Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT71 Gene

Aliases for KRT71 Gene

  • Keratin 71 2 3
  • Keratin 71, Type II 2 3 5
  • Type II Inner Root Sheath-Specific Keratin-K6irs1 3 4
  • Type-II Keratin Kb34 3 4
  • Cytokeratin-71 3 4
  • Keratin 6 Irs 3 4
  • Keratin-71 3 4
  • KRT6IRS1 3 4
  • HK6irs1 3 4
  • K6IRS1 3 4
  • HK6irs 3 4
  • CK-71 3 4
  • K71 3 4
  • KRT6IRS 3
  • HYPT13 3
  • KB34 4

External Ids for KRT71 Gene

Previous GeneCards Identifiers for KRT71 Gene

  • GC12M051224
  • GC12M052939
  • GC12M049982

Summaries for KRT71 Gene

Entrez Gene Summary for KRT71 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT71 Gene

KRT71 (Keratin 71) is a Protein Coding gene. Diseases associated with KRT71 include hypotrichosis 13 and woolly hair syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT73.

UniProtKB/Swiss-Prot for KRT71 Gene

  • Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT71 Gene

Genomics for KRT71 Gene

Regulatory Elements for KRT71 Gene

Genomic Location for KRT71 Gene

52,543,909 bp from pter
52,553,147 bp from pter
9,239 bases
Minus strand

Genomic View for KRT71 Gene

Genes around KRT71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT71 Gene

Proteins for KRT71 Gene

  • Protein details for KRT71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 71
    Protein Accession:
    Secondary Accessions:
    • B3KVC1
    • Q3SY85
    • Q96DU2

    Protein attributes for KRT71 Gene

    523 amino acids
    Molecular mass:
    57292 Da
    Quaternary structure:
    • Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity).
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

neXtProt entry for KRT71 Gene

Proteomics data for KRT71 Gene at MOPED

Post-translational modifications for KRT71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT71 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT71 Gene

Domains & Families for KRT71 Gene

Gene Families for KRT71 Gene

Suggested Antigen Peptide Sequences for KRT71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT71: view

Function for KRT71 Gene

Molecular function for KRT71 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.

Gene Ontology (GO) - Molecular Function for KRT71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT71: view
genes like me logo Genes that share phenotypes with KRT71: view

Human Phenotype Ontology for KRT71 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for KRT71 Gene

miRTarBase miRNAs that target KRT71

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT71 Gene

Localization for KRT71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT71 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for KRT71 Gene COMPARTMENTS Subcellular localization image for KRT71 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
mitochondrion 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for KRT71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KRT71: view

Pathways & Interactions for KRT71 Gene

SuperPathways for KRT71 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT71 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT71 Gene

Drugs & Compounds for KRT71 Gene

No Compound Related Data Available

Transcripts for KRT71 Gene

mRNA/cDNA for KRT71 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT71 Gene

Keratin 71:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT71 Gene

No ASD Table

Relevant External Links for KRT71 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT71 Gene

mRNA expression in normal human tissues for KRT71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT71 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x41.6) and Skin - Sun Exposed (Lower leg) (x8.8).

Protein differential expression in normal tissues from HIPED for KRT71 Gene

This gene is overexpressed in Hair follicle (45.5) and Saliva (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT71 Gene

SOURCE GeneReport for Unigene cluster for KRT71 Gene Hs.660007

mRNA Expression by UniProt/SwissProt for KRT71 Gene

Tissue specificity: Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level).
genes like me logo Genes that share expression patterns with KRT71: view

Protein tissue co-expression partners for KRT71 Gene

Primer Products

In Situ Assay Products

Orthologs for KRT71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT71 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT71 35
  • 91.91 (n)
  • 94.07 (a)
KRT71 36
  • 94 (a)
(Canis familiaris)
Mammalia KRT71 35
  • 90.38 (n)
  • 92.73 (a)
(Mus musculus)
Mammalia Krt71 35
  • 88.06 (n)
  • 91.76 (a)
Krt71 16
Krt71 36
  • 91 (a)
(Pan troglodytes)
Mammalia KRT71 35
  • 98.66 (n)
  • 99.24 (a)
KRT71 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Krt71 35
  • 88.19 (n)
  • 92.15 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
-- 36
  • 76 (a)
-- 36
  • 75 (a)
(Gallus gallus)
Aves LOC768881 35
  • 66.59 (n)
  • 59.82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for KRT71:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT71 Gene

Gene Tree for KRT71 (if available)
Gene Tree for KRT71 (if available)

Paralogs for KRT71 Gene

genes like me logo Genes that share paralogs with KRT71: view

Variants for KRT71 Gene

Sequence variations from dbSNP and Humsavar for KRT71 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs665522 - 52,552,759(+) ATTGA(C/T)GGTAA reference, missense
rs665470 - 52,552,714(+) GATCT(C/T)GGGGT reference, missense
rs35988863 - 52,547,898(+) CTGGA(A/T)GAGCC reference, missense
rs10783518 - 52,544,713(+) CATAG(A/C/G)CACTG reference, missense
rs2292506 - 52,544,536(+) TCTAC(C/T)GACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRT71 Gene

Variant ID Type Subtype PubMed ID
nsv832412 CNV Loss 17160897
nsv709 CNV Insertion 18451855

Variation tolerance for KRT71 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.75; 98.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT71 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT71 Gene

Disorders for KRT71 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KRT71 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 13
  • hypotrichosis with wooly hair
woolly hair syndrome
  • familial woolly hair
- elite association - COSMIC cancer census association via MalaCards
Search KRT71 in MalaCards View complete list of genes associated with diseases


  • Hypotrichosis 13 (HYPT13) [MIM:615896]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT13 is characterized by sparse woolly hair. {ECO:0000269 PubMed:22592156}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT71

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT71: view

No data available for Genatlas for KRT71 Gene

Publications for KRT71 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2003) 2 3 4 23 67
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle. (PMID: 11982755) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2002) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for KRT71 Gene

Sources for KRT71 Gene

Back to Top