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Aliases for KRT7 Gene

Aliases for KRT7 Gene

  • Keratin 7, Type II 2 3
  • Sarcolectin 2 3 4
  • Type-II Keratin Kb7 3 4
  • Cytokeratin 7 2 3
  • Cytokeratin-7 3 4
  • Keratin-7 3 4
  • CK-7 3 4
  • SCL 3 4
  • K7 3 4
  • Keratin, Simple Epithelial Type I, K7 3
  • Keratin, 55K Type II Cytoskeletal 3
  • Keratin, Type II Cytoskeletal 7 3
  • Type II Mesothelial Keratin K7 3
  • 55K Type II Cytoskeletal 2
  • Type II Cytoskeletal 7 2
  • Keratin 7 2
  • Keratin 2
  • K2C7 3
  • CK7 3

External Ids for KRT7 Gene

Previous GeneCards Identifiers for KRT7 Gene

  • GC12M052275
  • GC12P052657
  • GC12P052343
  • GC12P050913
  • GC12P049659
  • GC12P052626

Summaries for KRT7 Gene

Entrez Gene Summary for KRT7 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT7 Gene

KRT7 (Keratin 7, Type II) is a Protein Coding gene. Diseases associated with KRT7 include cell type cancer and mixed cell type cancer. Among its related pathways are Cytoskeletal Signaling and EGFR1 Signaling Pathway. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT7 Gene

  • Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Gene Wiki entry for KRT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT7 Gene

Genomics for KRT7 Gene

Regulatory Elements for KRT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRT7 Gene

52,232,520 bp from pter
52,252,186 bp from pter
19,667 bases
Plus strand

Genomic View for KRT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT7 Gene

Proteins for KRT7 Gene

  • Protein details for KRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 7
    Protein Accession:
    Secondary Accessions:
    • Q92676
    • Q9BUD8
    • Q9Y3R7

    Protein attributes for KRT7 Gene

    469 amino acids
    Molecular mass:
    51386 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7. Interacts with GPER1.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)
    • Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for KRT7 Gene

Proteomics data for KRT7 Gene at MOPED

Post-translational modifications for KRT7 Gene

  • Arg-20 is dimethylated, probably to asymmetric dimethylarginine
  • Ubiquitination at Lys101, Lys108, and Lys394
  • Modification sites at PhosphoSitePlus

Other Protein References for KRT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KRT7 (K7)

No data available for DME Specific Peptides for KRT7 Gene

Domains for KRT7 Gene

Gene Families for KRT7 Gene

  • IFF2 :Intermediate filaments type II, keratins (basic)

Suggested Antigen Peptide Sequences for KRT7 Gene

Graphical View of Domain Structure for InterPro Entry



  • P08729
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT7: view

Function for KRT7 Gene

Molecular function for KRT7 Gene

GENATLAS Biochemistry:
keratin 7,type II,simple epithelial
UniProtKB/Swiss-Prot Function:
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
UniProtKB/Swiss-Prot Induction:
Up-regulated by retinoic acid.

Gene Ontology (GO) - Molecular Function for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 11169732
genes like me logo Genes that share ontologies with KRT7: view

Phenotypes for KRT7 Gene

genes like me logo Genes that share phenotypes with KRT7: view

Animal Models for KRT7 Gene

MGI Knock Outs for KRT7:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KRT7 Gene

Localization for KRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT7 Gene


Subcellular locations from

Jensen Localization Image for KRT7 Gene COMPARTMENTS Subcellular localization image for KRT7 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
nucleus 4
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 2459129
GO:0005882 intermediate filament NAS 2415537
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT7: view

Pathways for KRT7 Gene

genes like me logo Genes that share pathways with KRT7: view

Pathways by source for KRT7 Gene

1 Cell Signaling Technology pathway for KRT7 Gene
1 BioSystems pathway for KRT7 Gene
1 GeneGo (Thomson Reuters) pathway for KRT7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0046417 chorismate metabolic process --
genes like me logo Genes that share ontologies with KRT7: view

Compounds for KRT7 Gene

(1) Drugbank Compounds for KRT7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
90-34-6 target other/unknown

(32) Novoseek inferred chemical compound relationships for KRT7 Gene

Compound -log(P) Hits PubMed IDs
mucicarmine 76.9 7
progesterone 59 55
paraffin 58.3 16
hematoxylin 58.3 12
estrogen 58.2 73
genes like me logo Genes that share compounds with KRT7: view

Transcripts for KRT7 Gene

mRNA/cDNA for KRT7 Gene

(13) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT7 Gene

Keratin 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP6: -

Relevant External Links for KRT7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT7 Gene

mRNA expression in normal human tissues for KRT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT7 Gene

This gene is overexpressed in Minor Salivary Gland (18.2), Lung (6.8), and Thyroid (6.1).

Protein differential expression in normal tissues for KRT7 Gene

This gene is overexpressed in Salivary gland (24.3), Placenta (8.3), and Islet of Langerhans (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRT7 Gene

SOURCE GeneReport for Unigene cluster for KRT7 Gene Hs.411501

mRNA Expression by UniProt/SwissProt for KRT7 Gene

Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
genes like me logo Genes that share expressions with KRT7: view

In Situ Assay Products

No data available for Expression partners for KRT7 Gene

Orthologs for KRT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRT7 35
  • 88.43 (n)
  • 84.48 (a)
KRT7 36
  • 84 (a)
(Canis familiaris)
Mammalia KRT7 35
  • 86.06 (n)
  • 84.7 (a)
(Mus musculus)
Mammalia Krt7 35
  • 84.46 (n)
  • 82.93 (a)
Krt7 16
Krt7 36
  • 83 (a)
(Pan troglodytes)
Mammalia KRT7 35
  • 99.08 (n)
  • 98.29 (a)
KRT7 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Krt7 35
  • 83.81 (n)
  • 82.34 (a)
(Monodelphis domestica)
Mammalia KRT7 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia KRT7 36
  • 68 (a)
(Gallus gallus)
Aves KRT7 35
  • 74.39 (n)
  • 74.39 (a)
KRT7 36
  • 42 (a)
(Anolis carolinensis)
Reptilia KRT7 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt5.7 35
  • 67.86 (n)
  • 69.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397878 35
(Danio rerio)
Actinopterygii krt4 36
  • 55 (a)
krt5 36
  • 49 (a)
krt8 36
  • 50 (a)
si:dkey-222f2.1 36
  • 53 (a)
zgc:158846 36
  • 49 (a)
Species with no ortholog for KRT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT7 Gene

Gene Tree for KRT7 (if available)
Gene Tree for KRT7 (if available)

Paralogs for KRT7 Gene

genes like me logo Genes that share paralogs with KRT7: view

Variants for KRT7 Gene

Sequence variations from dbSNP and Humsavar for KRT7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8801 -- 52,233,465(+) ATGGG(G/T)GCCCG reference, missense, nc-transcript-variant
rs10564 -- 52,243,059(+) CTCCG(A/G)AATAC synonymous-codon, reference, nc-transcript-variant
rs14364 -- 52,248,896(+) GCAGC(C/G)CTCAT utr-variant-3-prime, nc-transcript-variant
rs936331 -- 52,246,785(-) TGCCT(A/G)TGGGA intron-variant
rs936332 -- 52,246,493(-) CCTCC(A/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT7 Gene

Variant ID Type Subtype PubMed ID
dgv511e1 CNV Complex 17122850
nsv899087 CNV Loss 21882294

Relevant External Links for KRT7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT7 Gene

Disorders for KRT7 Gene

(96) Novoseek inferred disease relationships for KRT7 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 83.1 181
carcinoma 80.2 130
carcinoma mucinous 79.9 12
extramammary pagets disease 77.5 5
tumors 74.8 187
genes like me logo Genes that share disorders with KRT7: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for KRT7 Gene

Publications for KRT7 Gene

  1. Sarcolectin (SCL): structure and expression of the recombinant molecule. (PMID: 10492017) Kaba A. … Chany C. (Biochimie 1999) 3 4 23
  2. Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction. (PMID: 11962749) Jovanovic I. … Kanavaros P. (Histol. Histopathol. 2002) 3 23
  3. Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications. (PMID: 14631371) Driessen A. … Ectors N. (Mod. Pathol. 2004) 3 23
  4. Expression of CDX2, cytokeratins 7 and 20 in sinonasal intestinal-type adenocarcinoma. (PMID: 15894926) Ortiz-Rey J.A. … AntA^n I. (Appl. Immunohistochem. Mol. Morphol. 2005) 3 23
  5. Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study. (PMID: 15502805) Mazal P.R. … Susani M. (Mod. Pathol. 2005) 3 23

Products for KRT7 Gene

Sources for KRT7 Gene

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