KRT40 Gene
protein-coding GIFtS: 43
GCID: GC17M039133
|
|
keratin 40
| |
Aliases
for KRT40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin 401 2 | | Cytokeratin-403 | | KA361 2 3 | | Keratin, Type I Cytoskeletal 402 | | Type I Hair Keratin Ka362 3 | | Keratin-403 | | CK-402 3 | | Cytokeratin-403 | | K402 3 | | Keratin-403 | | FLJ366001 | | |
Export aliases for KRT40 gene to outside databasesPrevious GC identifers: GC17M036388 GC17M034928 |
Summaries
for KRT40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT40:
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediatefilament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. Thesefilaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type Ikeratin genes are clustered in a region of chromosome 17q12-q21. (provided by RefSeq, Jul 2009)
UniProtKB/Swiss-Prot: K1C40_HUMAN, Q6A162Function: May play a role in late hair differentiation
|
Genomic Views
for KRT40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT40 gene promoter:
GCNF IRF-1 LCR-F1 FOXL1 HEN1 FAC1 FOXJ2 (long isoform) GCNF-1 FOXJ2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRT40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2KRT40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M039133: view genomic region
(about GC identifiers)
Start:
|
39,133,968 bp from pter |
End:
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39,143,387 bp from pter |
Size:
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9,420 bases |
Orientation:
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minus strand |
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Proteins
for KRT40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K1C40_HUMAN, Q6A162 (See
protein sequence)Recommended Name: Keratin, type I cytoskeletal 40 Size: 431 amino acids; 48139 Da
Subunit: Heterotetramer of two type I and two type II keratins
Developmental stage: During differentiation of the hair, it is one of the last keratins expressed
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic)(40-55 and 56-70 kDa, respectively)
Secondary accessions: Q6IFU5Explore the universe of human proteins at neXtProt for KRT40: NX_Q6A162
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6A162
KRT40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872303.2
ENSEMBL proteins: ENSP00000434458 ENSP00000381500 ENSP00000366984
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRT40 for ontologies About GeneDecksing
KRT40 Antibody Products:
Assay Products for KRT40: |
Protein
Domains /
Families
for KRT40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT40 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6A162ProtoNet protein and cluster: Q6A162 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: K1C40_HUMAN, Q6A162Similarity: Belongs to the intermediate filament family |
Function
for KRT40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: K1C40_HUMAN, Q6A162Function: May play a role in late hair differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT40
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KRT40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT40 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- |
KRT40 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for KRT40:
|
Pathways & Interactions
for KRT40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT40
|
Drugs & Compounds
for KRT40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRT40
Search CenterWatch for drugs/clinical trials and news about KRT40 / K1C40
|
Transcripts
for KRT40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRT40 gene: NM_182497.3 Unigene Cluster for KRT40: Keratin 40 Hs.534929 [show with all ESTs]Unigene Representative Sequence: NM_1824973 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461923(uc002hvq.1 uc010cxh.1) ENST00000398486 ENST00000377755
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT40
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRT40 (NM_182497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRT40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT40 |
Additional cDNA sequence: AJ786658.1 BC130396.1 BC144250.1 BC150174.1 BC150191.1 2 DOTS entries: DT.75114219 DT.120973374 10 AceView cDNA sequences: BK004055 BX112843 AI141538 CD107509 AK093919 NM_182497 AJ786658 CD107829 CD251357 AX748364
GeneLoc Exon Structure
|
Expression
for KRT40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRT40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAATGTCA
About this image
See KRT40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRT40
SOURCE GeneReport for Unigene cluster: Hs.534929
UniProtKB/Swiss-Prot: K1C40_HUMAN, Q6A162Tissue specificity: Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and smallintestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex(at protein level)
SABiosciences Custom PCR Arrays for KRT40
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRT40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRT40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRT40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT40 |
Orthologs
for KRT40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KRT40 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for KRT40 (if available)
TreeFam Gene Tree for KRT40 (if available) |
Paralogs
for KRT40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRT40 gene
- KRT342 KRT2222 KRT312 ENSG000002640582 KRT352 KRT392 BFSP22 KRT372
- KRT322 KRT382 KRT362 KRT33B2 KRT33A2
18/40 SIMAP similar genes for KRT40 using alignment to 3 protein entries: K1C40_HUMAN (see all proteins)
(see all similar genes):KRT14 KRT33B KRT33A KRT15 KRT35 KRT13
KRT31 K14 KRT10 KRT20 KRT34 KRT36
GUCA1B KRT18 KRTHA7 KRT32 KRT12 keratin
KRT40 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KRT40
PGOHUM00000237074
|
Genomic Variants
for KRT40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRT40 (39133968 - 39143387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KRT40
1 CNV: 72924
1 Indel: 72923 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRT40 |
|
Disorders
/ Diseases
for KRT40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT40 for disorders About GeneDecksing
2  diseases for KRT40: About MalaCardsalpha thalassemia thalassemia
Export disorders for KRT40 gene to outside databases
|
Publications
for KRT40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRT40 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRT40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel type I hair keratins K39 and K40 are the last to be expressed in differentiation of the hair: completion of the human hair keratin catalog. (PubMed id 17301834)1, 2 Langbein L....Schweizer J. (2007)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Comprehensive analysis of keratin gene clusters in humans and rodents. (PubMed id 15085952)1, 2 Hesse M.... Magin T.M. (2004)
- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PubMed id 15617563)1, 2 Rogers M.A.... Schweizer J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KRT40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT40 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRT40 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRT40 gene:
Search GeneIP for patents involving KRT40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRT40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRT40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRT40 | | | OriGene Protein Over-expression Lysate for KRT40 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRT40 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRT40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRT40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |  |  |  | | | | |
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 | | | KRT40 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRT40 |
|  |  |  | | | | Search ThermoFisher Antibodies for KRT40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRT40 |
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