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Aliases for KRT7 Gene

Aliases for KRT7 Gene

  • Keratin 7, Type II 2 3
  • Sarcolectin 2 3 4
  • Type-II Keratin Kb7 3 4
  • Cytokeratin 7 2 3
  • Cytokeratin-7 3 4
  • Keratin-7 3 4
  • CK-7 3 4
  • SCL 3 4
  • K7 3 4
  • Keratin, Simple Epithelial Type I, K7 3
  • Keratin, 55K Type II Cytoskeletal 3
  • Type II Mesothelial Keratin K7 3
  • 55K Type II Cytoskeletal 2
  • Type II Cytoskeletal 7 2
  • Keratin 7 2
  • Keratin 2
  • K2C7 3
  • CK7 3

External Ids for KRT7 Gene

Previous GeneCards Identifiers for KRT7 Gene

  • GC12M052275
  • GC12P052657
  • GC12P052343
  • GC12P050913
  • GC12P049659
  • GC12P052626

Summaries for KRT7 Gene

Entrez Gene Summary for KRT7 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT7 Gene

KRT7 (Keratin 7, Type II) is a Protein Coding gene. Diseases associated with KRT7 include clear cell basal cell carcinoma and renal pelvis transitional cell carcinoma. Among its related pathways are Cytoskeletal Signaling and EGFR1 Signaling Pathway. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.

UniProtKB/Swiss-Prot for KRT7 Gene

  • Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Gene Wiki entry for KRT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT7 Gene

Genomics for KRT7 Gene

Regulatory Elements for KRT7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRT7 Gene

Chromosome:
12
Start:
52,232,520 bp from pter
End:
52,252,667 bp from pter
Size:
20,148 bases
Orientation:
Plus strand

Genomic View for KRT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT7 Gene

Proteins for KRT7 Gene

  • Protein details for KRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08729-K2C7_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 7
    Protein Accession:
    P08729
    Secondary Accessions:
    • Q92676
    • Q9BUD8
    • Q9Y3R7

    Protein attributes for KRT7 Gene

    Size:
    469 amino acids
    Molecular mass:
    51386 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7. Interacts with GPER1.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)
    SequenceCaution:
    • Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KRT7 Gene

neXtProt entry for KRT7 Gene

Proteomics data for KRT7 Gene at MOPED

Post-translational modifications for KRT7 Gene

  • Arg-20 is dimethylated, probably to asymmetric dimethylarginine
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT7 Gene

Domains & Families for KRT7 Gene

Gene Families for KRT7 Gene

Suggested Antigen Peptide Sequences for KRT7 Gene

Graphical View of Domain Structure for InterPro Entry

P08729

UniProtKB/Swiss-Prot:

K2C7_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT7: view

Function for KRT7 Gene

Molecular function for KRT7 Gene

GENATLAS Biochemistry:
keratin 7,type II,simple epithelial
UniProtKB/Swiss-Prot Function:
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
UniProtKB/Swiss-Prot Induction:
Up-regulated by retinoic acid.

Gene Ontology (GO) - Molecular Function for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 11169732
genes like me logo Genes that share ontologies with KRT7: view
genes like me logo Genes that share phenotypes with KRT7: view

Animal Models for KRT7 Gene

MGI Knock Outs for KRT7:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KRT7 Gene

Localization for KRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT7 Gene COMPARTMENTS Subcellular localization image for KRT7 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 2
golgi apparatus 2
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IDA 2459129
GO:0005882 intermediate filament NAS 2415537
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with KRT7: view

Pathways & Interactions for KRT7 Gene

genes like me logo Genes that share pathways with KRT7: view

Pathways by source for KRT7 Gene

1 Cell Signaling Technology pathway for KRT7 Gene
1 BioSystems pathway for KRT7 Gene
1 GeneGo (Thomson Reuters) pathway for KRT7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with KRT7: view

No data available for SIGNOR curated interactions for KRT7 Gene

Drugs & Compounds for KRT7 Gene

(12) Drugs for KRT7 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Primaquine Approved Pharma Target, other/unknown 58
Iron Approved Pharma 957
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1387
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453

(22) Additional Compounds for KRT7 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Acetylaminofluorene
5-Aza-2deoxycytidine
ANIT
B 723
Carbohydrates
genes like me logo Genes that share compounds with KRT7: view

Transcripts for KRT7 Gene

mRNA/cDNA for KRT7 Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT7 Gene

Keratin 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRT7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for KRT7 Gene

GeneLoc Exon Structure for
KRT7
ECgene alternative splicing isoforms for
KRT7

Expression for KRT7 Gene

mRNA expression in normal human tissues for KRT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT7 Gene

This gene is overexpressed in Minor Salivary Gland (x18.2), Lung (x6.8), and Thyroid (x6.1).

Protein differential expression in normal tissues from HIPED for KRT7 Gene

This gene is overexpressed in Salivary gland (24.3), Placenta (8.3), and Islet of Langerhans (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT7 Gene



SOURCE GeneReport for Unigene cluster for KRT7 Gene Hs.411501

mRNA Expression by UniProt/SwissProt for KRT7 Gene

P08729-K2C7_HUMAN
Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
genes like me logo Genes that share expression patterns with KRT7: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for KRT7 Gene

Orthologs for KRT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRT7 35
  • 88.43 (n)
  • 84.48 (a)
KRT7 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT7 35
  • 86.06 (n)
  • 84.7 (a)
mouse
(Mus musculus)
Mammalia Krt7 35
  • 84.46 (n)
  • 82.93 (a)
Krt7 16
Krt7 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KRT7 35
  • 99.08 (n)
  • 98.29 (a)
KRT7 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt7 35
  • 83.81 (n)
  • 82.34 (a)
oppossum
(Monodelphis domestica)
Mammalia KRT7 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT7 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves KRT7 35
  • 74.39 (n)
  • 74.39 (a)
KRT7 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRT7 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia krt5.7 35
  • 67.86 (n)
  • 69.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397878 35
zebrafish
(Danio rerio)
Actinopterygii krt4 36
  • 55 (a)
ManyToMany
krt5 36
  • 49 (a)
ManyToMany
krt8 36
  • 50 (a)
ManyToMany
si:dkey-222f2.1 36
  • 53 (a)
ManyToMany
zgc:158846 36
  • 49 (a)
ManyToMany
Species with no ortholog for KRT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT7 Gene

ENSEMBL:
Gene Tree for KRT7 (if available)
TreeFam:
Gene Tree for KRT7 (if available)

Paralogs for KRT7 Gene

genes like me logo Genes that share paralogs with KRT7: view

Variants for KRT7 Gene

Sequence variations from dbSNP and Humsavar for KRT7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8801 -- 52,233,465(+) ATGGG(C/G/T)GCCCG missense, reference, nc-transcript-variant
rs10564 -- 52,243,059(+) CTCCG(A/G/T)AATAC synonymous-codon, reference, nc-transcript-variant
rs14364 -- 52,248,896(+) GCAGC(C/G)CTCAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs936331 -- 52,246,785(-) TGCCT(A/G)TGGGA intron-variant
rs936332 -- 52,246,493(-) CCTCC(A/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT7 Gene

Variant ID Type Subtype PubMed ID
dgv511e1 CNV Complex 17122850
nsv899087 CNV Loss 21882294

Variation tolerance for KRT7 Gene

Residual Variation Intolerance Score: 73.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT7 Gene

HapMap Linkage Disequilibrium report
KRT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT7 Gene

Disorders for KRT7 Gene

MalaCards: The human disease database

(160) MalaCards diseases for KRT7 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
clear cell basal cell carcinoma
  • skin clear cell basal cell carcinoma
renal pelvis transitional cell carcinoma
  • urothelial cell carcinoma of renal pelvis
nephrogenic adenoma of urinary bladder
  • nephrogenic adenoma of the urinary bladder
ovarian large-cell neuroendocrine carcinoma
  • non-small-cell type neuroendocrine carcinoma of ovary
lung acinar adenocarcinoma
  • acinar adenocarcinoma of the lung
- elite association
Search KRT7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KRT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRT7
genes like me logo Genes that share disorders with KRT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT7 Gene

Publications for KRT7 Gene

  1. Urothelial carcinoma of the bladder, lipid cell variant: clinicopathologic findings and LOH analysis. (PMID: 20139762) Lopez-Beltran A. … Cheng L. (Am. J. Surg. Pathol. 2010) 23 67
  2. CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. (PMID: 19926591) Shin J.H. … Lee K.Y. (Jpn. J. Clin. Oncol. 2010) 23 67
  3. Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: an immunohistochemical comparison between dog and man. (PMID: 19369099) Ijzer J. … van den Ingh T.S. (Vet. J. 2010) 23 67
  4. Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (PMID: 20398190) Nagashio R. … Okayasu I. (Pathol. Int. 2010) 23 67
  5. Primary intradural chordoma: report on three cases and review of the literature. (PMID: 20423692) Bergmann M. … Probst-Cousin S. (Clin. Neuropathol. 2010) 23 67

Products for KRT7 Gene

Sources for KRT7 Gene

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