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KRT73 Gene

protein-coding   GIFtS: 49
GCID: GC12M053001

Keratin 73

  Search for KRT73
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 731 2     cytokeratin-732
K6IRS32 3 5     Keratin 6 Irs32
KRT6IRS32 3 5     Keratin, Type II Cytoskeletal 732
Type II Inner Root Sheath-Specific Keratin-K6irs32 3     keratin-732
Type-II Keratin Kb362 3     Cytokeratin-733
CK-732 3     KB363
K732 3     Keratin-733
IRT6IRS32     

External Ids:    HGNC: 289281   Entrez Gene: 3191012   Ensembl: ENSG000001860497   OMIM: 6082475   UniProtKB: Q86Y463   

Export aliases for KRT73 gene to outside databases

Previous GC identifers: GC12M051288 GC12M050045


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT73 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner
root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.(provided by
RefSeq, Jun 2009)

GeneCards Summary for KRT73 Gene:
KRT73 (keratin 73) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46
Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root
sheath (IRS) of the hair follicle (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT73 gene promoter:
         CHOP-10   PPAR-alpha   NF-1   AML1a   IRF-7A   STAT5A   Tal-1beta   C/EBPalpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT73 promoter sequence
   Search Chromatin IP Primers for KRT73

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT73 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053001:  view genomic region     (about GC identifiers)

Start:
53,001,354 bp from pter      End:
53,012,343 bp from pter
Size:
10,990 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 73  
Size: 540 amino acids; 58923 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Secondary accessions: Q32MB2
Alternative splicing: 2 isoforms:  Q86Y46-1   Q86Y46-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT73: NX_Q86Y46

Explore proteomics data for KRT73 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys149
  • Modification sites at PhosphoSitePlus

  • See KRT73 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778238.1  
    ENSEMBL proteins: 
     ENSP00000307014   ENSP00000449081  

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    Search eBioscience for ELISAs for KRT73 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q86Y46

    ProtoNet protein and cluster: Q86Y46

    3 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT73           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C73_HUMAN, Q86Y46
    Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root
    sheath (IRS) of the hair follicle (Probable)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with KRT73           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT73:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT73
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT73
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT73

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate KRT73:
    hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidKRT73 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KRT73
    Predesigned siRNA for gene silencing in human, mouse, rat KRT73

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    cytoskeleton2
    peroxisome2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with KRT73           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT73
    Interactions:

        Search GeneGlobe Interaction Network for KRT73

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for KRT73 (Q86Y463 ENSP000003070144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    SQSTM1Q135013I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT73 (K2C73)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT73 gene: 
    NM_175068.2  

    Unigene Cluster for KRT73:

    Keratin 73
    Hs.55410  [show with all ESTs]
    Unigene Representative Sequence: AJ508776
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305748(uc001sas.3) ENST00000546934 ENST00000552855
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate KRT73:
    hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidKRT73 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRT73
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT73
      QuantiTect SYBR Green Assays in human, mouse, rat KRT73
      QuantiFast Probe-based Assays in human, mouse, rat KRT73

    Additional mRNA sequence: AJ508776.1 

    2 DOTS entries:

    DT.106840  DT.121118073 

    2 AceView cDNA sequences:

    NM_175068 AJ508776 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT73 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTCCCTGG
    KRT73 Expression
    About this image


    KRT73 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Hair (Integumentary System)
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Heart (Cardiovascular System)
    KRT73 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT73 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55410

    UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46
    Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the
    inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of
    the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region
    where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where
    cuticle cells terminally differentiate (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT73

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT73 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt731 , 5 keratin 731, 5 84.54(n)1
    84.23(a)1
      15 (57.03 cM)5
    2239151  NM_212485.21  NP_997650.11 
     1017933085 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    many ↔ many
    2(95440022-95458665)


    ENSEMBL Gene Tree for KRT73 (if available)
    TreeFam Gene Tree for KRT73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT73 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT72  KRT792  KRT722  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT73 using alignment to 2 protein entries:     K2C73_HUMAN (see all proteins) (see all similar genes):
    KRTHB6    KRT7    KRT121P    KRT71    KRT5    KRT6A
    KRT6B    KRTHB1    KRT6C    KRT79    KRT72    KRT1B
    KRT78    KRT75    KRT4    KRT74    KRT2    KRT80

    Find genes that share paralogs with KRT73           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT73 (see all 438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0380944
    A colorectal cancer sample4--see VAR_0380942 T M mis40--------
    VAR_0380934
    A colorectal cancer sample4--see VAR_0380932 R H mis40--------
    rs1875018361,2
    --52835335(+) CACCCA/GTGCTC 1 -- ds50010--------
    rs6701421,2
    C,F,O,A,H--52835407(+) TCTACC/ATTTGG 1 -- ds500126Minor allele frequency- A:0.38NS EA NA WA CSA 2358
    rs120994571,2
    C,F--52835413(+) TTTGGG/TCCTTT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1917422841,2
    --52835534(+) TCCCTA/GCCAAT 1 -- ds50010--------
    rs1831936501,2
    --52835760(+) GAATCA/GGCCTG 1 -- ds50010--------
    rs1388146121,2
    --52835815(+) GGGAGA/GTGAGG 1 -- ut310--------
    rs1880817191,2
    --52835992(+) TGCAGA/GTCTAT 1 -- ut310--------
    rs1413828611,2
    C--52836210(+) GGGCTC/TCAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT73 (53001354 - 53012343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KRT73:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1004870CNV Deletion20482838
    nsv832415CNV Loss17160897
    nsv522631CNV Loss19592680
    nsv428281CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT73
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608247    OMIM disorders: --


    Find genes that share disorders with KRT73           About GenesLikeMe


    Export disorders for KRT73 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT73 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with KRT73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PubMed id 12648212)1, 2, 3, 9 Langbein L.... Schweizer J. (J. Invest. Dermatol. 2003)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    3. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)
    10. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 319101 HGNC: 28928 AceView: K6IRS3 Ensembl:ENSG00000186049 euGenes: HUgn319101
    ECgene: KRT73 H-InvDB: KRT73

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT73 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT73 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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