Aliases for KRT4 Gene
External Ids for KRT4 Gene
Previous HGNC Symbols for KRT4 Gene
Previous GeneCards Identifiers for KRT4 Gene
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT4 Gene
KRT4 (Keratin 4, Type II) is a Protein Coding gene. Diseases associated with KRT4 include white sponge nevus 1 and white sponge nevus of cannon, krt4-related. Among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT82.