Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KRT72 Gene

protein-coding   GIFtS: 50
GCID: GC12M052979

Keratin 72

  See KRT72-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Keratin 721 2     cytokeratin-722
K6IRS22 3 5     Keratin 6, Inner Root Sheath, 22
KRT6IRS22 3 5     Keratin Protein K6irs2
Type II Inner Root Sheath-Specific Keratin-K6irs22 3     Keratin, Type II Cytoskeletal 722
Type-II Keratin Kb352 3     keratin-722
CK-722 3     Cytokeratin-723
K722 3     KB353
KRT62 3     Keratin-723
K6irs2     

External Ids:    HGNC: 289321   Entrez Gene: 1408072   Ensembl: ENSG000001704867   OMIM: 6082465   UniProtKB: Q14CN43   

Export aliases for KRT72 gene to outside databases

Previous GC identifers: GC12M051266 GC12M050023


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KRT72 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type
II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains
coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II
keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are
clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been
found for this gene.(provided by RefSeq, Jun 2009)

GeneCards Summary for KRT72 Gene:
KRT72 (keratin 72) is a protein-coding gene. Diseases associated with KRT72 include pachyonychia congenita. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4
Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root
sheath (IRS) of the hair follicle (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT72 gene promoter:
         Oct-B1   NF-1   AML1a   Nkx2-5   C/EBPalpha   GATA-1   PPAR-alpha   CHOP-10   HSF2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT72 promoter sequence
   Search Chromatin IP Primers for KRT72

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT72 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052979:  view genomic region     (about GC identifiers)

Start:
52,979,373 bp from pter      End:
52,995,322 bp from pter
Size:
15,950 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 72  
Size: 511 amino acids; 55877 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Caution: Was initially thought to be the ortholog of mouse KRT71 (PubMed:11703281)
Sequence caution: Sequence=BAC04039.1; Type=Erroneous initiation;
Secondary accessions: B4DEI8 H9KV51 Q8NA87 Q8WWY9 Q8WWZ0
Alternative splicing: 3 isoforms:  Q14CN4-1   Q14CN4-2   Q14CN4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KRT72: NX_Q14CN4

Explore proteomics data for KRT72 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142
  • Modification sites at PhosphoSitePlus

  • See KRT72 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139697.1  NP_001139698.1  NP_542785.1  

    ENSEMBL proteins: 
     ENSP00000441160   ENSP00000346269   ENSP00000446881   ENSP00000449324   ENSP00000293745  
     ENSP00000446151  

    KRT72 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KRT72
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KRT72
    GenScript Custom Purified and Recombinant Proteins Services for KRT72
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT72

     
    Search eBioscience for Proteins for KRT72 

     
    antibodies-online proteins for KRT72 (2 products) 

     
    Search antibodies-online for peptides for KRT72

    KRT72 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KRT72
    Abcam antibodies for KRT72 (Q14CN4, P02538)
    Cloud-Clone Corp. Antibodies for KRT72
    ThermoFisher Antibodies for KRT72
    LSBio Antibodies in human, mouse, rat for KRT72
    antibodies-online antibodies for KRT72 (35 products) 

    KRT72 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KRT72
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT72
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KRT72
    Cloud-Clone Corp. CLIAs for KRT72
    Search eBioscience for ELISAs for KRT72 
    antibodies-online kits for KRT72 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q14CN4

    ProtoNet protein and cluster: Q14CN4

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT72           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C72_HUMAN, Q14CN4
    Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root
    sheath (IRS) of the hair follicle (Probable)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with KRT72           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KRT72:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT72
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT72

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT72
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT72

    miRNA
    Products:
        
    miRTarBase miRNAs that target KRT72:
    hsa-mir-335-5p (MIRT016775)

    Block miRNA regulation of human, mouse, rat KRT72 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT72:
    hsa-miR-137 hsa-miR-3150b-3p hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidKRT72 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KRT72
    Predesigned siRNA for gene silencing in human, mouse, rat KRT72

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KRT72

    Clone
    Products:
         
    OriGene clones in human, mouse for KRT72 (see all 14)
    OriGene ORF clones in mouse, rat for KRT72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KRT72 (NM_080747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT72

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KRT72
    Browse ESI BIO Cell Lines and PureStem Progenitors for KRT72 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT72


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    cytoskeleton2
    peroxisome2
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--

    Find genes that share ontologies with KRT72           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT72
    Interactions:

        Search GeneGlobe Interaction Network for KRT72

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for KRT72 (Q14CN43 ENSP000002937454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT17Q046953, ENSP000003084524I2D: score=1 STRING: ENSP00000308452
    KRT18P057833, ENSP000003734874I2D: score=1 STRING: ENSP00000373487
    TFP027873, ENSP000002649984I2D: score=1 STRING: ENSP00000264998
    UBA5Q9GZZ93I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT72 (K2C72)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KRT72 gene (3 alternative transcripts): 
    NM_001146225.1  NM_001146226.1  NM_080747.2  

    Unigene Cluster for KRT72:

    Keratin 72
    Hs.662013  [show with all ESTs]
    Unigene Representative Sequence: NM_080747
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537672 ENST00000354310 ENST00000550829 ENST00000549979 ENST00000293745(uc001sar.2 uc001saq.2 uc010sns.1)
    ENST00000398066(uc010snt.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT72 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate KRT72:
    hsa-miR-137 hsa-miR-3150b-3p hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidKRT72 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KRT72
    Predesigned siRNA for gene silencing in human, mouse, rat KRT72
    Clone
    Products:
         
    OriGene clones in human, mouse for KRT72 (see all 14)
    OriGene ORF clones in mouse, rat for KRT72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KRT72 (NM_080747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT72
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT72
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT72
      QuantiTect SYBR Green Assays in human, mouse, rat KRT72
      QuantiFast Probe-based Assays in human, mouse, rat KRT72

    Additional mRNA sequence: 

    AK093060.1 AK293645.1 AK302016.1 AY033495.1 BC113686.1 

    3 DOTS entries:

    DT.75142748  DT.100010973  DT.121117938 

    4 AceView cDNA sequences:

    AY033495 NM_080747 AX747893 AK093060 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KRT72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTCTTGG
    KRT72 Expression
    About this image


    KRT72 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Hair (Integumentary System)    fully expand to see all 4 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Testis (Reproductive System)
    KRT72 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT72 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.662013

    UniProtKB/Swiss-Prot: K2C72_HUMAN, Q14CN4
    Tissue specificity: Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar
    epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is
    specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in
    Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of
    the dermal papilla (at protein level)

        Custom PCR Arrays for KRT72
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT72
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT72
    QuantiTect SYBR Green Assays in human, mouse, rat KRT72
    QuantiFast Probe-based Assays in human, mouse, rat KRT72
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT72

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT72 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt721 , 5 keratin 72, pseudogene5
    keratin 721
    82.81(n)1
    83.14(a)1
      15 (57.02 cM)5
    1058661  NM_213728.11  NP_998893.11 
     1017761725 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    many ↔ many
    2(95440022-95458665)


    ENSEMBL Gene Tree for KRT72 (if available)
    TreeFam Gene Tree for KRT72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KRT72 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT72  KRT792  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT72 using alignment to 4 protein entries:     K2C72_HUMAN (see all proteins) (see all similar genes):
    KRT7    KRT71    KRTHB6    KRT79    KRT5    KRT121P
    KRT3    KRT6A    KRT6B    KRT6C    KRT4    KRT74
    KRT8    KRT75    KRT76    KRT78    KRT1    KRT1B

    Find genes that share paralogs with KRT72           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KRT72 (see all 555)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57982141,2
    C--50022859(+) GTGGG-/A/GAGAAT 3 -- ds50011NA 2
    rs2019918231,2
    --50026644(+) TATAT-/ATATAT 3 -- int10--------
    rs2000041611,2
    --50026647(+) ATATA-/TATTAA 3 -- int10--------
    rs6149841,2
    C,F,O,A,H--52813327(-) CCTAAT/CATGTA 3 -- ds500121Minor allele frequency- C:0.21NA NS EA WA CSA 936
    rs111701821,2
    C,F,H--52813355(+) TAAAAG/AAAGAG 3 -- ds500117Minor allele frequency- A:0.17NS EA NA WA 1418
    rs2015894821,2
    --52813425(+) AGACA-/GGTGGG 3 -- ds50010--------
    rs1132964221,2
    C--52813465(+) AGACAG/ATGAGT 3 -- ds50012Minor allele frequency- A:0.08WA 120
    rs124247921,2
    C,F,A,H--52813475(+) TGTGCT/ACAACC 3 -- ds500112Minor allele frequency- A:0.12NS EA NA CSA WA 788
    rs1440724751,2
    --52813510(+) GGAAGC/GCATGA 3 -- ds50010--------
    rs22925031,2
    C,F,O,A,H--52813528(-) ACAGAT/CGTTAG 3 -- ds500134Minor allele frequency- C:0.42EA NA NS CSA WA 4756

    HapMap Linkage Disequilibrium report for KRT72 (52979373 - 52995322 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT72:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832415CNV Loss17160897
    nsv428281CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT72
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT72

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608246    OMIM disorders: --

    1 disease for KRT72:    
    About MalaCards
    pachyonychia congenita

    1 disease from the University of Copenhagen DISEASES database for KRT72:
    Pachyonychia congenita

    Find genes that share disorders with KRT72           About GenesLikeMe


    Export disorders for KRT72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KRT72 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KRT72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans. (PubMed id 11703281)1, 2, 3, 9 Porter R.M....McLean W.H.I. (Br. J. Dermatol. 2001)
    2. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PubMed id 12648212)1, 2, 3 Langbein L.... Schweizer J. (J. Invest. Dermatol. 2003)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Comparison of immunohistochemical staining in breast papillary neoplasms of cytokeratin 5/6 and p63 in core needle biopsies and surgical excisions. (PubMed id 22553810)1 Koo J.S....Park B.W. (amp 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Reliability of the 34I^E12, keratin 5/6, p63, bcl-2, and AMACR in the diagnosis of prostate carcinoma. (PubMed id 20189848)1 Boran C....Akyol M. (Urol. Oncol. 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 140807 HGNC: 28932 AceView: K6IRS2 Ensembl:ENSG00000170486 euGenes: HUgn140807
    ECgene: KRT72 H-InvDB: KRT72

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KRT72 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KRT72 gene:
    Search GeneIP for patents involving KRT72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KRT72  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KRT72  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KRT72  
     OriGene qSTAR qPCR primer pairs in human, mouse for KRT72   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KRT72   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT72   OriGene Custom Protein Services for KRT72  

     
     
     Block miRNA regulation of human, mouse, rat KRT72 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KRT72
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT72 Predesigned siRNA for gene silencing in human, mouse, rat KRT72
     QuantiFast Probe-based Assays in human, mouse, rat KRT72 QuantiTect SYBR Green Assays in human, mouse, rat KRT72
     Custom PCR Arrays for KRT72 Search Chromatin IP Primers for KRT72
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KRT72  Search GeneGlobe Interaction Network for KRT72
     Regulatory tfbs in KRT72 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KRT72 GenScript cDNA clones with any tag delivered in your preferred vector for KRT72
     GenScript Custom Assay Services for KRT72 GenScript Custom overexpressing Cell Line Services for KRT72
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KRT72 (K2C72)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for KRT72
     See all of Abcam's Antibodies, Kits and Proteins for KRT72
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KRT72
     Antibodies for KRT72
     ELISAs for KRT72
     CLIAs for KRT72



     Browse ESI BIO Cell Lines and PureStem Progenitors for KRT72
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT72
     SwitchGear 3'UTR luciferase reporter plasmids for KRT72
     SwitchGear Promoter luciferase reporter plasmids for KRT72
     ThermoFisher Antibodies for KRT72
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT72
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT72
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT72
     LSBio Antibodies in human, mouse, rat for KRT72
     Browse compounds at ApexBio
     Search Addgene for plasmids for KRT72
      Search eBioscience for proteins for KRT72
      Search eBioscience for elisas for KRT72
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for KRT72 (35 products)
     antibodies-online kits for KRT72 (8 products)
      Search antibodies-online for peptides for KRT72
     antibodies-online proteins for KRT72 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KRT72 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4