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Aliases for KRT40 Gene

Aliases for KRT40 Gene

  • Keratin 40, Type I 2 3
  • Cytokeratin-40 3 4
  • Keratin-40 3 4
  • CK-40 3 4
  • KA36 3 4
  • K40 3 4
  • Keratin, Type I Cytoskeletal 40 3
  • Type I Hair Keratin KA36 3
  • Type I Hair Keratin Ka36 4
  • Keratin 40 2

External Ids for KRT40 Gene

Summaries for KRT40 Gene

Entrez Gene Summary for KRT40 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT40 Gene

KRT40 (Keratin 40, Type I) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT34.

UniProtKB/Swiss-Prot for KRT40 Gene

  • May play a role in late hair differentiation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT40 Gene

Genomics for KRT40 Gene

Genomic Location for KRT40 Gene

Start:
40,977,716 bp from pter
End:
40,987,135 bp from pter
Size:
9,420 bases
Orientation:
Minus strand

Genomic View for KRT40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRT40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT40 Gene

Regulatory Elements for KRT40 Gene

Proteins for KRT40 Gene

  • Protein details for KRT40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6A162-K1C40_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 40
    Protein Accession:
    Q6A162
    Secondary Accessions:
    • Q6IFU5

    Protein attributes for KRT40 Gene

    Size:
    431 amino acids
    Molecular mass:
    48139 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively)

neXtProt entry for KRT40 Gene

Proteomics data for KRT40 Gene at MOPED

Post-translational modifications for KRT40 Gene

No Post-translational modifications

Other Protein References for KRT40 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT40 Gene

Domains for KRT40 Gene

Gene Families for KRT40 Gene

HGNC:
  • IFF2 :Intermediate filaments type II, keratins (basic)

Protein Domains for KRT40 Gene

UniProtKB/Swiss-Prot:

K1C40_HUMAN
Family:
  • Belongs to the intermediate filament family.:
    • Q6A162
genes like me logo Genes that share domains with KRT40: view

Function for KRT40 Gene

Molecular function for KRT40 Gene

UniProtKB/Swiss-Prot Function: May play a role in late hair differentiation

Gene Ontology (GO) - Molecular Function for KRT40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT40: view
genes like me logo Genes that share phenotypes with KRT40: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRT40 Gene

Localization for KRT40 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRT40 Gene COMPARTMENTS Subcellular localization image for KRT40 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KRT40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT40: view

Pathways for KRT40 Gene

SuperPathways for KRT40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRT40 Gene

None

No data available for Pathways by source for KRT40 Gene

Transcripts for KRT40 Gene

mRNA/cDNA for KRT40 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT40 Gene

Keratin 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRT40 Gene

No ASD Table

Relevant External Links for KRT40 Gene

GeneLoc Exon Structure for
KRT40
ECgene alternative splicing isoforms for
KRT40

Expression for KRT40 Gene

mRNA expression in normal human tissues for KRT40 Gene

mRNA differential expression in normal tissues according to GTEx for KRT40 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (22.4), Pituitary (14.4), and Skin - Sun Exposed (Lower leg) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRT40 Gene

SOURCE GeneReport for Unigene cluster for KRT40 Gene Hs.534929

mRNA Expression by UniProt/SwissProt for KRT40 Gene

Q6A162-K1C40_HUMAN
Tissue specificity: Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).
genes like me logo Genes that share expressions with KRT40: view

Orthologs for KRT40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT40 36
  • 98.69 (n)
  • 97.45 (a)
KRT40 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRT40 36
  • 85.89 (n)
  • 83.26 (a)
KRT40 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRT40 36
  • 86.05 (n)
  • 83.49 (a)
KRT40 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krt40 36
  • 81.71 (n)
  • 79.53 (a)
Krt40 16
Krt40 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRT40 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRT40 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt40 36
  • 81.78 (n)
  • 79.77 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 38 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX469912.1 37
  • 19 (a)
ManyToMany
cyt1 37
  • 39 (a)
ManyToMany
cyt1l 37
  • 38 (a)
ManyToMany
krt1-19d 37
  • 36 (a)
ManyToMany
krt15 37
  • 36 (a)
ManyToMany
krt17 37
  • 38 (a)
ManyToMany
si:dkeyp-113d7.4 37
  • 33 (a)
ManyToMany
wu:fb17f05 37
  • 41 (a)
ManyToMany
zgc:109868 37
  • 37 (a)
ManyToMany
zgc:136902 37
  • 34 (a)
ManyToMany
zgc:153629 37
  • 35 (a)
ManyToMany
zgc:92035 37
  • 34 (a)
ManyToMany
zgc:92061 37
  • 39 (a)
ManyToMany
zgc:92533 37
  • 19 (a)
ManyToMany
Species with no ortholog for KRT40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT40 Gene

ENSEMBL:
Gene Tree for KRT40 (if available)
TreeFam:
Gene Tree for KRT40 (if available)

Paralogs for KRT40 Gene

Pseudogenes.org Pseudogenes for KRT40 Gene

genes like me logo Genes that share paralogs with KRT40: view

Variants for KRT40 Gene

Sequence variations from dbSNP and Humsavar for KRT40 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs713430 -- 40,981,463(+) ATTGT(C/T)ATCAA intron-variant
rs713431 -- 40,981,793(+) GTCTA(A/G)GGGTT intron-variant
rs713432 -- 40,981,698(+) GGGTG(A/G)CATAA intron-variant
rs713433 -- 40,981,785(+) CTGGC(A/G)CTGTC intron-variant
rs713434 -- 40,981,473(+) ACAAA(C/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRT40 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
esv22517 CNV Loss 19812545

Relevant External Links for KRT40 Gene

HapMap Linkage Disequilibrium report
KRT40

Disorders for KRT40 Gene

Relevant External Links for KRT40

Genetic Association Database (GAD)
KRT40
genes like me logo Genes that share disorders with KRT40: view

No data available for UniProtKB/Swiss-Prot for KRT40 Gene

Publications for KRT40 Gene

  1. Comprehensive analysis of keratin gene clusters in humans and rodents. (PMID: 15085952) Hesse M. … Magin T.M. (Eur. J. Cell Biol. 2004) 3 4
  2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers M.A. … Schweizer J. (Differentiation 2004) 3 4
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J. … Wright M.W. (J. Cell Biol. 2006) 2 3
  4. Novel type I hair keratins K39 and K40 are the last to be expressed in differentiation of the hair: completion of the human hair keratin catalog. (PMID: 17301834) Langbein L. … Schweizer J. (J. Invest. Dermatol. 2007) 3 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KRT40 Gene

Sources for KRT40 Gene

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