Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT71 Gene

protein-coding   GIFtS: 50
GCID: GC12M052939

Keratin 71

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 711 2     hK6irs12 3
K6IRS12 3 5     KRT6IRS2
KRT6IRS12 3 5     cytokeratin-712
Keratin 6 Irs2 3     Keratin, Type II Cytoskeletal 712
Type II Inner Root Sheath-Specific Keratin-K6irs12 3     keratin-712
Type-II Keratin Kb342 3     Cytokeratin-713
CK-712 3     KB343
K712 3     Keratin-713
hK6irs2 3     

External Ids:    HGNC: 289271   Entrez Gene: 1128022   Ensembl: ENSG000001396487   OMIM: 6082455   UniProtKB: Q3SY843   

Export aliases for KRT71 gene to outside databases

Previous GC identifers: GC12M051224 GC12M049982


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT71 Gene:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are
subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner
root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.(provided by
RefSeq, Jun 2009)

GeneCards Summary for KRT71 Gene: 
KRT71 (keratin 71) is a protein-coding gene. Diseases associated with KRT71 include hypotrichosis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

UniProtKB/Swiss-Prot: K2C71_HUMAN, Q3SY84
Function: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the
inner root sheath (IRS) of the hair follicle (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT71 gene promoter:
         RP58   AML1a   NRSF form 1   HTF   STAT5A   NRSF form 2   Roaz   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT71 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT71

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT71


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT71 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT71 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052939:  view genomic region     (about GC identifiers)

Start:
52,937,693 bp from pter      End:
52,946,931 bp from pter
Size:
9,239 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K2C71_HUMAN, Q3SY84 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 71  
Size: 523 amino acids; 57292 Da
Subunit: Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity)
Developmental stage: In all 3 IRS layers, expression begins simultaneously in adjacent cells of the lowermost bulb
above the germinative cell pool and terminated higher up in the follicle with the asynchronous terminal
differentiation of each cell layer (at protein level)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Secondary accessions: B3KVC1 Q3SY85 Q96DU2

Explore the universe of human proteins at neXtProt for KRT71: NX_Q3SY84

Explore proteomics data for KRT71 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3SY84

  • KRT71 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT71 Protein Expression
    REFSEQ proteins: NP_258259.1  
    ENSEMBL proteins: 
     ENSP00000267119  

    Human Recombinant Protein Products for KRT71: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KRT71
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KRT71
    GenScript Custom Purified and Recombinant Proteins Services for KRT71
    Novus Biologicals KRT71 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT71 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045095keratin filament IEA--

    KRT71 for ontologies           About GeneDecksing



    KRT71 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KRT71
    GenScript Custom Superior Antibodies Services for KRT71
    Novus Biologicals KRT71 Antibodies
    Abcam antibodies for KRT71
    Cloud-Clone Corp. Antibodies for KRT71 
    ThermoFisher Antibodies for KRT71
    LSBio Antibodies in human, mouse, rat for KRT71 

    Assay Products for KRT71: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KRT71
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT71
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KRT71 
    Cloud-Clone Corp. CLIAs for KRT71


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF2: Intermediate filaments type II, keratins (basic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry Q3SY84

    ProtoNet protein and cluster: Q3SY84

    3 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: K2C71_HUMAN, Q3SY84
    Similarity: Belongs to the intermediate filament family


    KRT71 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C71_HUMAN, Q3SY84
    Function: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the
    inner root sheath (IRS) of the hair follicle (Probable)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    KRT71 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 18 alleles(MGI details for Krt71):
     adipose tissue  endocrine/exocrine gland  integument  no phenotypic analysis 

    KRT71 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT71 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT71

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT71 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT71 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT71
    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT71:
    hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidKRT71 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT71
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT71

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KRT71
    Sirion Biotech Customized adenovirus for overexpression of KRT71

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KRT71 (see all 7)
    OriGene ORF clones in mouse, rat for KRT71
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT71 (NM_033448)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT71
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT71
    Sirion Biotech Customized lentivirus for stable overexpression of KRT71 
                         Customized lentivirus expression plasmids for stable overexpression of KRT71 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KRT71
    Search LifeMap BioReagents cell lines for KRT71
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT71


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT71

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/32 Interacting proteins for KRT71 (Q3SY843 ENSP000002671194) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=2 STRING: ENSP00000363970
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    GABARAPO951663I2D: score=2 
    ATG12O948173I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031069hair follicle morphogenesis IEA--

    KRT71 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT71 (K2C71)

    Search CenterWatch for drugs/clinical trials and news about KRT71 / K2C71

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT71 gene: 
    NM_033448.2  

    Unigene Cluster for KRT71:

    Keratin 71
    Hs.660007  [show with all ESTs]
    Unigene Representative Sequence: NM_033448
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000267119(uc001sao.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT71
    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT71:
    hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidKRT71 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT71
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT71
    Clone
    Products:
         
    OriGene clones in human, mouse for KRT71 (see all 7)
    OriGene ORF clones in mouse, rat for KRT71
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT71 (NM_033448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT71
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT71
    Sirion Biotech Customized lentivirus for stable overexpression of KRT71 
                         Customized lentivirus expression plasmids for stable overexpression of KRT71 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT71
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT71
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT71
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT71

    Additional mRNA sequence: 

    AJ308599.1 AJ308600.1 AJ308601.1 AK122795.1 BC103917.1 BC103918.1 

    3 DOTS entries:

    DT.95262692  DT.409205  DT.121118073 

    5 AceView cDNA sequences:

    AJ308599 NM_033448 AJ308601 AJ308600 AK122795 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT71 expression in normal human tissues (normalized intensities)      KRT71 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGACGACCT
    KRT71 Expression
    About this image


    KRT71 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Hair (Integumentary System)
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Heart (Cardiovascular System)

    See KRT71 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT71

    SOURCE GeneReport for Unigene cluster: Hs.660007

    UniProtKB/Swiss-Prot: K2C71_HUMAN, Q3SY84
    Tissue specificity: Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath
    (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also
    detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated
    Henle cells (at protein level)

        SABiosciences Custom PCR Arrays for KRT71
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT71
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT71
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT71
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT71
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT71

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KRT71 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt711 , 5 keratin 711, 5 88.06(n)1
    91.76(a)1
      15 (57.00 cM)5
    567351  NM_019956.11  NP_064340.11 
     1017339505 


    ENSEMBL Gene Tree for KRT71 (if available)
    TreeFam Gene Tree for KRT71 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT71 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    18/35 SIMAP similar genes for KRT71 using alignment to 1 protein entry:     K2C71_HUMAN(see all similar genes):
    KRT74    KRT72    KRT5    KRT7    KRT1B    KRT73
    KRT121P    KRT3    KRT79    KRT4    KRT77    KRT6A
    KRT6B    KRT6C    KRT8    KRT75    KRT2    KRT84

    KRT71 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/372 SNPs in KRT71 are shown (see all 372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875121431,2
    --52771697(+) GGAGGA/CCAGGC 1 -- ds50010--------
    rs47618021,2
    C,F,A,H--52771711(+) TGAGCG/AGTGAG 1 -- ds500124Minor allele frequency- A:0.35NS EA NA 2540
    rs1496033121,2
    C--52772010(+) GTACT-/TGTGTGT 1 -- ds50010--------
    rs1385208341,2
    C--52772057(+) GGTGCA/GCGCTC 1 -- ds50010--------
    rs1118519881,2
    C--52772070(+) GTGAGT/CGAATT 1 -- ds50012Minor allele frequency- C:0.07CSA WA 120
    rs1169442271,2
    C,F--52772095(+) TACTTT/CGAATA 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1923261001,2
    --52772155(+) GGAAGA/GCCATT 1 -- ut310--------
    rs22925051,2
    C,F,A,H--52772375(+) CTAGGC/TCCCAG 1 -- ut31 ese312Minor allele frequency- T:0.49EA NS NA 2328
    rs1415750041,2
    --52772485(+) GGGCTG/TGTGGT 1 -- ut310--------
    rs79635201,2
    C,H--52772555(+) AGCTTG/TGTCAT 1 -- ut313Minor allele frequency- T:0.04NS CSA WA 216

    HapMap Linkage Disequilibrium report for KRT71 (52937693 - 52946931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT71:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv709CNV Insertion18451855
    nsv832412CNV Loss17160897


    Human Gene Mutation Database (HGMD): KRT71
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT71
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT71

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608245    OMIM disorders: --

    2 diseases for KRT71:    About MalaCards
    hypotrichosis    

    1 disease from the University of Copenhagen DISEASES database for KRT71:
    Hypotrichosis

    KRT71 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KRT71

    Export disorders for KRT71 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT71 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with KRT71)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. (PubMed id 12648212)1, 2, 3, 9 Langbein L....Schweizer J. (2003)
    2. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle. (PubMed id 11982755)1, 2, 3 Langbein L....Schweizer J. (2002)
    3. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    6. A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis. (PubMed id 22592156)1 Fujimoto A....Shimomura Y. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112802 HGNC: 28927 AceView: KRT6IRS Ensembl:ENSG00000139648 euGenes: HUgn112802
    ECgene: KRT71 H-InvDB: KRT71

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT71 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT71 gene:
    Search GeneIP for patents involving KRT71

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KRT71  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KRT71  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KRT71  
     OriGene qSTAR qPCR primer pairs in human, mouse for KRT71   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KRT71   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KRT71   OriGene Custom Protein Services for KRT71  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT71
     QIAGEN SeqTarget long-range PCR primers for resequencing KRT71
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT71
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT71
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT71
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT71
     GenScript Custom Purified and Recombinant Proteins Services for KRT71 GenScript cDNA clones with any tag delivered in your preferred vector for KRT71
     GenScript Custom Assay Services for KRT71 GenScript Custom Superior Antibodies Services for KRT71
     GenScript Custom overexpressing Cell Line Services for KRT71 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KRT71 promoter
     Search Chromatin IP Primers for KRT71
     RT2 qPCR Primer Assay in human, mouse, rat KRT71
     Search GNC Networks for KRT71
     SABiosciences Custom PCR Arrays for KRT71
     Search Tocris compounds for KRT71 (K2C71)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KRT71 antibodies
     KRT71 proteins
     Antibodies for KRT71
     See all of Abcam's Antibodies, Kits and Proteins for KRT71
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KRT71
     Antibodies for KRT71
     ELISAs for KRT71
     CLIAs for KRT71
     Search LifeMap BioReagents cell lines for KRT71
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT71
     SwitchGear 3'UTR luciferase reporter plasmids for KRT71
     SwitchGear Promoter luciferase reporter plasmids for KRT71
     ThermoFisher Antibodies for KRT71
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT71
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT71
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT71
    Customized:
     lentivirus for stable overexpression of KRT71
     lentivirus expression plasmids for stable overexpression of KRT71
     adenovirus for overexpression of KRT71
     LSBio Antibodies in human, mouse, rat for KRT71
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KRT71 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4