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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRT7 Gene

protein-coding GIFtS: 65
GCID: GC12P052626

keratin 7

Explore 182 diseases affiliated with
KRT7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratin 7¹ ²		Keratin, 55K Type II Cytoskeletal²
K7¹ ² ³		Keratin, Simple Epithelial Type I, K7²
SCL¹ ² ³		Keratin, Type II Cytoskeletal 7²
CK7¹ ²		Keratin-7³
K2C7¹ ²		Sarcolectin³
Type-II Keratin Kb7² ³		Type II Mesothelial Keratin K7²
CK-7² ³		Cytokeratin-7³
Cytokeratin 7²		Keratin-7³
Cytokeratin-7³		Sarcolectin³

External Ids:	HGNC: 6445¹	Entrez Gene: 3855²	Ensembl: ENSG00000135480⁷	OMIM: 148059⁵	UniProtKB: P08729³

Export aliases for KRT7 gene to outside databases

Previous GC identifers: GC12M052275 GC12P052657 GC12P052343 GC12P050913 GC12P049659

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT7:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or

neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of

simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia

lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II

cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript

variants; however, not all variants have been fully described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729

Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational

regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)

Gene Wiki entry for KRT7 (Keratin 7)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRT7 gene promoter:
c-Fos PPAR-gamma1 p53 AP-1 c-Jun PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRT7 promoter sequence

Search SABiosciences Chromatin IP Primers for KRT7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13

KRT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT7 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P052626: view genomic region (about GC identifiers)

Start:	52,626,304 bp from pter	End:	52,645,970 bp from pter
Size:	19,667 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729 (See protein sequence)

Recommended Name: Keratin, type II cytoskeletal 7

Size: 469 amino acids; 51386 Da

Subunit: Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor

3 (eIF3) subunit EIF3S10 and with HPV16 E7

Subcellular location: Cytoplasm

Mass spectrometry: Mass=51203.48; Method=MALDI; Range=2-469; Source=PubMed:11840567;

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to

basic; 56-70 kDa)

Sequence caution: Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: Q92676 Q9BUD8 Q9Y3R7

Explore the universe of human proteins at neXtProt for KRT7: NX_P08729

Post-translational modifications:

Arg-20 is dimethylated, probably to asymmetric dimethylarginine¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08729

KRT7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005547.3

ENSEMBL proteins:

ENSP00000329243 ENSP00000447285

Human Recombinant Protein Products:

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	Novus Biologicals KRT7 Proteins Novus Biologicals KRT7 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KRT7

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0005882	intermediate filament	NAS	2415537

KRT7 for ontologies About GeneDecksing

KRT7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KRT7
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	OriGene Antibodies (see all 3): KRT7 OriGene Custom Antibody Services for KRT7
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	Novus Biologicals KRT7 Antibodies
	Abcam antibodies for KRT7
	Uscn Antibodies for KRT7
	ThermoFisher Antibody for KRT7

Assay Products for KRT7:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KRT7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT7 for domains About GeneDecksing

5 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR009053 Prefoldin

IPR016044 F

IPR003054 Keratin_II

Graphical View of Domain Structure for InterPro Entry P08729

ProtoNet protein and cluster: P08729

3 Blocks protein families:

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

IPB003054 Type II keratin signature

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729

Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational

regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)

Induction: Up-regulated by retinoic acid

Genatlas biochemistry entry for KRT7:

keratin 7,type II,simple epithelial

miRNA Products:		miRTarBase miRNAs that target KRT7: hsa-mir-133a (MIRT000331), hsa-mir-145 (MIRT004938), hsa-mir-30a (MIRT004939), hsa-mir-195 (MIRT004937), hsa-mir-199b-3p (MIRT004634), hsa-mir-125b (MIRT004936)

		OriGene 3'-UTR Clone: KRT7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT7
		1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT7:
		hsa-miR-489
		SwitchGear 3'UTR luciferase reporter plasmid: KRT7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT7 (see all 7) OriGene shRNA RFP: KRT7 OriGene siRNA: KRT7
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KRT7

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KRT7
		LifeMap BioReagents: cell line associated with KRT7: PureStem ES-210, Ecto-ntu Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT7

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	--
GO:0005515	protein binding	IPI	11169732

KRT7 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for KRT7:

Cell cycle / mitosis defect

Decreased cell number

S arrest

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Keratin filaments

Cytoskeleton remodeling Keratin filaments

1.00

Cytoskeleton remodeling_Keratin filaments

0.91

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KRT7

Cytoskeleton remodeling Keratin filaments

1 Cell Signaling Technology (CST) Pathway for KRT7

Cytoskeletal Signaling

1 GeneGo (Thomson Reuters) Pathway for KRT7

Cytoskeleton remodeling Keratin filaments

1 BioSystems Pathway for KRT7

EGFR1 Signaling Pathway

KRT7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KRT7

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/14 Interacting proteins for KRT7 (P08729^{1, 2, 3} ENSP00000329243⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCNA	P12004²^,³	MINT-7995244 I2D: score=2
EIF3A	Q14152¹^,³, ENSP00000358140⁴	EBI-297833,EBI-366617 I2D: score=2 STRING: ENSP00000358140
HSPA1A	P08107³, ENSP00000364802⁴	I2D: score=2 STRING: ENSP00000364802
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-61554 I2D: score=3 STRING: ENSP00000339007
KRT17	Q04695³, ENSP00000308452⁴	I2D: score=3 STRING: ENSP00000308452

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IDA	10492017
GO:0006417	regulation of translation	IDA	12072504
GO:0007010	cytoskeleton organization	NAS	--
GO:0019048	virus-host interaction	IEA	--
GO:0044419	interspecies interaction between organisms	--	--

KRT7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KRT7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT7

1 DrugBank Compound for KRT7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Primaquine	--	90-34-6	target	other/unknown	12711178 20713019

10/32 Novoseek chemical compound relationships for KRT7 gene (see all 32) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mucicarmine	76.9	8	16334025 (1), 18422977 (1), 9208972 (1), 9870855 (1) (see all 7)
progesterone	59	64	9160304 (2), 12217766 (1), 12455793 (1), 14506675 (1) (see all 54)
paraffin	58.3	18	16911464 (1), 10767834 (1), 11668468 (1), 11688464 (1) (see all 16)
hematoxylin	58.3	13	15900119 (1), 10767834 (1), 10926813 (1), 11586253 (1) (see all 12)
estrogen	58.2	84	9160304 (3), 12715337 (2), 11028811 (1), 12217766 (1) (see all 70)
b 723	57.2	13	16415794 (3), 10987260 (3), 12514785 (1), 15589579 (1) (see all 8)
reticulin	39.6	4	11511789 (1), 19669379 (1), 19329493 (1)
anit	38.8	1	17397517 (1)
glycogen	7.92	2	17034957 (1), 17952403 (1)
methotrexate	4.94	1	15023035 (1)

Search CenterWatch for drugs/clinical trials and news about KRT7 / K2C7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KRT7 gene:

NM_005556.3

Unigene Clusters for KRT7:

Keratin 7

Hs.411501 [show with all ESTs], Hs.670221 [show with all ESTs]

Unigene Representative Sequences: AK128505, BC042076

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000552400 ENST00000546666 ENST00000331817(uc001saa.1) ENST00000551537

ENST00000547613 ENST00000548088 ENST00000546856 ENST00000552183 ENST00000551130

ENST00000549127 ENST00000552322 ENST00000548657 ENST00000550153 ENST00000549638

miRNA Products:		OriGene 3'-UTR Clone: KRT7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT7
		1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT7:
		hsa-miR-489
		SwitchGear 3'UTR luciferase reporter plasmid: KRT7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KRT7 (NM_005556)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT7
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT7

Additional cDNA sequence: BC042076.1

24/71 DOTS entries (see all 71):

DT.99965532 DT.100669506 DT.100669505 DT.100052545 DT.100669499 DT.95378801 DT.100669501 DT.87013153

DT.121118117 DT.121118148 DT.95339736 DT.100669500 DT.449936 DT.91734014 DT.121119113 DT.86994981

DT.100060134 DT.121117843 DT.121117730 DT.121118563 DT.101986350 DT.121118498 DT.102836199 DT.86995055

2 AceView cDNA sequences:

BC042076 BF846639

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KRT7 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9
SP1:													-		-												-		-		-
SP2:													-		-
SP3:													-		-												-		-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for KRT7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRT7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTCCTGGT

About this image

KRT7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Trophoblast

Trophoblast Cells

Selective marker (cell-identifying gene)

Extraembryonic Tissues

Liver

Intrahepatic Biliary Tree

Biliary Epithelial Cells

Liver

Intrahepatic Biliary Tree

Oval Cells

Liver

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Kidney

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Trophoblast-like cells (Generation of tropho...)

See KRT7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT7

SOURCE GeneReport for Unigene clusters: Hs.411501 Hs.670221

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729

Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix

and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the

esophagus

SABiosciences Expression via Pathway-Focused PCR Array including KRT7:

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KRT7 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC395772⁶ KRT8⁶	--	61(a) 41(a)	1 ↔ 1 possible ortholog	E22C19W28_E50C23(687707-703948) E22C19W28_E50C23(508667-511528)
lizard (Anolis carolinensis)	Reptilia	-- KRT7⁶ (see all 3)	--	58(a) (see all 3)	possible ortholog 1 ↔ 1 (see all 3)	AAWZ02039762(4434-6932) 2(95868214-95891124)
African clawed frog (Xenopus laevis)	Amphibia	LOC397878²	Xenopus laevis mRNA for cytokeratin type II (XenCK55(5/6))	79.92(n)		BC045268.1
zebrafish (Danio rerio)	Actinopterygii	si:dkey-222f2.1¹	si:dkey-222f2.1	63.79(n) 60.91(a)		568321 XM_691644.4 XP_696736.2
worm (Caenorhabditis elegans)	Secernentea	ifp-1⁶ ifc-2⁶ (see all 12)	Intermediate filament protein ifc-2 (see all 12)	7(a) 6(a) (see all 12)	possible ortholog possible ortholog (see all 12)	X(9675786-9680111) X(642160-654902)

ENSEMBL Gene Tree for KRT7 (if available)
TreeFam Gene Tree for KRT7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KRT7 gene

KRT74² KRT77² KRT6B² KRT83² KRT76² KRT86² KRT3² KRT84²

KRT8² KRT81² KRT71² KRT8P11² KRT78² ENSG00000170442² KRT79² KRT72²

KRT73² KRT5² KRT6C² KRT6A² KRT85² KRT2² KRT75² KRT1²

KRT82² KRT4²

18/70 SIMAP similar genes for KRT7 using alignment to 4 protein entries: K2C7_HUMAN (see all proteins) (see all similar genes):

KRT5 KRT6A KRT6C KRT1B KRT3 KRT1

KRT72 KRT6B KRT8 KRT4 KRT79 KRT77

KRT78 KRT75 KRT84 KRT73 KRT76 KRT121P

KRT7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12312136^1,2	C,F,	--	52624970(+)	`GAAAAG/TCCCAG`	1	--	us2k¹		7		NA WA EA	366
rs190255995^1,2		--	52624974(+)	`AGCCCA/GGAGAC`	1	--	us2k¹		0	--	--	--	--
rs180818522^1,2		--	52625097(+)	`CAAGGA/CAACAG`	1	--	us2k¹		0	--	--	--	--
rs74093355^1,2	C,	--	52625196(+)	`GCAGAT/CCCTGT`	1	--	us2k¹		2		WA	120
rs79337965^1,2	F,	--	52625217(+)	`AGATGG/AGGACG`	1	--	us2k¹		1		WA	118
rs185089856^1,2		--	52625271(+)	`GAGCAC/GGCGTT`	1	--	us2k¹		0	--	--	--	--
rs151160909^1,2	C,	--	52625338(+)	`TTGGA-/GTG TGTGTGTGTG`	1	--	us2k¹		0	--	--	--	--
rs201804303^1,2	C	--	52625338(+)	`GTTGGA/TGNNNN`	1	--	us2k¹		0	--	--	--	--
rs151142282^1,2		--	52625435(+)	`CACAGC/GACCAG`	1	--	us2k¹		0	--	--	--	--
rs117053820^1,2		--	52625447(+)	`TAATCC/TGTATG`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for KRT7 (52626304 - 52645970 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KRT7
1 CNV: 3889

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT7

DNA2.0 Custom Variant and Variant Library Synthesis for KRT7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRT7 for disorders           About GeneDecksing

OMIM gene information: 148059    OMIM disorders: --

20/182 diseases for KRT7 (see all 182):    About MalaCards

sertoli-leydig cell tumor brooke-spiegler syndrome pseudomyxoma peritonei appendiceal neoplasm

signet ring cell adenocarcinoma malignant mixed mullerian tumor anal canal adenocarcinoma sinonasal undifferentiated carcinoma

thrombotic thrombocytopenic purpura leydig cell tumor ovarian large-cell neuroendocrine carcinoma secretory meningioma

ovarian primitive germ cell tumor myxopapillary ependymoma renal clear cell carcinoma non-small cell lung carcinoma

carcinoma pulmonary large cell neuroendocrine carcinoma sweat gland carcinoma ovarian sex cord tumors

20 diseases from the University of Copenhagen DISEASES database for KRT7:

Carcinoma Cholangiocarcinoma Renal cell carcinoma Pseudomyxoma peritonei

Renal oncocytoma Metanephric adenoma Oxyphilic adenoma Adenoma

Breast cancer Skin cancer Ovarian cancer Vulval Paget's disease

Lung cancer Mixed cell type cancer Hepatocellular carcinoma Colorectal cancer

Skin benign neoplasm Ovarian Brenner tumor Nephrogenic adenoma Synovial sarcoma

10/96 Novoseek disease relationships for KRT7 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma	83.1	303	15371952 (6), 14663355 (6), 11745209 (5), 19098678 (5) (see all 99)
carcinoma	80.2	199	14668551 (3), 18065959 (3), 10705819 (3), 10590374 (3) (see all 99)
carcinoma mucinous	79.9	16	12352188 (3), 16980943 (2), 15362373 (1), 17909724 (1) (see all 9)
extramammary pagets disease	77.5	6	9989849 (1), 9388055 (1), 19119096 (1), 10730755 (1) (see all 5)
tumors	74.8	466	9308728 (7), 12352188 (6), 8986525 (5), 7545815 (4) (see all 99)
metastatic carcinoma	74.8	29	12454811 (3), 14668551 (2), 11668468 (1), 11866966 (1) (see all 21)
oncocytoma	74.2	39	16927643 (9), 10765081 (4), 18603673 (3), 15933529 (3) (see all 15)
metaplasia	72.9	45	10088547 (3), 16951671 (3), 12826887 (3), 11710638 (3) (see all 26)
carcinoma neuroendocrine	72.8	11	16508780 (1), 20398190 (1), 10987260 (1), 15913431 (1) (see all 7)
cholangiocarcinoma	72.6	24	10931219 (4), 10843291 (2), 12429797 (2), 19094709 (2) (see all 15)

Export disorders for KRT7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRT7 gene, integrated from 9 sources (see all 1031):
(articles sorted by number of sources associating them with KRT7)

Utopia: connect your pdf to the dynamic
world of online information

Sarcolectin (SCL): structure and expression of the recombinant molecule. (PubMed id 10492017)^{1, 2, 9} Kaba A.... Chany C. (1999)
New consensus nomenclature for mammalian keratins. (PubMed id 16831889)^{1, 3} Schweizer J....Wright M.W. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse. (PubMed id 12359226)^{1, 2} Smith F.J.D....McLean W.H.I. (2002)
Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)^{1, 2} Harris R.A....Zvelebil M.J. (2002)
Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. (PubMed id 12072504)^{1, 2} Kanduc D. (2002)
Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)^{1, 2} Lin L.... Burger M.M. (2001)
Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PubMed id 1713141)^{1, 3} Rosenberg M....Shows T.B. (1991)
Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells. (PubMed id 2459129)^{1, 2} Glass C. and Fuchs E. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3855	HGNC: 6445	AceView: KRT7	Ensembl:ENSG00000135480	euGenes: HUgn3855
ECgene: KRT7	H-InvDB: KRT7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRT7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KRT7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KRT7 gene:
Search GeneIP for patents involving KRT7

GeneCards and IP:
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KRT7 Gene

keratin 7

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LUNG TUMOR
Pseudomyxoma Peritonei
Carcinoma Basal Cell
Oncocytoma
dysplasia
Secretory Meningioma
ADENOCARCINOMA LUNG
LUNG CARCINOMA
Ameloblastoma
Thymic Neoplasms
Metaplasia
Dysgerminoma
Carcinoma Pancreatic Ductal
primary tumor
ovarian carcinoma metastatic
Adenocarcinoma
BILIARY CIRRHOSIS PRIMARY
Carcinoma Transitional Cell
Brenner Tumor
Colorectal Carcinoma
Urachus
Carcinoma Acinar Cell
ADENOCARCINOMA GASTRIC
Sarcoma Epithelioid
Carcinosarcoma
GASTRIC CARCINOMA
cervical adenocarcinoma
GALLBLADDER CARCINOMA
Bowens Disease
TUMOR LIVER
Cysts
kidney tumor
Cystadenocarcinoma Mucinous
Sex Cord-Stromal Tumor
ENDOMETRIAL CARCINOMA
Tumors
Malignant mesothelioma
Carcinoma Lobular
Metastasis
prostatic adenocarcinoma
Carcinoma Ductal
Hepatoblastoma
Cystadenoma Mucinous
Pagets Disease Mammary
renal clear cell carcinoma
Barrett Esophagus
Ovarian Neoplasms
BREAST CARCINOMA
Appendiceal Neoplasms
Thymic Carcinoma
Carcinoma Mucoepidermoid
Cystadenoma
Carcinoma
Adenocarcinoma Basal Cell
PROSTATE CARCINOMA
epithelial tumor
Adenolymphoma
Focal Nodular Hyperplasia
METASTATIC CARCINOMA
Craniopharyngioma Papillary
Adenocarcinoma Tubular
Chordoma
Carcinoma Endometrioid
Carcinoma Papillary
HEPATOCELLULAR CARCINOMA
Carcinoma Bronchioloalveolar
Carcinoma Anaplastic
Carcinoma Renal Cell
Carcinoma Signet Ring Cell
small cell lung cancer
Wilms tumor
Sarcoma Synovial
Granulosa Cell Tumor
Carcinoma Large Cell
Adenoma Bile Duct
Sertoli-Leydig Cell Tumor
Carcinoma Undifferentiated
Carcinoma Mucinous
Adenoma
Carcinoma Adenoid Cystic
Carcinoma Medullary
Cholangiocarcinoma
OVARIAN CARCINOMA
Neoplasms Glandular
mesothelioma
Teratoma
Extramammary Pagets Disease
Carcinoma Squamous Cell
PANCREATIC CARCINOMA
stromal tumors
Sarcoma Spindle Cell
Carcinoma Neuroendocrine
Yolk Sac Tumor
Carcinoma Adenosquamous
DUODENAL CARCINOMA
adenocarcinoma bladder

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KRT7 Gene

keratin 7

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