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KRT74 Gene

protein-coding   GIFtS: 51
GCID: GC12M052959

Keratin 74

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 741 2     cytokeratin-742
K6IRS42 3 5     Keratin 5c2
KRT6IRS42 3 5     Keratin 6 Irs42
Type II Inner Root Sheath-Specific Keratin-K6irs42 3     Keratin, Type II Cytoskeletal 742
Type-II Keratin Kb372 3     keratin-5c2
CK-742 3     keratin-742
K5C2 3     Cytokeratin-743
K742 3     KB373
KRT5C2 3     Keratin-5c3
HTSS22 5     Keratin-743

External Ids:    HGNC: 289291   Entrez Gene: 1213912   Ensembl: ENSG000001704847   OMIM: 6082485   UniProtKB: Q7RTS73   

Export aliases for KRT74 gene to outside databases

Previous GC identifers: GC12M051246 GC12M050003


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT74 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are
specifically expressed in the inner root sheath of hair follicles.(provided by RefSeq, Jun 2009)

GeneCards Summary for KRT74 Gene:
KRT74 (keratin 74) is a protein-coding gene. Diseases associated with KRT74 include hypotrichosis simplex of the scalp 2, and woolly hair, autosomal dominant. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT77.

UniProtKB/Swiss-Prot: K2C74_HUMAN, Q7RTS7
Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root
sheath (IRS) of the hair follicle (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT74 gene promoter:
         ER-alpha   FOXF2   AML1a   p53   LCR-F1   E47   GATA-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT74 promoter sequence
   Search Chromatin IP Primers for KRT74

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT74 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052959:  view genomic region     (about GC identifiers)

Start:
52,959,566 bp from pter      End:
52,967,609 bp from pter
Size:
8,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: K2C74_HUMAN, Q7RTS7 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 74  
Size: 529 amino acids; 57865 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Sequence caution: Sequence=DAA00404.1; Type=Erroneous gene model prediction;
Secondary accessions: B5MD61 Q86Y45

Explore the universe of human proteins at neXtProt for KRT74: NX_Q7RTS7

Explore proteomics data for KRT74 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157
  • Modification sites at PhosphoSitePlus

  • See KRT74 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778223.2  
    ENSEMBL proteins: 
     ENSP00000447447   ENSP00000307240  

    KRT74 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for KRT74


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q7RTS7

    ProtoNet protein and cluster: Q7RTS7

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C74_HUMAN, Q7RTS7
    Similarity: Belongs to the intermediate filament family


    KRT74 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C74_HUMAN, Q7RTS7
    Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root
    sheath (IRS) of the hair follicle (Probable)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT74 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT74:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT74
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT74

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT74
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT74

    miRNA
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    Block miRNA regulation of human, mouse, rat KRT74 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KRT74:
    hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmidKRT74 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KRT74
    Predesigned siRNA for gene silencing in human, mouse, rat KRT74

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--

    KRT74 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT74
    Interactions:

        Search GeneGlobe Interaction Network for KRT74

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KRT74 (Q7RTS73 ENSP000003072404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT74 (K2C74)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRT74 gene: 
    NM_175053.3  

    Unigene Cluster for KRT74:

    Keratin 74
    Hs.660125  [show with all ESTs]
    Unigene Representative Sequence: AJ508777
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549343 ENST00000305620(uc001sap.1) ENST00000546384
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT74 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KRT74:
    hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmidKRT74 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KRT74
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    GenScript: all cDNA clones in your preferred vector: KRT74 (NM_175053)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT74
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT74
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT74
      QuantiTect SYBR Green Assays in human, mouse, rat KRT74
      QuantiFast Probe-based Assays in human, mouse, rat KRT74

    Additional mRNA sequence: 

    AF086480.1 AJ508777.1 

    1 DOTS entry:

    DT.111133 

    3 AceView cDNA sequences:

    NM_175053 AF086480 AJ508777 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT74 expression in normal human tissues (normalized intensities)      KRT74 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KRT74 Expression
    About this image


    KRT74 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Heart (Cardiovascular System)
     
     Testis (Reproductive System)
    KRT74 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT74 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660125

    UniProtKB/Swiss-Prot: K2C74_HUMAN, Q7RTS7
    Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the
    inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle
    of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along
    the area of differentiated Henle cells (at protein level)

        Custom PCR Arrays for KRT74
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT74

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT74 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt745 keratin 74   --   15 (57.01 cM) 101754259 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    many ↔ many
    2(95401721-95413964)


    ENSEMBL Gene Tree for KRT74 (if available)
    TreeFam Gene Tree for KRT74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT74 gene
    KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  KRT82  
    KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT74 using alignment to 2 protein entries:     K2C74_HUMAN (see all proteins) (see all similar genes):
    KRTHB6    KRT71    KRT79    KRT5    KRT72    KRT7
    KRT1B    KRT4    KRT6A    KRT6B    KRT6C    KRT78
    KRT75    KRT77    KRT73    KRT121P    KRT1    KRT2

    KRT74 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT74 (see all 396)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659514
    Hypotrichosis 3 (HYPT3)4--see VAR_0659512 D N mis40--------
    VAR_0635874
    Woolly hair autosomal dominant (ADWH)4--see VAR_0635872 N K mis40--------
    rs2676072051,2
    Cpathogenic152801542(-) CTGAAC/GGACAA 2 N K mis10--------
    rs6539561,2
    C,F,A,H--50005007(-) TATCTT/GATGGG 1 -- int17Minor allele frequency- G:0.33NA WA EA 252
    rs6117561,2
    C,F,A,H--50005008(+) CCATCA/GGATAG 1 -- int112Minor allele frequency- T:0.03EA NA WA 498
    rs668684961,2
    C--50007798(+) CAAAC-/GATAGT 1 -- int10--------
    rs1868673971,2
    --52793538(+) GAATGC/TTTCTG 1 -- ds50010--------
    rs1912987971,2
    --52793628(+) AGCACA/CTGAAA 1 -- ds50010--------
    rs6322051,2
    C,F,A,H--52793730(+) TCCTCC/TTCCAG 1 -- ds500114Minor allele frequency- T:0.22NA WA CSA EA 380
    rs733183961,2
    C,F--52793778(+) TACTAG/ACATTG 1 -- ds50012Minor allele frequency- A:0.07WA 120

    HapMap Linkage Disequilibrium report for KRT74 (52959566 - 52967609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KRT74:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv988599CNV Deletion20482838
    esv23533CNV Loss19812545
    nsv832415CNV Loss17160897
    nsv428281CNV Gain18775914

    Human Gene Mutation Database (HGMD): KRT74
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT74
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT74

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608248   
    OMIM disorders: 194300  613981  
    UniProtKB/Swiss-Prot: K2C74_HUMAN, Q7RTS7
  • Woolly hair autosomal dominant (ADWH) [MIM:194300]: A hair shaft disorder characterized by fine and
    tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly
    and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies,
    including trichorrhexis nodosa and tapered ends. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Hypotrichosis 3 (HYPT3) [MIM:613981]: A condition characterized by the presence of less than the normal
    amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss
    limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third
    decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 7 diseases for KRT74:    About MalaCards
    hypotrichosis simplex of the scalp 2    woolly hair, autosomal dominant    hypotrichosis simplex of scalp 1    hypotrichosis
    myocardial infarction    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for KRT74:
    Hypotrichosis

    KRT74 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KRT74
    Human Genome Epidemiology (HuGE) Navigator: KRT74 (3 documents)

    Export disorders for KRT74 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT74 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KRT74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PubMed id 12648212)1, 2, 3, 9 Langbein L.... Schweizer J. (J. Invest. Dermatol. 2003)
    2. Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families. (PubMed id 21188418)1, 2 Wasif N.... Ahmad W. (Hum. Genet. 2011)
    3. Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture. (PubMed id 20346438)1, 2 Shimomura Y.... Christiano A.M. (Am. J. Hum. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    6. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    7. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    8. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2 Hesse M.... Weber K. (J. Cell Sci. 2001)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121391 HGNC: 28929 AceView: K6IRS4 Ensembl:ENSG00000170484 euGenes: HUgn121391
    ECgene: KRT74 H-InvDB: KRT74

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT74 Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT74 gene:
    Search GeneIP for patents involving KRT74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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