KRT73 Gene
protein-coding GIFtS: 46
GCID: GC12M053001
|
|
keratin 73
| |
Aliases
for KRT73 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 731 2 | | Cytokeratin-733 | | K6IRS31 2 3 5 | | Keratin 6 Irs32 | | KRT6IRS31 2 3 5 | | Keratin, Type II Cytoskeletal 732 | | Type II Inner Root Sheath-Specific Keratin-K6irs32 3 | | Keratin-733 | | Type-II Keratin Kb362 3 | | Cytokeratin-733 | | CK-732 3 | | KB363 | | K732 3 | | Keratin-733 | | IRT6IRS32 | | |
Export aliases for KRT73 gene to outside databasesPrevious GC identifers: GC12M051288 GC12M050045 |
Summaries
for KRT73 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT73:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and aresubdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner rootsheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.(provided by RefSeq, Jun2009)
UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath(IRS) of the hair follicle (Probable)
|
Genomic Views
for KRT73 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT73 gene promoter:
CHOP-10 PPAR-alpha NF-1 AML1a IRF-7A STAT5A Tal-1beta C/EBPalpha E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT73
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT73 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.3KRT73 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M053001: view genomic region
(about GC identifiers)
Start:
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53,001,354 bp from pter |
End:
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53,012,343 bp from pter |
Size:
|
10,990 bases |
Orientation:
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minus strand |
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Proteins
for KRT73 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46 (See
protein sequence)Recommended Name: Keratin, type II cytoskeletal 73 Size: 540 amino acids; 58923 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)(40-55 and 56-70 kDa, respectively)
Secondary accessions: Q32MB2Alternative splicing: 2 isoforms: Q86Y46-1 Q86Y46-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KRT73: NX_Q86Y46
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Y46
KRT73 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778238.1
ENSEMBL proteins: ENSP00000307014 ENSP00000449081
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045095 | keratin filament |
IEA | -- |
KRT73 for ontologies About GeneDecksing
KRT73 Antibody Products:
Assay Products for KRT73: |
Protein
Domains /
Families
for KRT73 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT73 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Y46ProtoNet protein and cluster: Q86Y46 3 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46Similarity: Belongs to the intermediate filament family |
Function
for KRT73 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath(IRS) of the hair follicle (Probable)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT73 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT73
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT73 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT73 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT73:
|
Pathways & Interactions
for KRT73 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT73
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for KRT73 (Q86Y463 ENSP000003070144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRT73 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT73
Search CenterWatch for drugs/clinical trials and news about KRT73 / K2C73
|
Transcripts
for KRT73 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT73 gene: NM_175068.2 Unigene Cluster for KRT73: Keratin 73 Hs.55410 [show with all ESTs]Unigene Representative Sequence: AJ5087763 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000305748(uc001sas.3) ENST00000546934 ENST00000552855
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT73 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT73
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT73 (NM_175068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT73 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT73 |
Additional cDNA sequence: AJ508776.1 4 DOTS entries: DT.106840 DT.121117466 DT.121118073 DT.95206987 2 AceView cDNA sequences: NM_175068 AJ508776
GeneLoc Exon Structure
|
Expression
for KRT73 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT73 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTCCCTGG
About this image
See KRT73 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT73
SOURCE GeneReport for Unigene cluster: Hs.55410
UniProtKB/Swiss-Prot: K2C73_HUMAN, Q86Y46Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the innerroot sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. Inthe IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cellsundergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminallydifferentiate (at protein level)
SABiosciences Custom PCR Arrays for KRT73
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT73
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT73 |
Orthologs
for KRT73 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT73 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for KRT73 (if available)
TreeFam Gene Tree for KRT73 (if available) |
Paralogs
for KRT73 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT73 gene
- KRT742 KRT772 KRT6B2 KRT832 KRT762 KRT862 KRT32 KRT842
- KRT82 KRT812 KRT712 KRT8P112 KRT782 KRT72 ENSG000001704422 KRT792
- KRT722 KRT52 KRT6C2 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/43 SIMAP similar genes for KRT73 using alignment to 2 protein entries: K2C73_HUMAN (see all proteins)
(see all similar genes):KRTHB6 KRT7 KRT121P KRT71 KRT5 KRT6A
KRT6B KRTHB1 KRT6C KRT79 KRT72 KRT1B
KRT78 KRT75 KRT4 KRT74 KRT2 KRT80
KRT73 for paralogs About GeneDecksing
|
Genomic Variants
for KRT73 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT73 (53001354 - 53012343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT73: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT73 |
|
Disorders
/ Diseases
for KRT73 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT73 for disorders About GeneDecksing
OMIM gene information: 608247
OMIM disorders: --
4  diseases for KRT73: About MalaCardshepatocellular carcinoma pharyngitis carcinoma neuronitis
Export disorders for KRT73 gene to outside databases
|
Publications
for KRT73 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT73 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT73) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. (PubMed id 12648212)1, 2, 3, 9 Langbein L....Schweizer J. (2003)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PubMed id 16874310)2 Langbein L.... Schweizer J. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KRT73 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT73 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT73 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT73 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT73 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT73 gene:
Search GeneIP for patents involving KRT73
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT73 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | KRT73 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT73 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT73 |
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