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KRT75 Gene

protein-coding   GIFtS: 45
GCID: GC12M052817

Keratin 75

  See KRT75-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 751 2     PFB2 5
K6HF2 3 5     Cytokeratin Type II2
Keratin-6 Hair Follicle2 3     cytokeratin-752
Type II Keratin-K6hf2 3     Keratin, Type II Cytoskeletal 752
Type-II Keratin Kb182 3     keratin-752
CK-752 3     Type II Keratin-182
K752 3     Cytokeratin-753
KB182 3     Keratin-753
hK6hf2 3     

External Ids:    HGNC: 244311   Entrez Gene: 91192   Ensembl: ENSG000001704547   OMIM: 6090255   UniProtKB: O956783   

Export aliases for KRT75 gene to outside databases

Previous GC identifers: GC12M051105 GC12M049861


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT75 Gene:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II
keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is
expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair
shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been
associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS).
(provided by RefSeq, Oct 2008)

GeneCards Summary for KRT75 Gene:
KRT75 (keratin 75) is a protein-coding gene. Diseases associated with KRT75 include pseudofolliculitis barbae, and loose anagen hair syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

UniProtKB/Swiss-Prot: K2C75_HUMAN, O95678
Function: Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments
in the companion layer of the hair follicle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KRT75 gene promoter:
         TBP   AML1a   AP-1   Bach2   C/EBPalpha   GATA-2   CHOP-10   JunD   FOXC1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT75 promoter sequence
   Search Chromatin IP Primers for KRT75

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT75


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT75 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT75 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052817:  view genomic region     (about GC identifiers)

Start:
52,817,854 bp from pter      End:
52,828,309 bp from pter
Size:
10,456 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C75_HUMAN, O95678 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 75  
Size: 551 amino acids; 59560 Da
Subunit: Heterodimer of a type I and a type II keratin (By similarity). May associate with KRT17 (By similarity)
Miscellaneous: May be used as a marker of hair differentiation
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Sequence caution: Sequence=BAG61056.1; Type=Erroneous initiation;
Secondary accessions: B4DQU4 Q9NSA9

Explore the universe of human proteins at neXtProt for KRT75: NX_O95678

Explore proteomics data for KRT75 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys159, Lys166
  • Modification sites at PhosphoSitePlus

  • See KRT75 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004684.2  
    ENSEMBL proteins: 
     ENSP00000252245  

    KRT75 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for KRT75

     
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    Search eBioscience for ELISAs for KRT75 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry O95678

    ProtoNet protein and cluster: O95678

    3 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C75_HUMAN, O95678
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT75           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C75_HUMAN, O95678
    Function: Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments
    in the companion layer of the hair follicle

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with KRT75           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Krt75):
     integument 

    Find genes that share phenotypes with KRT75           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT75
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT75

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT75
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT75

    miRNA
    Products:
        
    miRTarBase miRNAs that target KRT75:
    hsa-mir-1 (MIRT023996)

    Block miRNA regulation of human, mouse, rat KRT75 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate KRT75:
    hsa-miR-633 hsa-miR-586 hsa-miR-642b hsa-miR-1256 hsa-miR-552
    SwitchGear 3'UTR luciferase reporter plasmidKRT75 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRT75

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    GenScript: all cDNA clones in your preferred vector: KRT75 (NM_004693)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT75


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    cytoskeleton2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--

    Find genes that share ontologies with KRT75           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT75
    Interactions:

        Search GeneGlobe Interaction Network for KRT75

    Selected Interacting proteins for KRT75 (O956783) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPO951663I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    MAP1LC3AQ9H4923I2D: score=2 
    MAP1LC3BQ9GZQ83I2D: score=2 
    AMBRA1Q9C0C73I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT75 (K2C75)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT75 gene: 
    NM_004693.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252245(uc001saj.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT75 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate KRT75:
    hsa-miR-633 hsa-miR-586 hsa-miR-642b hsa-miR-1256 hsa-miR-552
    SwitchGear 3'UTR luciferase reporter plasmidKRT75 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KRT75
    Predesigned siRNA for gene silencing in human, mouse, rat KRT75
    Clone
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    OriGene clones in human, mouse for KRT75 (see all 6)
    OriGene ORF clones in mouse, rat for KRT75
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT75 (NM_004693)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT75
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT75
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT75
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT75
      QuantiTect SYBR Green Assays in human, mouse, rat KRT75
      QuantiFast Probe-based Assays in human, mouse, rat KRT75

    2 AceView cDNA sequences:

    Y17282 NM_004693 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT75 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KRT75 Expression
    About this image


    KRT75 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Hair (Integumentary System)    fully expand to see all 3 entries
             Fetal Companion Cells Companion Layer
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
             limbal epithelial basal cells   
     
     Eye (Sensory Organs)
             limbal epithelial basal cells   
    KRT75 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT75 Protein Expression

    UniProtKB/Swiss-Prot: K2C75_HUMAN, O95678
    Tissue specificity: Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair
    companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer
    root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the
    isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the
    nail bed (at protein level)

        Custom PCR Arrays for KRT75
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT75

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT75 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt751 , 5 keratin 751, 5 83.64(n)1
    85.09(a)1
      15 (56.91 cM)5
    1090521  NM_133357.31  NP_579935.11 
     1015633455 
    chicken
    (Gallus gallus)
    Aves KRT6A1 keratin 6A 69.76(n)
    68.47(a)
      408041  NM_001001313.1  NP_001001313.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 → many
    2(95720906-95731292)


    ENSEMBL Gene Tree for KRT75 (if available)
    TreeFam Gene Tree for KRT75 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT75 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  
    KRT52  KRT6A2  KRT852  KRT22  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT75 using alignment to 1 protein entry:     K2C75_HUMAN(see all similar genes):
    KRT5    KRT6A    KRT6B    KRT6C    KRT79    KRT121P
    KRT7    KRTHB6    KRT1B    KRT72    KRT78    KRT86
    KRT8    KRT74    KRT4    KRT2    KRT71    KRT73

    Find genes that share paralogs with KRT75           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KRT75
    PGOHUM00000240526


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    K2C75_HUMAN, O95678: The Thr-161 variant may increase risk to develop pseudofolliculitis barbae (PFB) [MIM:612318]. PFB
    is a common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by
    ingrown hairs of the facial and submental (barbea) regions after regular shaving. It occurs predominantly in
    black males, while it is rather rare and usually far less severe in Caucasian males


    Selected SNPs for KRT75 (see all 364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22323981,2,,4
    C,FLoose anagen hair syndrome (LAHS)4 --52658704(-) GGGCCG/AAGGCT 2 /K /E mis1 ese35Minor allele frequency- A:0.01NA EU 5999
    rs22323871,2,,4
    C,F,A,Hother152661960(-) AGTTCG/ACCTCC 2 /T /A mis1 ese327Minor allele frequency- A:0.13NS EA NA WA CSA EU 8363
    rs678766061,2
    C--49861640(+) AAGGGC/-TGATG 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs111701181,2
    C,F,H--52651710(+) TTACTG/TGATAT 1 -- ds500111Minor allele frequency- T:0.04NS EA NA 1198
    rs733065441,2
    C,F--52651768(+) AAAGCG/ATTGCT 1 -- ds50012Minor allele frequency- A:0.03WA 120
    rs1395959211,2
    --52651823(+) TGCTGA/GGTCTG 1 -- ds50010--------
    rs780026261,2
    C,F--52651881(+) CACCCG/AGCGTC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1891877121,2
    --52651966(+) AGCTCC/TGGCTT 1 -- ds50010--------
    rs1473114731,2
    --52652032(+) CCTGCA/GCCTCT 1 -- ds50010--------
    rs730971491,2
    C,F--52652070(+) AGCTTT/ACTTAG 1 -- ds50013Minor allele frequency- A:0.12WA NA EA 358

    HapMap Linkage Disequilibrium report for KRT75 (52817854 - 52828309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KRT75:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1925677CNV Deletion18987734
    nsv832411CNV Loss17160897
    nsv832412CNV Loss17160897
    nsv520797CNV Gain19592680
    nsv832410CNV Gain17160897

    Human Gene Mutation Database (HGMD): KRT75
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT75
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT75

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609025   
    OMIM disorders: 612318  
    UniProtKB/Swiss-Prot: K2C75_HUMAN, O95678
  • Loose anagen hair syndrome (LAHS) [MIM:600628]: In LAHS, anagen hairs are easily pulled from the scalp.
    The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and
    an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.
    Note=The disease may be caused by mutations affecting the gene represented in this entry

  • 2 diseases for KRT75:    
    About MalaCards
    pseudofolliculitis barbae    loose anagen hair syndrome


    Find genes that share disorders with KRT75           About GenesLikeMe

    1 Novoseek inferred disease relationship for KRT75 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 8950218 (1), 7515536 (1)


    Export disorders for KRT75 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT75 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with KRT75)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle. (PubMed id 9856802)1, 2, 3, 9 Winter H.... Schweizer J. (J. Invest. Dermatol. 1998)
    2. Characterization of a 300 kbp region of human DNA containing the type II hair keratin. (PubMed id 10692104)1, 2, 3 Rogers M.A.... Schweizer J. (J. Invest. Dermatol. 2000)
    3. Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study. (PubMed id 11939812)1, 2, 9 Chapalain V.... Taieb A. (Arch. Dermatol. 2002)
    4. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    5. An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. (PubMed id 15086549)1, 2 Winter H.... Schweizer J. (J. Invest. Dermatol. 2004)
    6. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin. (PubMed id 15292489)1, 2 Roh C.... Lyle S. (Physiol. Genomics 2004)
    7. Cytokeratin 75 expression in central, centrifugal, cicatricial alopecia--new observations in normal and diseased hair follicles. (PubMed id 19614992)1, 9 Sperling L.C....Darling T. (J. Cutan. Pathol. 2010)
    8. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    9. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    10. Breast carcinoma with brain metastases: clinical analysis and immunoprofile on tissue microarrays. (PubMed id 21427063)1 Brogi E....Seidman A.D. (Ann. Oncol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9119 HGNC: 24431 AceView: K6HF Ensembl:ENSG00000170454 euGenes: HUgn9119
    ECgene: KRT75 H-InvDB: KRT75

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT75 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT75 gene:
    Search GeneIP for patents involving KRT75

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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