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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRT6B Gene

protein-coding   GIFtS: 54
GCID: GC12M052840

Keratin 6B

(Previous name: keratin-like 1 (a type II keratin sequence))
(Previous symbol: KRTL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin 6B1 2     Cytokeratin 6B2
KRTL11 2 3     cytokeratin-6B2
Keratin-Like 1 (A Type II Keratin Sequence)1 2     Keratin, Epidermal, Type II, K6B2
Type-II Keratin Kb102 3     Keratin, Type II Cytoskeletal 6B2
CK-6B2 3     keratin-6B2
K6B2 3     Cytokeratin-6B3
PC22 5     Keratin-6B3
CK6B2     

External Ids:    HGNC: 64441   Entrez Gene: 38542   Ensembl: ENSG000001854797   OMIM: 1480425   UniProtKB: P042593   

Export aliases for KRT6B gene to outside databases

Previous GC identifers: GC12U990045 GC12M052870 GC12M052558 GC12M051126 GC12M049884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT6B Gene:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic
or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation
of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been
identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are
expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified
epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular
epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins
are clustered in a region of chromosome 12q12-q13. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT6B Gene: 
KRT6B (keratin 6B) is a protein-coding gene. Diseases associated with KRT6B include pachyonychia congenita, and pachyonychia congenita type 2. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is KRT74.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT6B gene promoter:
         c-Fos   TBP   NRSF form 1   NRSF form 2   Egr-4   HNF-4alpha1   YY1   GATA-2   FOXO4   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT6B promoter sequence
   Search SABiosciences Chromatin IP Primers for KRT6B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT6B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052840:  view genomic region     (about GC identifiers)

Start:
52,840,435 bp from pter      End:
52,845,910 bp from pter
Size:
5,476 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 6B  
Size: 564 amino acids; 60067 Da
Subunit: Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17
Miscellaneous: There are at least six isoforms of human type II keratin-6 (K6)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Secondary accessions: P48669

Explore the universe of human proteins at neXtProt for KRT6B: NX_P04259

Explore proteomics data for KRT6B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04259

  • KRT6B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRT6B Protein Expression
    REFSEQ proteins: NP_005546.2  
    ENSEMBL proteins: 
     ENSP00000252252  

    Human Recombinant Protein Products for KRT6B: 
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    Novus Biologicals KRT6B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KRT6B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045095keratin filament IEA--

    KRT6B for ontologies           About GeneDecksing



    KRT6B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF2: Intermediate filaments type II, keratins (basic)

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P04259

    ProtoNet protein and cluster: P04259

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259
    Similarity: Belongs to the intermediate filament family


    KRT6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for KRT6B:
    keratin 6B,type II,upper outer hair root sheat,nail bed,palm and sole skin,suprabasal orogenital mucosal
    keratinocytes,dimerizing with KRT17

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton TAS9618173
         
    KRT6B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Krt6b):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  integument 
     mortality/aging 

    KRT6B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KRT6B: Krt6a/Krt6bKrt6a/tm1Cou Krt6a/Krt6bKrt6a/tm1Der

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRT6B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KRT6B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRT6B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT6B 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT6B
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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of KRT6B

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of KRT6B 

    Cell Line
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    Search LifeMap BioReagents cell lines for KRT6B
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KRT6B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KRT6B
        Cytoskeletal Signaling



    KRT6B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/53 Interacting proteins for KRT6B (P042592, 3 ENSP000002522524) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-66123 I2D: score=5 STRING: ENSP00000254043
    KRT19P087272, 3, ENSP000003551244MINT-66526 I2D: score=5 STRING: ENSP00000355124
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007398ectoderm development TAS9618173

    KRT6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KRT6B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT6B (K2C6B)

    1 Novoseek inferred chemical compound relationship for KRT6B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 15845576 (2), 17111037 (1)

    Search CenterWatch for drugs/clinical trials and news about KRT6B / K2C6B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRT6B gene: 
    NM_005555.3  

    Unigene Cluster for KRT6B:

    Keratin 6B
    Hs.708950  [show with all ESTs]
    Unigene Representative Sequence: NM_005555
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252252(uc001sak.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KRT6B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KRT6B
    SwitchGear 3'UTR luciferase reporter plasmidKRT6B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KRT6B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRT6B
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    GenScript: all cDNA clones in your preferred vector: KRT6B (NM_005555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT6B
    Sirion Biotech Customized lentivirus for stable overexpression of KRT6B 
                         Customized lentivirus expression plasmids for stable overexpression of KRT6B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KRT6B
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT6B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT6B

    Additional mRNA sequence: 

    AK296729.1 BC034535.1 L42612.1 

    24/65 DOTS entries (see all 65):

    DT.100651500  DT.92410359  DT.97773116  DT.95286244  DT.121119151  DT.92019058  DT.91671355  DT.91876411 
    DT.97845748  DT.100868025  DT.121118994  DT.92011339  DT.92470199  DT.92470200  DT.100740956  DT.121118029 
    DT.92470176  DT.100651511  DT.100740885  DT.121118150  DT.121118510  DT.87013324  DT.91944354  DT.95319524 

    24/26 AceView cDNA sequences (see all 26):

    AW389503 BQ348315 BG876901 BQ349872 BQ354200 BF349421 AW352377 BQ310807 
    AW238462 BF088609 BQ353581 BF088687 BQ354697 BG945769 BQ351425 BF356168 
    BQ310829 BF478295 BF357093 BF738447 BF840172 BQ300237 BQ300227 BQ359229 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRT6B expression in normal human tissues (normalized intensities)      KRT6B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAATGTCCT
    KRT6B Expression
    About this image


    KRT6B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Epithelium
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 6 entries
             Basal Cells Respiratory Bronchioles
             bronchus ; respiratory epithelial cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 4 entries
             Human Oral Keritinocytes (HOK)   
             Tongue   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Keratinocytes (HEK)   
     
     Esophagus
             esophagus ; squamous epithelial cells   

    See KRT6B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRT6B

    SOURCE GeneReport for Unigene cluster: Hs.708950

    UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259
    Tissue specificity: Constitutively expressed in distinct types of epithelia such as those in oral mucosa,
    esophagus, papillae of tongue and hair follicle outer root sheath

        SABiosciences Custom PCR Arrays for KRT6B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KRT6B gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt6b5 keratin 6B   --   15 (56.97 cM) 101676034 
    chicken
    (Gallus gallus)
    Aves --
    --
    58(a)
    possible ortholog
    LGE22C19W28_E50C23(558727-563179)


    ENSEMBL Gene Tree for KRT6B (if available)
    TreeFam Gene Tree for KRT6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRT6B gene
    KRT742  KRT772  KRT832  KRT762  KRT32  KRT842  KRT862  KRT82  
    KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    18/41 SIMAP similar genes for KRT6B using alignment to 1 protein entry:     K2C6B_HUMAN(see all similar genes):
    KRT6A    KRT6C    KRT5    KRT75    KRT7    KRT4
    KRT121P    KRT72    KRT1B    KRT77    KRT2    KRT79
    KRT1    KRT73    KRT74    KRT71    KRT76    KRT8

    KRT6B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/356 SNPs in KRT6B are shown (see all 356)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606277261,2,4
    CPachyonychia congenita 2 (PC2)4 pathogenic152675930(-) AGGGCA/GAGGAG 2 K E mis10--------
    rs57982121,2
    C--49888380(+) CCTGG-/CAGGTC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs4049701,2
    F--49889660(-) GCAGCG/ATCTCC 2 /I /V mis11Minor allele frequency- A:0.48MN 184
    rs105622741,2
    C--49890597(+) tccca-/ATCA  
            
    gagtc
    1 -- us2k10--------
    rs3739921,2
    C,F,A--52674394(-) CTCCCT/CGGCTC 1 -- ds500110Minor allele frequency- C:0.38NA WA CSA EA 371
    rs1825192011,2
    --52674470(+) ATAAAG/TGAATC 1 -- ds50010--------
    rs111701231,2
    C,F,H--52674604(+) GTCCAC/TCGGAG 1 -- ds500116Minor allele frequency- T:0.02NS EA NA CSA 2104
    rs111701241,2
    C,F,H--52674614(+) GTGTCC/TGACAG 1 -- ds50019Minor allele frequency- T:0.07NS EA NA WA CSA 546
    rs38478291,2
    C,A,H--52674659(+) GAGGGG/AGAGCT 1 -- ds50014Minor allele frequency- A:0.14NA WA EA 360
    rs1870319621,2
    --52674805(+) TCTCAA/GTATGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT6B (52840435 - 52845910 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KRT6B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832411CNV Loss17160897
    esv7827CNV Loss19470904
    nsv899090CNV Loss21882294
    nsv832412CNV Loss17160897
    esv2751106CNV Loss17911159
    nsv899091CNV Gain21882294
    nsv832410CNV Gain17160897


    Human Gene Mutation Database (HGMD): KRT6B
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 148042   
    OMIM disorders: 167210  
    UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259
  • Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by
    hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail),
    palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse
    eyebrow and body hair, and by the presence of natal teeth. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 19 diseases for KRT6B:    About MalaCards
    pachyonychia congenita    pachyonychia congenita type 2    glossitis    median rhomboid glossitis
    krt6b-related pachyonychia congenita    hereditary mucosal leukokeratosis    palmoplantar keratosis    monilethrix
    epidermolysis bullosa simplex    keratosis    keratitis    epidermolysis bullosa
    keratoderma    ectodermal dysplasia    sjogren's syndrome    hepatocellular carcinoma
    squamous cell carcinoma    adenocarcinoma    breast cancer

    5 diseases from the University of Copenhagen DISEASES database for KRT6B:
    Pachyonychia congenita     Median rhomboid glossitis     Monilethrix     Keratosis
    Hereditary mucosal leukokeratosis

    KRT6B for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for KRT6B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pachyonychia congenita, type 2 95.6 2 11886499 (1), 9618173 (1)
    pachyonychia congenita, type 1 90.8 1 11886499 (1)
    nail dystrophy 86.9 1 19609311 (1)
    genetic disorder 38.7 1 16250208 (1)
    tumors 0 1 10887174 (1)

    GeneTests: KRT6B
    GeneReviews: KRT6B

    Export disorders for KRT6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRT6B gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with KRT6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2. (PubMed id 9618173)1, 2, 9 Smith F.J.D.... McLean W.H.I. (1998)
    2. Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PubMed id 1713141)1, 3, 9 Rosenberg M....Shows T.B. (1991)
    3. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. (PubMed id 7543104)1, 2, 9 Takahashi K.... Coulombe P.A. (1995)
    4. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    7. The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. (PubMed id 2410904)1, 2 Tyner A.L.... Fuchs E. (1985)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    9. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    10. The diagnostic utility of D2-40, calretinin, CK5/6, de smin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pl eural effusion cytology. (PubMed id 23075894)1 Hyun T.S....Tabatabai Z.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3854 HGNC: 6444 AceView: KRT6B Ensembl:ENSG00000185479 euGenes: HUgn3854
    ECgene: KRT6B H-InvDB: KRT6B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRT6B Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KRT6B

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRT6B gene:
    Search GeneIP for patents involving KRT6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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