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KRT7 Gene

protein-coding   GIFtS: 65
GCID: GC12P052626

Keratin 7

  See KRT7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Keratin 71 2     K2C72
Cytokeratin 71 2     cytokeratin-72
sarcolectin1 2     Keratin, 55K Type II Cytoskeletal2
Type-II Keratin Kb72 3     Keratin, Simple Epithelial Type I, K72
CK-72 3     Keratin, Type II Cytoskeletal 72
K72 3     keratin-72
SCL2 3     Type II Mesothelial Keratin K72
55K Type II Cytoskeletal1     Cytokeratin-73
keratin1     Keratin-73
Type II Cytoskeletal 71     Sarcolectin3
CK72     

External Ids:    HGNC: 64451   Entrez Gene: 38552   Ensembl: ENSG000001354807   OMIM: 1480595   UniProtKB: P087293   
ORGUL members:         

Export aliases for KRT7 gene to outside databases

Previous GC identifers: GC12M052275 GC12P052657 GC12P052343 GC12P050913 GC12P049659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT7 Gene:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic
or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation
of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple
epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding
the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in
several transcript variants; however, not all variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT7 Gene:
KRT7 (keratin 7) is a protein-coding gene. Diseases associated with KRT7 include renal adenoma, and cell type cancer. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT74.

UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729
Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the
translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)

Gene Wiki entry for KRT7 (Keratin 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRT7 gene promoter:
         c-Fos   PPAR-gamma1   p53   AP-1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT7 promoter sequence
   Search Chromatin IP Primers for KRT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052626:  view genomic region     (about GC identifiers)

Start:
52,626,304 bp from pter      End:
52,645,970 bp from pter
Size:
19,667 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 7  
Size: 469 amino acids; 51386 Da
Subunit: Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator
factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7. Interacts with GPER1
Mass spectrometry: Mass=51203.48; Method=MALDI; Range=2-469; Source=PubMed:11840567;
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II
(neutral to basic; 56-70 kDa)
Sequence caution: Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q92676 Q9BUD8 Q9Y3R7

Explore the universe of human proteins at neXtProt for KRT7: NX_P08729

Explore proteomics data for KRT7 at MOPED

Post-translational modifications: 

  • Arg-20 is dimethylated, probably to asymmetric dimethylarginine1
  • Ubiquitination2 at Lys101, Lys108, Lys394
  • Modification sites at PhosphoSitePlus

  • See KRT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005547.3  
    ENSEMBL proteins: 
     ENSP00000329243  

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    Cloud-Clone Corp. Proteins for KRT7

     
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    Abcam antibodies for KRT7 (P08727, P05783, Q04695, P08729)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    4 InterPro protein domains:
     IPR009053 Prefoldin
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P08729

    ProtoNet protein and cluster: P08729

    3 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with KRT7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: K2C7_HUMAN, P08729
    Function: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the
    translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)
    Induction: Up-regulated by retinoic acid

         Genatlas biochemistry entry for KRT7:
    keratin 7,type II,simple epithelial

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI11169732
         
    Find genes that share ontologies with KRT7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for KRT7:
     Cell cycle / mitosis defect  Decreased cell number  S arrest 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Krt7):
     cellular  renal/urinary system 

    Find genes that share phenotypes with KRT7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Krt7tm1Whim for KRT7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KRT7

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT7

    miRNA
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    miRTarBase miRNAs that target KRT7:
    hsa-mir-133a-3p (MIRT000331), hsa-mir-145-5p (MIRT004938), hsa-mir-30a-3p (MIRT004939), hsa-mir-195-5p (MIRT004937), hsa-mir-7-5p (MIRT025743), hsa-mir-125b-5p (MIRT004936), hsa-mir-199a-3p (MIRT003324)

    Block miRNA regulation of human, mouse, rat KRT7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate KRT7:
    hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidKRT7 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: KRT7 (NM_005556)
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    Cell Line
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    PureStem ES-210, Ecto-ntu Progenitor
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10151 VA6-11562) for KRT7 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    K2C7_HUMAN, P08729: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus4
    nucleus4
    cytosol3
    extracellular2
    mitochondrion2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA2459129
    GO:0005794Golgi apparatus ----
    GO:0005882intermediate filament NAS2415537
    GO:0045095keratin filament IEA--

    Find genes that share ontologies with KRT7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KRT7 About    
    See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    2Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments
    3Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with KRT7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KRT7
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for KRT7
        Cytoskeleton remodeling Keratin filaments

    1 BioSystems Pathway for KRT7
        EGFR1 Signaling Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including KRT7: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KRT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for KRT7 (P087291, 2, 3 ENSP000003292434) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0046417chorismate metabolic process ----

    Find genes that share ontologies with KRT7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT7 (K2C7)

    1 DrugBank Compound for KRT7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Primaquine-- 90-34-6targetother/unknown12711178 20713019

    Selected Novoseek inferred chemical compound relationships for KRT7 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mucicarmine 76.9 8 16334025 (1), 18422977 (1), 9208972 (1), 9870855 (1) (see all 7)
    progesterone 59 64 9160304 (2), 12217766 (1), 12455793 (1), 14506675 (1) (see all 54)
    paraffin 58.3 18 16911464 (1), 10767834 (1), 11668468 (1), 11688464 (1) (see all 16)
    hematoxylin 58.3 13 15900119 (1), 10767834 (1), 10926813 (1), 11586253 (1) (see all 12)
    estrogen 58.2 84 9160304 (3), 12715337 (2), 11028811 (1), 12217766 (1) (see all 70)
    b 723 57.2 13 16415794 (3), 10987260 (3), 12514785 (1), 15589579 (1) (see all 8)
    reticulin 39.6 4 11511789 (1), 19669379 (1), 19329493 (1)
    anit 38.8 1 17397517 (1)
    glycogen 7.92 2 17034957 (1), 17952403 (1)
    methotrexate 4.94 1 15023035 (1)



    Find genes that share compounds with KRT7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRT7 gene: 
    NM_005556.3  

    Unigene Cluster for KRT7:

    Keratin 7
    Hs.411501  [show with all ESTs]
    Unigene Representative Sequence: AK128505
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552400 ENST00000546666 ENST00000331817(uc001saa.1) ENST00000547613
    ENST00000548088 ENST00000546856 ENST00000552183 ENST00000551130 ENST00000549127
    ENST00000552322 ENST00000548657 ENST00000550153 ENST00000549638
    miRNA
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    hsa-miR-489
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    Additional mRNA sequence: 

    AF509887.1 AK025881.1 AK128505.1 AK128848.1 AK129924.1 AK225498.1 BC002700.2 BC009521.1 
    BC107082.1 BC107083.1 X03212.1 Z36852.1 

    Selected DOTS entries (see all 65):

    DT.99965532  DT.100669506  DT.100669505  DT.100052545  DT.100669499  DT.95378801  DT.100669501  DT.87013153 
    DT.121118117  DT.95339736  DT.100669500  DT.121118148  DT.449936  DT.91734014  DT.121119113  DT.86994981 
    DT.100060134  DT.121117843  DT.121117730  DT.121118563  DT.101986350  DT.121118498  DT.86995055  DT.121118517 

    2 AceView cDNA sequences:

    BC042076 BF846639 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KRT7 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                                      -     -                                   -     -     -                           
    SP2:                                      -     -                                                                           
    SP3:                                      -     -                                   -     -     -     -                     
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for KRT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCCTGGT
    KRT7 Expression
    About this image


    KRT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
             Trophoblast-like cells
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Villous Cytotrophoblast Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells
             Syncytiotrophoblast-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
    KRT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411501

    UniProtKB/Swiss-Prot: K2C7_HUMAN, P08729
    Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon,
    ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but
    is absent in the esophagus

        Pathway & Disease-focused RT2 Profiler PCR Array including KRT7: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt71 , 5 keratin 71, 5 84.46(n)1
    82.93(a)1
      15 (56.88 cM)5
    1103101  NM_033073.31  NP_149064.11 
     1014110435 
    chicken
    (Gallus gallus)
    Aves KRT71 keratin 7 74.39(n)
    74.39(a)
      395772  NM_204932.1  NP_990263.1 
    lizard
    (Anolis carolinensis)
    Reptilia KRT76
    keratin 7
    61(a)
    1 ↔ 1
    2(95868214-95891633)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978782 Xenopus laevis mRNA for cytokeratin type II (XenCK55(5/6)) 79.92(n)    BC045268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii krt46
    si:dkey-222f2.16
    (see all 5)
    si:dkey-222f2.1
    (see all 5)
    55(a)
    53(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    6(39239362-39243891) ENSDARG00000017624
    22(5651840-5663447) ENSDARG00000043242


    ENSEMBL Gene Tree for KRT7 (if available)
    TreeFam Gene Tree for KRT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT7 gene
    KRT742  KRT772  KRT6B2  KRT832  KRT762  KRT32  KRT842  KRT862  
    KRT82  KRT812  KRT712  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT7 using alignment to 3 protein entries:     K2C7_HUMAN (see all proteins) (see all similar genes):
    KRT5    KRT6A    KRT6C    KRT3    KRT1    KRT8
    KRT6B    KRT72    KRT73    KRT75    KRT4    KRT78
    KRT1B    KRT79    KRT84    KRT76    KRT77    KRT71

    Find genes that share paralogs with KRT7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT7 (see all 470)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123121361,2
    C,F--52459187(+) GAAAAG/TCCCAG 1 -- us2k17Minor allele frequency- T:0.25NA WA EA 366
    rs1902559951,2
    --52459191(+) AGCCCA/GGAGAC 1 -- us2k10--------
    rs1808185221,2
    --52459314(+) CAAGGA/CAACAG 1 -- us2k10--------
    rs740933551,2
    C,F--52459413(+) GCAGAT/CCCTGT 1 -- us2k12Minor allele frequency- C:0.14WA 120
    rs793379651,2
    C,F--52459434(+) AGATGG/AGGACG 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1850898561,2
    --52459488(+) GAGCAC/GGCGTT 1 -- us2k10--------
    rs2018043031,2
    C--52459555(+) GTTGGA/TGNNNN 1 -- us2k10--------
    rs1511422821,2
    --52459652(+) CACAGC/GACCAG 1 -- us2k10--------
    rs1170538201,2
    --52459664(+) TAATCC/TGTATG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1918213061,2
    --52459703(+) CAGGTC/TGAATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KRT7 (52626304 - 52645970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KRT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899087CNV Loss21882294
    dgv511e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT7
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 148059    OMIM disorders: --

    Selected diseases for KRT7 (see all 53):    
    About MalaCards
    renal adenoma    cell type cancer    mixed cell type cancer    anal canal adenocarcinoma
    ovarian primitive germ cell tumor    eccrine adenocarcinoma    appendiceal neoplasm    sinonasal undifferentiated carcinoma
    signet ring cell adenocarcinoma    papillary adenoma    proliferating trichilemmal cyst    hidrocystoma
    malignant mixed mullerian tumor    bile duct disease    papillary serous adenocarcinoma    brooke-spiegler syndrome
    clear cell papillary renal cell carcinoma    ovarian brenner tumor    mucinous tubular and spindle cell carcinoma    anal fistula

    20 diseases from the University of Copenhagen DISEASES database for KRT7:
    Carcinoma     Cholangiocarcinoma     Renal cell carcinoma     Renal oncocytoma
    Pseudomyxoma peritonei     Metanephric adenoma     Oxyphilic adenoma     Adenoma
    Skin cancer     Mixed cell type cancer     Ovarian cancer     Vulval Paget's disease
    Breast cancer     Lung cancer     Skin benign neoplasm     Nephrogenic adenoma
    Hepatocellular carcinoma     Ovarian Brenner tumor     Colorectal cancer     Synovial sarcoma

    Find genes that share disorders with KRT7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KRT7 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 83.1 303 15371952 (6), 14663355 (6), 11745209 (5), 19098678 (5) (see all 99)
    carcinoma 80.2 199 14668551 (3), 18065959 (3), 10705819 (3), 10590374 (3) (see all 99)
    carcinoma mucinous 79.9 16 12352188 (3), 16980943 (2), 15362373 (1), 17909724 (1) (see all 9)
    extramammary pagets disease 77.5 6 9989849 (1), 9388055 (1), 19119096 (1), 10730755 (1) (see all 5)
    tumors 74.8 466 9308728 (7), 12352188 (6), 8986525 (5), 7545815 (4) (see all 99)
    metastatic carcinoma 74.8 29 12454811 (3), 14668551 (2), 11668468 (1), 11866966 (1) (see all 21)
    oncocytoma 74.2 39 16927643 (9), 10765081 (4), 18603673 (3), 15933529 (3) (see all 15)
    metaplasia 72.9 45 10088547 (3), 16951671 (3), 12826887 (3), 11710638 (3) (see all 26)
    carcinoma neuroendocrine 72.8 11 16508780 (1), 20398190 (1), 10987260 (1), 15913431 (1) (see all 7)
    cholangiocarcinoma 72.6 24 10931219 (4), 10843291 (2), 12429797 (2), 19094709 (2) (see all 15)


    Export disorders for KRT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT7 gene, integrated from 10 sources (see all 1042):
    (articles sorted by number of sources associating them with KRT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sarcolectin (SCL): structure and expression of the recombinant molecule. (PubMed id 10492017)1, 2, 9 Kaba A.... Chany C. (Biochimie 1999)
    2. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse. (PubMed id 12359226)1, 2 Smith F.J.D....McLean W.H.I. (Biochem. Biophys. Res. Commun. 2002)
    6. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (Proteomics 2002)
    7. Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. (PubMed id 12072504)1, 2 Kanduc D. (J. Virol. 2002)
    8. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2 Lin L.... Burger M.M. (J. Cell. Biochem. 2001)
    9. Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PubMed id 1713141)1, 3 Rosenberg M....Shows T.B. (Cytogenet. Cell Genet. 1991)
    10. Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells. (PubMed id 2459129)1, 2 Glass C. and Fuchs E. (J. Cell Biol. 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3855 HGNC: 6445 AceView: KRT7 Ensembl:ENSG00000135480 euGenes: HUgn3855
    ECgene: KRT7 H-InvDB: KRT7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KRT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRT7 gene:
    Search GeneIP for patents involving KRT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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