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Aliases for KRT71 Gene

Aliases for KRT71 Gene

  • Keratin 71, Type II 2 3
  • KRT6IRS1 3 4 6
  • K6IRS1 3 4 6
  • Type II Inner Root Sheath-Specific Keratin-K6irs1 3 4
  • Type-II Keratin Kb34 3 4
  • Cytokeratin-71 3 4
  • Keratin 6 Irs 3 4
  • Keratin-71 3 4
  • HK6irs1 3 4
  • HK6irs 3 4
  • CK-71 3 4
  • K71 3 4
  • Keratin, Type II Cytoskeletal 71 3
  • Keratin 71 2
  • KRT6IRS 3
  • HYPT13 3
  • KB34 4

External Ids for KRT71 Gene

Previous GeneCards Identifiers for KRT71 Gene

  • GC12M051224
  • GC12M052939
  • GC12M049982

Summaries for KRT71 Gene

Entrez Gene Summary for KRT71 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT71 Gene

KRT71 (Keratin 71, Type II) is a Protein Coding gene. Diseases associated with KRT71 include hypotrichosis 13 and woolly hair syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT71 Gene

  • Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT71 Gene

Genomics for KRT71 Gene

Regulatory Elements for KRT71 Gene

Genomic Location for KRT71 Gene

52,543,909 bp from pter
52,553,147 bp from pter
9,239 bases
Minus strand

Genomic View for KRT71 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT71 Gene

Proteins for KRT71 Gene

  • Protein details for KRT71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 71
    Protein Accession:
    Secondary Accessions:
    • B3KVC1
    • Q3SY85
    • Q96DU2

    Protein attributes for KRT71 Gene

    523 amino acids
    Molecular mass:
    57292 Da
    Quaternary structure:
    • Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity).
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)

neXtProt entry for KRT71 Gene

Proteomics data for KRT71 Gene at MOPED

Post-translational modifications for KRT71 Gene

  • Ubiquitination at Lys147
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT71 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT71 Gene

Domains for KRT71 Gene

Gene Families for KRT71 Gene

  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q3SY84
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT71: view

Function for KRT71 Gene

Molecular function for KRT71 Gene

UniProtKB/Swiss-Prot Function: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.

Gene Ontology (GO) - Molecular Function for KRT71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT71: view
genes like me logo Genes that share phenotypes with KRT71: view

Animal Model Products

miRNA for KRT71 Gene

miRTarBase miRNAs that target KRT71

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT71

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRT71 Gene

Localization for KRT71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT71 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for KRT71 Gene COMPARTMENTS Subcellular localization image for KRT71 gene
Compartment Confidence
cytosol 3
mitochondrion 3
cytoskeleton 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for KRT71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005882 intermediate filament --
GO:0045095 keratin filament IDA 22592156
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT71: view

Pathways for KRT71 Gene

SuperPathways for KRT71 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031069 hair follicle morphogenesis IMP 22592156
GO:0045109 intermediate filament organization IMP 22592156
genes like me logo Genes that share ontologies with KRT71: view

No data available for Pathways by source for KRT71 Gene

Transcripts for KRT71 Gene

mRNA/cDNA for KRT71 Gene

(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT71 Gene

Keratin 71:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT71

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRT71
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT71 Gene

No ASD Table

Relevant External Links for KRT71 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT71 Gene

mRNA expression in normal human tissues for KRT71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT71 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (41.6) and Skin - Sun Exposed (Lower leg) (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT71 Gene

SOURCE GeneReport for Unigene cluster for KRT71 Gene Hs.660007

mRNA Expression by UniProt/SwissProt for KRT71 Gene

Tissue specificity: Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level).
genes like me logo Genes that share expressions with KRT71: view

In Situ Assay Products

Orthologs for KRT71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT71 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT71 35
  • 98.66 (n)
  • 99.24 (a)
KRT71 36
  • 99 (a)
(Bos Taurus)
Mammalia KRT71 35
  • 91.91 (n)
  • 94.07 (a)
KRT71 36
  • 94 (a)
(Canis familiaris)
Mammalia KRT71 35
  • 90.38 (n)
  • 92.73 (a)
(Mus musculus)
Mammalia Krt71 35
  • 88.06 (n)
  • 91.76 (a)
Krt71 16
Krt71 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
-- 36
  • 76 (a)
-- 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Krt71 35
  • 88.19 (n)
  • 92.15 (a)
(Gallus gallus)
Aves LOC768881 35
  • 66.59 (n)
  • 59.82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for KRT71:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT71 Gene

Gene Tree for KRT71 (if available)
Gene Tree for KRT71 (if available)

Paralogs for KRT71 Gene

genes like me logo Genes that share paralogs with KRT71: view

Variants for KRT71 Gene

Sequence variations from dbSNP and Humsavar for KRT71 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs588887 -- 52,553,741(-) GGGGG(A/T)GAAGT upstream-variant-2KB
rs595705 -- 52,554,501(-) GGAAT(G/T)CAGAG upstream-variant-2KB
rs603193 -- 52,546,384(+) ATCCG(C/T)GCCAG synonymous-codon, reference
rs622446 -- 52,548,578(+) TGCGG(A/G)AGATG intron-variant
rs625682 -- 52,553,846(+) AATTC(A/G)GGGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRT71 Gene

Variant ID Type Subtype PubMed ID
nsv832412 CNV Loss 17160897
nsv709 CNV Insertion 18451855

Relevant External Links for KRT71 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT71 Gene

Disorders for KRT71 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KRT71 Gene including...

Search for KRT71 Gene in MalaCards »


  • Hypotrichosis 13 (HYPT13) [MIM:615896]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT13 is characterized by sparse woolly hair. {ECO:0000269 PubMed:22592156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KRT71 Gene

Relevant External Links for KRT71

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with KRT71: view

Publications for KRT71 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2003) 2 3 4 23
  2. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle. (PMID: 11982755) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2002) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  5. A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis. (PMID: 22592156) Fujimoto A. … Shimomura Y. (J. Invest. Dermatol. 2012) 3 4

Products for KRT71 Gene

Sources for KRT71 Gene

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