KRT6C Gene
protein-coding GIFtS: 49
GCID: GC12M052865
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keratin 6C(Previous name: keratin 6E )
(Previous symbol: KRT6E)
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Aliases
for KRT6C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 6C1 2 | | K6E2 | | KRT6E1 2 3 | | Cytokeratin-6C3 | | Keratin 6E1 2 | | Cytokeratin-6E3 | | Keratin K6h2 3 | | Keratin, Type II Cytoskeletal 6C2 | | Type-II Keratin Kb122 3 | | Keratin-6C3 | | CK-6C2 3 | | Cytokeratin-6C3 | | CK-6E2 3 | | Cytokeratin-6E3 | | K6C2 3 | | Keratin-6C3 |
Export aliases for KRT6C gene to outside databasesPrevious GC identifers: GC12U990221 GC12M052911 GC12M052597 GC12M051169 GC12M051172 GC12M051174 GC12M051150 GC12M049906 |
Summaries
for KRT6C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT6C:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and aresubdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome12q13. (provided by RefSeq, Jul 2009)
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Genomic Views
for KRT6C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT6C gene promoter:
AREB6 AML1a Pax-5 FOXO4 STAT5A HNF-4alpha1 YY1 GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT6C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT6C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13KRT6C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M052865: view genomic region
(about GC identifiers)
Start:
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52,862,300 bp from pter |
End:
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52,867,569 bp from pter |
Size:
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5,270 bases |
Orientation:
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minus strand |
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Proteins
for KRT6C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K2C6C_HUMAN, P48668 (See
protein sequence)Recommended Name: Keratin, type II cytoskeletal 6C Size: 564 amino acids; 60025 Da
Subunit: Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17
Miscellaneous: There are at least six isoforms of human type II keratin-6 (K6)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)(40-55 and 56-70 kDa, respectively)
Secondary accessions: A1L4L5 P48666 Q2TAZ9 Q7RTN9Explore the universe of human proteins at neXtProt for KRT6C: NX_P48668
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48668
KRT6C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775109.2
ENSEMBL proteins: ENSP00000252250
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
KRT6C for ontologies About GeneDecksing
KRT6C Antibody Products:
Assay Products for KRT6C: |
Protein
Domains /
Families
for KRT6C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT6C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48668ProtoNet protein and cluster: P48668 2 Blocks protein families: IPB001664 Intermediate filament protein IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: K2C6C_HUMAN, P48668Similarity: Belongs to the intermediate filament family |
Function
for KRT6C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT6C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT6C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT6C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT6C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
NAS | -- |
KRT6C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KRT6C:
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Pathways & Interactions
for KRT6C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeleton remodeling Keratin filaments | | | 2 | Cytoskeletal Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for KRT6C
1 
Cell Signaling Technology (CST) Pathway for KRT6C
1  GeneGo (Thomson Reuters) Pathway for KRT6C
KRT6C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT6C
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/42 Interacting proteins for KRT6C (P486683 ENSP000002522504) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007010 | cytoskeleton organization |
NAS | -- |
KRT6C for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT6C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT6C
Search CenterWatch for drugs/clinical trials and news about KRT6C / K2C6C
|
Transcripts
for KRT6C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT6C gene: NM_173086.4 Unigene Cluster for KRT6C: Keratin 6C Hs.709234 [show with all ESTs]Unigene Representative Sequence: BC1106392 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000252250(uc001sal.4) ENST00000553087
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT6C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT6C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT6C (NM_173086) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT6C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT6C |
Additional cDNA sequence: AK299478.1 AK313239.1 BC110639.1 BC130583.1 BC130585.1 L42611.1 24/77 DOTS entries (see all 77): DT.97773116 DT.95206987 DT.97845748 DT.91944354 DT.121117466 DT.121118029 DT.121118150 DT.100740885 DT.92011339 DT.121118016 DT.121118707 DT.100651500 DT.92410359 DT.95319513 DT.100651504 DT.100868025 DT.121117842 DT.91671355 DT.92019058 DT.100872408 DT.98083683 DT.100651511 DT.121118544 DT.91796941 4 AceView cDNA sequences: BQ351997 BF835702 BG997608 BG997611
GeneLoc Exon Structure
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Expression
for KRT6C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT6C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGCACAAG
About this image
See KRT6C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT6C
SOURCE GeneReport for Unigene cluster: Hs.709234
UniProtKB/Swiss-Prot: K2C6C_HUMAN, P48668Tissue specificity: Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus,papillae of tongue and hair follicle outer root sheath
SABiosciences Custom PCR Arrays for KRT6C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT6C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KRT6C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT6C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT6C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6C |
Orthologs
for KRT6C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KRT6C gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for KRT6C (if available)
TreeFam Gene Tree for KRT6C (if available) |
Paralogs
for KRT6C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT6C gene
- KRT742 KRT772 KRT6B2 KRT832 KRT762 KRT862 KRT32 KRT842
- KRT82 KRT812 KRT712 KRT8P112 KRT782 KRT72 ENSG000001704422 KRT792
- KRT722 KRT732 KRT52 KRT6A2 KRT852 KRT22 KRT752 KRT12
- KRT822 KRT42
18/46 SIMAP similar genes for KRT6C using alignment to 1 protein entry: K2C6C_HUMAN(see all similar genes):KRT6A KRT6B KRT5 KRT75 KRT7 KRT79
KRT4 KRT121P KRT72 KRT1B KRT2 KRT1
KRT78 KRT74 KRT77 KRT71 KRT73 KRT76
KRT6C for paralogs About GeneDecksing
|
Genomic Variants
for KRT6C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT6C (52862300 - 52867569 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for KRT6C
4 CNVs: 61242 4778 9207 49087
Human Gene Mutation Database (HGMD): KRT6C
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT6C |
|
Disorders
/ Diseases
for KRT6C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT6C for disorders About GeneDecksing
OMIM gene information: 612315
OMIM disorders: --
7  diseases for KRT6C: About MalaCardsfocal palmoplantar keratoderma pachyonychia congenita palmoplantar keratosis keratoderma
keratosis pharyngitis neuronitis
Export disorders for KRT6C gene to outside databases
|
Publications
for KRT6C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT6C gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with KRT6C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. (PubMed id 7543104)1, 2, 3 Takahashi K.... Coulombe P.A. (1995)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PubMed id 11683385)1, 2 Hesse M.... Weber K. (2001)
- Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431. (PubMed id 9054461)1, 2 Ku N.-O. and Omary M.B. (1997)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Keratin K6c mutations cause focal palmoplantar kerato derma. (PubMed id 19609311)1 Wilson N.J....Smith F.J. (2010)
- Mutations in a keratin 6 isomer (K6c) cause a type of focal palmoplantar keratoderma. (PubMed id 20081885)1 Bowden P.E. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
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External Searches for KRT6C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT6C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT6C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT6C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT6C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT6C gene:
Search GeneIP for patents involving KRT6C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT6C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRT6C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT6C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT6C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT6C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT6C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT6C |
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| | Antibodies & Assays for KRT6C (K6c) |
| | | | Search Tocris compounds for KRT6C |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6C |
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