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Aliases for KRT74 Gene

Aliases for KRT74 Gene

  • Keratin 74, Type II 2 3
  • KRT6IRS4 3 4 6
  • K6IRS4 3 4 6
  • Type II Inner Root Sheath-Specific Keratin-K6irs4 3 4
  • Type-II Keratin Kb37 3 4
  • Cytokeratin-74 3 4
  • Keratin-5c 3 4
  • Keratin-74 3 4
  • HTSS2 3 6
  • CK-74 3 4
  • KRT5C 3 4
  • K5C 3 4
  • K74 3 4
  • Keratin, Type II Cytoskeletal 74 3
  • Keratin 6 Irs4 3
  • Keratin 74 2
  • Keratin 5c 3
  • HYPT3 3
  • ADWH 3
  • KB37 4

External Ids for KRT74 Gene

Previous GeneCards Identifiers for KRT74 Gene

  • GC12M051246
  • GC12M052959
  • GC12M050003

Summaries for KRT74 Gene

Entrez Gene Summary for KRT74 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT74 Gene

KRT74 (Keratin 74, Type II) is a Protein Coding gene. Diseases associated with KRT74 include woolly hair, autosomal dominant and hypotrichosis 3. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT74 Gene

  • Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT74 Gene

Genomics for KRT74 Gene

Regulatory Elements for KRT74 Gene

Genomic Location for KRT74 Gene

52,565,782 bp from pter
52,573,825 bp from pter
8,044 bases
Minus strand

Genomic View for KRT74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT74 Gene

Proteins for KRT74 Gene

  • Protein details for KRT74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 74
    Protein Accession:
    Secondary Accessions:
    • B5MD61
    • Q86Y45

    Protein attributes for KRT74 Gene

    529 amino acids
    Molecular mass:
    57865 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)
    • Sequence=DAA00404.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KRT74 Gene

Proteomics data for KRT74 Gene at MOPED

Post-translational modifications for KRT74 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT74 Gene

Domains for KRT74 Gene

Gene Families for KRT74 Gene

  • IFF2 :Intermediate filaments type II, keratins (basic)

Protein Domains for KRT74 Gene

Suggested Antigen Peptide Sequences for KRT74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7RTS7
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT74: view

Function for KRT74 Gene

Molecular function for KRT74 Gene

UniProtKB/Swiss-Prot Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Gene Ontology (GO) - Molecular Function for KRT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:1990254 keratin filament binding IPI 20346438
genes like me logo Genes that share ontologies with KRT74: view

Phenotypes for KRT74 Gene

GenomeRNAi human phenotypes for KRT74:
genes like me logo Genes that share phenotypes with KRT74: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT74

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT74 Gene

Localization for KRT74 Gene

Subcellular locations from

Jensen Localization Image for KRT74 Gene COMPARTMENTS Subcellular localization image for KRT74 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20346438
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT74: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT74 Gene

Pathways for KRT74 Gene

SuperPathways for KRT74 Gene

No Data Available

Interacting Proteins for KRT74 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000307240 Q7RTS7-K2C74_HUMAN for KRT74 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KRT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045104 intermediate filament cytoskeleton organization IDA 20346438
genes like me logo Genes that share ontologies with KRT74: view

No data available for Pathways by source for KRT74 Gene

Transcripts for KRT74 Gene

mRNA/cDNA for KRT74 Gene

(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT74 Gene

Keratin 74:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT74

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT74
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT74 Gene

No ASD Table

Relevant External Links for KRT74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT74 Gene

mRNA expression in normal human tissues for KRT74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT74 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (42.3) and Skin - Sun Exposed (Lower leg) (6.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT74 Gene

SOURCE GeneReport for Unigene cluster for KRT74 Gene Hs.660125

mRNA Expression by UniProt/SwissProt for KRT74 Gene

Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level).
genes like me logo Genes that share expressions with KRT74: view

In Situ Assay Products

Orthologs for KRT74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT74 35
  • 99.18 (n)
  • 98.87 (a)
KRT74 36
  • 96 (a)
(Bos Taurus)
Mammalia KRT74 35
  • 84.69 (n)
  • 81.85 (a)
KRT74 36
  • 80 (a)
(Canis familiaris)
Mammalia KRT74 35
  • 85.07 (n)
  • 82.8 (a)
KRT74 36
  • 82 (a)
(Mus musculus)
Mammalia Krt74 16
Krt74 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
-- 36
  • 70 (a)
-- 36
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
Species with no ortholog for KRT74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT74 Gene

Gene Tree for KRT74 (if available)
Gene Tree for KRT74 (if available)

Paralogs for KRT74 Gene

genes like me logo Genes that share paralogs with KRT74: view

Variants for KRT74 Gene

Sequence variations from dbSNP and Humsavar for KRT74 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13121 -- 52,565,921(+) CAGTA(C/G)CACTC utr-variant-3-prime
rs584436 -- 52,566,284(-) CTCCT(A/G)TTCTC utr-variant-3-prime
rs592720 -- 52,574,076(-) GGTCC(C/T)TAATT upstream-variant-2KB
rs597048 -- 52,570,934(-) TGGAT(C/T)CTAGC intron-variant
rs608690 -- 52,570,618(-) GGGAG(G/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT74 Gene

Variant ID Type Subtype PubMed ID
esv988599 CNV Deletion 20482838
nsv832415 CNV Loss 17160897
nsv428281 CNV Gain 18775914
esv23533 CNV Loss 19812545

Relevant External Links for KRT74 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT74 Gene

Disorders for KRT74 Gene

(2) OMIM Diseases for KRT74 Gene (608248)


  • Woolly hair autosomal dominant (ADWH) [MIM:194300]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. {ECO:0000269 PubMed:20346438}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypotrichosis 3 (HYPT3) [MIM:613981]: A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. {ECO:0000269 PubMed:21188418}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ectodermal dysplasia 7, hair/nail type (ECTD7) [MIM:614929]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Ectodermal dysplasia of the hair/nail type is characterized by hypotrichosis and nail dystrophy without non-ectodermal or other ectodermal manifestations. {ECO:0000269 PubMed:24714551}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KRT74 Gene

Relevant External Links for KRT74

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KRT74: view

Publications for KRT74 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2003) 2 3 4 23
  2. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M. … Weber K. (J. Cell Sci. 2001) 3 4
  3. Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis. (PMID: 24714551) Raykova D. … Dahl N. (PLoS ONE 2014) 3 4
  4. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48

Products for KRT74 Gene

Sources for KRT74 Gene

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