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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT7 Gene

protein-coding   GIFtS: 64
GCID: GC12P052626

Keratin 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 71 2     K2C72
Cytokeratin 71 2     cytokeratin-72
sarcolectin1 2     Keratin, 55K Type II Cytoskeletal2
Type-II Keratin Kb72 3     Keratin, Simple Epithelial Type I, K72
CK-72 3     Keratin, Type II Cytoskeletal 72
K72 3     keratin-72
SCL2 3     Type II Mesothelial Keratin K72
55K Type II Cytoskeletal1     Cytokeratin-73
keratin1     Keratin-73
Type II Cytoskeletal 71     Sarcolectin3
CK72     

External Ids:    HGNC: 64451   Entrez Gene: 38552   Ensembl: ENSG000001354807   OMIM: 1480595   UniProtKB: P087293   

Export aliases for KRT7 gene to outside databases

Previous GC identifers: GC12M052275 GC12P052657 GC12P052343 GC12P050913 GC12P049659


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT7 Gene:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic
or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation
of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple
epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding
the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in
several transcript variants; however, not all variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT7 Gene: 
KRT7 (keratin 7) is a protein-coding gene. Diseases associated with KRT7 include renal adenoma, and ovarian large-cell neuroendocrine carcinoma, and among its related super-pathways are Cytoskeleton remodeling Keratin filaments. GO annotations related to this gene include protein binding and structural molecule activity. An important paralog of this gene is KRT74.

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729
Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the
translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)

Gene Wiki entry for KRT7 (Keratin 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT7 gene promoter:
         c-Fos   PPAR-gamma1   p53   AP-1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT7 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052626:  view genomic region     (about GC identifiers)

Start:
52,626,304 bp from pter      End:
52,645,970 bp from pter
Size:
19,667 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 7  
Size: 469 amino acids; 51386 Da
Subunit: Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator
factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7
Subcellular location: Cytoplasm
Mass spectrometry: Mass=51203.48; Method=MALDI; Range=2-469; Source=PubMed:11840567;
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Sequence caution: Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q92676 Q9BUD8 Q9Y3R7

Explore the universe of human proteins at neXtProt for KRT7: NX_P08729

Explore proteomics data for KRT7 at MOPED 

Post-translational modifications:

  • UniProtKB: Arg-20 is dimethylated, probably to asymmetric dimethylarginine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08729

  • KRT7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT7 Protein Expression
    REFSEQ proteins: NP_005547.3  
    ENSEMBL proteins: 
     ENSP00000329243  

    Human Recombinant Protein Products for KRT7: 
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    Cloud-Clone Corp. Proteins for KRT7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005882intermediate filament NAS2415537

    KRT7 for ontologies           About GeneDecksing



    KRT7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF2: Intermediate filaments type II, keratins (basic)

    5 InterPro protein domains:
     IPR009053 Prefoldin
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P08729

    ProtoNet protein and cluster: P08729

    3 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729
    Similarity: Belongs to the intermediate filament family


    KRT7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C7_HUMAN, P08729
    Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the
    translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)
    Induction: Up-regulated by retinoic acid

         Genatlas biochemistry entry for KRT7:
    keratin 7,type II,simple epithelial

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS--
    GO:0005515protein binding IPI11169732
         
    KRT7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KRT7:
     Cell cycle / mitosis defect  Decreased cell number  S arrest 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Krt7):
     cellular  renal/urinary system 

    KRT7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Krt7tm1Whim for KRT7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT7

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT7 

    miRNA
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    miRTarBase miRNAs that target KRT7:
    hsa-mir-133a (MIRT000331), hsa-mir-145 (MIRT004938), hsa-mir-30a (MIRT004939), hsa-mir-195 (MIRT004937), hsa-mir-199b-3p (MIRT004634), hsa-mir-125b (MIRT004936)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT7
    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT7:
    hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidKRT7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KRT7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments0.91
    2EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    3Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KRT7
        Cytoskeleton remodeling Keratin filaments


    1 Cell Signaling Technology (CST) Pathway for KRT7
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for KRT7
        Cytoskeleton remodeling Keratin filaments

    1 BioSystems Pathway for KRT7
        EGFR1 Signaling Pathway



    KRT7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/22 Interacting proteins for KRT7 (P087291, 2, 3 ENSP000003292434) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation ----
    GO:0007010cytoskeleton organization NAS--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0046417chorismate metabolic process ----

    KRT7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT7 (K2C7)

    1 DrugBank Compound for KRT7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Primaquine-- 90-34-6targetother/unknown12711178 20713019

    10/32 Novoseek inferred chemical compound relationships for KRT7 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mucicarmine 76.9 8 16334025 (1), 18422977 (1), 9208972 (1), 9870855 (1) (see all 7)
    progesterone 59 64 9160304 (2), 12217766 (1), 12455793 (1), 14506675 (1) (see all 54)
    paraffin 58.3 18 16911464 (1), 10767834 (1), 11668468 (1), 11688464 (1) (see all 16)
    hematoxylin 58.3 13 15900119 (1), 10767834 (1), 10926813 (1), 11586253 (1) (see all 12)
    estrogen 58.2 84 9160304 (3), 12715337 (2), 11028811 (1), 12217766 (1) (see all 70)
    b 723 57.2 13 16415794 (3), 10987260 (3), 12514785 (1), 15589579 (1) (see all 8)
    reticulin 39.6 4 11511789 (1), 19669379 (1), 19329493 (1)
    anit 38.8 1 17397517 (1)
    glycogen 7.92 2 17034957 (1), 17952403 (1)
    methotrexate 4.94 1 15023035 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT7 / K2C7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT7 gene: 
    NM_005556.3  

    Unigene Clusters for KRT7:

    Keratin 7
    Hs.411501  [show with all ESTs], Hs.670221  [show with all ESTs]
    Unigene Representative Sequences: AK128505, BC042076
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552400 ENST00000546666 ENST00000331817(uc001saa.1) ENST00000547613
    ENST00000548088 ENST00000546856 ENST00000552183 ENST00000551130 ENST00000549127
    ENST00000552322 ENST00000548657 ENST00000550153 ENST00000549638
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate KRT7:
    hsa-miR-489
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    Inhib. RNA
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    Additional mRNA sequence: BC042076.1 

    24/71 DOTS entries (see all 71):

    DT.99965532  DT.100669506  DT.100669505  DT.100052545  DT.100669499  DT.95378801  DT.100669501  DT.87013153 
    DT.121118117  DT.121118148  DT.95339736  DT.100669500  DT.449936  DT.91734014  DT.121119113  DT.86994981 
    DT.100060134  DT.121117843  DT.121117730  DT.121118563  DT.101986350  DT.121118498  DT.102836199  DT.86995055 

    2 AceView cDNA sequences:

    BC042076 BF846639 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KRT7 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                                      -     -                                   -     -     -                           
    SP2:                                      -     -                                                                           
    SP3:                                      -     -                                   -     -     -     -                     
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for KRT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT7 expression in normal human tissues (normalized intensities)      KRT7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCCTGGT
    KRT7 Expression
    About this image


    KRT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 8 entries
             Trachea
             lung ; pneumocytes   
     
     Uncategorized (Uncategorized)    fully expand to see all 6 entries
             PureStem Progenitor E72
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             S-shaped Body
             kidney ; cells in tubules   
             visceral organ/metanephros/calyx   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             urinary bladder ; urothelial cells   
             visceral organ/bladder   

    See KRT7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT7

    SOURCE GeneReport for Unigene clusters: Hs.411501 Hs.670221

    UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729
    Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon,
    ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but
    is absent in the esophagus

        SABiosciences Expression via Pathway-Focused PCR Array including KRT7: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT7 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt71 , 5 keratin 71, 5 84.97(n)1
    83.37(a)1
      15 (56.88 cM)5
    1103101  NM_033073.31  NP_149064.11 
     1014110435 
    lizard
    (Anolis carolinensis)
    Reptilia KRT76
    Uncharacterized protein
    60(a)
    1 ↔ 1
    2(95868214-95891633)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978782 Xenopus laevis mRNA for cytokeratin type II (XenCK55(5/6)) 79.92(n)    BC045268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-222f2.11 si:dkey-222f2.1 63.79(n)
    60.91(a)
      568321  XM_691644.4  XP_696736.2 


    ENSEMBL Gene Tree for KRT7 (if available)
    TreeFam Gene Tree for KRT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT7 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    18/69 SIMAP similar genes for KRT7 using alignment to 3 protein entries:     K2C7_HUMAN (see all proteins) (see all similar genes):
    KRT5    KRT6A    KRT6C    KRT3    KRT1    KRT8
    KRT6B    KRT72    KRT73    KRT75    KRT4    KRT78
    KRT1B    KRT79    KRT84    KRT76    KRT77    KRT71

    KRT7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/470 SNPs in KRT7 are shown (see all 470)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123121361,2
    C,F--52459187(+) GAAAAG/TCCCAG 1 -- us2k17Minor allele frequency- T:0.25NA WA EA 366
    rs1902559951,2
    --52459191(+) AGCCCA/GGAGAC 1 -- us2k10--------
    rs1808185221,2
    --52459314(+) CAAGGA/CAACAG 1 -- us2k10--------
    rs740933551,2
    C,F--52459413(+) GCAGAT/CCCTGT 1 -- us2k12Minor allele frequency- C:0.14WA 120
    rs793379651,2
    C,F--52459434(+) AGATGG/AGGACG 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1850898561,2
    --52459488(+) GAGCAC/GGCGTT 1 -- us2k10--------
    rs2018043031,2
    C--52459555(+) GTTGGA/TGNNNN 1 -- us2k10--------
    rs1511422821,2
    --52459652(+) CACAGC/GACCAG 1 -- us2k10--------
    rs1170538201,2
    --52459664(+) TAATCC/TGTATG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1918213061,2
    --52459703(+) CAGGTC/TGAATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KRT7 (52626304 - 52645970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899087CNV Loss21882294
    dgv511e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT7
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 148059    OMIM disorders: --

    20/173 diseases for KRT7 (see all 173):    About MalaCards
    renal adenoma    ovarian large-cell neuroendocrine carcinoma    sinonasal undifferentiated carcinoma    anal canal adenocarcinoma
    choriocarcinoma of the testis    skin benign neoplasm    eccrine adenocarcinoma    ovarian primitive germ cell tumor
    appendiceal neoplasm    papillary serous adenocarcinoma    proliferating trichilemmal cyst    perinephritis
    signet ring cell adenocarcinoma    papillary adenoma    ampulla of vater adenocarcinoma    bile duct disease
    ovarian brenner tumor    mucinous tubular and spindle cell carcinoma    anal fistula    translocation renal cell carcinoma

    20 diseases from the University of Copenhagen DISEASES database for KRT7:
    Carcinoma     Cholangiocarcinoma     Renal cell carcinoma     Renal oncocytoma
    Pseudomyxoma peritonei     Metanephric adenoma     Oxyphilic adenoma     Adenoma
    Skin cancer     Mixed cell type cancer     Ovarian cancer     Vulval Paget's disease
    Breast cancer     Lung cancer     Skin benign neoplasm     Nephrogenic adenoma
    Hepatocellular carcinoma     Ovarian Brenner tumor     Colorectal cancer     Synovial sarcoma

    KRT7 for disorders           About GeneDecksing

    10/96 Novoseek inferred disease relationships for KRT7 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 83.1 303 15371952 (6), 14663355 (6), 11745209 (5), 19098678 (5) (see all 99)
    carcinoma 80.2 199 14668551 (3), 18065959 (3), 10705819 (3), 10590374 (3) (see all 99)
    carcinoma mucinous 79.9 16 12352188 (3), 16980943 (2), 15362373 (1), 17909724 (1) (see all 9)
    extramammary pagets disease 77.5 6 9989849 (1), 9388055 (1), 19119096 (1), 10730755 (1) (see all 5)
    tumors 74.8 466 9308728 (7), 12352188 (6), 8986525 (5), 7545815 (4) (see all 99)
    metastatic carcinoma 74.8 29 12454811 (3), 14668551 (2), 11668468 (1), 11866966 (1) (see all 21)
    oncocytoma 74.2 39 16927643 (9), 10765081 (4), 18603673 (3), 15933529 (3) (see all 15)
    metaplasia 72.9 45 10088547 (3), 16951671 (3), 12826887 (3), 11710638 (3) (see all 26)
    carcinoma neuroendocrine 72.8 11 16508780 (1), 20398190 (1), 10987260 (1), 15913431 (1) (see all 7)
    cholangiocarcinoma 72.6 24 10931219 (4), 10843291 (2), 12429797 (2), 19094709 (2) (see all 15)


    Export disorders for KRT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT7 gene, integrated from 9 sources (see all 1039):
    (articles sorted by number of sources associating them with KRT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sarcolectin (SCL): structure and expression of the recombinant molecule. (PubMed id 10492017)1, 2, 9 Kaba A.... Chany C. (1999)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse. (PubMed id 12359226)1, 2 Smith F.J.D....McLean W.H.I. (2002)
    6. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
    7. Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. (PubMed id 12072504)1, 2 Kanduc D. (2002)
    8. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2 Lin L.... Burger M.M. (2001)
    9. Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PubMed id 1713141)1, 3 Rosenberg M....Shows T.B. (1991)
    10. Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells. (PubMed id 2459129)1, 2 Glass C. and Fuchs E. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3855 HGNC: 6445 AceView: KRT7 Ensembl:ENSG00000135480 euGenes: HUgn3855
    ECgene: KRT7 H-InvDB: KRT7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT7 gene:
    Search GeneIP for patents involving KRT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Proteins for KRT7
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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