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Aliases for KRT73 Gene

Aliases for KRT73 Gene

  • Keratin 73, Type II 2 3
  • KRT6IRS3 3 4 6
  • K6IRS3 3 4 6
  • Type II Inner Root Sheath-Specific Keratin-K6irs3 3 4
  • Type-II Keratin Kb36 3 4
  • Cytokeratin-73 3 4
  • Keratin-73 3 4
  • CK-73 3 4
  • K73 3 4
  • Keratin, Type II Cytoskeletal 73 3
  • Keratin 6 Irs3 3
  • Keratin 73 2
  • IRT6IRS3 3
  • KB36 4

External Ids for KRT73 Gene

Previous GeneCards Identifiers for KRT73 Gene

  • GC12M051288
  • GC12M053001
  • GC12M050045

Summaries for KRT73 Gene

Entrez Gene Summary for KRT73 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT73 Gene

KRT73 (Keratin 73, Type II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT73 Gene

  • Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT73 Gene

Genomics for KRT73 Gene

Regulatory Elements for KRT73 Gene

Genomic Location for KRT73 Gene

Start:
52,607,570 bp from pter
End:
52,618,559 bp from pter
Size:
10,990 bases
Orientation:
Minus strand

Genomic View for KRT73 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT73 Gene

Proteins for KRT73 Gene

  • Protein details for KRT73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y46-K2C73_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 73
    Protein Accession:
    Q86Y46
    Secondary Accessions:
    • Q32MB2

    Protein attributes for KRT73 Gene

    Size:
    540 amino acids
    Molecular mass:
    58923 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)

    Alternative splice isoforms for KRT73 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT73 Gene

Proteomics data for KRT73 Gene at MOPED

Post-translational modifications for KRT73 Gene

  • Ubiquitination at Lys149
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT73 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT73 Gene

Domains for KRT73 Gene

Gene Families for KRT73 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y46

UniProtKB/Swiss-Prot:

K2C73_HUMAN :
  • Q86Y46
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT73: view

Function for KRT73 Gene

Molecular function for KRT73 Gene

UniProtKB/Swiss-Prot Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Gene Ontology (GO) - Molecular Function for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT73: view

Phenotypes for KRT73 Gene

GenomeRNAi human phenotypes for KRT73:
genes like me logo Genes that share phenotypes with KRT73: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT73

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT73 Gene

Localization for KRT73 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT73 Gene COMPARTMENTS Subcellular localization image for KRT73 gene
Compartment Confidence
cytosol 3
mitochondrion 3
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005882 intermediate filament --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with KRT73: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT73 Gene

Pathways for KRT73 Gene

SuperPathways for KRT73 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with KRT73: view

No data available for Pathways by source for KRT73 Gene

Transcripts for KRT73 Gene

mRNA/cDNA for KRT73 Gene

(1) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT73 Gene

Keratin 73:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT73

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT73

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT73 Gene

No ASD Table

Relevant External Links for KRT73 Gene

GeneLoc Exon Structure for
KRT73
ECgene alternative splicing isoforms for
KRT73

Expression for KRT73 Gene

mRNA expression in normal human tissues for KRT73 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT73 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (23.0), Skin - Not Sun Exposed (Suprapubic) (21.8), and Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT73 Gene

SOURCE GeneReport for Unigene cluster for KRT73 Gene Hs.55410

mRNA Expression by UniProt/SwissProt for KRT73 Gene

Q86Y46-K2C73_HUMAN
Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level).
genes like me logo Genes that share expressions with KRT73: view

In Situ Assay Products

Orthologs for KRT73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT73 35
  • 98.4 (n)
  • 98.33 (a)
KRT73 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT73 35
  • 88.33 (n)
  • 88.15 (a)
KRT73 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT73 35
  • 89.07 (n)
  • 91.11 (a)
mouse
(Mus musculus)
Mammalia Krt73 35
  • 84.54 (n)
  • 84.23 (a)
Krt73 16
Krt73 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Krt73 35
  • 84.6 (n)
  • 84.42 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
Species with no ortholog for KRT73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT73 Gene

ENSEMBL:
Gene Tree for KRT73 (if available)
TreeFam:
Gene Tree for KRT73 (if available)

Paralogs for KRT73 Gene

genes like me logo Genes that share paralogs with KRT73: view

Variants for KRT73 Gene

Sequence variations from dbSNP and Humsavar for KRT73 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs581690 -- 52,616,327(-) CTGCT(A/G)CAGCA reference, synonymous-codon
rs590743 -- 52,616,351(+) TCCAG(C/T)ACCTG synonymous-codon, reference
rs597520 -- 52,616,801(-) AGAGA(A/C)TAGGC intron-variant
rs606688 -- 52,617,302(-) ACTGA(A/G)GAACA intron-variant
rs622747 -- 52,618,884(+) GTAGG(G/T)GTACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT73 Gene

Variant ID Type Subtype PubMed ID
nsv832415 CNV Loss 17160897
nsv428281 CNV Gain 18775914
nsv522631 CNV Loss 19592680
esv1004870 CNV Deletion 20482838

Relevant External Links for KRT73 Gene

HapMap Linkage Disequilibrium report
KRT73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT73 Gene

Disorders for KRT73 Gene

No disorders were found for KRT73 Gene.

No data available for UniProtKB/Swiss-Prot for KRT73 Gene

Publications for KRT73 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2003) 2 3 4 23
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  4. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for KRT73 Gene

Sources for KRT73 Gene

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