 | cytoskeleton organization |
NAS | 1282112 |
KRT76 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT76 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT76
Search CenterWatch for drugs/clinical trials and news about KRT76 / K22O
|
Transcripts
for KRT76 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT76 gene: NM_015848.4 Unigene Cluster for KRT76: Keratin 76 Hs.654392 [show with all ESTs]Unigene Representative Sequence: NM_0158481 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332411(uc001sax.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT76
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT76 (NM_015848) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT76 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT76 |
Additional cDNA sequence: AK299390.1 M99063.1 3 DOTS entries: DT.40127956 DT.100740885 DT.441275 24/251 AceView cDNA sequences (see all 251): BE735977 BM715509 BP371899 AJ564105 AK130156 BQ027522 BC039148 AW265613 AW082111 AU077018 AA629199 BG741384 BE742142 BF830977 BM697307 C00570 NM_175834 CD710424 BG742537 BE271353 BG696382 BG680256 NM_057088 BQ352789
GeneLoc Exon Structure
|
Expression
for KRT76 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT76 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KRT76 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT76
SOURCE GeneReport for Unigene cluster: Hs.654392
SABiosciences Custom PCR Arrays for KRT76
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT76
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT76 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT76 |
Orthologs
for KRT76 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT76 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for KRT76 (if available)
TreeFam Gene Tree for KRT76 (if available) |
Paralogs
for KRT76 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT76 gene
- KRT742 KRT772 KRT6B2 KRT832 KRT862 KRT32 KRT842 KRT82
- KRT812 KRT712 KRT8P112 KRT782 KRT72 ENSG000001704422 KRT792 KRT722
- KRT732 KRT52 KRT6C2 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/45 SIMAP similar genes for KRT76 using alignment to 1 protein entry: K22O_HUMAN(see all similar genes):KRTHB6 KRT3 KRT7 KRT1B KRT72 KRT5
KRT2 KRT8 KRT6A KRT6B KRT6C KRT77
KRT1 KRT78 KRT4 KRT75 KRT74 KRT80
KRT76 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KRT76
PGOHUM00000239459
|
Genomic Variants
for KRT76 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT76 (53161939 - 53171129 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT76: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT76 |
|
Disorders
/ Diseases
for KRT76 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT76 for disorders About GeneDecksing
7  diseases for KRT76: About MalaCardsobstructive jaundice jaundice cervical cancer cervicitis
pharyngitis hepatitis neuronitis
Export disorders for KRT76 gene to outside databases
|
Publications
for KRT76 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT76 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with KRT76) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. (PubMed id 1282112)1, 2, 3, 9 Collin C.... Franke W.W. (1992)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
|
External Searches for KRT76 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT76 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT76 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT76 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT76 | Pharmacogenomics, SNPs, Pathways | | Human Intermediate Filament Mutation Database | http://www.interfil.org |
|
| | |
About This Section
| Patent Information for KRT76 gene:
Search GeneIP for patents involving KRT76
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT76 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT76 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT76 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT76 | | | OriGene Protein Over-expression Lysate for KRT76 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT76 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT76 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT76 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT76 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT76 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT76 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT76 |
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| |  |  |  |  | | | | |
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 | | | KRT76 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT76 |
|  |  |  | | | | Search ThermoFisher Antibodies for KRT76 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT76 |
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