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KRT6B Gene

protein-coding   GIFtS: 52
GCID: GC12M052840

Keratin 6B

(Previous name: keratin-like 1 (a type II keratin sequence))
(Previous symbol: KRTL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratin 6B1 2     Cytokeratin 6B2
KRTL11 2 3     cytokeratin-6B2
Keratin-Like 1 (A Type II Keratin Sequence)1 2     Keratin, Epidermal, Type II, K6B2
Type-II Keratin Kb102 3     Keratin, Type II Cytoskeletal 6B2
CK-6B2 3     keratin-6B2
K6B2 3     Cytokeratin-6B3
CK6B2     Keratin-6B3
PC22     PC45

External Ids:    HGNC: 64441   Entrez Gene: 38542   Ensembl: ENSG000001854797   OMIM: 1480425   UniProtKB: P042593   

Export aliases for KRT6B gene to outside databases

Previous GC identifers: GC12U990045 GC12M052870 GC12M052558 GC12M051126 GC12M049884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KRT6B Gene:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic
or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation
of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been
identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are
expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified
epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular
epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins
are clustered in a region of chromosome 12q12-q13. (provided by RefSeq, Jul 2008)

GeneCards Summary for KRT6B Gene:
KRT6B (keratin 6B) is a protein-coding gene. Diseases associated with KRT6B include glossitis, and median rhomboid glossitis. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is KRT74.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KRT6B gene promoter:
         c-Fos   TBP   NRSF form 1   NRSF form 2   Egr-4   HNF-4alpha1   YY1   GATA-2   FOXO4   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRT6B promoter sequence
   Search Chromatin IP Primers for KRT6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRT6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

KRT6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT6B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M052840:  view genomic region     (about GC identifiers)

Start:
52,840,435 bp from pter      End:
52,845,910 bp from pter
Size:
5,476 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259 (See protein sequence)
Recommended Name: Keratin, type II cytoskeletal 6B  
Size: 564 amino acids; 60067 Da
Subunit: Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17
Miscellaneous: There are at least six isoforms of human type II keratin-6 (K6)
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to
basic) (40-55 and 56-70 kDa, respectively)
Secondary accessions: P48669

Explore the universe of human proteins at neXtProt for KRT6B: NX_P04259

Explore proteomics data for KRT6B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys173, Lys180, Lys252
  • Modification sites at PhosphoSitePlus

  • See KRT6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005546.2  
    ENSEMBL proteins: 
     ENSP00000252252  

    KRT6B Human Recombinant Protein Products:

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    Abcam antibodies for KRT6B (P48668, Q3SY84, P04259, P48666, P05783, P02538, Q9C075)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF2: Intermediate filaments type II, keratins (basic)

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR003054 Keratin_II

    Graphical View of Domain Structure for InterPro Entry P04259

    ProtoNet protein and cluster: P04259

    2 Blocks protein domains:
    IPB001664 Intermediate filament protein
    IPB003054 Type II keratin signature


    UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259
    Similarity: Belongs to the intermediate filament family


    KRT6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for KRT6B:
    keratin 6B,type II,upper outer hair root sheat,nail bed,palm and sole skin,suprabasal orogenital mucosal
    keratinocytes,dimerizing with KRT17

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS9618173
         
    KRT6B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Krt6b):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size/body  integument 
     mortality/aging 

    KRT6B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KRT6B: Krt6a/Krt6bKrt6a/tm1Cou Krt6a/Krt6bKrt6a/tm1Der

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KRT6B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KRT6B

    miRNA
    Products:
        
    miRTarBase miRNAs that target KRT6B:
    hsa-mir-30a-5p (MIRT028499), hsa-mir-155-5p (MIRT020647)

    Block miRNA regulation of human, mouse, rat KRT6B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KRT6B
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KRT6B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: KRT6B (NM_005555)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT6B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament ----
    GO:0045095keratin filament IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    KRT6B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KRT6B About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KRT6B
        Cytoskeletal Signaling



    KRT6B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRT6B
    Interactions:

        Search GeneGlobe Interaction Network for KRT6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for KRT6B (P042592, 3 ENSP000002522524) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-66123 I2D: score=5 STRING: ENSP00000254043
    KRT19P087272, 3, ENSP000003551244MINT-66526 I2D: score=5 STRING: ENSP00000355124
    PPP2R2BQ000053, ENSP000003365914I2D: score=1 STRING: ENSP00000336591
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007398ectoderm development TAS9618173

    KRT6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRT6B (K2C6B)

    1 Novoseek inferred chemical compound relationship for KRT6B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 3 15845576 (2), 17111037 (1)



    KRT6B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KRT6B gene: 
    NM_005555.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252252(uc001sak.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KRT6B using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidKRT6B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KRT6B
    Predesigned siRNA for gene silencing in human, mouse, rat KRT6B
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KRT6B (NM_005555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KRT6B
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KRT6B
      QuantiTect SYBR Green Assays in human, mouse, rat KRT6B
      QuantiFast Probe-based Assays in human, mouse, rat KRT6B

    Selected AceView cDNA sequences (see all 26):

    AW389503 BQ348315 BG876901 BQ349872 BF349421 BQ354200 AW352377 AW238462 
    BQ310807 BF088687 BF088609 BQ351425 BG945769 BF356168 BQ354697 BQ353581 
    BQ310829 BF478295 BF357093 BF738447 BQ300237 BQ359229 BF840172 BQ356376 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRT6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAATGTCCT
    KRT6B Expression
    About this image


    KRT6B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Tonsil (Hematopoietic System)
    KRT6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRT6B Protein Expression

    UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259
    Tissue specificity: Constitutively expressed in distinct types of epithelia such as those in oral mucosa,
    esophagus, papillae of tongue and hair follicle outer root sheath

        Custom PCR Arrays for KRT6B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KRT6B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krt6b5
    Krt6a1
    keratin 6B5
    keratin 6A1
    85.93(n)1
    87.5(a)1
      15 (56.97 cM)5
    166871  NM_008476.31  NP_032502.31 
     1016760345 
    chicken
    (Gallus gallus)
    Aves KRT6A6
    KRT756
    Gallus gallus keratin 75 (KRT75), mRNA.
    72(a)
    66(a)
    many ↔ many
    many ↔ many
    LGE22C19W28_E50C23(679789-684914)
    LGE22C19W28_E50C23(688657-692492)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    2(95720906-95731292)


    ENSEMBL Gene Tree for KRT6B (if available)
    TreeFam Gene Tree for KRT6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRT6B gene
    KRT742  KRT772  KRT832  KRT762  KRT32  KRT842  KRT862  KRT82  
    KRT812  KRT712  KRT72  KRT792  KRT722  KRT732  KRT6C2  KRT52  
    KRT6A2  KRT852  KRT22  KRT752  KRT12  KRT822  KRT42  
    Selected SIMAP similar genes for KRT6B using alignment to 1 protein entry:     K2C6B_HUMAN(see all similar genes):
    KRT6A    KRT6C    KRT5    KRT75    KRT7    KRT4
    KRT121P    KRT72    KRT1B    KRT77    KRT2    KRT79
    KRT1    KRT73    KRT74    KRT71    KRT76    KRT8

    KRT6B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRT6B (see all 356)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606277261,2,,4
    CPachyonychia congenita 2 (PC2)4 pathogenic152675930(-) AGGGCA/GAGGAG 2 K E mis10--------
    rs57982121,2
    C--49888380(+) CCTGG-/CAGGTC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs4049701,2
    F--49889660(-) GCAGCG/ATCTCC 2 /I /V mis11Minor allele frequency- A:0.48MN 184
    rs105622741,2
    C--49890597(+) tccca-/ATCA  
            
    gagtc
    1 -- us2k10--------
    rs3739921,2
    C,F,A--52674394(-) CTCCCT/CGGCTC 1 -- ds500110Minor allele frequency- C:0.38NA WA CSA EA 371
    rs1825192011,2
    --52674470(+) ATAAAG/TGAATC 1 -- ds50010--------
    rs111701231,2
    C,F,H--52674604(+) GTCCAC/TCGGAG 1 -- ds500116Minor allele frequency- T:0.02NS EA NA CSA 2104
    rs111701241,2
    C,F,H--52674614(+) GTGTCC/TGACAG 1 -- ds50019Minor allele frequency- T:0.07NS EA NA WA CSA 546
    rs38478291,2
    C,A,H--52674659(+) GAGGGG/AGAGCT 1 -- ds50014Minor allele frequency- A:0.14NA WA EA 360
    rs1870319621,2
    --52674805(+) TCTCAA/GTATGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KRT6B (52840435 - 52845910 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KRT6B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832411CNV Loss17160897
    esv7827CNV Loss19470904
    nsv899090CNV Loss21882294
    nsv832412CNV Loss17160897
    esv2751106CNV Loss17911159
    nsv899091CNV Gain21882294
    nsv832410CNV Gain17160897

    Human Gene Mutation Database (HGMD): KRT6B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KRT6B
    DNA2.0 Custom Variant and Variant Library Synthesis for KRT6B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 148042   
    OMIM disorders: 167210  
    UniProtKB/Swiss-Prot: K2C6B_HUMAN, P04259
  • Pachyonychia congenita 2 (PC2) [MIM:167210]: An autosomal dominant ectodermal dysplasia characterized by
    hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail),
    palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse
    eyebrow and body hair, and by the presence of natal teeth. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • Selected diseases for KRT6B (see all 25):    
    About MalaCards
    glossitis    median rhomboid glossitis    krt6b-related pachyonychia congenita    pachyonychia congenita type 2
    pachyonychia congenita    hereditary mucosal leukokeratosis    palmoplantar keratosis    focal palmoplantar keratoderma
    monilethrix    epidermolysis bullosa simplex    keratosis    keratoderma
    epidermolysis bullosa    ectodermal dysplasia    keratitis    sjogren's syndrome
    bronchiolitis    tonsillitis    hepatocellular carcinoma    squamous cell carcinoma

    5 diseases from the University of Copenhagen DISEASES database for KRT6B:
    Pachyonychia congenita     Median rhomboid glossitis     Monilethrix     Keratosis
    Hereditary mucosal leukokeratosis

    KRT6B for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for KRT6B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pachyonychia congenita, type 2 95.6 2 11886499 (1), 9618173 (1)
    pachyonychia congenita, type 1 90.8 1 11886499 (1)
    nail dystrophy 86.9 1 19609311 (1)
    genetic disorder 38.7 1 16250208 (1)
    tumors 0 1 10887174 (1)

    GeneTests: KRT6B
    GeneReviews: KRT6B

    Export disorders for KRT6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRT6B gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with KRT6B)
        Utopia: connect your pdf to the dynamic
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    1. A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2. (PubMed id 9618173)1, 2, 9 Smith F.J.D.... McLean W.H.I. (Hum. Mol. Genet. 1998)
    2. Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PubMed id 1713141)1, 3, 9 Rosenberg M....Shows T.B. (Cytogenet. Cell Genet. 1991)
    3. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. (PubMed id 7543104)1, 2, 9 Takahashi K.... Coulombe P.A. (J. Biol. Chem. 1995)
    4. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (J. Cell Biol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    7. The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. (PubMed id 2410904)1, 2 Tyner A.L.... Fuchs E. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    10. The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology. (PubMed id 23075894)1 Hyun T.S....Tabatabai Z.L. (Acta Cytol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3854 HGNC: 6444 AceView: KRT6B Ensembl:ENSG00000185479 euGenes: HUgn3854
    ECgene: KRT6B H-InvDB: KRT6B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRT6B Pharmacogenomics, SNPs, Pathways
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/329440/

    (Patent information from GeneIP,
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    Patent Information for KRT6B gene:
    Search GeneIP for patents involving KRT6B

    GeneCards and IP:
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