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Aliases for KRT6C Gene

Aliases for KRT6C Gene

  • Keratin 6C 2 3
  • Keratin 6C, Type II 2 3 5
  • Type-II Keratin Kb12 3 4
  • Cytokeratin-6C 3 4
  • Cytokeratin-6E 3 4
  • Keratin K6h 3 4
  • Keratin-6C 3 4
  • Keratin 6E 2 3
  • CK-6C 3 4
  • CK-6E 3 4
  • KRT6E 3 4
  • K6C 3 4
  • K6E 3

External Ids for KRT6C Gene

Previous HGNC Symbols for KRT6C Gene

  • KRT6E

Previous GeneCards Identifiers for KRT6C Gene

  • GC12U990221
  • GC12M052911
  • GC12M052597
  • GC12M051169
  • GC12M051172
  • GC12M051174
  • GC12M051150
  • GC12M052865
  • GC12M049906

Summaries for KRT6C Gene

Entrez Gene Summary for KRT6C Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT6C Gene

KRT6C (Keratin 6C) is a Protein Coding gene. Diseases associated with KRT6C include Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse and Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Cytoskeletal Signaling. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT73.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT6C Gene

Genomics for KRT6C Gene

Regulatory Elements for KRT6C Gene

Enhancers for KRT6C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRT6C on UCSC Golden Path with GeneCards custom track

Genomic Location for KRT6C Gene

52,468,516 bp from pter
52,473,785 bp from pter
5,270 bases
Minus strand

Genomic View for KRT6C Gene

Genes around KRT6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT6C Gene

Proteins for KRT6C Gene

  • Protein details for KRT6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 6C
    Protein Accession:
    Secondary Accessions:
    • A1L4L5
    • P48666
    • Q2TAZ9
    • Q7RTN9

    Protein attributes for KRT6C Gene

    564 amino acids
    Molecular mass:
    60025 Da
    Quaternary structure:
    • Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.
    • There are at least six isoforms of human type II keratin-6 (K6).
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

neXtProt entry for KRT6C Gene

Proteomics data for KRT6C Gene at MOPED

Post-translational modifications for KRT6C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT6C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT6C Gene

Domains & Families for KRT6C Gene

Gene Families for KRT6C Gene

Suggested Antigen Peptide Sequences for KRT6C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT6C: view

Function for KRT6C Gene

Gene Ontology (GO) - Molecular Function for KRT6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT6C: view
genes like me logo Genes that share phenotypes with KRT6C: view

Human Phenotype Ontology for KRT6C Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for KRT6C Gene

miRTarBase miRNAs that target KRT6C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT6C Gene

Localization for KRT6C Gene

Subcellular locations from

Jensen Localization Image for KRT6C Gene COMPARTMENTS Subcellular localization image for KRT6C gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRT6C Gene

Pathways & Interactions for KRT6C Gene

genes like me logo Genes that share pathways with KRT6C: view

Pathways by source for KRT6C Gene

1 Cell Signaling Technology pathway for KRT6C Gene
1 GeneGo (Thomson Reuters) pathway for KRT6C Gene

Gene Ontology (GO) - Biological Process for KRT6C Gene


No data available for SIGNOR curated interactions for KRT6C Gene

Drugs & Compounds for KRT6C Gene

No Compound Related Data Available

Transcripts for KRT6C Gene

mRNA/cDNA for KRT6C Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT6C Gene

Keratin 6C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT6C Gene

No ASD Table

Relevant External Links for KRT6C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT6C Gene

mRNA expression in normal human tissues for KRT6C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT6C Gene

This gene is overexpressed in Esophagus - Mucosa (x28.7), Vagina (x9.7), Cervix - Ectocervix (x7.7), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for KRT6C Gene

This gene is overexpressed in Saliva (41.8) and Urinary Bladder (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT6C Gene

SOURCE GeneReport for Unigene cluster for KRT6C Gene Hs.709234

mRNA Expression by UniProt/SwissProt for KRT6C Gene

Tissue specificity: Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.
genes like me logo Genes that share expression patterns with KRT6C: view

Protein tissue co-expression partners for KRT6C Gene

Primer Products

Orthologs for KRT6C Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT6C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT6B 35
  • 98.58 (n)
  • 98.94 (a)
-- 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 86 (a)
KRT6B 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
(Mus musculus)
Mammalia Gm5414 36
  • 69 (a)
Krt6a 36
  • 87 (a)
Krt6b 36
  • 86 (a)
(Gallus gallus)
Aves KRT6A 36
  • 72 (a)
KRT75 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
Species with no ortholog for KRT6C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT6C Gene

Gene Tree for KRT6C (if available)
Gene Tree for KRT6C (if available)

Paralogs for KRT6C Gene

genes like me logo Genes that share paralogs with KRT6C: view

Variants for KRT6C Gene

Sequence variations from dbSNP and Humsavar for KRT6C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11608915 - 52,472,276(+) GGAAC(C/T)GCACC reference, missense
rs17099602 - 52,472,141(-) GGACA(A/G)CATCG reference, missense
rs412533 - 52,469,429(+) TCCAA(C/T)GCCTT reference, missense
VAR_071309 Palmoplantar keratoderma, non-epidermolytic, focal or diffuse (PPKNEFD)
rs2567 -- 52,468,983(-) CTATC(C/G)TCTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRT6C Gene

Variant ID Type Subtype PubMed ID
nsv832410 CNV Gain 17160897
nsv832411 CNV Loss 17160897
nsv832412 CNV Loss 17160897
esv2751106 CNV Loss 17911159
nsv899090 CNV Loss 21882294
nsv899091 CNV Gain 21882294
esv7827 CNV Loss 19470904
esv2745892 CNV Deletion 23290073
esv2660079 CNV Deletion 23128226
dgv95n21 CNV Loss 19592680

Variation tolerance for KRT6C Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.15; 99.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRT6C Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT6C Gene

Disorders for KRT6C Gene

MalaCards: The human disease database

(3) MalaCards diseases for KRT6C Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and Swiss-Prot

- elite association - COSMIC cancer census association via MalaCards
Search KRT6C in MalaCards View complete list of genes associated with diseases


  • Palmoplantar keratoderma, non-epidermolytic, focal or diffuse (PPKNEFD) [MIM:615735]: A dermatological disorder characterized by non-epidermolytic abnormal thickening of the skin on the palms and soles. Diffuse palmoplantar keratoderma is characterized by uniform involvement of the palmoplantar surface, while the focal form consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction. {ECO:0000269 PubMed:19609311, ECO:0000269 PubMed:21801157, ECO:0000269 PubMed:23662636}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KRT6C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRT6C: view

No data available for Genatlas for KRT6C Gene

Publications for KRT6C Gene

  1. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. (PMID: 7543104) Takahashi K. … Coulombe P.A. (J. Biol. Chem. 1995) 2 3 4 67
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3

Products for KRT6C Gene

Sources for KRT6C Gene