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Aliases for KRT74 Gene

Aliases for KRT74 Gene

  • Keratin 74 2 3
  • Keratin 74, Type II 2 3 5
  • Type II Inner Root Sheath-Specific Keratin-K6irs4 3 4
  • Type-II Keratin Kb37 3 4
  • Cytokeratin-74 3 4
  • Keratin-5c 3 4
  • Keratin-74 3 4
  • KRT6IRS4 3 4
  • K6IRS4 3 4
  • CK-74 3 4
  • KRT5C 3 4
  • K5C 3 4
  • K74 3 4
  • Keratin 6 Irs4 3
  • Keratin 5c 3
  • HTSS2 3
  • HYPT3 3
  • ADWH 3
  • KB37 4

External Ids for KRT74 Gene

Previous GeneCards Identifiers for KRT74 Gene

  • GC12M051246
  • GC12M052959
  • GC12M050003

Summaries for KRT74 Gene

Entrez Gene Summary for KRT74 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT74 Gene

KRT74 (Keratin 74) is a Protein Coding gene. Diseases associated with KRT74 include Hypotrichosis 3 and Ectodermal Dysplasia 7, Hair/Nail Type. GO annotations related to this gene include structural molecule activity and keratin filament binding. An important paralog of this gene is KRT73.

UniProtKB/Swiss-Prot for KRT74 Gene

  • Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT74 Gene

Genomics for KRT74 Gene

Regulatory Elements for KRT74 Gene

Enhancers for KRT74 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT74 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT74 Gene

52,565,722 bp from pter
52,574,092 bp from pter
8,371 bases
Minus strand

Genomic View for KRT74 Gene

Genes around KRT74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT74 Gene

Proteins for KRT74 Gene

  • Protein details for KRT74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 74
    Protein Accession:
    Secondary Accessions:
    • B5MD61
    • Q86Y45

    Protein attributes for KRT74 Gene

    529 amino acids
    Molecular mass:
    57865 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
    • Sequence=DAA00404.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KRT74 Gene

Proteomics data for KRT74 Gene at MOPED

Post-translational modifications for KRT74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT74 Gene

Domains & Families for KRT74 Gene

Gene Families for KRT74 Gene

Suggested Antigen Peptide Sequences for KRT74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT74: view

Function for KRT74 Gene

Molecular function for KRT74 Gene

UniProtKB/Swiss-Prot Function:
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Phenotypes for KRT74 Gene

genes like me logo Genes that share phenotypes with KRT74: view

Human Phenotype Ontology for KRT74 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT74 Gene

Localization for KRT74 Gene

Subcellular locations from

Jensen Localization Image for KRT74 Gene COMPARTMENTS Subcellular localization image for KRT74 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20346438
genes like me logo Genes that share ontologies with KRT74: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT74 Gene

Pathways & Interactions for KRT74 Gene

SuperPathways for KRT74 Gene

No Data Available

Interacting Proteins for KRT74 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000307240 Q7RTS7-K2C74_HUMAN for KRT74 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KRT74 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT74 Gene

Drugs & Compounds for KRT74 Gene

No Compound Related Data Available

Transcripts for KRT74 Gene

mRNA/cDNA for KRT74 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT74 Gene

Keratin 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT74 Gene

No ASD Table

Relevant External Links for KRT74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT74 Gene

mRNA expression in normal human tissues for KRT74 Gene

mRNA differential expression in normal tissues according to GTEx for KRT74 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x42.3) and Skin - Sun Exposed (Lower leg) (x6.6).

Protein differential expression in normal tissues from HIPED for KRT74 Gene

This gene is overexpressed in Saliva (33.0), Urine (12.7), and Cervix (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT74 Gene

SOURCE GeneReport for Unigene cluster for KRT74 Gene Hs.660125

mRNA Expression by UniProt/SwissProt for KRT74 Gene

Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level).
genes like me logo Genes that share expression patterns with KRT74: view

Protein tissue co-expression partners for KRT74 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRT74 Gene

Orthologs for KRT74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT74 35
  • 84.69 (n)
  • 81.85 (a)
KRT74 36
  • 80 (a)
(Canis familiaris)
Mammalia KRT74 35
  • 85.07 (n)
  • 82.8 (a)
KRT74 36
  • 82 (a)
(Pan troglodytes)
Mammalia KRT74 35
  • 99.18 (n)
  • 98.87 (a)
KRT74 36
  • 96 (a)
(Mus musculus)
Mammalia Krt74 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
-- 36
  • 70 (a)
-- 36
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
Species with no ortholog for KRT74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT74 Gene

Gene Tree for KRT74 (if available)
Gene Tree for KRT74 (if available)

Paralogs for KRT74 Gene

genes like me logo Genes that share paralogs with KRT74: view

Variants for KRT74 Gene

Sequence variations from dbSNP and Humsavar for KRT74 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11170177 - 52,572,644(+) ACCTG(C/G)TTCTG reference, missense
rs670741 - 52,571,389(-) AAAGA(A/C/T)ATCAA reference, missense
rs11170176 - 52,572,606(+) GGTCC(A/T)GCTGC reference, missense
rs57387512 - 52,568,349(+) CTCCC(C/T)GCTGC reference, missense
rs57711382 - 52,568,254(+) GTACT(C/T)GCGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT74 Gene

Variant ID Type Subtype PubMed ID
esv988599 CNV Deletion 20482838
nsv832415 CNV Loss 17160897
nsv428281 CNV Gain 18775914
esv23533 CNV Loss 19812545

Variation tolerance for KRT74 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.15; 96.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT74 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT74 Gene

Disorders for KRT74 Gene

MalaCards: The human disease database

(16) MalaCards diseases for KRT74 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 3
  • hypotrichosis simplex of the scalp 2
ectodermal dysplasia 7, hair/nail type
  • ectd7
woolly hair, autosomal dominant
  • woolly hair autosomal dominant
ectodermal dysplasia 4, hair/nail type
  • ectd4
hypotrichosis simplex of the scalp
  • hereditary hypotrichosis simplex of the scalp
- elite association - COSMIC cancer census association via MalaCards
Search KRT74 in MalaCards View complete list of genes associated with diseases


  • Ectodermal dysplasia 7, hair/nail type (ECTD7) [MIM:614929]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. Ectodermal dysplasia of the hair/nail type is characterized by hypotrichosis and nail dystrophy without non-ectodermal or other ectodermal manifestations. {ECO:0000269 PubMed:24714551}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypotrichosis 3 (HYPT3) [MIM:613981]: A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. {ECO:0000269 PubMed:21188418}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Woolly hair autosomal dominant (ADWH) [MIM:194300]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. {ECO:0000269 PubMed:20346438}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT74

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT74: view

No data available for Genatlas for KRT74 Gene

Publications for KRT74 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2003) 2 3 4 23 67
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis. (PMID: 24714551) Raykova D. … Dahl N. (PLoS ONE 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families. (PMID: 21188418) Wasif N. … Ahmad W. (Hum. Genet. 2011) 3

Products for KRT74 Gene

Sources for KRT74 Gene