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Aliases for KRT73 Gene

Aliases for KRT73 Gene

  • Keratin 73 2 3 5
  • Type II Inner Root Sheath-Specific Keratin-K6irs3 3 4
  • Type-II Keratin Kb36 3 4
  • Keratin 73, Type II 2 3
  • Cytokeratin-73 3 4
  • KRT6IRS3 3 4
  • K6IRS3 3 4
  • CK-73 3 4
  • K73 3 4
  • Keratin, Type II Cytoskeletal 73 3
  • Keratin 6 Irs3 3
  • Keratin-73 4
  • IRT6IRS3 3
  • KB36 4

External Ids for KRT73 Gene

Previous GeneCards Identifiers for KRT73 Gene

  • GC12M051288
  • GC12M053001
  • GC12M050045

Summaries for KRT73 Gene

Entrez Gene Summary for KRT73 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT73 Gene

KRT73 (Keratin 73) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT71.

UniProtKB/Swiss-Prot for KRT73 Gene

  • Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Additional gene information for KRT73 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT73 Gene

Genomics for KRT73 Gene

Regulatory Elements for KRT73 Gene

Enhancers for KRT73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H052579 1.1 FANTOM5 ENCODE 6.8 +38.7 38671 3.7 CTCF KLF17 ZIC2 ZNF2 RAD21 CC2D1A ZFHX2 ZBTB48 SCRT2 HNF4G KRT72 KRT1 KRT71 KRT78 KRT79 KRT2 KRT84 KRT4 KRT6C KRT76
GH12H052630 0.8 ENCODE dbSUPER 8.3 -10.7 -10744 0.4 NFIL3 ZNF707 GATA3 HLF KRT72 ENSG00000257605 HNRNPA3P10 ATG101 KRT73 LOC105369772
GH12H052583 0.7 ENCODE 6.9 +36.7 36718 0.1 SCRT1 CTCF TRIM22 REST ZBTB8A ZNF2 RAD21 ZNF217 CC2D1A JUND KRT1 KRT78 KRT84 KRT2 KRT73 KRT74 KRT73-AS1
GH12H052609 0.5 ENCODE dbSUPER 6.8 +9.9 9943 1.9 KRT72 KRT2 KRT71 KRT78 KRT76 KRT79 KRT73 GC12P052616
GH12H052626 0.6 dbSUPER 5.4 -7.0 -6957 1.6 SIX4 MNT ELF1 GABPA GATA3 ZNF766 ZNF701 KLF9 NR2C2 KRT72 PCBP2 HNRNPA3P10 SP1 AAAS ATF7 LOC100652999 ZNF740 KRT73 ENSG00000257475
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRT73 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRT73 Gene

Genomic Locations for KRT73 Gene
chr12:52,602,883-52,620,116
(GRCh38/hg38)
Size:
17,234 bases
Orientation:
Minus strand
chr12:53,001,354-53,012,343
(GRCh37/hg19)

Genomic View for KRT73 Gene

Genes around KRT73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT73 Gene

Proteins for KRT73 Gene

  • Protein details for KRT73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y46-K2C73_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 73
    Protein Accession:
    Q86Y46
    Secondary Accessions:
    • Q32MB2

    Protein attributes for KRT73 Gene

    Size:
    540 amino acids
    Molecular mass:
    58923 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Alternative splice isoforms for KRT73 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT73 Gene

Post-translational modifications for KRT73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT73 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT73 Gene

Domains & Families for KRT73 Gene

Gene Families for KRT73 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y46

UniProtKB/Swiss-Prot:

K2C73_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT73: view

Function for KRT73 Gene

Molecular function for KRT73 Gene

UniProtKB/Swiss-Prot Function:
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Gene Ontology (GO) - Molecular Function for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT73: view
genes like me logo Genes that share phenotypes with KRT73: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT73 Gene

Localization for KRT73 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT73 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT73: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT73 Gene

Pathways & Interactions for KRT73 Gene

SuperPathways for KRT73 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT73: view

Pathways by source for KRT73 Gene

2 Reactome pathways for KRT73 Gene

Gene Ontology (GO) - Biological Process for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT73: view

No data available for SIGNOR curated interactions for KRT73 Gene

Drugs & Compounds for KRT73 Gene

No Compound Related Data Available

Transcripts for KRT73 Gene

mRNA/cDNA for KRT73 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT73 Gene

Keratin 73:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT73 Gene

No ASD Table

Relevant External Links for KRT73 Gene

GeneLoc Exon Structure for
KRT73
ECgene alternative splicing isoforms for
KRT73

Expression for KRT73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT73 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT73 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x23.0), Skin - Not Sun Exposed (Suprapubic) (x21.8), and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for KRT73 Gene

This gene is overexpressed in Saliva (60.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT73 Gene



Protein tissue co-expression partners for KRT73 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT73 Gene:

KRT73

SOURCE GeneReport for Unigene cluster for KRT73 Gene:

Hs.55410

mRNA Expression by UniProt/SwissProt for KRT73 Gene:

Q86Y46-K2C73_HUMAN
Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level).

Evidence on tissue expression from TISSUES for KRT73 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with KRT73: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT73 Gene

Orthologs for KRT73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT73 33 34
  • 98.4 (n)
dog
(Canis familiaris)
Mammalia KRT73 33
  • 89.07 (n)
cow
(Bos Taurus)
Mammalia KRT73 33 34
  • 88.33 (n)
rat
(Rattus norvegicus)
Mammalia Krt73 33
  • 84.6 (n)
mouse
(Mus musculus)
Mammalia Krt73 33 16 34
  • 84.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
ManyToMany
Species where no ortholog for KRT73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT73 Gene

ENSEMBL:
Gene Tree for KRT73 (if available)
TreeFam:
Gene Tree for KRT73 (if available)

Paralogs for KRT73 Gene

Variants for KRT73 Gene

Sequence variations from dbSNP and Humsavar for KRT73 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs142246988 A colorectal cancer sample 52,614,655(+) TGCTC(A/C/G)TGTAA intron-variant, nc-transcript-variant, reference, missense
VAR_038093 A colorectal cancer sample
rs1000072587 -- 52,620,816(+) TGTTG(C/T)TTGTT upstream-variant-2KB
rs1000655764 -- 52,605,854(+) CTACT(G/T)AGCCT intron-variant, utr-variant-3-prime
rs1000875914 -- 52,610,198(+) AGCCT(C/T)CCAAG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT73 Gene

Variant ID Type Subtype PubMed ID
nsv975493 CNV duplication 23825009
nsv832415 CNV loss 17160897
nsv522631 CNV loss 19592680
nsv428281 CNV gain 18775914
esv3629522 CNV loss 21293372
esv1004870 CNV deletion 20482838

Variation tolerance for KRT73 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT73 Gene

Disorders for KRT73 Gene

Relevant External Links for KRT73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT73

No disorders were found for KRT73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT73 Gene

Publications for KRT73 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L … Schweizer J (The Journal of investigative dermatology 2003) 2 3 4 22 60
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 60

Products for KRT73 Gene

Sources for KRT73 Gene

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